LOCUS       NM_001308476            4763 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2), transcript
            variant V, mRNA.
ACCESSION   NM_001308476
VERSION     NM_001308476.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Du,K., Zhang,M., Yao,S., Luo,T., Yu,H. and Lou,H.
  TITLE     The IL-31/CysLT2R axis is associated with itching in patients with
            allergic rhinitis
  JOURNAL   Int Forum Allergy Rhinol 14 (6), 1070-1078 (2024)
   PUBMED   38088514
  REMARK    GeneRIF: The IL-31/CysLT2R axis is associated with itching in
            patients with allergic rhinitis.
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Ghatak,S., Satapathy,S.R. and Sjolander,A.
  TITLE     DNA Methylation and Gene Expression of the Cysteinyl Leukotriene
            Receptors as a Prognostic and Metastatic Factor for Colorectal
            Cancer Patients
  JOURNAL   Int J Mol Sci 24 (4), 3409 (2023)
   PUBMED   36834820
  REMARK    GeneRIF: DNA Methylation and Gene Expression of the Cysteinyl
            Leukotriene Receptors as a Prognostic and Metastatic Factor for
            Colorectal Cancer Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Hossain,M.S., Mawatari,S. and Fujino,T.
  TITLE     Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic
            Activity of NK Cells against the Target Cells
  JOURNAL   J Immunol 209 (2), 310-325 (2022)
   PUBMED   35777853
  REMARK    GeneRIF: Plasmalogen-Mediated Activation of GPCR21 Regulates
            Cytolytic Activity of NK Cells against the Target Cells.
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Voisin,T., Perner,C., Messou,M.A., Shiers,S., Ualiyeva,S.,
            Kanaoka,Y., Price,T.J., Sokol,C.L., Bankova,L.G., Austen,K.F. and
            Chiu,I.M.
  TITLE     The CysLT2R receptor mediates leukotriene C4-driven acute and
            chronic itch
  JOURNAL   Proc Natl Acad Sci U S A 118 (13) (2021)
   PUBMED   33753496
  REMARK    GeneRIF: The CysLT2R receptor mediates leukotriene C4-driven acute
            and chronic itch.
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Nell,R.J., Menger,N.V., Versluis,M., Luyten,G.P.M., Verdijk,R.M.,
            Madigan,M.C., Jager,M.J. and van der Velden,P.A.
  TITLE     Involvement of mutant and wild-type CYSLTR2 in the development and
            progression of uveal nevi and melanoma
  JOURNAL   BMC Cancer 21 (1), 164 (2021)
   PUBMED   33588787
  REMARK    GeneRIF: Involvement of mutant and wild-type CYSLTR2 in the
            development and progression of uveal nevi and melanoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4763)
  AUTHORS   Mita,H., Hasegawa,M., Saito,H. and Akiyama,K.
  TITLE     Levels of cysteinyl leukotriene receptor mRNA in human peripheral
            leucocytes: significantly higher expression of cysteinyl
            leukotriene receptor 2 mRNA in eosinophils
  JOURNAL   Clin Exp Allergy 31 (11), 1714-1723 (2001)
   PUBMED   11696047
REFERENCE   7  (bases 1 to 4763)
  AUTHORS   Nothacker,H.P., Wang,Z., Zhu,Y., Reinscheid,R.K., Lin,S.H. and
            Civelli,O.
  TITLE     Molecular cloning and characterization of a second human cysteinyl
            leukotriene receptor: discovery of a subtype selective agonist
  JOURNAL   Mol Pharmacol 58 (6), 1601-1608 (2000)
   PUBMED   11093801
REFERENCE   8  (bases 1 to 4763)
  AUTHORS   Heise,C.E., O'Dowd,B.F., Figueroa,D.J., Sawyer,N., Nguyen,T.,
            Im,D.S., Stocco,R., Bellefeuille,J.N., Abramovitz,M., Cheng,R.,
            Williams,D.L. Jr., Zeng,Z., Liu,Q., Ma,L., Clements,M.K.,
            Coulombe,N., Liu,Y., Austin,C.P., George,S.R., O'Neill,G.P.,
            Metters,K.M., Lynch,K.R. and Evans,J.F.
