LOCUS       NM_007253               2908 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily F member 8
            (CYP4F8), mRNA.
ACCESSION   NM_007253
VERSION     NM_007253.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2908)
  AUTHORS   Liu,J., Machalz,D., Wolber,G., Sorensen,E.J. and Bureik,M.
  TITLE     New Proluciferin Substrates for Human CYP4 Family Enzymes
  JOURNAL   Appl Biochem Biotechnol 193 (1), 218-237 (2021)
   PUBMED   32869209
  REMARK    GeneRIF: New Proluciferin Substrates for Human CYP4 Family Enzymes.
REFERENCE   2  (bases 1 to 2908)
  AUTHORS   Aslibekyan,S., Kabagambe,E.K., Irvin,M.R., Straka,R.J.,
            Borecki,I.B., Tiwari,H.K., Tsai,M.Y., Hopkins,P.N., Shen,J.,
            Lai,C.Q., Ordovas,J.M. and Arnett,D.K.
  TITLE     A genome-wide association study of inflammatory biomarker changes
            in response to fenofibrate treatment in the Genetics of Lipid
            Lowering Drug and Diet Network
  JOURNAL   Pharmacogenet Genomics 22 (3), 191-197 (2012)
   PUBMED   22228203
REFERENCE   3  (bases 1 to 2908)
  AUTHORS   Vainio,P., Gupta,S., Ketola,K., Mirtti,T., Mpindi,J.P., Kohonen,P.,
            Fey,V., Perala,M., Smit,F., Verhaegh,G., Schalken,J., Alanen,K.A.,
            Kallioniemi,O. and Iljin,K.
  TITLE     Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8
            identified as putative novel therapeutic targets in prostate cancer
  JOURNAL   Am J Pathol 178 (2), 525-536 (2011)
   PUBMED   21281786
  REMARK    GeneRIF: The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly
            expressed in prostate cancer.
REFERENCE   4  (bases 1 to 2908)
  AUTHORS   Saito,A., Kawamoto,M. and Kamatani,N.
  TITLE     Association study between single-nucleotide polymorphisms in 199
            drug-related genes and commonly measured quantitative traits of 752
            healthy Japanese subjects
  JOURNAL   J Hum Genet 54 (6), 317-323 (2009)
   PUBMED   19343046
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2908)
  AUTHORS   Stark,K., Wongsud,B., Burman,R. and Oliw,E.H.
  TITLE     Oxygenation of polyunsaturated long chain fatty acids by
            recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125
            and Gly-328 of CYP4F8
  JOURNAL   Arch Biochem Biophys 441 (2), 174-181 (2005)
   PUBMED   16112640
  REMARK    GeneRIF: We conclude that CYP4F8 and CYP4F12 catalyze epoxidation
            of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6.
REFERENCE   6  (bases 1 to 2908)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2908)
  AUTHORS   Oliw,E.H., Stark,K. and Bylund,J.
  TITLE     Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by
            human cytochromes P450: analysis of omega-side chain hydroxy
            metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by
            mass spectrometry
  JOURNAL   Biochem Pharmacol 62 (4), 407-415 (2001)
   PUBMED   11448449
REFERENCE   8  (bases 1 to 2908)
  AUTHORS   Bylund,J., Hidestrand,M., Ingelman-Sundberg,M. and Oliw,E.H.
  TITLE     Identification of CYP4F8 in human seminal vesicles as a prominent
            19-hydroxylase of prostaglandin endoperoxides
  JOURNAL   J Biol Chem 275 (29), 21844-21849 (2000)
   PUBMED   10791960
REFERENCE   9  (bases 1 to 2908)
  AUTHORS   Bylund,J., Finnstrom,N. and Oliw,E.H.
  TITLE     Gene expression of a novel cytochrome P450 of the CYP4F subfamily
            in human seminal vesicles
  JOURNAL   Biochem Biophys Res Commun 261 (1), 169-174 (1999)
   PUBMED   10405341
REFERENCE   10 (bases 1 to 2908)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA871128.1, DA877298.1,
            AF133298.1, DB329701.1, AI401776.1 and AD000685.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007253.3.
