LOCUS       NM_000896               5053 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily F member 3
            (CYP4F3), transcript variant 1, mRNA.
ACCESSION   NM_000896
VERSION     NM_000896.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5053)
  AUTHORS   Ananthakrishnan,A.N., Khalili,H., Song,M., Higuchi,L.M.,
            Lochhead,P., Richter,J.M. and Chan,A.T.
  TITLE     Genetic Polymorphisms in Fatty Acid Metabolism Modify the
            Association Between Dietary n3: n6 Intake and Risk of Ulcerative
            Colitis: A Prospective Cohort Study
  JOURNAL   Inflamm Bowel Dis 23 (11), 1898-1904 (2017)
   PUBMED   28991856
  REMARK    GeneRIF: High n3:n6 polyunsaturated fatty acids (PUFA) intake was
            associated with a reduced risk of ulcerative colitis (UC) in
            individuals with the GG/AG genotype at a single nucleotide
            polymorphism in CYP4F3 but not those with the AA genotype. The
            association between dietary n3:n6 PUFA intake and risk of UC may be
            modified variants at CYP4F3.
REFERENCE   2  (bases 1 to 5053)
  AUTHORS   Yin,J., Liu,H., Liu,Z., Owzar,K., Han,Y., Su,L., Wei,Y., Hung,R.J.,
            Brhane,Y., McLaughlin,J., Brennan,P., Bickeboeller,H.,
            Rosenberger,A., Houlston,R.S., Caporaso,N., Landi,M.T.,
            Heinrich,J., Risch,A., Christiani,D.C., Amos,C.I. and Wei,Q.
  TITLE     Pathway-analysis of published genome-wide association studies of
            lung cancer: A potential role for the CYP4F3 locus
  JOURNAL   Mol Carcinog 56 (6), 1663-1672 (2017)
   PUBMED   28150878
  REMARK    GeneRIF: The results suggest that a potentially functional
            single-nucleotide polymorphisms in CYP4F3 (rs4646904) may
            contribute to the etiology of lung cancer, especially in smokers.
REFERENCE   3  (bases 1 to 5053)
  AUTHORS   Costea,I., Mack,D.R., Lemaitre,R.N., Israel,D., Marcil,V., Ahmad,A.
            and Amre,D.K.
  TITLE     Interactions between the dietary polyunsaturated fatty acid ratio
            and genetic factors determine susceptibility to pediatric Crohn's
            disease
  JOURNAL   Gastroenterology 146 (4), 929-931 (2014)
   PUBMED   24406470
  REMARK    GeneRIF: Children who consumed a higher dietary ratio of
            omega6/omega3 were susceptible for Crohn's disease if they were
            also carriers of specific variants of CYP4F3 and FADS2 genes.
REFERENCE   4  (bases 1 to 5053)
  AUTHORS   Corcos,L., Lucas,D., Le Jossic-Corcos,C., Dreano,Y., Simon,B.,
            Plee-Gautier,E., Amet,Y. and Salaun,J.P.
  TITLE     Human cytochrome P450 4F3: structure, functions, and prospects
  JOURNAL   Drug Metabol Drug Interact 27 (2), 63-71 (2012)
   PUBMED   22706230
  REMARK    GeneRIF: In this short review, emphasis will be placed on the
            regulation and the functional roles of human CYP4F3--{REVIEW}
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5053)
  AUTHORS   Reina Ortiz,M., Schreiber,F., Benitez,S., Broncano,N., Chico,M.E.,
            Vaca,M., Alexander,N., Lewis,D.J., Dougan,G. and Cooper,P.J.
  TITLE     Effects of chronic ascariasis and trichuriasis on cytokine
            production and gene expression in human blood: a cross-sectional
            study
  JOURNAL   PLoS Negl Trop Dis 5 (6), e1157 (2011)
   PUBMED   21666788
REFERENCE   6  (bases 1 to 5053)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 5053)
  AUTHORS   Kikuta,Y., Kato,M., Yamashita,Y., Miyauchi,Y., Tanaka,K., Kamada,N.
            and Kusunose,M.
  TITLE     Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular
            cloning and chromosomal localization
  JOURNAL   DNA Cell Biol 17 (3), 221-230 (1998)
   PUBMED   9539102
REFERENCE   8  (bases 1 to 5053)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
REFERENCE   9  (bases 1 to 5053)
  AUTHORS   Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
            Kusunose,M.
