LOCUS       NM_001320768            3099 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens cysteine and tyrosine rich 1 (CYYR1), transcript
            variant 1, mRNA.
ACCESSION   NM_001320768 XM_011529449
VERSION     NM_001320768.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Perron,T., Boissan,M., Bieche,I., Courtois,L., Dingli,F., Loew,D.,
            Chouchene,M., Colasse,S., Levy,L. and Prunier,C.
  TITLE     CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and
            is associated with favorable prognosis in breast cancer
  JOURNAL   J Biol Chem 300 (9), 107601 (2024)
   PUBMED   39059493
  REMARK    GeneRIF: CYYR1 promotes the degradation of the E3 ubiquitin ligase
            WWP1 and is associated with favorable prognosis in breast cancer.
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Casadei,R., Pelleri,M.C., Vitale,L., Facchin,F., Canaider,S.,
            Strippoli,P., Vian,M., Piovesan,A., Bianconi,E., Mariani,E.,
            Piva,F. and Frabetti,F.
  TITLE     Characterization of human gene locus CYYR1: a complex
            multi-transcript system
  JOURNAL   Mol Biol Rep 41 (9), 6025-6038 (2014)
   PUBMED   24981926
  REMARK    GeneRIF: New CYYR1 alternative isoforms were identified and
            characterized.
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
            Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
            Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
            Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
            Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
            Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
            Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
            Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
            Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
            Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
            Rotter,J.I., Soler Artigas,M., Starr,J.M., Uitterlinden,A.G.,
            Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
            Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
            Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
            Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
            and Stricker,B.H.
  TITLE     Genome-wide association studies identify CHRNA5/3 and HTR4 in the
            development of airflow obstruction
  JOURNAL   Am J Respir Crit Care Med 186 (7), 622-632 (2012)
   PUBMED   22837378
REFERENCE   4  (bases 1 to 3099)
  AUTHORS   Vitale,L., Frabetti,F., Huntsman,S.A., Canaider,S., Casadei,R.,
            Lenzi,L., Facchin,F., Carinci,P., Zannotti,M., Coppola,D. and
            Strippoli,P.
  TITLE     Sequence, 'subtle' alternative splicing and expression of the CYYR1
            (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors
  JOURNAL   BMC Cancer 7, 66 (2007)
   PUBMED   17442112
  REMARK    GeneRIF: A new 'subtle' splicing isoform (CAG+) of CYYR1 mRNA, the
            sequence & expression of this gene were defined in a series of NE
            tumors. This CAG+ codon determines the presence of an Ala residue
            at the exon 3/exon 4 junction of the CYYR1 mRNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3099)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
REFERENCE   6  (bases 1 to 3099)
  AUTHORS   Vitale,L., Casadei,R., Canaider,S., Lenzi,L., Strippoli,P.,
            D'Addabbo,P., Giannone,S., Carinci,P. and Zannotti,M.
  TITLE     Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on
            human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich
            protein and defines a new family of highly conserved
            vertebrate-specific genes
  JOURNAL   Gene 290 (1-2), 141-151 (2002)
   PUBMED   12062809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC382466.1, AK054581.1, AK223576.1, AF401639.1 and BX100308.1.
            
            On Nov 7, 2018 this sequence version replaced NM_001320768.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.138805.1,
                                           SRR1803611.28666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000652641.2/
                                                ENSP00000498505.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC382466.1         28-29
            3-165               AK054581.1         1-163
            166-1336            AK223576.1         1-1171
            1337-2432           AF401639.1         1057-2152
            2433-3099           BX100308.1         17-683
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..3099
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="cysteine and tyrosine rich 1"
                     /db_xref="GeneID:116159"
                     /db_xref="HGNC:HGNC:16274"
                     /db_xref="MIM:616020"
     exon            1..419
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..814
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; proline-rich domain-containing protein;
                     cysteine/tyrosine-rich 1"
                     /codon_start=1
