LOCUS       NM_001353258            3904 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens CYFIP related Rac1 interactor B (CYRIB), transcript
            variant 20, mRNA.
ACCESSION   NM_001353258 XM_011517108
VERSION     NM_001353258.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Nikolaou,S., Juin,A., Whitelaw,J.A., Paul,N.R., Fort,L., Nixon,C.,
            Spence,H.J., Bryson,S. and Machesky,L.M.
  TITLE     CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake
  JOURNAL   Elife 13, e83712 (2024)
   PUBMED   38712822
  REMARK    GeneRIF: CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3904)
  AUTHORS   Huang,H., Tsui,Y.M., Ho,D.W., Chung,C.Y., Sze,K.M., Lee,E.,
            Cheung,G.C., Zhang,V.X., Wang,X., Lyu,X. and Ng,I.O.
  TITLE     LANCL1, a cell surface protein, promotes liver tumor initiation
            through FAM49B-Rac1 axis to suppress oxidative stress
  JOURNAL   Hepatology 79 (2), 323-340 (2024)
   PUBMED   37540188
  REMARK    GeneRIF: LANCL1, a cell surface protein, promotes liver tumor
            initiation through FAM49B-Rac1 axis to suppress oxidative stress.
REFERENCE   3  (bases 1 to 3904)
  AUTHORS   Kuiper,J.W.P., Krause,J., Potgeter,L., Adrian,J. and Hauck,C.R.
  TITLE     A genome-wide genetic screen identifies CYRI-B as a negative
            regulator of CEACAM3-mediated phagocytosis
  JOURNAL   J Cell Sci 136 (11) (2023)
   PUBMED   37264948
  REMARK    GeneRIF: A genome-wide genetic screen identifies CYRI-B as a
            negative regulator of CEACAM3-mediated phagocytosis.
REFERENCE   4  (bases 1 to 3904)
  AUTHORS   Xi,Y., Zhang,T., Sun,W., Liang,R., Ganesh,S. and Chen,H.
  TITLE     GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on
            Bioinformatics and Immunohistochemical Analysis
  JOURNAL   Int J Mol Sci 23 (23), 15433 (2022)
   PUBMED   36499755
  REMARK    GeneRIF: GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on
            Bioinformatics and Immunohistochemical Analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3904)
  AUTHORS   Yelland,T., Le,A.H., Nikolaou,S., Insall,R., Machesky,L. and
            Ismail,S.
  TITLE     Structural Basis of CYRI-B Direct Competition with Scar/WAVE
            Complex for Rac1
  JOURNAL   Structure 29 (3), 226-237 (2021)
   PUBMED   33217330
  REMARK    GeneRIF: Structural Basis of CYRI-B Direct Competition with
            Scar/WAVE Complex for Rac1.
REFERENCE   6  (bases 1 to 3904)
  AUTHORS   Nalls,M.A., Couper,D.J., Tanaka,T., van Rooij,F.J., Chen,M.H.,
            Smith,A.V., Toniolo,D., Zakai,N.A., Yang,Q., Greinacher,A.,
            Wood,A.R., Garcia,M., Gasparini,P., Liu,Y., Lumley,T., Folsom,A.R.,
            Reiner,A.P., Gieger,C., Lagou,V., Felix,J.F., Volzke,H.,
            Gouskova,N.A., Biffi,A., Doring,A., Volker,U., Chong,S.,
            Wiggins,K.L., Rendon,A., Dehghan,A., Moore,M., Taylor,K.,
            Wilson,J.G., Lettre,G., Hofman,A., Bis,J.C., Pirastu,N., Fox,C.S.,
            Meisinger,C., Sambrook,J., Arepalli,S., Nauck,M., Prokisch,H.,
            Stephens,J., Glazer,N.L., Cupples,L.A., Okada,Y., Takahashi,A.,
            Kamatani,Y., Matsuda,K., Tsunoda,T., Tanaka,T., Kubo,M.,
            Nakamura,Y., Yamamoto,K., Kamatani,N., Stumvoll,M., Tonjes,A.,
            Prokopenko,I., Illig,T., Patel,K.V., Garner,S.F., Kuhnel,B.,
            Mangino,M., Oostra,B.A., Thein,S.L., Coresh,J., Wichmann,H.E.,
            Menzel,S., Lin,J., Pistis,G., Uitterlinden,A.G., Spector,T.D.,
            Teumer,A., Eiriksdottir,G., Gudnason,V., Bandinelli,S.,
            Frayling,T.M., Chakravarti,A., van Duijn,C.M., Melzer,D.,
            Ouwehand,W.H., Levy,D., Boerwinkle,E., Singleton,A.B.,
            Hernandez,D.G., Longo,D.L., Soranzo,N., Witteman,J.C., Psaty,B.M.,
            Ferrucci,L., Harris,T.B., O'Donnell,C.J. and Ganesh,S.K.