  TITLE     Cloning and expression of a novel form of leukotriene B4
            omega-hydroxylase from human liver
  JOURNAL   FEBS Lett 348 (1), 70-74 (1994)
   PUBMED   8026587
REFERENCE   10 (bases 1 to 5053)
  AUTHORS   Kikuta,Y., Kusunose,E., Endo,K., Yamamoto,S., Sogawa,K.,
            Fujii-Kuriyama,Y. and Kusunose,M.
  TITLE     A novel form of cytochrome P-450 family 4 in human
            polymorphonuclear leukocytes. cDNA cloning and expression of
            leukotriene B4 omega-hydroxylase
  JOURNAL   J Biol Chem 268 (13), 9376-9380 (1993)
   PUBMED   8486631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB002454.1, D12621.1 and
            AD000685.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000896.2.
            
            Summary: This gene, CYP4F3, encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum. The enzyme
            starts the process of inactivating and degrading leukotriene B4, a
            potent mediator of inflammation. This gene is part of a cluster of
            cytochrome P450 genes on chromosome 19. Another member of this
            family, CYP4F8, is approximately 18 kb away. Several transcript
            variants encoding two different isoforms have been found for this
            gene. [provided by RefSeq, Apr 2019].
            
            Transcript Variant: This variant (1) encodes isoform a, which is
            the same length but has internal differences compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002454.1, D12620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221307.13/ ENSP00000221307.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-855               AB002454.1         1-855
            856-1093            D12621.1           822-1059
            1094-1123           AB002454.1         1094-1123
            1124-1219           D12621.1           1090-1185
            1220-1447           AB002454.1         1220-1447
            1448-2988           AD000685.1         44464-46004
            2989-5053           AD000685.1         46005-48069
FEATURES             Location/Qualifiers
     source          1..5053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..5053
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /note="cytochrome P450 family 4 subfamily F member 3"
                     /db_xref="GeneID:4051"
                     /db_xref="HGNC:HGNC:2646"
                     /db_xref="MIM:601270"
     exon            1..49
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            50..248
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1613
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /EC_number="1.14.14.94"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.79"
                     /note="isoform a is encoded by transcript variant 1;
                     leukotriene-B4 20-monooxygenase; cytochrome
                     P450-LTB-omega; cytochrome P450, subfamily IVF,
                     polypeptide 3 (leukotriene B4 omega hydroxylase);
                     leukotriene-B(4) omega-hydroxylase 2; cytochrome P-450;
                     cytochrome P450 4F3; leukotriene-B(4) 20-monooxygenase 2;
                     20-HETE synthase; 20-hydroxyeicosatetraenoic acid
                     synthase; docosahexaenoic acid omega-hydroxylase CYP4F3;
                     cytochrome P450, family 4, subfamily F, polypeptide 3"
                     /codon_start=1
                     /product="cytochrome P450 4F3 isoform a"
                     /protein_id="NP_000887.2"
                     /db_xref="CCDS:CCDS12332.1"
                     /db_xref="GeneID:4051"
                     /db_xref="HGNC:HGNC:2646"
                     /db_xref="MIM:601270"
                     /translation="MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDN
                     CCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIF
                     HPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNIL
