LOCUS       NM_001082               2361 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily F member 2
            (CYP4F2), mRNA.
ACCESSION   NM_001082
VERSION     NM_001082.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Sato,Y., Hishinuma,E., Yamazaki,S., Ueda,A., Kumondai,M., Saito,S.,
            Tadaka,S., Kinoshita,K., Nakayoshi,T., Oda,A., Maekawa,M., Mano,N.,
            Hirasawa,N. and Hiratsuka,M.
  TITLE     Functional Characterization of 29 Cytochrome P450 4F2 Variants
            Identified in a Population of 8380 Japanese Subjects and Assessment
            of Arachidonic Acid omega-Hydroxylation
  JOURNAL   Drug Metab Dispos 51 (12), 1561-1568 (2023)
   PUBMED   37775333
  REMARK    GeneRIF: Functional Characterization of 29 Cytochrome P450 4F2
            Variants Identified in a Population of 8380 Japanese Subjects and
            Assessment of Arachidonic Acid omega-Hydroxylation.
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Ilut,S., Vesa,S.C., Vacaras,V., Sipos-Lascu,D., Barsan,C.,
            Pop,R.M., Crisan,S., Macarie,A.E., Coada,C.A., Perju-Dumbrava,L.,
            Muresanu,D.F. and Buzoianu,A.D.
  TITLE     Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX
            rs11676382 polymorphisms and acute ischemic stroke
  JOURNAL   Medicine (Baltimore) 102 (34), e34836 (2023)
   PUBMED   37653796
  REMARK    GeneRIF: Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX
            rs11676382 polymorphisms and acute ischemic stroke.
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Giraldo-Ocampo,S., Diaz-Ordonez,L., Silva-Cuero,Y.K.,
            Gutierrez-Medina,J.D., Candelo,E., Diaz,J.A. and Pachajoa,H.
  TITLE     Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes
            related to the metabolism of Warfarin in healthy donors from Cali,
            Colombia
  JOURNAL   Medicine (Baltimore) 102 (30), e34204 (2023)
   PUBMED   37505171
  REMARK    GeneRIF: Frequency of polymorphisms in the CYP2C9, VKORC1, and
            CYP4F2 genes related to the metabolism of Warfarin in healthy
            donors from Cali, Colombia.
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Tanzo,J.T., Li,V.L., Wiggenhorn,A.L., Moya-Garzon,M.D., Wei,W.,
            Lyu,X., Dong,W., Tahir,U.A., Chen,Z.Z., Cruz,D.E., Deng,S., Shi,X.,
            Zheng,S., Guo,Y., Sims,M., Abu-Remaileh,M., Wilson,J.G.,
            Gerszten,R.E., Long,J.Z. and Benson,M.D.
  TITLE     CYP4F2 is a human-specific determinant of circulating N-acyl amino
            acid levels
  JOURNAL   J Biol Chem 299 (6), 104764 (2023)
   PUBMED   37121548
  REMARK    GeneRIF: CYP4F2 is a human-specific determinant of circulating
            N-acyl amino acid levels.
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Farajzadeh-Dehkordi,M., Mafakher,L., Samiee-Rad,F. and Rahmani,B.
  TITLE     Computational analysis of missense variant CYP4F2*3 (V433M) in
            association with human CYP4F2 dysfunction: a functional and
            structural impact
  JOURNAL   BMC Mol Cell Biol 24 (1), 17 (2023)
   PUBMED   37161313
  REMARK    GeneRIF: Computational analysis of missense variant CYP4F2*3
            (V433M) in association with human CYP4F2 dysfunction: a functional
            and structural impact.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2361)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2361)
  AUTHORS   Jin,R., Koop,D.R., Raucy,J.L. and Lasker,J.M.
  TITLE     Role of human CYP4F2 in hepatic catabolism of the proinflammatory
            agent leukotriene B4
  JOURNAL   Arch Biochem Biophys 359 (1), 89-98 (1998)
   PUBMED   9799565
REFERENCE   8  (bases 1 to 2361)
  AUTHORS   Powell,P.K., Wolf,I., Jin,R. and Lasker,J.M.
  TITLE     Metabolism of arachidonic acid to 20-hydroxy-5,8,11,
            14-eicosatetraenoic acid by P450 enzymes in human liver:
            involvement of CYP4F2 and CYP4A11
  JOURNAL   J Pharmacol Exp Ther 285 (3), 1327-1336 (1998)
   PUBMED   9618440
REFERENCE   9  (bases 1 to 2361)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
REFERENCE   10 (bases 1 to 2361)
  AUTHORS   Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
            Kusunose,M.