  TITLE     Multiple loci are associated with white blood cell phenotypes
  JOURNAL   PLoS Genet 7 (6), e1002113 (2011)
   PUBMED   21738480
REFERENCE   7  (bases 1 to 3904)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   8  (bases 1 to 3904)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3904)
  AUTHORS   Melzer,D., Perry,J.R., Hernandez,D., Corsi,A.M., Stevens,K.,
            Rafferty,I., Lauretani,F., Murray,A., Gibbs,J.R., Paolisso,G.,
            Rafiq,S., Simon-Sanchez,J., Lango,H., Scholz,S., Weedon,M.N.,
            Arepalli,S., Rice,N., Washecka,N., Hurst,A., Britton,A., Henley,W.,
            van de Leemput,J., Li,R., Newman,A.B., Tranah,G., Harris,T.,
            Panicker,V., Dayan,C., Bennett,A., McCarthy,M.I., Ruokonen,A.,
            Jarvelin,M.R., Guralnik,J., Bandinelli,S., Frayling,T.M.,
            Singleton,A. and Ferrucci,L.
  TITLE     A genome-wide association study identifies protein quantitative
            trait loci (pQTLs)
  JOURNAL   PLoS Genet 4 (5), e1000072 (2008)
   PUBMED   18464913
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3904)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131568.5 and AC022973.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001353258.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.864831.1,
                                           SRR14038197.1475762.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000694912.1/ ENSP00000511587.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC131568.5         81723-81913         c
            192-244             AC131568.5         36296-36348         c
            245-331             AC022973.5         44513-44599
            332-370             AC022973.5         45748-45786
            371-453             AC022973.5         69627-69709
            454-575             AC022973.5         77602-77723
            576-681             AC022973.5         86764-86869
            682-818             AC022973.5         93351-93487
            819-896             AC022973.5         94755-94832
            897-1013            AC022973.5         96820-96936
            1014-1093           AC022973.5         98184-98263
            1094-1220           AC022973.5         99729-99855
            1221-1291           AC022973.5         102224-102294
            1292-3904           AC022973.5         106893-109505
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..3904
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /note="CYFIP related Rac1 interactor B"
                     /db_xref="GeneID:51571"
                     /db_xref="HGNC:HGNC:25216"
                     /db_xref="MIM:617978"
     exon            1..191
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..244
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..331
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..370
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..453
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..1355
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /note="isoform 1 is encoded by transcript variant 20;
                     protein FAM49B; FAM49B/JPH1 fusion; MTSS1/FAM49B fusion;
                     family with sequence similarity 49 member B"
                     /codon_start=1
