LOCUS       NM_004228               4443 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytohesin 2 (CYTH2), transcript variant 2, mRNA.
ACCESSION   NM_004228
VERSION     NM_004228.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4443)
  AUTHORS   Viegas,A., Yin,D.M., Borggrafe,J., Viennet,T., Falke,M.,
            Schmitz,A., Famulok,M. and Etzkorn,M.
  TITLE     Molecular Architecture of a Network of Potential Intracellular EGFR
            Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment
  JOURNAL   Structure 28 (1), 54-62 (2020)
   PUBMED   31780432
  REMARK    GeneRIF: Molecular Architecture of a Network of Potential
            Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the
            Juxtamembrane Segment.
REFERENCE   4  (bases 1 to 4443)
  AUTHORS   Luong,P., Hedl,M., Yan,J., Zuo,T., Fu,T.M., Jiang,X.,
            Thiagarajah,J.R., Hansen,S.H., Lesser,C.F., Wu,H., Abraham,C. and
            Lencer,W.I.
  TITLE     INAVA-ARNO complexes bridge mucosal barrier function with
            inflammatory signaling
  JOURNAL   Elife 7, e38539 (2018)
   PUBMED   30355448
  REMARK    GeneRIF: INAVA-CUPID exhibits dual functions, coordinated directly
            by ARNO, that bridge epithelial barrier function with extracellular
            signals and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4443)
  AUTHORS   Manzanillo,P., Mouchess,M., Ota,N., Dai,B., Ichikawa,R., Wuster,A.,
            Haley,B., Alvarado,G., Kwon,Y., Caothien,R., Roose-Girma,M.,
            Warming,S., McKenzie,B.S., Keir,M.E., Scherl,A., Ouyang,W. and
            Yi,T.
  TITLE     Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates
            Intestinal Epithelial Permeability
  JOURNAL   Immunohorizons 2 (5), 164-171 (2018)
   PUBMED   31022698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4443)
  AUTHORS   Mossessova,E., Gulbis,J.M. and Goldberg,J.
  TITLE     Structure of the guanine nucleotide exchange factor Sec7 domain of
            human arno and analysis of the interaction with ARF GTPase
  JOURNAL   Cell 92 (3), 415-423 (1998)
   PUBMED   9476900
REFERENCE   7  (bases 1 to 4443)
  AUTHORS   Frank,S., Upender,S., Hansen,S.H. and Casanova,J.E.
  TITLE     ARNO is a guanine nucleotide exchange factor for ADP-ribosylation
            factor 6
  JOURNAL   J Biol Chem 273 (1), 23-27 (1998)
   PUBMED   9417041
REFERENCE   8  (bases 1 to 4443)
  AUTHORS   Meacci,E., Tsai,S.C., Adamik,R., Moss,J. and Vaughan,M.
  TITLE     Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for
            ADP-ribosylation factor
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1745-1748 (1997)
   PUBMED   9050849
REFERENCE   9  (bases 1 to 4443)
  AUTHORS   Chardin,P., Paris,S., Antonny,B., Robineau,S., Beraud-Dufour,S.,
            Jackson,C.L. and Chabre,M.
  TITLE     A human exchange factor for ARF contains Sec7- and
            pleckstrin-homology domains
  JOURNAL   Nature 384 (6608), 481-484 (1996)
   PUBMED   8945478
REFERENCE   10 (bases 1 to 4443)
  AUTHORS   Kolanus,W., Nagel,W., Schiller,B., Zeitlmann,L., Godar,S.,
            Stockinger,H. and Seed,B.
  TITLE     Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by
            cytohesin-1, a cytoplasmic regulatory molecule
  JOURNAL   Cell 86 (2), 233-242 (1996)
   PUBMED   8706128
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC344850.1, X99753.1,
            AC008403.8 and BC012771.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004228.6.
