LOCUS       NM_004288               2207 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytohesin 1 interacting protein (CYTIP), mRNA.
ACCESSION   NM_004288
VERSION     NM_004288.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Tompkins,N., MacKenzie,B., Ward,C., Salgado,D., Leidal,A.,
            McCormick,C. and Pohajdak,B.
  TITLE     Cytohesin-associated scaffolding protein (CASP) is involved in
            migration and IFN-gamma secretion in natural killer cells
  JOURNAL   Biochem Biophys Res Commun 451 (2), 165-170 (2014)
   PUBMED   25058460
  REMARK    GeneRIF: CASP has a direct role in the secretion of IFN-gamma, and
            NK cell motility and ability to kill tumor cells. CASP polarizes to
            the leading edge of migrating NK cells, and to the immunological
            synapse when engaged with tumor cells.
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Boehm,T., Hofer,S., Winklehner,P., Kellersch,B., Geiger,C.,
            Trockenbacher,A., Neyer,S., Fiegl,H., Ebner,S., Ivarsson,L.,
            Schneider,R., Kremmer,E., Heufler,C. and Kolanus,W.
  TITLE     Attenuation of cell adhesion in lymphocytes is regulated by CYTIP,
            a protein which mediates signal complex sequestration
  JOURNAL   EMBO J 22 (5), 1014-1024 (2003)
   PUBMED   12606567
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Mansour,M., Lee,S.Y. and Pohajdak,B.
  TITLE     The N-terminal coiled coil domain of the cytohesin/ARNO family of
            guanine nucleotide exchange factors interacts with the scaffolding
            protein CASP
  JOURNAL   J Biol Chem 277 (35), 32302-32309 (2002)
   PUBMED   12052827
  REMARK    GeneRIF: observations suggest that CASP is a scaffolding protein
            that facilitates the function of at least one member of the
            cytohesin/ARNO family in response to specific cellular stimuli
REFERENCE   8  (bases 1 to 2207)
  AUTHORS   Tang,P., Cheng,T.P., Agnello,D., Wu,C.Y., Hissong,B.D.,
            Watford,W.T., Ahn,H.J., Galon,J., Moss,J., Vaughan,M., O'Shea,J.J.
            and Gadina,M.
  TITLE     Cybr, a cytokine-inducible protein that binds cytohesin-1 and
            regulates its activity
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2625-2629 (2002)
   PUBMED   11867758
REFERENCE   9  (bases 1 to 2207)
  AUTHORS   Kim,H.S.
  TITLE     Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band
            q11.2 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 95 (1999)
   PUBMED   10343115
REFERENCE   10 (bases 1 to 2207)
  AUTHORS   Dixon,B., Sahely,B., Liu,L. and Pohajdak,B.
  TITLE     Cloning a cDNA from human NK/T cells which codes for an unusual
            leucine zipper containing protein
  JOURNAL   Biochim Biophys Acta 1216 (2), 321-324 (1993)
   PUBMED   8241278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB219691.1, BC036449.2 and
            AC019201.6.
            
            On Nov 23, 2018 this sequence version replaced NM_004288.4.
            
            Summary: The protein encoded by this gene contains 2 leucine zipper
            domains and a putative C-terminal nuclear targeting signal, but
            does not have any hydrophobic regions. This protein is expressed
            weakly in resting NK and T cells. The encoded protein modulates the
            activation of ARF genes by CYTH1. This protein interacts with CYTH1
            and SNX27 proteins and may act to sequester CYTH1 protein in the
            cytoplasm.[provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036449.2, SRR1803613.251262.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264192.8/ ENSP00000264192.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DB219691.1         5-43
            40-1825             BC036449.2         1-1786
            1826-1826           AC019201.6         82125-82125         c
            1827-2207           BC036449.2         1788-2168
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.1"
     gene            1..2207
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="cytohesin 1 interacting protein"
                     /db_xref="GeneID:9595"
                     /db_xref="HGNC:HGNC:9506"
                     /db_xref="MIM:604448"
     exon            1..243
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1149
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="cytohesin binding protein HE; cytohesin binder and
                     regulator; cbp HE; cytohesin-associated scaffolding
                     protein; pleckstrin homology Sec7 and coiled-coil