            
            Summary: This gene, CYP4F8, encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and functions
            as a 19-hydroxylase of prostaglandins in seminal vesicles. This
            gene is part of a cluster of cytochrome P450 genes on chromosome
            19. Another member of this family, CYP4F3, is approximately 18 kb
            away. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155984, SAMEA2159368
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612078.5/ ENSP00000477567.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DA871128.1         1-35
            36-262              DA877298.1         1-227
            263-1378            AF133298.1         206-1321
            1379-1461           DB329701.1         354-436             c
            1462-1644           AF133298.1         1405-1587
            1645-1812           DB329701.1         93-260              c
            1813-1907           AI401776.1         1-95                c
            1908-2908           AD000685.1         14883-15883
FEATURES             Location/Qualifiers
     source          1..2908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2908
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /note="cytochrome P450 family 4 subfamily F member 8"
                     /db_xref="GeneID:11283"
                     /db_xref="HGNC:HGNC:2648"
                     /db_xref="MIM:611545"
     exon            1..63
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            64..262
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1627
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /EC_number="1.14.14.1"
                     /note="flavoprotein-linked monooxygenase; cytochrome P450,
                     subfamily IVF, polypeptide 8; microsomal monooxygenase;
                     cytochrome P450, family 4, subfamily F, polypeptide 8"
                     /codon_start=1
                     /product="cytochrome P450 4F8"
                     /protein_id="NP_009184.1"
                     /db_xref="CCDS:CCDS74303.1"
                     /db_xref="GeneID:11283"
                     /db_xref="HGNC:HGNC:2648"
                     /db_xref="MIM:611545"
                     /translation="MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHN
                     GRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLC
                     HPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNIL
                     KPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKP
                     SEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRR
                     TLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTA
                     SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLH
                     PPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENA
                     QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRA
                     EDGLWLRVEPLG"
     exon            263..407
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            408..461
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            462..589
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            590..711
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            712..982
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1049
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1179
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1313
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1378
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1461
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2908
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /note="hexamer: AGTAAA"
     polyA_site      1908
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /note="major polyA site"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /note="hexamer: AATAAA"