            
            Summary: The protein encoded by this gene is a member of the PSCD
            family. Members of this family have identical structural
            organization that consists of an N-terminal coiled-coil motif, a
            central Sec7 domain, and a C-terminal pleckstrin homology (PH)
            domain. The coiled-coil motif is involved in homodimerization, the
            Sec7 domain contains guanine-nucleotide exchange protein (GEP)
            activity, and the PH domain interacts with phospholipids and is
            responsible for association of PSCDs with membranes. Members of
            this family appear to mediate the regulation of protein sorting and
            membrane trafficking. The encoded protein exhibits GEP activity in
            vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) lacks a 3-nucleotide exon in
            the PH domain region, compared to variant 1. This results in a
            protein (isoform 2)  missing a single glycine residue, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.194741.1,
                                           SRR3476690.267525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452733.7/ ENSP00000408236.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               DC344850.1         162-300
            140-153             X99753.1           1-14
            154-154             AC008403.8         53036-53036
            155-960             X99753.1           16-821
            961-961             AC008403.8         61596-61596
            962-1339            X99753.1           823-1200
            1340-4052           AC008403.8         62725-65437
            4053-4443           BC012771.2         906-1296
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4443
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /note="cytohesin 2"
                     /db_xref="GeneID:9266"
                     /db_xref="HGNC:HGNC:9502"
                     /db_xref="MIM:602488"
     exon            1..158
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1339
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pleckstrin homology, Sec7 and coiled/coil domains 2
                     (cytohesin-2); ARF nucleotide-binding site opener; ARF
                     exchange factor; PH, SEC7 and coiled-coil
                     domain-containing protein 2; pleckstrin homology, Sec7 and
                     coiled-coil domains 2; CTC-273B12.8"
                     /codon_start=1
                     /product="cytohesin-2 isoform 2"
                     /protein_id="NP_004219.3"
                     /db_xref="CCDS:CCDS12722.1"
                     /db_xref="GeneID:9266"
                     /db_xref="HGNC:HGNC:9502"
                     /db_xref="MIM:602488"
                     /translation="MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAM
                     SEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYK
                     GEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKI
                     DRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
                     GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTW
                     KRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLI
                     KACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISV
                     KKKQEQP"
     exon            159..306
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            307..373
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            374..492
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            493..573
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            574..686
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            687..835
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            836..947
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1024
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1096
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1251
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..4443
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1512
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /note="major polyA site"
     regulatory      4422..4427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /note="hexamer: ATTAAA"
     polyA_site      4443
                     /gene="CYTH2"
                     /gene_synonym="ARNO; CTS18; CTS18.1; cytohesin-2; PSCD2;
                     PSCD2L; SEC7L; Sec7p-L; Sec7p-like"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgagg actggcgctg aggaggcggc ggtggctccc ggggcgtttg agcgggctca
       61 cccgagcccg cgggccaacg cggatccagg cccgactggc gggaccgccc cggattcccc
      121 gcgggccttc ctagccgcca tggaggacgg cgtctatgaa cccccagacc tgactccgga
      181 ggagcggatg gagctggaga acatccggcg gcggaagcag gagctgctgg tggagattca
      241 gcgcctgcgg gaggagctca gtgaagccat gagcgaggtg gaggggctgg aggccaatga
      301 gggcagtaag accttgcaac ggaaccggaa gatggcaatg ggcaggaaga agttcaacat
      361 ggaccccaag aaggggatcc agttcttggt ggagaatgaa ctgctgcaga acacacccga