  TITLE     Characterization of the human cysteinyl leukotriene 2 receptor
  JOURNAL   J Biol Chem 275 (39), 30531-30536 (2000)
   PUBMED   10851239
REFERENCE   9  (bases 1 to 4763)
  AUTHORS   Takasaki,J., Kamohara,M., Matsumoto,M., Saito,T., Sugimoto,T.,
            Ohishi,T., Ishii,H., Ota,T., Nishikawa,T., Kawai,Y., Masuho,Y.,
            Isogai,T., Suzuki,Y., Sugano,S. and Furuichi,K.
  TITLE     The molecular characterization and tissue distribution of the human
            cysteinyl leukotriene CysLT(2) receptor
  JOURNAL   Biochem Biophys Res Commun 274 (2), 316-322 (2000)
   PUBMED   10913337
REFERENCE   10 (bases 1 to 4763)
  AUTHORS   Van Keer,C., Kersters,K. and De Ley,J.
  TITLE     L-Sorbose metabolism in Agrobacterium tumefaciens
  JOURNAL   Antonie Van Leeuwenhoek 42 (1-2), 13-24 (1976)
   PUBMED   1085123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EF141527.1 and AL137118.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001308476.2.
            
            Summary: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are
            important mediators of human bronchial asthma. Pharmacologic
            studies have determined that cysteinyl leukotrienes activate at
            least 2 receptors, the protein encoded by this gene and CYSLTR1.
            This encoded receptor is a member of the superfamily of G
            protein-coupled receptors. It seems to play a major role in
            endocrine and cardiovascular systems. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (V) differs in the 5' UTR compared
            to variant I. All 11 variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.155719.1, EF141527.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682523.1/ ENSP00000508181.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               EF141527.1         1-293
            294-294             AL137118.20        93739-93739
            295-398             EF141527.1         295-398
            399-4763            AL137118.20        104034-108398
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..4763
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /note="cysteinyl leukotriene receptor 2"
                     /db_xref="GeneID:57105"
                     /db_xref="HGNC:HGNC:18274"
                     /db_xref="MIM:605666"
     exon            1..89
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /inference="alignment:Splign:2.1.0"
     exon            90..179
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /inference="alignment:Splign:2.1.0"
     exon            180..252
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /inference="alignment:Splign:2.1.0"
     exon            253..353
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /inference="alignment:Splign:2.1.0"
     exon            354..4763
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1395
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /note="cysteinyl leukotriene CysLT2 receptor; G-protein
                     coupled receptor HG57; G-protein coupled receptor GPCR21"
                     /codon_start=1
                     /product="cysteinyl leukotriene receptor 2"
                     /protein_id="NP_001295405.1"
                     /db_xref="CCDS:CCDS9412.1"
                     /db_xref="GeneID:57105"
                     /db_xref="HGNC:HGNC:18274"
                     /db_xref="MIM:605666"
