LOCUS       NM_024033               1494 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cell cycle regulator of NHEJ (CYREN), transcript
            variant 1, mRNA.
ACCESSION   NM_024033
VERSION     NM_024033.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Arnoult,N., Correia,A., Ma,J., Merlo,A., Garcia-Gomez,S., Maric,M.,
            Tognetti,M., Benner,C.W., Boulton,S.J., Saghatelian,A. and
            Karlseder,J.
  TITLE     Regulation of DNA repair pathway choice in S and G2 phases by the
            NHEJ inhibitor CYREN
  JOURNAL   Nature 549 (7673), 548-552 (2017)
   PUBMED   28959974
  REMARK    GeneRIF: proposition that CYREN is a direct cell-cycle-dependent
            inhibitor of cNHEJ that promotes error-free repair by homologous
            recombination during cell cycle phases when sister chromatids are
            present
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Grundy,G.J., Rulten,S.L., Arribas-Bosacoma,R., Davidson,K.,
            Kozik,Z., Oliver,A.W., Pearl,L.H. and Caldecott,K.W.
  TITLE     The Ku-binding motif is a conserved module for recruitment and
            stimulation of non-homologous end-joining proteins
  JOURNAL   Nat Commun 7, 11242 (2016)
   PUBMED   27063109
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1494)
  AUTHORS   Lipovich,L., Tarca,A.L., Cai,J., Jia,H., Chugani,H.T.,
            Sterner,K.N., Grossman,L.I., Uddin,M., Hof,P.R., Sherwood,C.C.,
            Kuzawa,C.W., Goodman,M. and Wildman,D.E.
  TITLE     Developmental changes in the transcriptome of human cerebral cortex
            tissue: long noncoding RNA transcripts
  JOURNAL   Cereb Cortex 24 (6), 1451-1459 (2014)
   PUBMED   23377288
REFERENCE   5  (bases 1 to 1494)
  AUTHORS   Slavoff,S.A., Heo,J., Budnik,B.A., Hanakahi,L.A. and Saghatelian,A.
  TITLE     A human short open reading frame (sORF)-encoded polypeptide that
            stimulates DNA end joining
  JOURNAL   J Biol Chem 289 (16), 10950-10957 (2014)
   PUBMED   24610814
  REMARK    GeneRIF: Interacts with Ku and enhances efficiency of DNA double
            strand break ligation in vitro
REFERENCE   6  (bases 1 to 1494)
  AUTHORS   Agarwal,S., Harada,J., Schreifels,J., Lech,P., Nikolai,B.,
            Yamaguchi,T., Chanda,S.K. and Somia,N.V.
  TITLE     Isolation, characterization, and genetic complementation of a
            cellular mutant resistant to retroviral infection
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15933-15938 (2006)
   PUBMED   17043244
  REMARK    GeneRIF: Characterizes the hamster ortholog and suggests that it
            may modulate the ability of the proteasome to degrade retroviral
            cores upon cellular infection.
REFERENCE   7  (bases 1 to 1494)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083862.2.
            
            On Apr 16, 2020 this sequence version replaced NM_024033.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as MRI-1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000168.2, SRR14038192.3561438.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393114.8/ ENSP00000376823.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC083862.2         145325-145380       c
            57-331              AC083862.2         143459-143733       c
            332-407             AC083862.2         142405-142480       c
            408-1494            AC083862.2         140458-141544       c
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1494
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /note="cell cycle regulator of NHEJ"
                     /db_xref="GeneID:78996"
                     /db_xref="HGNC:HGNC:22432"
                     /db_xref="MIM:616980"
     exon            1..56
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..331
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..668
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     modulator of retrovirus infection homolog; cell cycle
                     regulator of non-homologous end joining"
                     /codon_start=1
                     /product="cell cycle regulator of non-homologous end
                     joining isoform 1"
                     /protein_id="NP_076938.2"
                     /db_xref="CCDS:CCDS5838.2"
                     /db_xref="GeneID:78996"
                     /db_xref="HGNC:HGNC:22432"
                     /db_xref="MIM:616980"
                     /translation="METLQSETKTRVLPSWLTAQVATKNVAPMKAPKRMRMAAVPVAA
                     ARLPATRTVYCMNEAEIVDVALGILIESRKQEKACEQPALAGADNPEHSPPCSVSPHT
                     SSGSSSEEEDSGKQALAPGLSPSQRPGGSSSACSRSPEEEEEEDVLKYVREIFFS"
     exon            332..407
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..1494
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /note="hexamer: AATACA"
     polyA_site      1494
                     /gene="CYREN"
                     /gene_synonym="C7orf49; CYREN-1; CYREN-2; MRI; MRI-2"
                     /note="major polyA site"
ORIGIN      
        1 agtggaggtc cgcagagttt gggcgccagg cgagacggca gggcttaaag ttccgggaat
       61 caaagatcaa ctcccactga ggacaaatgg acctgtaatt ccgggtgtga cgagagaacg
      121 agatttacct tcctgaatta aaaaacaggt cattaagctt gggccctgac tcttctttgt
      181 gagaaggtac agagatggaa accttacaat ccgagactaa aacgagggtc cttccctcat
      241 ggctgacagc ccaggtggct acaaagaatg tggcaccaat gaaggccccc aagaggatga
      301 gaatggcagc agtgccagtg gcagcagcaa gactccctgc gacaaggact gtgtactgca
      361 tgaatgaggc tgagatagtt gatgttgctc tgggaatcct gattgagagc cgcaaacagg
      421 aaaaggcctg cgagcagccg gccctggcgg gggctgataa cccagagcac tcccctccct
      481 gctccgtgtc gcctcacaca agttctggga gcagcagtga ggaagaggac agtgggaaac
      541 aggcactggc tccaggcctc agcccttccc agaggccggg gggttccagc tctgcctgta
      601 gcaggagccc tgaggaggag gaggaagagg atgtgctgaa atacgtccgg gagatctttt
      661 tcagctaggg cataaactgt gcactgaact gtctgccgag agcagctgga ggacagctga
      721 gcttccactg gtgctgctgg gccgcccgcc tgtgggaatg gggctctctg tgctcctacc
      781 tttgtgcctt cttgggcctg gcagattcac ctcaggccag aagcccctgg acactccggg
      841 ccttggggct gccgttctga gtgtgcggaa ggcaggactc aaaatgagat cccatttgac
      901 tccctctgta tgtactgtgc cctctcctgg ctcttgaggc tctggagtcc caattgtctg
      961 tgttagtcag tgaccaggtt ccagggaaaa tgatgtcatg tggtggtcca acttactgga
     1021 accaaagaga cagtactttg caaagaaaag gatcactgcc aggtgcactg gaattgctac
     1081 agtttagtcc gcatgatctc tcctgaagga ggaagcctgt ttcaaaaata gtttccatca
     1141 tgagtctatc aatgagctcc cacctctcca gccagcctag aaagcaaacg agctgcccac
     1201 agttctctgc cctgtctggg aggttgaggc cacagtgtat agactggtaa gccagacagg
     1261 cctcctcccg caagctgcta ccttgctttc acctgtacct tggtccccgg gcagctagct
     1321 ataaagcaag agggacagga gcccagaaga gacactgagg acaagagatc acaccagagt
     1381 acatgtctct gcctctgttt tcagtgtggc tttggacagg aatatatgaa taaatcactg
     1441 ccatacaggt tttccaatac acaagtgcta gaaaatacac acaattcccc aatg
//