                     /product="CYFIP-related Rac1 interactor B isoform 1"
                     /protein_id="NP_001340187.1"
                     /db_xref="CCDS:CCDS6361.1"
                     /db_xref="GeneID:51571"
                     /db_xref="HGNC:HGNC:25216"
                     /db_xref="MIM:617978"
                     /translation="MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLK
                     DAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEA
                     ALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYR
                     RTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIE
                     NTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKT
                     SKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSMLQ"
     exon            454..575
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..681
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..818
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..896
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1013
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1093
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1220
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1291
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..3904
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /note="major polyA site"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
                     /note="hexamer: AATAAA"
     polyA_site      3904
                     /gene="CYRIB"
                     /gene_synonym="BM-009; CYRI; CYRI-B; FAM49B; L1"
ORIGIN      
        1 agttatttct cgcctggcac tcgcccgggc tgctgctgct gctgctgctg ccgccgcggc
       61 gggggcagct cgcaaacctg tggcggtgac gtgagccccg ccaacccgga aacggcggcg
      121 gcggcggcac cggaggctcc gaggctcctg cgctcccgcg ccgcgctccc ctcgcccgcc
      181 cgggccgcca ggagaagaaa ctgaggcctg gaatttgatt aactcattca aggttaccca
      241 gttggtaatt catttgcaca cctgttagca agaaacagaa gttgaaggac tggaacaagt
      301 gaactaggaa agagggaacg ccaatccaag gatagaagga caaggacaga atcaccagca
      361 ctggctgaag gtaccttaac atggggaatc ttcttaaagt tttgacatgc acagaccttg
      421 agcaggggcc aaattttttc cttgattttg aaaatgccca gcctacagag tctgagaagg
      481 aaatttataa tcaggtgaat gtagtattaa aagatgcaga aggcatcttg gaggacttgc
      541 agtcatacag aggagctggc cacgaaatac gagaggcaat ccagcatcca gcagatgaga
      601 agttgcaaga gaaggcatgg ggtgcagttg ttccactagt aggcaaatta aagaaatttt
      661 acgaattttc tcagaggtta gaagcagcat taagaggtct tctgggagcc ttaacaagta
      721 ccccatattc tcccacccag catctagagc gagagcaggc tcttgctaaa cagtttgcag
      781 aaattcttca tttcacactc cggtttgatg aactcaagat gacaaatcct gccatacaga
      841 atgatttcag ctattataga agaacattga gtcgtatgag gattaacaat gtaccggcag
      901 aaggagaaaa tgaagtaaat aatgaattgg caaatcgaat gtctttgttt tatgctgagg
      961 caactccaat gctgaaaacc ttgagtgatg ccacaacaaa atttgtatca gagaataaaa
     1021 atttaccaat agaaaatacc acagattgtt taagcacaat ggctagtgta tgcagagtca
     1081 tgctggaaac accggaatac agaagcagat ttacaaatga agagacagtg tcattctgct
     1141 tgagggtaat ggtgggtgtc ataatactct atgaccacgt acatccagtg ggagcatttg
     1201 ctaaaacttc caaaattgat atgaaaggtt gtatcaaagt tcttaaggac caacctccta
     1261 atagtgtgga aggtcttcta aatgctctca ggtacacaac aaaacatttg aatgatgaga