                     /translation="MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIV
                     YLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGS
                     NWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCG
                     IIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLS
                     ICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKV
                     GLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVF
                     PVSVWLRKETRV"
     regulatory      4744..4749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /note="hexamer: ATTAAA"
     polyA_site      4763
                     /gene="CYSLTR2"
                     /gene_synonym="CYSLT2; CYSLT2R; GPCR21; HG57; hGPCR21;
                     HPN321; KPG_011; PSEC0146"
                     /note="major polyA site"
ORIGIN      
        1 gaaatgagca acctgaatta ctcggaggag aaaggcagga gagatagagg cagcagaagc
       61 cagggcagct gaaagacaga gaccttcagt ctgaaccaac aacaagcaaa gttaaattat
      121 ggatatccaa gggagtctat agaaggtcca tgcaaggtat ggagagttcc tcaacagaga
      181 cattttgact acttgtctga actagatatc ccttgaatgt gcacacaaaa agtgaatggg
      241 tcatttgata agggaaaact aggttccaag atggctgaat aggaagagct ccaatctgca
      301 gatcccagtg tgagcaacgt ggaagacggg tgatttctgc atttccaact gagcatggag
      361 agaaaattta tgtccttgca accatccatc tccgtatcag aaatggaacc aaatggcacc
      421 ttcagcaata acaacagcag gaactgcaca attgaaaact tcaagagaga atttttccca
      481 attgtatatc tgataatatt tttctgggga gtcttgggaa atgggttgtc catatatgtt
      541 ttcctgcagc cttataagaa gtccacatct gtgaacgttt tcatgctaaa tctggccatt
      601 tcagatctcc tgttcataag cacgcttccc ttcagggctg actattatct tagaggctcc
      661 aattggatat ttggagacct ggcctgcagg attatgtctt attccttgta tgtcaacatg
      721 tacagcagta tttatttcct gaccgtgctg agtgttgtgc gtttcctggc aatggttcac
      781 ccctttcggc ttctgcatgt caccagcatc aggagtgcct ggatcctctg tgggatcata
      841 tggatcctta tcatggcttc ctcaataatg ctcctggaca gtggctctga gcagaacggc
      901 agtgtcacat catgcttaga gctgaatctc tataaaattg ctaagctgca gaccatgaac
      961 tatattgcct tggtggtggg ctgcctgctg ccatttttca cactcagcat ctgttatctg
     1021 ctgatcattc gggttctgtt aaaagtggag gtcccagaat cggggctgcg ggtttctcac
     1081 aggaaggcac tgaccaccat catcatcacc ttgatcatct tcttcttgtg tttcctgccc
     1141 tatcacacac tgaggaccgt ccacttgacg acatggaaag tgggtttatg caaagacaga
     1201 ctgcataaag ctttggttat cacactggcc ttggcagcag ccaatgcctg cttcaatcct
     1261 ctgctctatt actttgctgg ggagaatttt aaggacagac taaagtctgc actcagaaaa
     1321 ggccatccac agaaggcaaa gacaaagtgt gttttccctg ttagtgtgtg gttgagaaag
     1381 gaaacaagag tataaggagc tcttagatga gacctgttct tgtatccttg tgtccatctt
     1441 cattcactca tagtctccaa atgactttgt atttacatca ctcccaacaa atgttgattc
     1501 ttaatattta gttgaccatt acttttgtta ataagaccta cttcaaaaat tttattcagt
     1561 gtattttcag ttgttgagtc ttaatgaggg atacaggagg aaaaatccct actagagtcc
     1621 tgtgggctga aatatcagac tgggaaaaaa tgcaaagcac attggatcct acttttcttc
     1681 agatattgaa ccagatctct ggcccatcag gctttctaaa ttcttcaaaa gagccacaac
     1741 ttccccagct tctccagctc ccctgtcctc ttcaatccct tgagatatag ccaactaacg
     1801 acgctactgg aagccccaga gcagaaaaga agcacatcct aagattcagg gaaagactaa
     1861 ctgtgaaaag gaaggctgtc ctataacaaa gcagcatcaa gtcccaagta aggacagtga
     1921 gagaaaaggg ggagaaggat tggagcaaaa gagaactggc aataagtagg ggaaggaaga
     1981 atttcatttt gcattgggag agaggttcta acacactgaa ggcaacccta tttctactgt
