LOCUS       NM_178134               2162 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily Z member 1
            (CYP4Z1), mRNA.
ACCESSION   NM_178134 XM_942395 XM_945941
VERSION     NM_178134.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Al-Saraireh,Y.M., Alshammari,F.O.F.O., Satari,A.O., Al-Mahdy,Y.S.,
            Almuhaisen,G.H., Abu-Azzam,O.H., Uwais,A.N., Abufraijeh,S.M.,
            Al-Kharabsheh,A.M., Al-Dalain,S.M., Al-Qtaitat,A., Al-Tarawneh,F.,
            Al Shuneigat,J.M. and Al-Sarayreh,S.A.
  TITLE     Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian
            Cancers
  JOURNAL   Medicina (Kaunas) 58 (9), 1263 (2022)
   PUBMED   36143940
  REMARK    GeneRIF: Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis
            in Ovarian Cancers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Al-Saraireh,Y.M., Alshammari,F.O.F.O., Youssef,A.M.M.,
            Al-Sarayra,Y.M., Al-Saraireh,R.A., Al-Muhaisen,G.H., Al-Mahdy,Y.S.,
            Al-Kharabsheh,A.M., Abufraijeh,S.M. and Alrawashdeh,H.M.
  TITLE     Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in
            Patients with Cervical Cancer
  JOURNAL   Curr Oncol 28 (5), 3573-3584 (2021)
   PUBMED   34590601
  REMARK    GeneRIF: Cytochrome 4Z1 Expression Is Correlated with Poor
            Prognosis in Patients with Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Al-Saraireh,Y.M., Alshammari,F.O.F.O., Youssef,A.M.M.,
            Al-Sarayreh,S., Almuhaisen,G.H., Alnawaiseh,N., Al Shuneigat,J.M.
            and Alrawashdeh,H.M.
  TITLE     Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers
  JOURNAL   Sci Rep 11 (1), 5581 (2021)
   PUBMED   33692504
  REMARK    GeneRIF: Profiling of CYP4Z1 and CYP1B1 expression in bladder
            cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Liu,J., Machalz,D., Wolber,G., Sorensen,E.J. and Bureik,M.
  TITLE     New Proluciferin Substrates for Human CYP4 Family Enzymes
  JOURNAL   Appl Biochem Biotechnol 193 (1), 218-237 (2021)
   PUBMED   32869209
  REMARK    GeneRIF: New Proluciferin Substrates for Human CYP4 Family Enzymes.
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Du,W., Machalz,D., Yan,Q., Sorensen,E.J., Wolber,G. and Bureik,M.
  TITLE     Importance of asparagine-381 and arginine-487 for substrate
            recognition in CYP4Z1
  JOURNAL   Biochem Pharmacol 174, 113850 (2020)
   PUBMED   32044355
  REMARK    GeneRIF: Importance of asparagine-381 and arginine-487 for
            substrate recognition in CYP4Z1.
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Savas,U., Hsu,M.H., Griffin,K.J., Bell,D.R. and Johnson,E.F.
  TITLE     Conditional regulation of the human CYP4X1 and CYP4Z1 genes
  JOURNAL   Arch Biochem Biophys 436 (2), 377-385 (2005)
   PUBMED   15797250
  REMARK    GeneRIF: PPARalpha has a role in CYP4X1 regulation, and the
            glucocorticoid and progesterone receptors have roles in CYP4Z1 gene
            activation
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Rieger,M.A., Ebner,R., Bell,D.R., Kiessling,A., Rohayem,J.,
            Schmitz,M., Temme,A., Rieber,E.P. and Weigle,B.
  TITLE     Identification of a novel mammary-restricted cytochrome P450,
            CYP4Z1, with overexpression in breast carcinoma
  JOURNAL   Cancer Res 64 (7), 2357-2364 (2004)
   PUBMED   15059886
  REMARK    GeneRIF: Human cytochrome P450 (CYP), termed CYP4Z1,was identified,
            and the cDNA was cloned from a breast carcinoma line .
