LOCUS       NM_030797               4670 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CYFIP related Rac1 interactor A (CYRIA), mRNA.
ACCESSION   NM_030797 XM_005262629
VERSION     NM_030797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4670)
  AUTHORS   Le,A.H., Yelland,T., Paul,N.R., Fort,L., Nikolaou,S., Ismail,S. and
            Machesky,L.M.
  TITLE     CYRI-A limits invasive migration through macropinosome formation
            and integrin uptake regulation
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34165494
  REMARK    GeneRIF: CYRI-A limits invasive migration through macropinosome
            formation and integrin uptake regulation.
REFERENCE   2  (bases 1 to 4670)
  AUTHORS   Whitelaw,J.A., Lilla,S., Paul,N.R., Fort,L., Zanivan,S. and
            Machesky,L.M.
  TITLE     CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors
  JOURNAL   Commun Integr Biol 12 (1), 112-118 (2019)
   PUBMED   31413787
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4670)
  AUTHORS   Chen,C., Guo,Q., Shi,J., Jiao,X., Lv,K., Liu,X., Jiang,Y., Hui,X.
            and Song,T.
  TITLE     Genetic variants of MGMT, RHPN2, and FAM49A contributed to
            susceptibility of nonsyndromic orofacial clefts in a Chinese
            population
  JOURNAL   J Oral Pathol Med 47 (8), 796-801 (2018)
   PUBMED   29949196
  REMARK    GeneRIF: confirmed that three genes (rs7922405 of MGMT, rs73039426
            of RHPN2, and rs7552 of FAM49A) may contribute to nonsyndromic
            orofacial clefts in Chinese populations
REFERENCE   4  (bases 1 to 4670)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   5  (bases 1 to 4670)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA188616.1, BC038971.1 and AC104623.4.
            
            On Nov 23, 2018 this sequence version replaced NM_030797.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660803.209069.1, SRR1803611.248031.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381323.7/ ENSP00000370724.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA188616.1         33-49
            18-1468             BC038971.1         1-1451
            1469-4670           AC104623.4         45134-48335         c
FEATURES             Location/Qualifiers
     source          1..4670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..4670
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="CYFIP related Rac1 interactor A"
                     /db_xref="GeneID:81553"
                     /db_xref="HGNC:HGNC:25373"
     exon            1..55
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            56..211
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            212..291
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1193
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="protein FAM49A; family with sequence similarity 49
                     member A"
                     /codon_start=1
                     /product="CYFIP-related Rac1 interactor A"
                     /protein_id="NP_110424.1"
                     /db_xref="CCDS:CCDS1688.1"
                     /db_xref="GeneID:81553"
                     /db_xref="HGNC:HGNC:25373"
                     /translation="MGNLLKVLTREIENYPHFFLDFENAQPTEGEREIWNQISAVLQD
                     SESILADLQAYKGAGPEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKA
                     LQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPAIQNDFSYYRR
                     TISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIEN
                     TTDCLSTMTSVCKVMLETPEYRSRFTSEETLMFCMRVMVGVIILYDHVHPVGAFCKTS
                     KIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRAMLQ"
     exon            292..413
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            414..519
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            520..656
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            657..734
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            735..851
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            852..931
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1058
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1129
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..4670
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="hexamer: AATAAA"
     polyA_site      3989
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="major polyA site"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="hexamer: TATAAA"
     polyA_site      4542
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
                     /note="hexamer: ATTAAA"
     polyA_site      4670
                     /gene="CYRIA"
                     /gene_synonym="CYRI-A; FAM49A"
ORIGIN      
        1 agaggcgtac tcggcggcgg cggagcgggc ggcagagcag ggcggcggcg actcgcaggg
       61 taccaccatc ttaaggacag aaaagctaca ggactctagg aggccaccgt cctgatttgg
      121 gaagtccaac ttactttggc cagacagcag ctaagctggt tcatcccatc agcctggatt
      181 ggtgaaactg aatcacagga gatatttcca ggtttgctgg gatgggaaac ctgctcaaag
      241 tccttaccag ggaaattgaa aactatccac actttttcct ggattttgaa aatgctcagc
      301 ctacagaagg agagagagaa atctggaacc agatcagcgc cgtccttcag gattctgaga
      361 gcatccttgc agacctgcag gcttacaaag gcgcaggccc agagatccga gatgcaattc
      421 aaaatcccaa tgacattcag cttcaagaaa aagcttggaa tgcggtgtgc cctcttgttg
      481 tgaggctaaa gagattttac gagttttcca ttagactaga aaaagctctt cagagtttat
      541 tggaatctct gacttgtcca ccctacacac caacccaaca cctggaaagg gaacaggccc
      601 tggcaaagga gtttgccgaa attttacatt ttacccttcg attcgatgag ctgaagatga
      661 ggaacccggc tattcagaat gacttcagct actacagaag aacaatcagt cgcaaccgca
      721 tcaacaacat gcacctagac attgagaatg aagtcaataa tgagatggcc aatcgaatgt
      781 ccctcttcta tgcagaagcc acgccaatgc tgaaaaccct tagcaatgcc acaatgcact
      841 ttgtctctga aaacaaaact ctgccaatag agaacaccac agactgcctc agcacaatga
      901 caagtgtctg taaagtcatg ctggaaactc cggagtacag aagtaggttt acgagtgaag
      961 agaccctgat gttctgcatg agggtgatgg tgggagtcat catcctctat gaccatgtcc
     1021 accctgtggg agctttctgc aagacatcca agatcgatat gaaaggctgc ataaaagttt
     1081 tgaaggagca ggccccagac agtgtggagg ggctgctaaa tgccctcagg ttcactacaa
     1141 agcacttgaa cgatgaatca acttccaaac agattcgagc aatgcttcag tagagctctg
     1201 ctcaaagaag aggatctatg tgctgacctc agaagatgta tatgtttaca taatttaata
     1261 cagattgatg ttaatacttg tgtatttaca taaccgtttc cttcttgtca ctgaaatata
     1321 tggaccttaa tttgtatcct gactgactca acccagcaga gcataaattg acttgagagc
     1381 cttacctttg atgtctgaaa tgaaaccccc ttctccaaag gcaaaattcg gagactttga
     1441 tctttgctac tggagtcctt taacaacatc tataacgata aaaaattcct aattgtttgt
     1501 ggtagtattt taattctaga tgtgttatct ctctgggaag tatagtttat agaaacacaa
     1561 aatatttgat ttcctgtgtc ggctcagcta caagaaacac aactgttatc ttgacagagg
     1621 aagagaggaa tccaagaaaa atgcatgtgg agaattaaac ccaagtgttt cgaattcagc
     1681 acaccccctc tctgtcctca gactgcagtc cacacgtgca acttttctgt ttgcacgtgt
     1741 tttattaatc agcatactcc ttttctgttt ggatttatat ccctctaatg ttctccttta
     1801 atttcacatg aaaaaaaaat ctcctgtatt tttttcagtt agtgggagag cagcagaaat
