LOCUS       NM_006639               2700 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript
            variant 3, mRNA.
ACCESSION   NM_006639
VERSION     NM_006639.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Ghatak,S., Satapathy,S.R. and Sjolander,A.
  TITLE     DNA Methylation and Gene Expression of the Cysteinyl Leukotriene
            Receptors as a Prognostic and Metastatic Factor for Colorectal
            Cancer Patients
  JOURNAL   Int J Mol Sci 24 (4), 3409 (2023)
   PUBMED   36834820
  REMARK    GeneRIF: DNA Methylation and Gene Expression of the Cysteinyl
            Leukotriene Receptors as a Prognostic and Metastatic Factor for
            Colorectal Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Zhao,M., Li,H. and Li,H.
  TITLE     The relevance of CYSLTR1 gene polymorphism to the severity of
            allergic rhinitis and clinical responsiveness of montelukast in
            children
  JOURNAL   Eur Arch Otorhinolaryngol 278 (12), 4847-4853 (2021)
   PUBMED   33837837
  REMARK    GeneRIF: The relevance of CYSLTR1 gene polymorphism to the severity
            of allergic rhinitis and clinical responsiveness of montelukast in
            children.
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Rabinovitch,N., Jones,M.J., Gladish,N., Faino,A.V., Strand,M.,
            Morin,A.M., MacIsaac,J., Lin,D.T.S., Reynolds,P.R., Singh,A.,
            Gelfand,E.W., Kobor,M.S. and Carlsten,C.
  TITLE     Methylation of cysteinyl leukotriene receptor 1 genes associates
            with lung function in asthmatics exposed to traffic-related air
            pollution
  JOURNAL   Epigenetics 16 (2), 177-185 (2021)
   PUBMED   32657253
  REMARK    GeneRIF: Methylation of cysteinyl leukotriene receptor 1 genes
            associates with lung function in asthmatics exposed to
            traffic-related air pollution.
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Koller,A., Bruckner,D., Aigner,L., Reitsamer,H. and Trost,A.
  TITLE     Cysteinyl leukotriene receptor 1 modulates autophagic activity in
            retinal pigment epithelial cells
  JOURNAL   Sci Rep 10 (1), 17659 (2020)
   PUBMED   33077798
  REMARK    GeneRIF: Cysteinyl leukotriene receptor 1 modulates autophagic
            activity in retinal pigment epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Satapathy,S.R. and Sjolander,A.
  TITLE     Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance
            and resistance-derived stemness in colon cancer cells
  JOURNAL   Cancer Lett 488, 50-62 (2020)
   PUBMED   32474153
  REMARK    GeneRIF: Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil
            resistance and resistance-derived stemness in colon cancer cells.
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Mellor,E.A., Maekawa,A., Austen,K.F. and Boyce,J.A.
  TITLE     Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor
            and is expressed by human mast cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7964-7969 (2001)
   PUBMED   11438743
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Sjostrom,M., Jakobsson,P.J., Heimburger,M., Palmblad,J. and
            Haeggstrom,J.Z.
  TITLE     Human umbilical vein endothelial cells generate leukotriene C4 via
            microsomal glutathione S-transferase type 2 and express the
            CysLT(1) receptor
  JOURNAL   Eur J Biochem 268 (9), 2578-2586 (2001)
   PUBMED   11322876
REFERENCE   8  (bases 1 to 2700)
  AUTHORS   Gronert,K., Martinsson-Niskanen,T., Ravasi,S., Chiang,N. and
            Serhan,C.N.
  TITLE     Selectivity of recombinant human leukotriene D(4), leukotriene
            B(4), and lipoxin A(4) receptors with aspirin-triggered
            15-epi-LXA(4) and regulation of vascular and inflammatory responses
  JOURNAL   Am J Pathol 158 (1), 3-9 (2001)
   PUBMED   11141472
REFERENCE   9  (bases 1 to 2700)
  AUTHORS   Sarau,H.M., Ames,R.S., Chambers,J., Ellis,C., Elshourbagy,N.,
            Foley,J.J., Schmidt,D.B., Muccitelli,R.M., Jenkins,O.,
            Murdock,P.R., Herrity,N.C., Halsey,W., Sathe,G., Muir,A.I.,
            Nuthulaganti,P., Dytko,G.M., Buckley,P.T., Wilson,S., Bergsma,D.J.
            and Hay,D.W.
