LOCUS       NM_001365037            3343 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cytohesin 1 (CYTH1), transcript variant 5, mRNA.
ACCESSION   NM_001365037 XM_017025337
VERSION     NM_001365037.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Bhatt,J.M., Hancock,W., Meissner,J.M., Kaczmarczyk,A., Lee,E.,
            Viktorova,E., Ramanadham,S., Belov,G.A. and Sztul,E.
  TITLE     Promiscuity of the catalytic Sec7 domain within the guanine
            nucleotide exchange factor GBF1 in ARF activation, Golgi
            homeostasis, and effector recruitment
  JOURNAL   Mol Biol Cell 30 (12), 1523-1535 (2019)
   PUBMED   30943106
  REMARK    GeneRIF: GBF1 alone maintains Golgi architecture; facilitates
            secretion; activates ADP-ribosylation factor (ARF)1, 3, 4, and 5;
            and recruits ARF effectors to Golgi membranes.
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Manzanillo,P., Mouchess,M., Ota,N., Dai,B., Ichikawa,R., Wuster,A.,
            Haley,B., Alvarado,G., Kwon,Y., Caothien,R., Roose-Girma,M.,
            Warming,S., McKenzie,B.S., Keir,M.E., Scherl,A., Ouyang,W. and
            Yi,T.
  TITLE     Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates
            Intestinal Epithelial Permeability
  JOURNAL   Immunohorizons 2 (5), 164-171 (2018)
   PUBMED   31022698
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Nagel,W., Zeitlmann,L., Schilcher,P., Geiger,C., Kolanus,J. and
            Kolanus,W.
  TITLE     Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion
            pathway and induces membrane recruitment of cytohesin-1
  JOURNAL   J Biol Chem 273 (24), 14853-14861 (1998)
   PUBMED   9614087
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Meacci,E., Tsai,S.C., Adamik,R., Moss,J. and Vaughan,M.
  TITLE     Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for
            ADP-ribosylation factor
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1745-1748 (1997)
   PUBMED   9050849
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Kolanus,W., Nagel,W., Schiller,B., Zeitlmann,L., Godar,S.,
            Stockinger,H. and Seed,B.
  TITLE     Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by
            cytohesin-1, a cytoplasmic regulatory molecule
  JOURNAL   Cell 86 (2), 233-242 (1996)
   PUBMED   8706128
REFERENCE   9  (bases 1 to 3343)
  AUTHORS   Dixon,B., Mansour,M. and Pohajdak,B.
  TITLE     Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by
            PCR analysis of somatic cell hybrids and fluorescence in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 63 (1), 42-44 (1993)
   PUBMED   8449036
REFERENCE   10 (bases 1 to 3343)
  AUTHORS   Liu,L. and Pohajdak,B.
  TITLE     Cloning and sequencing of a human cDNA from cytolytic NK/T cells
            with homology to yeast SEC7
  JOURNAL   Biochim Biophys Acta 1132 (1), 75-78 (1992)
   PUBMED   1511013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022966.13 and AC099804.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001365037.1.