     2041 ttctctcttg ccagggtatt aggaaggaca ggaaaagtag gaggaggatc tggggcattg
     2101 ccctaggaaa tgaaagaatt gtgtatagaa tggaaggggg atcatcaagg acatgtatct
     2161 caaattttct ttgagatgca ggttagttga ccttgctgca gttctccttc ccattaattc
     2221 attgggatgg aagccaaaaa taaaagaggt gcctctgagg attagggttg agcactcaag
     2281 ggaaagatgg agtagagggc aaatagcaaa agttgttgca ctcctgaaat tctattaaca
     2341 tttccgcaga agatgagtag ggagatgctg ccttcccttt tgagatagtg tagaaaaaca
     2401 ctagatagtg tgagaggttc ctttctgtcc actgaaacaa ggctaaggat actaccaact
     2461 actatcacca tgaccattgt actgacaaca attgaatgca gtctccctgc agggcagatt
     2521 atgccaggca ctttacattt gttgatccca tttgacattc acaccaaagc tctgagttcc
     2581 attttacagc tgaagaaatt gaagcttaga gaaattaaga agcttgttta agtttacaca
     2641 gctagtaaga gttttaaaaa tctctgtgca gaagtgttgg ctgggtgctc tccccaccac
     2701 tacccttgta aacttccagg aagattggtt gaaagtctga ataaaagctg tcctttccta
     2761 ccaatttcct ccccctcctc actctcacaa gaaaaccaaa agtttctctt cagagttgtt
     2821 gactcatagt acagtaaagg gtggaggtga tatggcattc tgaaagtagg gagggactaa
     2881 gtcagtcatc atactaaaca aaaatcccag taccctttcc ttatttagct accagaatga
     2941 tgacagacag actcaaaccc tgtcaagaca ggaccctgga ggatcctcct atggggaaac
     3001 tgcataatct gaaaaaaagg ctgacagata caaatagttg aggatccttc aacacaaaag
     3061 ctgcgtgtct gccctattac tcacctgacg atgaagccca caatgcaaca aatcccttcc
     3121 actcacagca tttggtcaac ctgtcagagc ctcattctta attatgaaaa gtagtcaatg
     3181 aacacaatac atttgaggga aaggccgtaa catgaaaggc accaacaaat aaatgtgaga
     3241 gtagatagag accttttgag tataaaagat cctccaaaat aagagattaa accaagatag
     3301 aggaaaacac agtagctggg aaacaaggaa tccaacgcag gagaaagtga agagaattcc
     3361 caggatgttg gtgtgtagca ggcttagaaa gcaagtcatt catgttggag caggactctt
     3421 aaaggactct aggagagatg tctcccagaa aaagaagaaa ttaattgatt catacacatt
     3481 gagagggatt tagatttctc ttgcagagat tgagataaac tagtcgtaaa tacatagaaa
     3541 aataagcaag taaaaacgca atacagtttt taagtgctag aggaaaagaa acttttgtat
     3601 tagagaggaa atataaccac agtacactac atggctcagc tgtgaataat atttacatag
     3661 aggataatgt gaatataata gtctcccatt atctgtggtt ttgctttctg cagttcagtt
     3721 acagccagcc agtctgaaaa tattaaatgg aaaattccag aaataattct taagttttaa
     3781 aacatgtgct gttttgagta gcatgttgaa atctcgcact atcaccctcc acccatgttc
     3841 tgggcagggc aaagtgggat ggtgtgagat ttctccagtg gatccacaat gtatatgcta
     3901 cccacccatg agtcacttag tcatcatcca gttgctcaga tcaactgttg tggtataaca
     3961 gtgcttgtgt taaagtcact cttattttac ttactaatgt ccccaaagca taagagtagt
     4021 gatgctggca aataagatac accaaagaga agctgtaaag tgcttcctct aacagaaaat
     4081 gtgaaagttc ttgacttaat aaggaaagaa aaaaaacaca tgctgaagtt gctaagatct
     4141 acagtaagaa caaatccatc tgtaaaattg tgaagaaggc aaaagaaatt tgtgctagtt
     4201 ttgctgttgc accacaagct gcaaaaatta tttattacac cccacggtgt gtgataaaca
     4261 cttagttaag atgaaaaggt attaaatttg tgggtggaag acatgaacag aaatgtgttc
     4321 caattgacag caatcgggtt tggtactatt tgggtttggt gctattcgta ttcagggtct
     4381 tggaatgcaa ctcccacaga taagggggtg ctgctggagt gaaatactgt gatataacct
     4441 ttttttcagg aaatgaaggg agaagatgtg tacgtgtgtg ggagaggtat aagagaccta
     4501 ggttgccata ttctatcaca gaaaatgcat aataactaaa tctggaaaat gatgaatagc
     4561 tgtacaacca tattatttag caataggagg taaatacagg tagaagcaga agaaagaatg
     4621 ggcaggggtt acctctatgg agaagctggg gtgggaggat agggtgggga cttattttac
     4681 gaactgtgta attgcctaac ttgtgaatat gtatttctga agtaaaataa aaattaagtt
     4741 aaaattaaat tttaaaattc aaa
//
