LOCUS       NM_018659                989 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cytokine like 1 (CYTL1), mRNA.
ACCESSION   NM_018659
VERSION     NM_018659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Zhou,F., Lin,Q. and Zheng,Z.
  TITLE     Cytokine-Like Protein 1 (CYTL1) as a Key Target of M-Stage Immune
            Infiltration in Stomach Adenocarcinoma
  JOURNAL   Biomed Res Int 2023, 2926218 (2023)
   PUBMED   36825034
  REMARK    GeneRIF: Cytokine-Like Protein 1 (CYTL1) as a Key Target of M-Stage
            Immune Infiltration in Stomach Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Xue,W., Li,X., Li,W., Wang,Y., Jiang,C., Zhou,L., Gao,J., Yu,Y.,
            Shen,Y. and Xu,Q.
  TITLE     Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to
            inhibit metabolic reprogramming in breast cancer
  JOURNAL   Signal Transduct Target Ther 7 (1), 35 (2022)
   PUBMED   35115484
  REMARK    GeneRIF: Intracellular CYTL1, a novel tumor suppressor, stabilizes
            NDUFV1 to inhibit metabolic reprogramming in breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Sevin,M., Debeurme,F., Laplane,L., Badel,S., Morabito,M.,
            Newman,H.L., Torres-Martin,M., Yang,Q., Badaoui,B.,
            Wagner-Ballon,O., Saada,V., Selimoglu-Buet,D., Kraus-Berthier,L.,
            Banquet,S., Derreal,A., Fenaux,P., Itzykson,R., Braun,T.,
            Etienne,G., Berthon,C., Thepot,S., Kepp,O., Kroemer,G., Padron,E.,
            Figueroa,M.E., Droin,N. and Solary,E.
  TITLE     Cytokine-like protein 1-induced survival of monocytes suggests a
            combined strategy targeting MCL1 and MAPK in CMML
  JOURNAL   Blood 137 (24), 3390-3402 (2021)
   PUBMED   33690800
  REMARK    GeneRIF: Cytokine-like protein 1-induced survival of monocytes
            suggests a combined strategy targeting MCL1 and MAPK in CMML.
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Zhu,W., Yang,X., Liu,S., Wang,M., Ye,S., Luo,H. and Cui,S.
  TITLE     The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and
            cartilage metabolism
  JOURNAL   Biochem Biophys Res Commun 529 (3), 608-614 (2020)
   PUBMED   32736681
  REMARK    GeneRIF: The involvement of cytokine-like 1 (Cytl1) in
            chondrogenesis and cartilage metabolism.
REFERENCE   5  (bases 1 to 989)
  AUTHORS   Zhu,S., Kuek,V., Bennett,S., Xu,H., Rosen,V. and Xu,J.
  TITLE     Protein Cytl1: its role in chondrogenesis, cartilage homeostasis,
            and disease
  JOURNAL   Cell Mol Life Sci 76 (18), 3515-3523 (2019)
   PUBMED   31089746
  REMARK    Review article
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Deng,X., Zhao,H.S., Peng,Z., Deng,W.W., Li,N., Guo,S. and Shi,T.P.
  TITLE     [Study on the mechanism of C17orf62 induced cell death]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 43 (2), 168-172 (2011)
   PUBMED   21503106
  REMARK    GeneRIF: C17orf62-L could induce cell death accompanied with rising
            of cleaved PARP.
REFERENCE   7  (bases 1 to 989)
  AUTHORS   Tomczak,A. and Pisabarro,M.T.
  TITLE     Identification of CCR2-binding features in Cytl1 by a CCL2-like
            chemokine model
  JOURNAL   Proteins 79 (4), 1277-1292 (2011)
   PUBMED   21322034
  REMARK    GeneRIF: We report a structural-functional characterization of
            cytokine-like protein 1 (Cytl1) by a combination of different
            computational structure-based techniques.
REFERENCE   8  (bases 1 to 989)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 989)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 989)
  AUTHORS   Liu,X., Rapp,N., Deans,R. and Cheng,L.
  TITLE     Molecular cloning and chromosomal mapping of a candidate cytokine
            gene selectively expressed in human CD34+ cells
  JOURNAL   Genomics 65 (3), 283-292 (2000)
   PUBMED   10857752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108139.5.
            
            On Nov 23, 2018 this sequence version replaced NM_018659.2.
            
            Summary: C17 is a cytokine-like protein specifically expressed in
            bone marrow and cord blood mononuclear cells that bear the CD34
            (MIM 142230) surface marker (Liu et al., 2000 [PubMed
            10857752]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031391.1, AF193766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307746.9/ ENSP00000303550.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC108139.5         37783-37948         c
            167-211             AC108139.5         35625-35669         c
            212-340             AC108139.5         35326-35454         c
            341-989             AC108139.5         33076-33724         c
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..989
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /note="cytokine like 1"
                     /db_xref="GeneID:54360"
                     /db_xref="HGNC:HGNC:24435"
                     /db_xref="MIM:607930"
     exon            1..166
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..424
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /note="cytokine-like protein C17; cytokine-like protein 1"
                     /codon_start=1
                     /product="cytokine-like protein 1 precursor"
                     /protein_id="NP_061129.1"
                     /db_xref="CCDS:CCDS3379.1"
                     /db_xref="GeneID:54360"
                     /db_xref="HGNC:HGNC:24435"
                     /db_xref="MIM:607930"
                     /translation="MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNL
                     LQVSEPSEPCVRYLPRLYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTI
                     MNSFCRRDLVFLLDDCNALEYPIPVTTVLPDRQR"
     exon            167..211
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            212..340
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..989
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      964..969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /note="hexamer: AATAAA"
     polyA_site      989
                     /gene="CYTL1"
                     /gene_synonym="C17; C4orf4"
                     /note="major polyA site"
ORIGIN      
        1 agcgcctggc accatgagga cgcctgggcc tctgcccgtg ctgctgctgc tcctggcggg
       61 agcccccgcc gcgcggccca ctcccccgac ctgctactcc cgcatgcggg ccctgagcca
      121 ggagatcacc cgcgacttca acctcctgca ggtctcggag ccctcggagc catgtgtgag
      181 atacctgccc aggctgtacc tggacataca caattactgt gtgctggaca agctgcggga
      241 ctttgtggcc tcgcccccgt gttggaaagt ggcccaggta gattccttga aggacaaagc
      301 acggaagctg tacaccatca tgaactcgtt ctgcaggaga gatttggtat tcctgttgga
      361 tgactgcaat gccttggaat acccaatccc agtgactacg gtcctgccag atcgtcagcg
      421 ctaagggaac tgagaccaga gaaagaaccc aagagaacta cagttatgtc agctacccag
      481 acttaatggg ccagagccat gaccctcaca ggtcttgtgt tagttgtatc tgaaactgtt
      541 atgtatctct ctaccttctg gaaaacaggg ctggtattcc tacccaggaa cctcctttga
      601 gcatagagtt agcaaccatg cttctcattc ccttgactca tgtcttgcca ggatggttag
      661 atacacagca tgttgatttg gtcactaaaa agaagaaaag gactaacaag cttcactttt
      721 atgaacaact attttgagaa cttgcacaat agtatgtttt tattactggt ttaatggagt
      781 aatggtactt ttattctttc ttgatagaaa cctgcttaca tttaaccaag cttctattat
      841 gcctttttct aacacagact ttcttcactg tctttcattt aaaaagaaat taatgctctt
      901 aagatatata ttttacgtag tgctgacagg acccactctt tcattgaaag gtgatgaaaa
      961 tcaaataaag aatctcttca catgagaaa
//
