LOCUS       NM_199001                762 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens cysteine rich tail 1 (CYSRT1), mRNA.
ACCESSION   NM_199001 XM_005266083 XM_351886
VERSION     NM_199001.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 762)
  AUTHORS   Niehues,H., Rikken,G., Kersten,F.F.J., Eeftens,J.M., van
            Vlijmen-Willems,I.M.J.J., Rodijk-Olthuis,D., Jansen,P.A.M.,
            Hendriks,W.J.A.J., Ederveen,T.H.A., Schalkwijk,J., van den
            Bogaard,E.H. and Zeeuwen,P.L.J.M.
  TITLE     CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with
            Late Cornified Envelope Proteins
  JOURNAL   J Invest Dermatol 143 (8), 1498-1508 (2023)
   PUBMED   36804407
  REMARK    GeneRIF: CYSRT1: An Antimicrobial Epidermal Protein that Can
            Interact with Late Cornified Envelope Proteins.
REFERENCE   2  (bases 1 to 762)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 762)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 762)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018787.1, BE563091.1, BC052297.1 and BX255925.17.
            
            On May 17, 2019 this sequence version replaced NM_199001.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.348873.1, BC018787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650725.2/ ENSP00000498316.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               BC018787.1         540-929
            391-676             BE563091.1         341-626
            677-758             BC052297.1         659-740
            759-762             BX255925.17        21692-21695
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..762
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /note="cysteine rich tail 1"
                     /db_xref="GeneID:375791"
                     /db_xref="HGNC:HGNC:30529"
     exon            1..60
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /inference="alignment:Splign:2.1.0"
     exon            61..762
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..503
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /note="UPF0574 protein C9orf169"
                     /codon_start=1
                     /product="cysteine-rich tail protein 1"
                     /protein_id="NP_945352.4"
                     /db_xref="CCDS:CCDS48064.3"
                     /db_xref="GeneID:375791"
                     /db_xref="HGNC:HGNC:30529"
                     /translation="MDPQEMVVKNPYAHISIPRAHLRPDLGQQLEVASTCSSSSEMQP
                     LPVGPCAPEPTHLLQPTEVPGPKGAKGNQGAAPIQNQQAWQQPGNPYSSSQRQAGLTY
                     AGPPPAGRGDDIAHHCCCCPCCHCCHCPPFCRCHSCCCCVIS"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /note="hexamer: AATAAA"
     polyA_site      762
                     /gene="CYSRT1"
                     /gene_synonym="C9orf169"
                     /note="major polyA site"
ORIGIN      
        1 aggcactggg acctagagct cagaagaccg agaggacaga ctgccgtgtt gccaccacag
       61 gctggaccat ggacccccaa gagatggtcg tcaagaaccc atatgcccac atcagcatcc
      121 cccgggctca cctgcggcct gacctggggc agcagttaga ggtggcttcc acctgttcct
      181 catcctcgga gatgcagccc ctgccagtgg ggccctgtgc cccagagcca acccacctct
      241 tgcagccgac cgaggtccca gggcccaagg gcgccaaggg taaccagggg gctgccccca
      301 tccagaacca gcaggcctgg cagcagcctg gcaaccccta cagcagcagt cagcgccagg
      361 ccggactgac ctacgctggc cctccgcccg cggggcgcgg ggatgacatc gcccaccact
      421 gctgctgctg cccctgctgc cactgctgcc actgcccccc cttctgccgc tgccacagct
      481 gctgctgctg tgtcatctcc tagcccagcc caccctgcca gggccaggac ccagacttca
      541 gcaaatgtgg ctcacacagt gccgggacat gccgggacat gcggggtggc tgttgtcatg
      601 ggcgtctgcc ccttcacacc aggcactggg gctcagaccc accaggaagg tggccgttca
      661 gcccgagctc ctgaaacgga atcccaggtc ctggctggag agggacaccc ctgattacct
      721 taaggcccag gcaataaagc agggtgatct tcctcccagc aa
//