  TITLE     Identification, molecular cloning, expression, and characterization
            of a cysteinyl leukotriene receptor
  JOURNAL   Mol Pharmacol 56 (3), 657-663 (1999)
   PUBMED   10462554
REFERENCE   10 (bases 1 to 2700)
  AUTHORS   Lynch,K.R., O'Neill,G.P., Liu,Q., Im,D.S., Sawyer,N., Metters,K.M.,
            Coulombe,N., Abramovitz,M., Figueroa,D.J., Zeng,Z., Connolly,B.M.,
            Bai,C., Austin,C.P., Chateauneuf,A., Stocco,R., Greig,G.M.,
            Kargman,S., Hooks,S.B., Hosfield,E., Williams,D.L. Jr.,
            Ford-Hutchinson,A.W., Caskey,C.T. and Evans,J.F.
  TITLE     Characterization of the human cysteinyl leukotriene CysLT1 receptor
  JOURNAL   Nature 399 (6738), 789-793 (1999)
   PUBMED   10391245
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ131799.1, AF133266.1 and
            DQ131803.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006639.3.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family. The encoded protein is a receptor for cysteinyl
            leukotrienes, and is involved in mediating bronchoconstriction via
            activation of a phosphatidylinositol-calcium second messenger
            system. Activation of the encoded receptor results in contraction
            and proliferation of bronchial smooth muscle cells, eosinophil
            migration, and damage to the mucus layer in the lung. Upregulation
            of this gene is associated with asthma and dysregulation may also
            be implicated in cancer. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, and 4 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.398155.1,
                                           SRR1803615.240729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373304.4/ ENSP00000362401.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               DQ131799.1         81-567
            488-1435            AF133266.1         67-1014
            1436-2700           DQ131803.1         73-1337
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..2700
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /note="cysteinyl leukotriene receptor 1"
                     /db_xref="GeneID:10800"
                     /db_xref="HGNC:HGNC:17451"
                     /db_xref="MIM:300201"
     exon            1..307
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /inference="alignment:Splign:2.1.0"
     exon            308..394
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /inference="alignment:Splign:2.1.0"
     exon            395..2700
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1435
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /note="cysteinyl leukotriene D4 receptor; LTD4 receptor;
                     G-protein coupled receptor HG55"
                     /codon_start=1
                     /product="cysteinyl leukotriene receptor 1"
                     /protein_id="NP_006630.1"
                     /db_xref="CCDS:CCDS14439.1"
                     /db_xref="GeneID:10800"
                     /db_xref="HGNC:HGNC:17451"
                     /db_xref="MIM:300201"
                     /translation="MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFV
                     LYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYA
                     LYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLM
                     AKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLK
                     KSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKS
                     VVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEI
                     CKV"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /note="hexamer: AATAAA"
     polyA_site      2686