  TITLE     Cloning and expression of a novel form of leukotriene B4
            omega-hydroxylase from human liver
  JOURNAL   FEBS Lett 348 (1), 70-74 (1994)
   PUBMED   8026587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC362034.1, BC067439.1,
            U02388.2, AK290790.1 and AC004791.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001082.4.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum. The enzyme
            starts the process of inactivating and degrading leukotriene B4, a
            potent mediator of inflammation. This gene is part of a cluster of
            cytochrome P450 genes on chromosome 19. Another member of this
            family, CYP4F11, is approximately 16 kb away. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290790.1, U02388.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221700.11/ ENSP00000221700.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC362034.1         47-59
            14-1652             BC067439.1         1-1639
            1653-2153           U02388.2           1662-2162
            2154-2360           AK290790.1         2154-2360
            2361-2361           AC004791.1         43328-43328         c
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2361
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /note="cytochrome P450 family 4 subfamily F member 2"
                     /db_xref="GeneID:8529"
                     /db_xref="HGNC:HGNC:2645"
                     /db_xref="MIM:604426"
     exon            1..49
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            50..248
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1613
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /EC_number="1.14.14.94"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.78"
                     /EC_number="1.14.14.79"
                     /note="cytochrome P450, subfamily IVF, polypeptide 2;
                     leukotriene-B(4) omega-hydroxylase 1; CYPIVF2; cytochrome
                     P450 4F2; cytochrome P450-LTB-omega; leukotriene-B(4)
                     20-monooxygenase 1; 20-HETE synthase; arachidonic acid
                     omega-hydroxylase; 20-hydroxyeicosatetraenoic acid
                     synthase; phylloquinone omega-hydroxylase CYP4F2;
                     cytochrome P450, family 4, subfamily F, polypeptide 2;
                     docosahexaenoic acid omega-hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 4F2 precursor"
                     /protein_id="NP_001073.3"
                     /db_xref="CCDS:CCDS12336.1"
                     /db_xref="GeneID:8529"
                     /db_xref="HGNC:HGNC:2645"
                     /db_xref="MIM:604426"
                     /translation="MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDN
                     CRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLC
                     HPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
                     KPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
                     SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR
                     TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
                     SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLH
                     PPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENI
                     KERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
                     EGGLWLRVEPLS"
     exon            249..393
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..447
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..575
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..697
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..968
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1035
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1165
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1299
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1364
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1447
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..2361
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /note="hexamer: AATGAA"
     polyA_site      1987
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /note="major polyA site"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2361
                     /gene="CYP4F2"
                     /gene_synonym="CPF2"
                     /note="major polyA site"
ORIGIN      
        1 agcagacaga gagaggaggt tgtctgggac agactgctcc tgacagaagg atgtcccagc
       61 tgagcctgtc ctggctgggc ctctggccag tggcagcatc cccttggctg ctcctcctgc
      121 tggtcggggc ctcctggctc ctggcccatg tcctggcctg gacctacgcc ttctatgaca
      181 actgccgccg ccttcggtgt ttcccacaac ccccaagacg gaactggttt tggggacacc
      241 agggcatggt caaccccaca gaggagggca tgagagttct gactcagctg gtggccacct
      301 acccccaggg ctttaaggtc tggatgggac ccatctcccc cctcctcagt ttgtgccacc
      361 ccgacatcat ccggtctgtc atcaacgcct cagctgccat tgcaccaaag gacaagttct
      421 tctacagctt cctggagccc tggctggggg atgggctcct gctgagtgct ggtgacaagt
      481 ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg aagccctata
      541 tgaagatttt caatgagagt gtgaacatca tgcacgccaa gtggcagctc ctggcctcag
      601 agggtagtgc ctgtttggat atgtttgagc acatcagcct catgaccttg gacagtctac
      661 agaaatgtgt cttcagcttt gacagccatt gtcaggagaa acccagtgaa tatattgccg
      721 ccatcttgga gctcagtgcc cttgtatcaa aaagacacca tgagatcctc ctgcatattg
      781 acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc cgcctggtgc
      841 acgacttcac agatgccgtc atccaggagc ggcgccgcac tctccctagc cagggtgttg
      901 atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat gtactcctgc
      961 tgagcaagga tgaagacggg aagaagttat ctgatgagga cataagagca gaagctgaca
     1021 cctttatgtt tgagggccat gacaccacgg ccagtggtct ctcctgggtc ctgtaccacc
     1081 ttgcaaagca cccagaatac caggagcgct gccggcagga ggtgcaagaa cttctgaagg
     1141 accgtgagcc taaagagatt gaatgggacg acctggccca tttgcccttc ctgaccatgt
     1201 gcatgaagga gagcctgcgg ctgcatcccc cagtcccggt catctcccgc catgtcaccc
     1261 aggacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc ctcatcagtg
     1321 ttttcggaac ccatcacaac ccagctgtgt ggccggaccc tgaggtctac gacccctttc
     1381 gctttgaccc agagaacatc aaggagaggt cacctctggc ttttattccc ttctcggcag
     1441 ggcccaggaa ctgcatcggg cagacgttcg cgatggcgga gatgaaggtg gtcctggcgc
     1501 tcacgctgct gcgcttccgc gtcctgcctg accacaccga gccccgcagg aagccggagc
     1561 tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc tgagttctgc
     1621 agagacccac tctgacccca ctaaaatgac ccctgattca tcaaaagtga agcctagaat
     1681 taccctaaga ccctgttcca cagtcctgta ttccatccta gatatctact caaaataatt
     1741 gagacaagtg ttcaaacaga aagacgcttg tgcgtgaatg ttcatggcgg ccctattcac
     1801 agtagccaaa cgatgaaaac aaccccaagc tatatattac cagatgaaag gataaacaaa
     1861 atgtggtcca tccatacaat ggagtattac acagccataa aaaggaatga agcagtgatc
     1921 cctactacac tgtggatgaa ccttgaatgc atgatactga atgaaagacg tcagatgcaa
     1981 aaggtcacat agtgtactgt ccttttatac gaaatttcca gaacaggcca atctgaagag
     2041 atgcatagcg gattggtggc tttcagcagc tgtggggagg tgggactgag gagcgactgc
     2101 taatcagtat ggggtttcct cccgggatgg tgaaaatgtt ccggacctag atagtgacga
     2161 aggtagcacg acactgtgag tgcactaaat gctattgaat tggacacttt gaaatggtga
     2221 atttcgtggt atgtgaattc tacctcaatc aaaaaaattt gctattttat ctcacataca
     2281 ttttttttct gtccaggttg ttcatataat aatatgctgt gagcatcttt ccatgacatt
     2341 aaatcatctt aggaaacatt a
//