                     /product="cysteine and tyrosine-rich protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001307697.2"
                     /db_xref="CCDS:CCDS93083.1"
                     /db_xref="GeneID:116159"
                     /db_xref="HGNC:HGNC:16274"
                     /db_xref="MIM:616020"
                     /translation="MDAPRLPVRPGVLLPKLVLLFVYADDCLAQCGKDCKSYCCDGTT
                     PYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTT
                     HINTVSSYPAGPPPYGHDHEMEYCADLPPPYSPTPQGPAQRSPPPPYPGNARK"
     exon            420..522
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            523..680
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /inference="alignment:Splign:2.1.0"
     exon            681..3099
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="hexamer: AATAAA"
     polyA_site      2050
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="major polyA site"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="hexamer: AATAAA"
     polyA_site      3099
                     /gene="CYYR1"
                     /gene_synonym="C21orf95"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgttg ccacccgcgg agatgaaatg tgagcctggg tggccaagga cgccggagtg
       61 gccgccttcc ccgcgcctga gcgcagtggg gcgagacaaa gagacctggg cccccagcgc
      121 agcccgtctc gggccacggg cgccccagct ccgcggagtc ccgcagtcgc tggcccggga
      181 cgcgcccggc ccgggctccc ttggaaggct ccctaggcaa tggccgggtc tctgctccac
      241 ccggctctca ggagcgctgc tctctccatc tgatcgccct ccatcctccc cattccctcc
      301 ggttccgggc tctcccttcg ctccaagcct caggccaccg gcttggatgg acgctccgag
      361 gctacccgtg cgtccagggg tcttgcttcc gaagttggtc ctgctctttg tctacgcaga
      421 tgattgcctt gctcagtgtg gcaaagattg caaatcttac tgctgtgatg gaaccacgcc
      481 ctactgttgc tcctactacg cttatattgg gaatatcctc tcgggcactg caattgcggg
      541 cattgttttt ggaatagtat ttatcatggg ggtcattgct gggattgcca tatgcatctg
      601 catgtgcatg aagaaccaca gggcgacccg cgtgggcatc ctcaggacga ctcacatcaa
      661 caccgtctcc tcctatcctg caggaccacc accctacggt cacgaccacg agatggaata
      721 ctgtgcagac ttgcctcctc catactcccc caccccacag ggtccagcac agcgttctcc
      781 accccctcct tatcctggaa acgcaaggaa ataatctatc tcccagaaca gaacatgtgc
      841 caatgggcga tcttgcctgg aataaaatgc ctctactcag aaacaggcag gaaagaattg
      901 ctccaaggaa tactttttgg ggtcagataa tgtgtcaggt ggaatatccc tgctaggaga
      961 tataggattt ctactctgct caaagctgac cccatctgga gtattaatgt ttggttctat
     1021 ggaaccacat tttaagagat ctgctgatcc acctaagcac attcagggaa gagtaatgta
     1081 attgacaaaa tatctgataa tcatgttgtt taagggctag gtgaagaaag tttcagtatt
     1141 gatcctggaa aaaaagaaga tctaagtagg atgggagaat gatttggccc acacaaggaa
     1201 gcaactttat tctatatagc tttaaaagtc agaactagaa ttgttcattc tttcattcat
     1261 caataaatgt attttgagtg cctaagagtt tactatgtgc ctagcactgt ttgaggtcct
     1321 gatggaagtt acaggacggg tactctggtt ttagtacaag aaagagcaat gactagattg
     1381 ctttgtgaag ctcttggtag agacacgctc cagaagggat aacaaaatca aatagtagat
     1441 gggttcattg ggcctcagaa gttctgctcg tattttaggt gggtgtgaag tgaatttcta
     1501 tatgtccagg agtgaataca acagaaagag ttggatctta tttatttaat tagggagtta
     1561 aaacaagacc aaaaagactc aacagccgct tgaagccaag aactcttcaa tgccagctac
     1621 tgccacctaa aaatcatctg gctttatagt ggatcagaat aaaggttatt ctaactgtgg
     1681 ggagaaaaaa aaaattgtat caagttccac aggtagcaga cacttcactt ccaagtaaaa
     1741 gatgagaaat caattattcc cacaggattt taggtcaggg agcaaaaatc tcagaacttg
     1801 accatgaaga tacacaacag actcgcaaaa ataaagtggg aaatgaagtt cagattccct
     1861 tctgtagatt tccttaaaac tattattttt ttcttcttcg taaaattttg ataatctgtt
     1921 ctcttaaaaa agttaatgac acaattaaga tactgacatc aaattgttgc cttttaccaa
     1981 aatgcaaatt ttatgaagtg cctaccttta tatgtataaa gcatttaata aataattcta
     2041 atgtgccata ttttgctgtg agtgacctta acatttatat ttttatatga attgtttcat
     2101 gtatttataa aaattgtata ttgaacattg gaaatagatg attagatttt tgtgtcattt
     2161 tacaattaaa tctaaaatgc ttaatccaat atcatcatca aaattcagtg aaatcccaaa
     2221 acagtgccaa gaattttgct gaatgaaaca atcaaacaaa gcattttaag gtgtaagtta
     2281 tagtacctgt acttgcagat aagaagctta ctatatcatt attataagta gcatatatta
     2341 ctttcaaata cctatattag aaagatattg atctgactga aatataacct acctgccagt
     2401 aaggtccaaa ggctgaattt gttttgaatg agttccttga tctttaagca ctgatgattt
     2461 tcttatatat gaggatgcaa agcattcaag agtttcagcc tgttctggtg aggggctccc
     2521 tgacttacat aaagttttca gtgcaatttt aatagtacat atgctttaat ttatttttct
     2581 tctgcgtgtg gtcagaccca attacactgt ggctaagact ctcaaagtgc cagggtttct
     2641 gtgatgattc tgagaatgct gaatacaaat ataccttata ttctttaagg aaaacggaaa
     2701 ggaaagatca gcagaaatag ggttttctca tcttcaccat caataaacat ttattgcgta
     2761 cctcctatat tctgcaaatt ttccccaaat agaagccagt tcagtccaca ccatctcttc
     2821 tttgagttgt ttatggcctc ccttaaggca ttttacaaac ccataagcct acaatagatg
     2881 agtattttta ctatttgtat taagtgtcat aatagcatca atgtgcacat taccagtata
     2941 gactgttgga gttcactgat tgttttcata gatgatgctt cttggggaaa aatagtatag
     3001 gatgtgaaag ttttgaatta cggttattta aaaactaaca tttgctatgg ccaaagtgtt
     3061 tacaataagc aataaagtga aagaacctat tataacaca
//