            
            Summary: The protein encoded by this gene is a member of the PSCD
            family. Members of this family have identical structural
            organization that consists of an N-terminal coiled-coil motif, a
            central Sec7 domain, and a C-terminal pleckstrin homology (PH)
            domain. The coiled-coil motif is involved in homodimerization, the
            Sec7 domain contains guanine-nucleotide exchange protein activity,
            and the PH domain interacts with phospholipids and is responsible
            for association of PSCDs with membranes. Members of this family
            appear to mediate the regulation of protein sorting and membrane
            trafficking. This gene is highly expressed in natural killer and
            peripheral T cells, and regulates the adhesiveness of integrins at
            the plasma membrane of lymphocytes. A pseudogene of this gene has
            been defined on the X chromosome. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.131837.1,
                                           SRR1803616.171757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC022966.13        89074-89145         c
            73-155              AC099804.3         102323-102405       c
            156-220             AC099804.3         100870-100934       c
            221-287             AC099804.3         95211-95277         c
            288-406             AC099804.3         94795-94913         c
            407-487             AC099804.3         94344-94424         c
            488-600             AC099804.3         93004-93116         c
            601-749             AC099804.3         91493-91641         c
            750-861             AC099804.3         90942-91053         c
            862-938             AC099804.3         85090-85166         c
            939-1010            AC099804.3         73644-73715         c
            1011-1165           AC099804.3         72863-73017         c
            1166-1221           AC099804.3         69668-69723         c
            1222-3343           AC099804.3         66721-68842         c
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3343
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /note="cytohesin 1"
                     /db_xref="GeneID:9267"
                     /db_xref="HGNC:HGNC:9501"
                     /db_xref="MIM:182115"
     exon            1..72
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1193
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /note="isoform 4 is encoded by transcript variant 5;
                     pleckstrin homology, Sec7 and coiled-coil domains 1;
                     cytoadhesin 1; homolog of secretory protein SEC7; SEC7
                     homolog B2-1; PH, SEC7 and coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="cytohesin-1 isoform 4"
                     /protein_id="NP_001351966.1"
                     /db_xref="GeneID:9267"
                     /db_xref="HGNC:HGNC:9501"
                     /db_xref="MIM:182115"
                     /translation="MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEV
                     ANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLY
                     KGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQK
                     IDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMN
                     RGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKT
                     WKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQV
                     IKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKFQVSPGEP"
     exon            73..155
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            156..220
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            221..287
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            288..406
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            407..487
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            601..749
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            750..861
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            862..938
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1010
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1165
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1221
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..3343
