LOCUS       NM_023944               1714 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily F member 12
            (CYP4F12), transcript variant 1, mRNA.
ACCESSION   NM_023944
VERSION     NM_023944.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1714)
  AUTHORS   Chen,Y., Wang,L., Wang,Y., Fang,Y., Shen,W., Si,Y., Zheng,X. and
            Zeng,S.
  TITLE     Integrative Analysis of Histone Acetylation Regulated CYP4F12 in
            Esophageal Cancer Development
  JOURNAL   Drug Metab Dispos 52 (8), 813-823 (2024)
   PUBMED   38811154
  REMARK    GeneRIF: Integrative Analysis of Histone Acetylation Regulated
            CYP4F12 in Esophageal Cancer Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1714)
  AUTHORS   Jia,W., Chen,S., Wei,R., Yang,X., Zhang,M., Qian,Y., Liu,H. and
            Lei,D.
  TITLE     CYP4F12 is a potential biomarker and inhibits cell migration of
            head and neck squamous cell carcinoma via EMT pathway
  JOURNAL   Sci Rep 13 (1), 10956 (2023)
   PUBMED   37414830
  REMARK    GeneRIF: CYP4F12 is a potential biomarker and inhibits cell
            migration of head and neck squamous cell carcinoma via EMT pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1714)
  AUTHORS   Li,N., Shi,H., Hou,P., Gao,L., Shi,Y., Mi,W., Zhang,G., Wang,N.,
            Dai,W., Wei,L., Jin,T., Shi,Y. and Guo,S.
  TITLE     Genetic variants of CYP4F12 gene are associated with glioma
            susceptibility
  JOURNAL   Int J Cancer 149 (11), 1910-1915 (2021)
   PUBMED   34319593
  REMARK    GeneRIF: Genetic variants of CYP4F12 gene are associated with
            glioma susceptibility.
REFERENCE   4  (bases 1 to 1714)
  AUTHORS   Cauffiez,C., Klinzig,F., Rat,E., Tournel,G., Allorge,D.,
            Chevalier,D., Pottier,N., Lovecchio,T., Colombel,J.F.,
            Lhermitte,M., Lo-Guidice,J.M. and Broly,F.
  TITLE     Human CYP4F12 genetic polymorphism: identification and functional
            characterization of seven variant allozymes
  JOURNAL   Biochem Pharmacol 68 (12), 2417-2425 (2004)
   PUBMED   15548388
REFERENCE   5  (bases 1 to 1714)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   6  (bases 1 to 1714)
  AUTHORS   Hashizume,T., Imaoka,S., Mise,M., Terauchi,Y., Fujii,T.,
            Miyazaki,H., Kamataki,T. and Funae,Y.
  TITLE     Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in
            human intestinal microsomes
  JOURNAL   J Pharmacol Exp Ther 300 (1), 298-304 (2002)
   PUBMED   11752129
REFERENCE   7  (bases 1 to 1714)
  AUTHORS   Hashizume,T., Imaoka,S., Hiroi,T., Terauchi,Y., Fujii,T.,
            Miyazaki,H., Kamataki,T. and Funae,Y.
  TITLE     cDNA cloning and expression of a novel cytochrome p450 (cyp4f12)
            from human small intestine
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1135-1141 (2001)
   PUBMED   11162645
REFERENCE   8  (bases 1 to 1714)
  AUTHORS   Bylund,J., Bylund,M. and Oliw,E.H.
  TITLE     cDna cloning and expression of CYP4F12, a novel human cytochrome
            P450
  JOURNAL   Biochem Biophys Res Commun 280 (3), 892-897 (2001)
   PUBMED   11162607
REFERENCE   9  (bases 1 to 1714)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
REFERENCE   10 (bases 1 to 1714)
  AUTHORS   Knight,J.A., Fronk,S. and Haymond,R.E.