     polyA_site      2442
                     /gene="CYP4F8"
                     /gene_synonym="CPF8; CYPIVF8"
                     /note="major polyA site"
ORIGIN      
        1 agcaaaaacc tcctggcaaa ggaggagagg aggttgtgcg ggacaacctt ctcctgacag
       61 aaggatgtcg ctgctgagcc tgtcttggct gggcctcagg ccggtggcag catccccgtg
      121 gctgctcctg ctggtggtcg gggcctcctg gctcctggcc cgcatcctgg cctggaccta
      181 tgccttctat cacaacggcc gccgcctccg gtgtttcccg cagccccgga aacagaactg
      241 gttcttgggt cacctgggcc tggtcactcc cacagaggag ggcttgaggg tcctgaccca
      301 gctggtggcc acctaccccc agggctttgt gaggtggttg ggccccatca ctcccatcat
      361 caacttgtgc caccctgaca tcgtccgatc tgtcatcaat acctcagatg ccattacaga
      421 caaggacata gtcttctaca agaccctgaa gccctggctg ggggatgggc tcttgttaag
      481 tgttggtgac aagtggagac accaccgtcg cttgctgacg cctgccttcc atttcaacat
      541 cctgaagccc tatataaaga ttttcagcaa gagtgcaaac atcatgcatg ccaagtggca
      601 acgcctggcc atggagggca gcacctgtct ggatgtgttt gagcacatca gccttatgac
      661 cctggacagt ctgcagaaat gcatcttcag ctttgacagc aattgtcagg agaagcccag
      721 tgaatatatt actgcgatca tggagctcag tgcccttgta gtgaaacgga ataaccagtt
      781 cttccggtac aaggacttcc tgtacttcct cactccctgt ggacggcgct tccacagggc
      841 ctgcagactg gtgcacgact tcacagatgc cgtcatccag gagcggcgcc gcaccctcac
      901 tagccagggt gttgatgact tcctccaagc caaggccaag tccaagactt tggactttat
      961 tgatgtgctc ctgctgagcg aggataaaaa tggtaaagag ttgtcagatg aggacataag
     1021 agcagaagct gacactttca tgtttggagg ccatgacacc acggccagtg gcctctcctg
     1081 ggtcttgtac aacctcgcga ggcacccaga ataccaagaa cgctgccggc aggaggtgca
     1141 agagcttctg aaggaccgtg agcctaaaga gattgaatgg gacgacctgg cccagttgcc
     1201 cttcctgacc atgtgcctga aggagagcct gcggttgcat cccccaatcc ctacattcgc
     1261 ccgcggctgc acccaggacg tggtgctccc agacagccga gtcatcccca aagggaatgt
     1321 ctgtaacatc aacatcttcg caatccatca caacccctca gtctggccag accctgaggt
     1381 ctatgacccc ttccgcttcg acccagaaaa cgcccagaag aggtcaccta tggcttttat
     1441 tcctttctcg gcggggccca ggaactgcat cgggcagaag ttcgcgatgg cagagatgaa
     1501 ggtggtcctg gcgctcacgc tgctgcgctt ccgcatcctg cccgaccaca gggagccacg
     1561 caggacgccg gagattgttt tgcgtgcgga ggacggactt tggctgcgag tagaacccct
     1621 gggctgaggc ctgcagtgac ccacccacct acctttgcat cacctacctt tgcaccaact
     1681 accttttcag atttccggta ataaatctgt gttggcccct gtgcctcagt cccgcggatg
     1741 gccagtaggg ggcgctggag gactgcgggg atctagggcc tggctgggaa gaggcgggga
     1801 gatgtctctg tgcccaagat actcactgcc tctctgggtg agcacaggag ccccgtgctg
     1861 agggtgggat ctcccagagt ctaagtaaag actttttccc ccccaaaata attgtgtatt
     1921 ctgatataaa tttttgccaa tttagaatcc ctgtttttta gctaggtgca tagcagcctg
     1981 aaatacagat cacatttgaa agcctttctt gaagctcaat tggttaagtg actgtggctg
     2041 tcccatgtgt agaagccaaa gattatgtgg taattctggt aacctttctt aagagaaagc
     2101 tgctacagtc tgtctgctca gtcctcccct cttccttcct gctgcttgga agattttttt
     2161 ttttttttga gacatggtgt ctctcgtcgc ccaggccgga gtgcagtggc tcactgcaac
     2221 ctccacctcc tgggttcaag tgattctcct gactcagtcg cctgagtaga taggataaca
     2281 ggcgcctacc accacacccg gctaattgta tttttagtac agatggggtt ttgctatgtt
     2341 ggccaggctg gtctcaaact cctggcctca agtgatcagc ccacctcagc ctcccaaagt
     2401 gccagaattg caggtgtgag aataaaaatt cttgagtttc aatgtttatt ttagaatcag
     2461 gtgctaacat gcaaatttat tacaaaggta tattgcatca tgctgaggtt tggagtatga
     2521 atgactccat cacccatgta gtgagcatag tatctaatag gcagtttttc agcttttccc
     2581 cctccctgct tcccctgtct agtagtcccc aggatctgtt gttcccatct ttattaccat
     2641 gtgtatccaa tgcatacctc ccacttataa gtgagaacat gcaatatttt gttttctgtt
     2701 cctgcattag tttgcttagg ataatggccc ccagctgcat ctatgttgct gcaaacgaca
     2761 tgattttgta ctttttaatg actgcatagt atttcatggt gtatttctac acattttctt
     2821 tatccactcc accattgatg ggcacctgtg ttgattcagc atcttcgcta ttgtgattag
     2881 agctgcgata aacatgtgga tgcttgtg
//