                     KPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
                     SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR
                     TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
                     SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH
                     PPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNI
                     KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRA
                     EGGLWLRVEPLS"
     exon            249..393
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            394..447
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            448..575
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            576..697
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            698..968
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1035
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1165
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1299
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1364
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1447
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..5053
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /note="hexamer: AATGAA"
     polyA_site      1987
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
     regulatory      5032..5037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /note="hexamer: AATAAA"
     polyA_site      5053
                     /gene="CYP4F3"
                     /gene_synonym="CPF3; CYP4F; CYPIVF3; LTB4H"
                     /note="major polyA site"
ORIGIN      
        1 agaagaaggg gagaggaggt tgtgtgggac aaggtgctcc tgacagaagg atgccacagc
       61 tgagcctgtc ctcgctgggc ctttggccaa tggcagcatc cccgtggctg ctcctgctgc
      121 tggttggggc ctcctggctc ctggcccgca tcctggcctg gacctatacc ttctatgaca
      181 actgctgccg cctccggtgt ttcccgcaac ccccgaaacg gaattggttc ttgggtcacc
      241 tgggcctgat tcacagctcg gaggaaggtc tcctatacac acaaagcctg gcatgcacct
      301 tcggtgatat gtgctgctgg tgggtggggc cctggcacgc aatcgtccgc atcttccacc
      361 ccacctacat caagcctgtg ctctttgctc cagctgccat tgtaccaaag gacaaggtct
      421 tctacagctt cctgaagccc tggctggggg atgggctcct gctgagtgct ggtgaaaagt
      481 ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg aagccctata
      541 tgaagatttt caatgagagt gtgaacatca tgcatgccaa gtggcagctc ctggcctcag
      601 agggtagtgc ccgtctggac atgtttgagc acatcagcct catgaccttg gacagtctgc
      661 agaaatgtgt cttcagcttt gacagccatt gccaggagaa gcccagtgaa tatattgccg
      721 ccatcttgga gctcagtgcc cttgtgacaa aaagacacca gcagatcctc ctgtacatag
      781 acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc cgcctggtgc
      841 acgacttcac agatgccgtc atccaggagc ggcgccgcac cctccctagc cagggtgttg
      901 atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat gtactcctgc
      961 tgagcaagga tgaagatggg aagaagttgt ccgatgagga cataagagca gaagctgaca
     1021 cctttatgtt tgagggccat gacaccacag ccagtggtct ctcctgggtc ctgtaccacc
     1081 ttgcaaagca cccggaatac caggagcgct gtcggcagga ggtgcaagag cttctgaagg
     1141 accgtgagcc taaagagatt gaatgggacg acctggccca gctgcccttc ctgaccatgt
     1201 gcattaagga gagcctgagg ctgcatcccc cagtccctgc cgtctctcgc tgctgcaccc
     1261 aagacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc ctcatcagtg
     1321 tttttggaac ccatcacaac ccagccgtgt ggccggaccc tgaggtctat gacccctttc
     1381 gctttgaccc aaagaacatc aaggagaggt cacctctggc ttttattccc ttctcagcag
     1441 ggcccaggaa ctgcatcggg caggcgttcg cgatggcgga gatgaaggtg gtcctggggc
     1501 tcacgctgct gcgcttccgc gtcctgcctg accacaccga gccccgcagg aagccggagc
     1561 tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc tgagttctgc
     1621 agagacccac tctgacccca ctaaaatgac ccctgattca tcaaaagtga ggcctagaat
     1681 taccctaaga ccctgttcca cagtcctgta ttccatccta gatatctact caaaataatt
     1741 gagacaagtg ttcaaacaga aagacgcttg tgcgtgaatg ttcatggcag ccctattcac
     1801 agtagccaaa cgatgaaaac aaccccaagc tatatattac cagatgaaag gataaacaaa
     1861 atatggtcca tccatacaat ggagtattac acagccataa aaaggaatga agcagtgatc