     1321 ctacctccaa gcaaattaaa tccatgctgc aataacaatt ctggaataag cacctgctgt
     1381 agacagaaga cagtattctg caatgactga gaatgcagtt ttttagtgat tgcaattact
     1441 atctcattta ttcttgcttt tatttctttc ctctgttcct cttccctctt ttttaatcat
     1501 gttcttaaga cttcttttct gtgccaaaat cagtaaagtt acactctgaa gggatatcat
     1561 cctttcaaac gggccatcta aggcagctaa ttatgcattg cattggggtc tctactgaga
     1621 aaaattctgt gacttgaact aaatattttt aaatgtggat tttttttgaa actaatattt
     1681 aatattgctt ctcctgcatg gcaaaactgc ctattctgct atttaaaaac cctcaatgac
     1741 tttattttct actgccgcct ttttcatgtg caaccaaaat gaaaatgttt aaattaactg
     1801 tgttgtacaa atggtaccca acacaaactt tttttaaatt agtaatactt ttgtttaaag
     1861 ttttaagttt gcattttgac tttttttgta aggatgtatg ttgtgtgttt aacctttatt
     1921 aactaacgtt aaaagctgtg atgtgtgcgt agaatattac gtatgcatgt tcatgtctaa
     1981 agaatggctg ttgatgataa aataaaaatc agctttcatt tttctaagtg tggcttggtt
     2041 tactgatgtt ttgtttttag gcttctgaag ttttccccat gtatgttttt atggaatgca
     2101 tatatacatt acatgatttt ttcttctttt aggggagagc cgggtctttt cattagaatt
     2161 ttgatcattg tctatgtata tacttttaat tgcctttaaa attttgctaa gtatattaag
     2221 accagtgatc ttttcattaa ctggactttt attcttgatt tactcttgta tggatgtagt
     2281 aatggaagga aaaccgcatc cttgcttgat tctccatttc caggggagcg ggtagcaaca
     2341 tgaaggcaga gtagcccttt aatcatggga agagagtgat tataagaggg acttcccagg
     2401 agaaaagcag aggccatgat ctcactagtg gtagaaaact aacaggtttc agtttaagat
     2461 cataaaacct aaatcatgaa atctaaatct catggttgga acaaactact taaaggttgt
     2521 ctagttcaac catgccagtg ttttaaatat ttaggaatat ccgaggtata atacaattaa
     2581 aatgtttaac catggaagag aatcacagag gcttccatca gacccttctg gattaatagg
     2641 gccagatcat ggcacacaca gcttctcaag atcacatccc tgctgatctc tctggccctc
     2701 ctgatcactg ctcccccact tcacaccctg tcctgcagcc aggccctact gcttgctgtt
     2761 cacaaattgt tccatgtgat gtcacttcct tagctctggt ctggctggtc cctgaacctg
     2821 acattccctt cctccccttg tgaccctcta atgaacgcca actttcatct ttgaagggtt
     2881 agcttctatt acctccttca tgaagccttc tggataacat tggccatatc cttctaggca
     2941 tcttctaaga atagtgtaat aggctgaata gtggccccca ggagatacat tcactgggaa
     3001 tctccacgtg tgacattatt tggaaaaagt ttttgcagat gaaatcaagg acctggaaat
     3061 gagatcaacc tgtagtaggg tgggccctaa attcaatgac tagctcttag aaaagaaggg
     3121 gaaatagaca cacagagctg aaggccatgg gaagatggag gcagagatta gagcaatgca
     3181 tctatgagcc aaagaaccct aagaattgga ggaagtcact agaagctagg aaaacaggca
     3241 tgtcacagat tctccctcag agtctcgaga aggaaccaac cctaccaata tcttgatttc
     3301 agacatctgg cctccaggat tgtgagggaa taaatttctg ttgttttaag ccatgcagtt
     3361 tgtggtattt tggtacagca gccttaagaa tctgatacat gtatctcgta aaacacctct
     3421 gatacttacc tgcgcttgtg gctgtgtttt ctgatactat gagagccgta gtatctggat
     3481 accggagagt ctgcgaactt gagagaaggg ccgtgtctga ttttccttca gtgtcccaag
     3541 gaaggatctt gcacagtacc cagatttgga gaggtgccaa gtgaatgctt cggtggactg
     3601 aatgaataca aatcaaaaat aatgatgcag cgggaatgga tgcagtaaga ttgctgtggc
     3661 ctatgcagtt cacacagttc acactctgca tgttgaggag taagtggaca gatctcttaa
     3721 gcccaggggc tagcaaaccg gtctgtgggc caatttactc accgtctgtt tttgtacagc
     3781 ttgtgagcta aaaatggttt ttaaaaaggt tgaatacaat caaaagaata atattttgtg
     3841 gcatgagaaa agcatatgaa attcaaattt tagtgttcat aaataaaatt ttattggaac
     3901 ctaa
//