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /note="major polyA site"
     polyA_site      2700
                     /gene="CYSLTR1"
                     /gene_synonym="CYSLT1; CYSLT1R; CYSLTR; HMTMF81"
                     /note="major polyA site"
ORIGIN      
        1 agtttgaagg ctaatctgaa agaggaagaa gaatctgtat atctgtatat attggctagc
       61 aaatgtgccc tgctctctcc cctcttaaaa atagcagcaa cccatctttg caaagaagct
      121 tgcctataga gcaggcactc tgtgaatgga ctgtgctttt acgaccctac agggtatcaa
      181 gatactgtgc agctcgccaa caaggattaa ttgcaaggac tggtagatcg aatttactga
      241 agacttggag cttgcttctg agaacaaacg caaaaggaca gtaaactgtg gaccttgaag
      301 ttagcagcgt gggcttcctc taatattaca ccgtaaaagg cattgatcac cataagaagg
      361 aacatttgtg aaggtactcc agtgccagaa agaggcacaa agcagacatt cgtagagaaa
      421 catggatgaa acaggaaatc tgacagtatc ttctgccaca tgccatgaca ctattgatga
      481 cttccgcaat caagtgtatt ccaccttgta ctctatgatc tctgttgtag gcttctttgg
      541 caatggcttt gtgctctatg tcctcataaa aacctatcac aagaagtcag ccttccaagt
      601 atacatgatt aatttagcag tagcagatct actttgtgtg tgcacactgc ctctccgtgt
      661 ggtctattat gttcacaaag gcatttggct ctttggtgac ttcttgtgcc gcctcagcac
      721 ctatgctttg tatgtcaacc tctattgtag catcttcttt atgacagcca tgagcttttt
      781 ccggtgcatt gcaattgttt ttccagtcca gaacattaat ttggttacac agaaaaaagc
      841 caggtttgtg tgtgtaggta tttggatttt tgtgattttg accagttctc catttctaat
      901 ggccaaacca caaaaagatg agaaaaataa taccaagtgc tttgagcccc cacaagacaa
      961 tcaaactaaa aatcatgttt tggtcttgca ttatgtgtca ttgtttgttg gctttatcat
     1021 cccttttgtt attataattg tctgttacac aatgatcatt ttgaccttac taaaaaaatc
     1081 aatgaaaaaa aatctgtcaa gtcataaaaa ggctatagga atgatcatgg tcgtgaccgc
     1141 tgccttttta gtcagtttca tgccatatca tattcaacgt accattcacc ttcatttttt
     1201 acacaatgaa actaaaccct gtgattctgt ccttagaatg cagaagtccg tggtcataac
     1261 cttgtctctg gctgcatcca attgttgctt tgaccctctc ctatatttct tttctggggg
     1321 taactttagg aaaaggctgt ctacattcag aaagcattct ttgtccagcg tgacttatgt
     1381 acccagaaag aaggcctctt tgccagaaaa aggagaagaa atatgtaaag tatagtttaa
     1441 acccatttcc agtccaaacc aatgaaaata gtttcccaaa taagtatttt gtcaaatcat
     1501 ttacaaaaaa aataaaaatt ttacttaata ttttacaaat acttaactat ttgggcctac
     1561 aactctatct catttatgca tccacatgat tagatattta tagatatttt aagtgctaaa
     1621 aattcggtcc acaactatga actgaattat aaataatttt gaccactcac cagaatttgg
     1681 agaatatttt tatctttgca ctataaaata tgtcttatat taaagttttc ctcttcaaat
     1741 aaaagcttta caaacgataa aatatataaa attagtcaat aaaaatacat gcaagctaaa
     1801 agttataaaa tataaaacta gatataaaat tggcaaatag ttctgaatca ttctaacata
     1861 ttcctttgca tgcatgccat cagatgagaa ctggagatga ctcaggagct acataaaacg
     1921 tactgtcacc cttctttgta gtactgattc gctaggcaaa ttagggccat ttcttccaaa
     1981 agagaatgta aaagtgctag aacagactag tattcagcta aagggtccta aaagcaccat
     2041 acaatgttca atatggcaac aggagaaatc tggtcaaaag ccagtttgtc tccagttttc
     2101 ttctgccttt gcctcaggct cccaaaattg aatagtggag ttttagctgc tcagtgaggt
     2161 tcctgtagag atttctctcc atccatgaca tataattctt ccttaagaag ccagacaact
     2221 ggcactccta tatataaata gaagtaatta aaaacttatc tgaagaagag aaaaggaaaa
     2281 ggaatctact tttctatatg ccaattgctg ggatcaaaat aaactacaaa ggatttatga
     2341 agaaaattgt gaatgttcac attacaaatt cttttaagaa gtgcatacat ttatgtatat
     2401 gtatacaact atatgtaaga gattttgctg tatgatatgc attatgggtg aaagttcacg
     2461 ataagtttta ttattgcttt attacttttt attggtatgt tgacaggaat atcatggata
     2521 tgtttacagt gacttttata ttacagtgga cgctttgatc ttaaaacagc cacaacaact
     2581 catctacggc tgaaatataa tatgcgtgga caagcttttg ctgaagtgta gtgtgtcctt
     2641 taagtttgtt ttttaaaaag taacttacct cagaagaaat aaataactat aaagaaaaaa
//