     1921 cccactacac tgtggatgaa ccttgaatgc atgatactga atgaaagaca tcagatgcaa
     1981 aaggtcacat agtgtactgt ccttttatat gaaatttcca gaacaggcca atctgaagag
     2041 atgtatagtg gattggtggc tttcagcagc tgtggggagg tgggactgag gagcgactgc
     2101 taatcaggat ggggtttcct cctgggatgg tgaaaatgtt ccggacctag atagtgatga
     2161 aggtagcacg acactgtgag tgcactaaat gctattgaat tggacacttt agaatggttg
     2221 aaatagtgat ttttatgtga attctaccta aacatgctat tacagctcat atatactttt
     2281 tccatctgga ttcttcacaa aagaatatgt tgtgagcatc tttccatgat attaaatcat
     2341 cttaggaaac attattttgt gttcttcaaa atgtgcatgt taagtattca aatcagtctt
     2401 aaatttttaa aaatatgtaa ttttagaaaa taatttaaaa ggttttgttt cagtttgtaa
     2461 gatttctttt ctggcacttt aatggcttga ggtatcatta tcagttacaa attgagttat
     2521 tcttcatcaa atgacttttg gagtagagat tttattttta tagcaataga tgcacagata
     2581 ttcctgtaag atacaggtgt ggttagacac ttttctagaa caggcatgcc ctgcaaactc
     2641 cacagacact gactgttttt gtcctattaa gaagtagacc actgagaagg gagaaggtga
     2701 cattttagct ttcccaggta aaagtggttt tcatcctcac accaatttta tggactggac
     2761 gttaactctc ttgctcaagg tcactctgag tggaagagtg gggataaatc tggttcgttt
     2821 ggcatcagag gccatgactt ttcctaccac agaagtaatt ttcaaagtaa gtctctgccc
     2881 taggcacatc agatcacctg gggaccactc cagagtgagt agacaagact ttgacagggg
     2941 tgcctaattt tttttttttt ttgagatgga gtctcgctct gttgcccagg ctggagtgca
     3001 gtggcatgat ctcagttcac tgcaacctcc gcctcctgcg ttcaagtgat tgtcctgtct
     3061 cagcctccca agtagctggg attacaggca cccaccacca catccagcta attgttgtat
     3121 ttttaataga ggcggggttt cgccatgttg cactggctgg tgttgaactc ctaacctcag
     3181 gtgatccacc cgcctcggcc tcccaaagtg ctgggattac aggcccggtc cagtttgata
     3241 gtttgttatc atgttatacg tacacttaga ataatgatcc agccatctca ttctaacagc
     3301 aatgagaact taggctcccc tctctactaa aatacaaaag ttagctggtc atggtggtgc
     3361 gggcctgtaa tcccagctac tcgggaggct gatgcgggag aatcacttga aacccacagg
     3421 cggaggttgc agtgagctga ggtggtgcca ctacgctcca gcctggggga gggggacata
     3481 gcgagactcg gtctcaaaaa caaaacaaaa caaaacaaaa caaaacaaaa acaaaacaaa
     3541 acaaaacaaa acactgccaa actgtttcca aagcatctgc atcgtgttta atttccataa
     3601 gtaacgtatg agaattctag gtcctccaaa taattagcag tccttcgtag tgtcagtttt
     3661 tgtttcagcc ttccttatgg gtatgctgtg gcatatccct gagattttaa ttcgcatttt
     3721 ccagtgacta agggtgttga accactcgtg ccttcctgtg cctatttgac actcctatat
     3781 tttctttggt gaagtgtctg ttcaatcatc tgctcattaa attttccttc ggttgtttgc
     3841 cttcttattg ttggattttg agagttctat gtacaagtcc tttgtcagtc gtgtgatttg
     3901 caagtcttct tcctagtctc tgaagtttct ttctttcata gagcaaacgt tttaaatttt
     3961 tatgaagtaa gacttctcag ttttattttt ggtgaattat gtttatactg ccatatatag
     4021 gaactctttg cttaactgga ggtcatggag attttctcct acattttctt ttaaaagttt
     4081 tatagtttca gagtttacat gtaattccat aatctccatt tagttaaatt ttgtatgggg
     4141 tgtgaactgt ggtttgactg ttttcttgta tatggatatc caattgtttc acacaatttt
     4201 tttgaaaaga atatccttgg cagggcacgg tagctcacac ctgtaatccc agcactttag
     4261 gaggtcaagg tgggcagatc atgaggtcag gagtttgaga ccagcctggc caatatggtg
     4321 aaaccacgtc tctattaaaa atagaaaaat tagccaggcg tggtggtgtg tgcctgtatt
     4381 cacagctgct tggatggctg aggcaggaga atcgcttgaa cccaggagtc agaggtttca
     4441 gtgagccgag attgtgccac tgcactccag cctgggtgaa agagctagat tctctctctc
     4501 aaaaaaaaaa aaaaaaaaaa ggaaagaaag aaagaaaaga aaagaaaatc ctttttgctt
     4561 taacttgcct tgcaggtttg tagaaaactc aattgttgaa atttgggtgg atatatttct
     4621 ggattttcta ttctattcca tgttggacca ataccacact gccctagtca ctgttgcatt
     4681 atagtatatc tttaaaggag taatgggaat ccttcaacta cattttttcc ccaataattt
     4741 ttggctattc tgcttccttt gtgtttctat gtaaatttta tcatcagtgt gtctatttct
     4801 acaaatagtc ctgatagggt ttgaattggg atttctgtga atctatagat caatctgagg
     4861 agacttaata atgatattga ttctcccaat tcatgaatat agtatacccc tgtatttatt
     4921 tgttttcttg aatttctttt atcattgttt tgtagttttc accatgacag tcttgcacat
     4981 attttgttaa atgtacagct gagaatttaa ttttttctgg tgtacaatgc taataaaatg
     5041 gtgctttaaa aga
//