      421 ggagatcgcc cgcttcctgt acaagggcga ggggctgaac aagacagcca tcggggacta
      481 cctgggggag agggaagaac tgaacctggc agtgctccat gcttttgtgg atctgcatga
      541 gttcaccgac ctcaatctgg tgcaggccct caggcagttt ctatggagct ttcgcctacc
      601 cggagaggcc cagaaaattg accggatgat ggaggccttc gcccagcgat actgcctgtg
      661 caaccctggg gttttccagt ccacagacac gtgctatgtg ctgtccttcg ccgtcatcat
      721 gctcaacacc agtctccaca atcccaatgt ccgggacaag ccgggcctgg agcgctttgt
      781 ggccatgaac cggggcatca acgagggcgg ggacctgcct gaggagctgc tcaggaacct
      841 gtacgacagc atccgaaatg agcccttcaa gattcctgag gatgacggga atgacctgac
      901 ccacaccttc ttcaacccgg accgggaggg ctggctcctg aagctggggg gccgggtgaa
      961 gacgtggaag cggcgctggt ttatcctcac agacaactgc ctctactact ttgagtacac
     1021 cacggacaag gagccccgag gaatcatccc cctggagaat ctgagcatcc gagaggtgga
     1081 cgacccccgg aaaccgaact gctttgaact ttacatcccc aacaacaagg ggcagctcat
     1141 caaagcctgc aaaactgagg cggacggccg agtggtggag ggaaaccaca tggtgtaccg
     1201 gatctcggcc cccacgcagg aggagaagga cgagtggatc aagtccatcc aggcggctgt
     1261 gagtgtggac cccttctatg agatgctggc agcgagaaag aagcggattt cagtcaagaa
     1321 gaagcaggag cagccctgac cccctgcccc caactccatt atttattacg gagctgcccc
     1381 gcctgggtgg ccggacccct gggccttggg gctgtggatc ctggttccct gtttggaaaa
     1441 ttcaccacct ctagctcctc actgttcttt gtaattaaca cgctgttggt aatcttatta
     1501 attatttaac cacttggcct gctgaccccc tcatttcttg gggttgacag agtcgaggtg
     1561 ctccgtggag ccagcctgtt tccctggaca ggggcctgga cccgcctgtc tctgggtgct
     1621 gcctgggctg tcccggtggg tctgttctgg tttcaccccg agcccagcag gagtggagta
     1681 aagggagaag gttaatatgg tgggagtctg gagttggaat tggccgggga cagagtttag
     1741 aatgcaggga ttcagggtca aggtctagca ttcattctag aagttacttg acagccatca
     1801 gccagttacg ctacagccat cagctagttc ccatcgttgc tttcatgggg cttgaggtct
     1861 ttgaggggca ggagatgaag ctggtgaggt tgtgagctgg gccagggctt tgaggacaac
     1921 ctggagctgg aagaacatgc gaccacctca gggagggtca gggaaggatg agtggggagg
     1981 tggcccatgt cctgcaaggg ccttgctgat gggatgtcct gaagggctgg gcagccttag
     2041 atcgggctaa gagggcagga ctgtgggcca gtgccagagc caggcttgtc tgttctcaaa
     2101 ggatcagcct cctttggagg acattttgtg tcaaggatag ggctgaggac ctgcgttctg
     2161 aacgtctttc ctgggattct tgacagccaa agaaattcga ggatcgcctc tatgaaggtg
     2221 aagtcttggc atgtggggta cccctgaatc ctgggctaag gtctgtgacc ttttgccctc
     2281 cagttggggt atgtgtggtg tccccaaaga acaagggctc gtggatcccg agcagggtgc
     2341 gatggcggat tgggaggtcc catgtcactc tcccatgccc gcctttgaag ctgaggcgct
     2401 ctttagttaa caaactacaa gtcccagcag ggaccgggac gcgggtggga gaggcgcctg
     2461 tggccccgag gcgtgccgcg agttgtagtc cctcctgccc gctgtgttcg cttttgagct
     2521 ctccgatggg atgcggcgct tcggaatttc gggctttgat ccctgtcccg cccttggcca
     2581 caggcacctg ccggcctgaa ggcccccgcg gtgggggtac cctgcgcccc tccgcgggaa
     2641 ggtggactac agttatcggc aggctgtgcg gcgccaaagc cacggtgacc cagacccgag
     2701 gtttttccgg gcgtcgcagt ttcccgagac tccgtggcgg cgtttgtctt ctttttctta
     2761 gtcagatccc gtacttttgt ggagggtaga ggaggctttg accgccgcgg ccccgggggc
     2821 tggtgggaaa tggagttcca aatgagaaaa tagaattccc cacttctctt tcccacaggt
     2881 gccagggaaa cggagtcatc gacccaagaa ggtcgtggga gatgaggtcc cagggtaaac
     2941 agcgggtccc gccactatgt caccctttcc tgccgcctcc ccggatgaac tgcatgcagg
     3001 gcggccggct ccgtggcagg cagaggcagg aagaggcgcg gagcccgctg gtggcgaaga
     3061 ggggagtgcg gcgggagggg agggcagagg caggcggccg gtcgcgtggg gcctgggccg
     3121 ccccaggagg gcctctggct ggattcttag cagatggaag ccgtgcaagg gcaggaggca
     3181 ggggcctgac gtgtttggat tgaggttgca ggaggggccc ctggctgctt cagggagaat
     3241 aatttggagg cgagcgggga ggtgagagga agctgtgcgg tgcaggatgg cgtggctgtg
     3301 gaggtggaga acgttgggcc acgctaggag tcttgaaaga ggagccaaaa ggacttgctg
     3361 agagccgccg cagctggtga atgacggtgc catgactgag gtggtcgaaa gggagtattt
     3421 aaggggaaat caggcattcc gttttgacca aattaagctg gagatgcctg tggaacattc
     3481 cagccaggct gcatcacgtc acactgacct tcagcattgc ccacagtcca tcttccccca
     3541 ggacctgagg attttgcgtc cggctccctc ctcgcccagg acccccaagc tcccagcacg
     3601 cttctgattt tttttgtagg tttttttttt tgttttttgt tttgttttgt tttgtttttg
     3661 agagggagtc tcactttgtg ccctagactg gagtgcaatg gcgccatctc ggcttactgc
     3721 aacctccacc tcccaggtgc aagcgattcc cctgcctcag cttcccgagt agctgggatt
     3781 acagatgtga gccaccgtac ccagctaatt tttgtatttt tagtagagac ggggtttcac
     3841 catattggcc aagctggtct cgaactcctg acctcaggcg atccatctgt ctcagcctcc
     3901 caaagtgctg ggattacagg tgtgagccac cgcgccaggc ctcagcccac ttcttttggg
     3961 tggcaatggt ttggatatcg tttgtcctca ctaaaattca tgttgagatt cgagccccag
     4021 tgtggcaggt gttgggatgt ggggcctcat aaggagctgt gtggtcttgg aggtggagtc
     4081 ctcatggata gattaatgcc tgccttaagg ggtgagtgag tgctcaccct tgggaatttg
     4141 ggaatttggt tttctctccc ttgcttcctt cagcaccatg tgatctctgt gcacacagct
     4201 gcatccttct gccctccccc agaagcagca gcagcctcag ggatgaggga ggtcctcagt
     4261 gagtgcacct gcccagtctt gaaccttcca gccatcagaa tctgagccaa atcaacctct
     4321 tcctttataa agacccagcc tcaggtcttc tgtcagagca acacaaaatg gactcagcac
     4381 ggatcaaatt gtgtctcccc cacccccaca aaaaacttta tattaaaatc ctaaccccca
     4441 gca
//