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450996.2 and AL135960.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_178134.2.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This gene is part of a cluster of cytochrome P450 genes on
            chromosome 1p33. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358631.1, AK292175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334194.4/ ENSP00000334246.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AL450996.2         59803-60239
            438-579             AL450996.2         61194-61335
            580-624             AL450996.2         73195-73239
            625-752             AL450996.2         74906-75033
            753-877             AL450996.2         77192-77316
            878-1032            AL450996.2         77396-77550
            1033-1136           AL135960.1         183282-183385       c
            1137-1327           AL135960.1         178667-178857       c
            1328-1461           AL135960.1         171690-171823       c
            1462-1526           AL135960.1         162358-162422       c
            1527-1609           AL135960.1         161219-161301       c
            1610-2162           AL135960.1         159633-160185       c
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2162
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /note="cytochrome P450 family 4 subfamily Z member 1"
                     /db_xref="GeneID:199974"
                     /db_xref="HGNC:HGNC:20583"
                     /db_xref="MIM:618953"
     exon            1..437
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1778
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.130"
                     /note="CYPIVZ1; cytochrome P450, family 4, subfamily Z,
                     polypeptide 1; laurate 7-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4Z1"
                     /protein_id="NP_835235.1"
                     /db_xref="CCDS:CCDS545.1"
                     /db_xref="GeneID:199974"
                     /db_xref="HGNC:HGNC:20583"
                     /db_xref="MIM:618953"
                     /translation="MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALH
                     LFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKIL
                     LKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESV
                     RMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNL
                     SKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDT
                     TQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYP
                     EHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITF
                     PDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLR
                     NCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC"
     exon            438..579
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            580..624
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            625..752
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            753..877
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1032
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1136
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1327
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1461
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1526
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1609
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..2162
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /note="hexamer: AATAAA"
     polyA_site      2162
                     /gene="CYP4Z1"
                     /gene_synonym="CYP4A20"
                     /note="major polyA site"
ORIGIN      
        1 atatgggtgt gagctgtcat gcacatggct cctatctgaa aatcttgttc ttctagaatc
       61 caggtctgct ggccaacatc tcagcagttt tcaccctgca gacttaatta ggcttcctct
      121 tccttatgtc ccctccctga atatggcatt ttgaaagccc agtgttgccc agggggcatc
      181 tcctttgtgt ttatgagaga cctgcattct ccctggctca gttctctcag gctctccaga
      241 gctcaggacc tctgagaaga atggagccct cctggcttca ggaactcatg gctcacccct
      301 tcttgctgct gatcctcctc tgcatgtctc tgctgctgtt tcaggtaatc aggttgtacc
      361 agaggaggag atggatgatc agagccctgc acctgtttcc tgcaccccct gcccactggt
      421 tctatggcca caaggagttt tacccagtaa aggagtttga ggtgtatcat aagctgatgg
      481 aaaaataccc atgtgctgtt cccttgtggg ttggaccctt tacgatgttc ttcagtgtcc
      541 atgacccaga ctatgccaag attctcctga aaagacaaga tcccaaaagt gctgttagcc
      601 acaaaatcct tgaatcctgg gttggtcgag gacttgtgac cctggatggt tctaaatgga
      661 aaaagcaccg ccagattgtg aaacctggct tcaacatcag cattctgaaa atattcatca
      721 ccatgatgtc tgagagtgtt cggatgatgc tgaacaaatg ggaggaacac attgcccaaa
      781 actcacgtct ggagctcttt caacatgtct ccctgatgac cctggacagc atcatgaagt
      841 gtgccttcag ccaccagggc agcatccagt tggacagtac cctggactca tacctgaaag
      901 cagtgttcaa ccttagcaaa atctccaacc agcgcatgaa caattttcta catcacaacg
      961 acctggtttt caaattcagc tctcaaggcc aaatcttttc taaatttaac caagaacttc
     1021 atcagttcac agagaaagta atccaggacc ggaaggagtc tcttaaggat aagctaaaac
     1081 aagatactac tcagaaaagg cgctgggatt ttctggacat acttttgagt gccaaaagcg
     1141 aaaacaccaa agatttctct gaagcagatc tccaggctga agtgaaaacg ttcatgtttg
     1201 caggacatga caccacatcc agtgctatct cctggatcct ttactgcttg gcaaagtacc
     1261 ctgagcatca gcagagatgc cgagatgaaa tcagggaact cctaggggat gggtcttcta
     1321 ttacctggga acacctgagc cagatgcctt acaccacgat gtgcatcaag gaatgcctcc
     1381 gcctctacgc accggtagta aacatatccc ggttactcga caaacccatc acctttccag
     1441 atggacgctc cttacctgca ggaataactg tgtttatcaa tatttgggct cttcaccaca
     1501 acccctattt ctgggaagac cctcaggtct ttaacccctt gagattctcc agggaaaatt
     1561 ctgaaaaaat acatccctat gccttcatac cattctcagc tggattaagg aactgcattg
     1621 ggcagcattt tgccataatt gagtgtaaag tggcagtggc attaactctg ctccgcttca
     1681 agctggctcc agaccactca aggcctcccc agcctgttcg tcaagttgtc ctcaagtcca
     1741 agaatggaat ccatgtgttt gcaaaaaaag tttgctaatt ttaagtcctt tcgtataaga
     1801 attaatgaga caattttcct accaaaggaa gaacaaaagg ataaatataa tacaaaatat
     1861 atgtatatgg ttgtttgaca aattatataa cttaggatac ttctgactgg ttttgacatc
     1921 cattaacagt aattttaatt tctttgctgt atctggtgaa acccacaaaa acacctgaaa
     1981 aaactcaagc tgacttccac tgcgaaggga aattattggt ttgtgtaact agtggtagag
     2041 tggctttcaa gcatagtttg atcaaaactc cactcagtat ctgcattact tttatctctg
     2101 caaatatctg catgatagct ttattctcag ttatctttcc ccataataaa aaatatctgc
     2161 ca
//