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3318..3323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /note="hexamer: AATAAA"
     polyA_site      3343
                     /gene="CYTH1"
                     /gene_synonym="B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgggac gcgagcggcg agccggagcg cggagcccgg ctcccgcacc atggaggagg
       61 acgacagcta cgttcccagt gacctgacag cagaggagcg tcaagaactg gagaacatcc
      121 gacggagaaa acaggagctg ctggctgaca ttcagaggct gaaggatgag atagcagaag
      181 tagctaatga aattgaaaac ctgggatcca cagaggaaag gaaaaacatg cagaggaaca
      241 aacaggtagc catgggcagg aaaaaattta atatggaccc taaaaagggg atccagttct
      301 taatagagaa cgacctcctg aagaacactt gtgaagacat tgcccagttc ttatataaag
      361 gcgaagggct caacaagaca gccatcggcg actacctagg ggagagagat gagtttaata
      421 tccaggttct tcatgcattt gtggagctgc atgagttcac tgatcttaat ctcgtccagg
      481 cactacggca gttcctgtgg agcttccggc tacccggaga ggcccagaag atcgaccgga
      541 tgatggaggc gtttgcccag cgatattgtc agtgcaataa tggcgtgttc cagtccacgg
      601 atacttgtta cgtcctctcc tttgccatca tcatgttgaa caccagtctg cacaacccca
      661 atgtcaaaga taagcccact gtggagaggt tcattgccat gaaccgaggc atcaatgatg
      721 ggggagacct gccggaggag ctcctccgga atctctatga gagcataaaa aatgaaccct
      781 ttaaaatccc agaagacgac gggaatgacc tcactcacac tttcttcaat ccagaccgag
      841 aaggctggct attgaaactc ggtggcaggg taaagacttg gaagagacgc tggttcattc
      901 tgactgacaa ctgcctttac tactttgagt ataccacgga taaggagccc cgtggaatca
      961 tccctttaga gaatctgagt atccgggaag tggaggactc caaaaaacca aactgctttg
     1021 agctttatat ccccgacaat aaagaccaag ttatcaaggc ctgcaagacc gaggctgacg
     1081 ggcgggtggt ggaggggaac cacactgttt accggatctc agctccgacg cccgaggaga
     1141 aggaggagtg gattaagtgc attaagttcc aggtcagccc aggagagcca tagcagctgc
     1201 tggtgccacc gttcagcagg gagcagccat cagcagggac cctttctacg aaatgctcgc
     1261 agcacggaaa aagaaggtct cctccacgaa gcgacactga gcgtgcagcc aagggcgttg
     1321 gtctgcgggg gccttggagc tcctgctctt ctcccgcacc tccatggatg cactgctgcc
     1381 gagcagagcg tcctctgcca ggccccgccc tggattccta gagactagct tcagcttttg
     1441 ctattttttt taagtgggag aagggtgggc agttatcact ggggaagaga ggaccggcca
     1501 cctgtccagc atgggctcca gagccttcct ctctcacagg gcagagctct tgtcggcagg
     1561 gcagcctcct ggccagtttc tctgctcagt gttctggtag cagagctcag agccaactgt
     1621 ttacctcttg gttgtccccg tgaagaagcc ttcaaaccct gcaccataaa tacatgtgtc
     1681 catatattat tatatgttaa gagaaaaagg tggaaaggaa gagaagccac atactataaa
     1741 gatctatttt ttttttttta agagagaacg tagggctgtt caggtgcatt ctgccctggc
     1801 tgcgctgggg agcttctccc tggagaagag cacctggggc tgcggccaag gggcatcagc
     1861 ctgggcccgc ggcagggcct ggcctgcctc tcctgtgctg tgggagctcg ctgcctggtg
     1921 cttgtctggg cgagatggac aggtgaggtc gaggacgcag agggcagagg cccagtggag
     1981 cctcagacgg cacagtcaga gtcgggggcc tgccctggcc ggggtcgcag tcggcagcag
     2041 cgtgcagtcc ggcatctccc gcggatgctt ttccatccca agtgcctgcg gagcgccgag
     2101 gagaggagag agctgactgg acgcttacgt tattttcctc cttcagaatc caagttcttg
     2161 ttgggcttta aagtagaaag tcagcatttt ccttgagcta aatacctaat aaccaaaact
     2221 gtgaggaagg ttatcgggac agaggttccg gataacctgt ttcattttgg gttttcttcc
     2281 tcttccccag actccagtcc tcgttctaga ggaaggagta ggacttcccc gatccccgta
     2341 gggcttcagc tttttctgcc tcaaaaccag ccctaactgg actactctgg atgcattttg
     2401 tggtgggccc cctagagggg aagatgggcc tttatctgct ccgtggggtg cactggagtg
     2461 aggggggtgg ccgggctgcc tctcgcatct ctgtcttccc ctgcaggcgc tgtgtgagct
     2521 ggccctgccc ctcctcatta cagtatgaag ggagccgtga cacgcagcat tttcctgccg
     2581 ttctctcagg gactctcagg gcagctcctg ccactccgcc agggccagca tgccagtcca
     2641 ggcagagcag gtggctggct gtctggccgt ctcgccccgc ccctccacag gaccctggac
     2701 cagggcggtg cagggcgcag ccctgaggag gcaggtggag gagctgcggg ttttcacagg
     2761 gccgcgtcgc cacggctcct ctgatccttt agggttggcg agcatctctg gaaatagctt
     2821 ttgcagagga gtggtgggag gaatagaggg ggacagtctg tcacctccct ccccgccact
     2881 ttgtgtagat cctacctgga gggaatggct ttaggcactt ttgtgccaga gcttgtgagg
     2941 gtgacagaag agggtccagg ctggaaacct gaactttctg ggtgggagaa ccaggtggtg
     3001 cctgccgagg tctgggcgtg tttgggccgg tgctggagcc tgtccagctg gcccgggccc
     3061 tggcctggtt ctcaagtgtt tcctagacag agaggcacct gggtcagtat tagtctattt
     3121 atcagaggtg taaataatct atgtatagtt tttctccttt tagattattt tgtatttgtt
     3181 taaaagaagt tttgtcaaaa tacaaaaata taaagaaatg actgaaagtt gttgacaggg
     3241 tttttaagaa ataattattc taattgtttt tgtttgtttg tttttgcctt gtaaactagc
     3301 gccaaggaac tgcagcaaat aaactccaac tctgcccaag cca
//