  TITLE     Chemical basis and specificity of chemical screening tests for
            urinary vanilmandelic acid
  JOURNAL   Clin Chem 21 (1), 130-133 (1975)
   PUBMED   1116264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122702.2, DC418592.1,
            AB035130.1 and DR422336.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_023944.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein likely localizes to the endoplasmic reticulum. When
            expressed in yeast the enzyme is capable of oxdizing arachidonic
            acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3
            polyunsaturated long-chain fatty acids. This gene is part of a
            cluster of cytochrome P450 genes on chromosome 19. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035130.1, AB035131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550308.6/ ENSP00000448998.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC122702.2         16014-16062
            50-317              DC418592.1         61-328
            318-1613            AB035130.1         298-1593
            1614-1679           DR422336.1         340-405
            1680-1714           AB035130.1         1660-1694
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1714
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /note="cytochrome P450 family 4 subfamily F member 12"
                     /db_xref="GeneID:66002"
                     /db_xref="HGNC:HGNC:18857"
                     /db_xref="MIM:611485"
     exon            1..49
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..248
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1625
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IVF, polypeptide 12;
                     cytochrome P450, family 4, subfamily F, polypeptide 12"
                     /codon_start=1
                     /product="cytochrome P450 4F12"
                     /protein_id="NP_076433.3"
                     /db_xref="CCDS:CCDS42517.1"
                     /db_xref="GeneID:66002"
                     /db_xref="HGNC:HGNC:18857"
                     /db_xref="MIM:611485"
                     /translation="MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNN
                     CRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLC
                     HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
                     KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
                     SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
                     TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
                     SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
                     PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
                     KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
                     EGGLWLRVEPLNVSLQ"
     exon            249..393
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..447
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..575
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..697
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..968
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1035
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1165
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1299
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1364
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1447
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1714
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="CYP4F12"
                     /gene_synonym="CYPIVF12; F22329_1"
                     /note="major polyA site"
ORIGIN      
        1 agcagaagag gagaagaggt tgtgtgggac aagctgctcc cgacagaagg atgtcgctgc
       61 tgagcctgcc ctggctgggc ctcagaccgg tggcaacgtc cccatggcta ctcctgctgc
      121 tggttgtggg ctcctggcta ctcgcccgca tcctggcttg gacctatgcc ttctataaca
      181 actgccgccg gctccagtgt ttcccacagc ccccaaaacg gaactggttt tggggtcacc
      241 tgggcctgat cactcctaca gaggagggct tgaagaactc gacccagatg tcggccacct
      301 attcccaggg ctttacggta tggctgggtc ccatcatccc cttcatcgtt ttatgccacc
      361 ctgacaccat ccggtctatc accaatgcct cagctgccat tgcacccaag gataatctct
      421 tcatcaggtt cctgaagccc tggctgggag aagggatact gctgagtggc ggtgacaagt
      481 ggagccgcca ccgtcggatg ctgacgcccg ccttccattt caacatcctg aagtcctata
      541 taacgatctt caacaagagt gcaaacatca tgcttgacaa gtggcagcac ctggcctcag
      601 agggcagcag tcgtctggac atgtttgagc acatcagcct catgaccttg gacagtctac
      661 agaaatgcat cttcagcttt gacagccatt gtcaggagag gcccagtgaa tatattgcca
      721 ccatcttgga gctcagtgcc cttgtagaga aaagaagcca gcatatcctc cagcacatgg
      781 actttctgta ttacctctcc catgacgggc ggcgcttcca cagggcctgc cgcctggtgc
      841 atgacttcac agacgctgtc atccgggagc ggcgtcgcac cctccccact cagggtattg
      901 atgatttttt caaagacaaa gccaagtcca agactttgga tttcattgat gtgcttctgc
      961 tgagcaagga tgaagatggg aaggcattgt cagatgagga tataagagca gaggctgaca
     1021 ccttcatgtt tggaggccat gacaccacgg ccagtggcct ctcctgggtc ctgtacaacc
     1081 ttgcgaggca cccagaatac caggagcgct gccgacagga ggtgcaagag cttctgaagg
     1141 accgcgatcc taaagagatt gaatgggacg acctggccca gctgcccttc ctgaccatgt
     1201 gcgtgaagga gagcctgagg ttacatcccc cagctccctt catctcccga tgctgcaccc
     1261 aggacattgt tctcccagat ggccgagtca tccccaaagg cattacctgc ctcatcgata
     1321 ttataggggt ccatcacaac ccaactgtgt ggccggatcc tgaggtctac gaccccttcc
     1381 gctttgaccc agagaacagc aaggggaggt cacctctggc ttttattcct ttctccgcag
     1441 ggcccaggaa ctgcatcggg caggcgttcg ccatggcgga gatgaaagtg gtcctggcgt
     1501 tgatgctgct gcacttccgg ttcctgccag accacactga gccccgcagg aagctggaat
     1561 tgatcatgcg cgccgagggc gggctttggc tgcgggtgga gcccctgaat gtaagcttgc
     1621 agtgactttc tgacccatcc acctgttttt ttgcagattg tcatgaataa aacggtgctg
     1681 tcacctctgc ctgggcctca ctgacagcct gcag
//