     1861 agatagatgt gctgttgcca ctggactgat gaaggtggct gtcttggaac tgggagacag
     1921 gtcctcagag gtgcactcag gcaacaggac agccatctct ctgcttcagc cctctgccta
     1981 cagggattag ggaaatggag ctctggcttt gaagttattt gtgagtttag caaccttcca
     2041 gttacctgca gagttctggg tgcacagcca cccctcataa gagccctgtt ctctgaagac
     2101 cattcatatg agaacaaagg tctaggatac tgcattagtt accagaaaac taggggaatt
     2161 tagagggaaa aaaaatccat gttttctatt tcccaggttt ttaaaaagta gctcttcccc
     2221 aaccccgttg ctagcttgtt gcaatataaa agccctggtg cacctgaatt tactcctggc
     2281 cttactaatg attcataatg tgatcttgag aaatgtgttt aagctttctg agtcttaacc
     2341 tccttgtctc taaaatgggc aattaaaaca atcttcaaga gccctgtaag gttaatgccg
     2401 ataaaatgac tgactccgcc cttcttcctt agtacgtagt atccagcaag catttgcccc
     2461 accttgtctt gttgatgaac aatattatga agcctgcagt cattctctct gtacatcaga
     2521 gcttagttcg aatggaatca tgaaaatctc tgattctgac ctcctaagga aaaatgaaac
     2581 ccagaggatg tggtcataca ggatggctcc catgtgggcc tagaacccag gatgcttcac
     2641 tcttgactcc atgctcttcc ttttatacca tgtggctgtg aatacatact atgggatggg
     2701 attcaaccct tctaagtaaa tcctcagtct ggtctatatt gttacttgcc tgtttccact
     2761 agaaggagtc acccaggcat ttagtgaatg ataatcctag aagttgagtc tgagtacatc
     2821 agagtttggc attatttgca acatcccagg aatgagctat aagactccat tgctttctgg
     2881 actttagtga ccagctgatc ttcccttgga tcctccaata aaggggaaaa aatacttgtc
     2941 ttatgttgtt ttagcaaggg agttcagcca agtgacagga aagattccct ggtctgcatc
     3001 taaacattag tcaacagaag gaaaaggctc ttttccttgg agattttcaa gttgaaaaag
     3061 tacagctgct tggatggagt ttctctcatc agaatagaaa tatgctaggt ggtcttcaag
     3121 acctttttga acctacagat tctaaacctt agaggaagcc agaatatgtg atcataccag
     3181 gtgaggaaag ttaggagata ttcatcttaa gagatatcct atttggcagt cacatgttac
     3241 acttgagcaa caattgtcta ggctagaaat atagaaccac acaatattta tcatcattgg
     3301 gtcaatttct ccccctctat caagtgagga gattaaggct taaagaaagg aaaggacttg
     3361 ccagccacca cagggctcat gaggggcttg aacccatgtc gtgtgtctct accacagctg
     3421 actctcagct ggctaatgga gaaaatgtga ggaattacct gtcaaattag attgagctca
     3481 gagtaaatag atgagcacat ttataactct aaattagact ttctatcaaa tgggaccaaa
     3541 catatggaag gggctgctgt cctgcctcaa tttagccaag acttgtcttg tctcaaagcc
     3601 aagactcagc agtacatgga ttctgagaag tccagggtct gaattgttgt ctctgattac
     3661 tggaaggaca ggttaactga atgtctgtga tcactaacag gtgatgggct ttgtgcccac
     3721 tccagagata ttgtgggaga caaattcttt taacagcctg tcctcccggc atcaggagtc
     3781 attgaacaat catggattgt tgtgtttggg attttttttt ttttggcttt gtttttggtt
     3841 tttgtgtgtg tgtgtgtgtg ctgcatgcac atgcgtccaa gacttacggg tggtttaggg
     3901 gaaagtgcta gcaacagtgt caatgtcatt gttaactata tttcatattt gaggtctcat
     3961 tgttttcaaa taaacagtgt tttccatgac tgagatattt atttttggga aagcaacgag
     4021 gtaaaaatta tgtttctcag atgcactgct actttggcgt tattactgtg ttctcagaaa
     4081 ctcgttgtgc accactagga attagtagta gaaaaaaaaa aacaataaca aaaaaaaaaa
     4141 acaactggaa atggatgtct tcacattagg ggtggagtat taacaaccag aaagaaagtt
     4201 tggatattac cttttaacta ctagttaaca tcatgcttga tcaacatttg ctcctagtta
     4261 tcaccattaa attaagacct taatggtaaa ctgaggttac tgatgcatca tcacatttaa
     4321 gtaaaaataa tttcatgttt tccccaaaga aaaattaagc ctcccaatct taggatccaa
     4381 ttgtgcagta gaattcagag acttctcatt caatcttgta tcctatgcag ctacaaatat
     4441 tttttaaatg ttagtaataa acattggaat tttgtcttaa agagttcaaa accttggaac
     4501 ccagttttct cactacgtct ataaaggcca ttacagaccc aaggctgttt tgcagttttc
     4561 atatgttgtt tgctgaagtc attgtaattt tttttgcctg ctttgccttt ttttctacag
     4621 gagttttgag tgtgaaatga aaattaaagt ttggtacata tatttaaaaa
//