                     domains-binding protein"
                     /codon_start=1
                     /product="cytohesin-interacting protein"
                     /protein_id="NP_004279.3"
                     /db_xref="CCDS:CCDS2204.1"
                     /db_xref="GeneID:9595"
                     /db_xref="HGNC:HGNC:9506"
                     /db_xref="MIM:604448"
                     /translation="MSLQRLLQHSSNGNLADFCAGPAYSSYSTLTGSLTMDDNRRIQM
                     LADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNA
                     CSSEMFTLICKIQEDSPAHCAGLQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTI
                     ETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDL
                     DELSLFGPLPGPGPALVDRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSR
                     QTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMFGTLPRKSRK
                     GSVRKQLLKFIPGLHRAVEEEESRF"
     exon            244..293
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            294..348
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            349..451
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            452..545
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            546..615
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            616..682
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2207
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="hexamer: AATAAA"
     polyA_site      1515
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="major polyA site"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="major polyA site"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="CYTIP"
                     /gene_synonym="B3-1; CASP; CYBR; CYTHIP; HE; PSCDBP"
ORIGIN      
        1 gtacttttag cttcccccat cctgcaaggc cactcaacca tgtgctagct ggagtgatct
       61 ttattcacaa tgtctttaca aaggctcctg caacacagca gcaatggcaa tttggcggac
      121 ttctgcgctg ggccagcgta tagctcttac tccacactca ccggcagcct tacgatggac
      181 gataatagaa ggattcaaat gctagcagac acggtggcta ctctgcctcg gggacgaaag
      241 cagcttgctt tgaccagatc aagttcttta agtgactttt cctggtctca aagaaagctt
      301 gttactgtgg agaagcagga taatgaaaca tttggatttg aaattcagtc ttacaggccc
      361 cagaatcaga atgcctgctc ctcggaaatg ttcactttga tatgcaaaat acaggaggac
      421 agcccagctc actgtgctgg cctgcaagct ggtgatgtcc ttgcaaatat caatggtgtg
      481 agcacagaag gttttaccta caaacaagtc gttgacctga tcagatcgtc cggaaacctg
      541 ctaacgatag agactcttaa tggaacaatg attctgaaaa gaacggagct tgaagcaaag
      601 ctgcaggttt taaagcaaac tttgaaacaa aaatgggtgg agtacagatc tctgcagtta
      661 caggaacatc gtctgcttca tggtgatgca gctaattgcc ccagtttgga aaacatggac
      721 ttggatgaat tgtctttgtt tggacccctg cctgggccag gcccagccct tgtggaccgg
      781 aatcgattat ccagtgagag cagctgtaag agctggctga gctccatgac gatggacagt
      841 gaagatggct accagacgtg tgtgtctgag gactccagca ggggtgcctt cagtcggcag
      901 acgagtacag atgatgagtg ctttatcccc aaggaggggg atgattttct gaggaggtca
      961 tcttcaagga ggaaccggag catcagtaac accagcagcg gatccatgtc tcccttgtgg
     1021 gagggcaact tatcaagcat gtttgggacc ctgccccgga agagcagaaa gggaagtgtc
     1081 cgaaagcaac tcttgaaatt tatccctggc cttcatcgtg ctgtggaaga ggaagaaagt
     1141 cgcttttgac ggattgtggt gtcctttcaa attagcttat ttcacaaata tctctagact
     1201 cacccagatc ccagcttggt gggaaagtgc agaagaattg caaaactgac atcccatttc
     1261 acagcaatag tgacctttat ttaaattgtt gtgttatagt ttatgcttct taaatcattt
     1321 ttcaacctaa acagccaatt tctaagcaga caggaaaact aaataataag ttaattaata
     1381 taacaaagat gcaggttcct gctcattcca gtaatgtctt tgaaagcaaa actaatattt
     1441 attttctaga ttatccctgt gaataattga gaactttttg gagtcaagta tgaataaagg
     1501 tgtggcagaa tataataatc tggactattt tctataggat aattgctggg ttataaaatc
     1561 ttaggtttgc ttatgcccag tagctcctgc ggaggcttaa taataggcaa ttttgaattt
     1621 gttcaaacct gtaatggctt gtaaacaaag atgaccatca gctgtttctc acatctatag
     1681 tgacaataaa gcgggaagta taagatttaa taggaggggt taaggttcat gagaaccatg
     1741 gaaagatgtg gtctgagatg ggtgctgcaa agatcataat aaagtcattt ttatagacag
     1801 tctaaacaaa atgggtgggg atgtcgtgtt ttttgcccaa ttcagctttt gttctgcctg
     1861 aacattaatg gcaagtctag aactctccga atcctacagc tttgtaattt tttttctaca
     1921 aatgtctaac atccaaaact gagggttggg aaaaggactt ccctcctgta gtttttttca
     1981 tattacttct cactttatat cttatattct aaatagctat cacctcagca gtcttttgcc
     2041 tattggttat gttagtatca cattacttct agcctttcaa ttactccatg ttttatttaa
     2101 tatccattga agtctatgaa ttctctgttc tggtggcaca gctattcata acctatattc
     2161 tagagtagac aatctggact atgtaataaa tagtctgctg attttaa
//
