LOCUS       NM_021187               3051 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily F member 11
            (CYP4F11), transcript variant 1, mRNA.
ACCESSION   NM_021187
VERSION     NM_021187.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Jia,H., Brixius,B., Bocianoski,C., Ray,S., Koes,D.R. and
            Brixius-Anderko,S.
  TITLE     Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in Lung
            Cancer and Its Potential As a Drug Target
  JOURNAL   Drug Metab Dispos 52 (2), 69-79 (2024)
   PUBMED   37973374
  REMARK    GeneRIF: Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in
            Lung Cancer and Its Potential As a Drug Target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Handa,Y., Fukushima,S., Yo,S., Osawa,M., Murao,T., Handa,O.,
            Matsumoto,H., Umegaki,E., Sakakibara,T. and Shiotani,A.
  TITLE     A novel gene associated with small bowel bleeding in patients
            taking low-dose aspirin
  JOURNAL   Dig Liver Dis 53 (7), 841-845 (2021)
   PUBMED   34059446
  REMARK    GeneRIF: A novel gene associated with small bowel bleeding in
            patients taking low-dose aspirin.
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Zhang,T., Zhan,Z., Chen,Y., Chen,J., Han,W., Liang,Z., Liu,Q.,
            Liu,S. and Tang,L.
  TITLE     Regulation of cytochrome P450 4F11 expression by liver X receptor
            alpha
  JOURNAL   Int Immunopharmacol 90, 107240 (2021)
   PUBMED   33310663
  REMARK    GeneRIF: Regulation of cytochrome P450 4F11 expression by liver X
            receptor alpha.
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Yi,M., Cho,S.A., Min,J., Kim,D.H., Shin,J.G. and Lee,S.J.
  TITLE     Functional characterization of a common CYP4F11 genetic variant and
            identification of functionally defective CYP4F11 variants in
            erythromycin metabolism and 20-HETE synthesis
  JOURNAL   Arch Biochem Biophys 620, 43-51 (2017)
   PUBMED   28347661
  REMARK    GeneRIF: results suggest that the metabolism of CYP4F11 substrates
            may be reduced in individuals carrying the CYP4F11 D315N genetic
            variant and individuals carrying the common D446N CYP4F11 variant
            likely exhibit comparable 20-HETE synthesis as individuals
            expressing wild-type CYP4F11.
REFERENCE   6  (bases 1 to 3051)
  AUTHORS   Kalsotra,A., Turman,C.M., Kikuta,Y. and Strobel,H.W.
  TITLE     Expression and characterization of human cytochrome P450 4F11:
            Putative role in the metabolism of therapeutic drugs and
            eicosanoids
  JOURNAL   Toxicol Appl Pharmacol 199 (3), 295-304 (2004)
   PUBMED   15364545
REFERENCE   7  (bases 1 to 3051)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   8  (bases 1 to 3051)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   9  (bases 1 to 3051)
  AUTHORS   Cui,X., Nelson,D.R. and Strobel,H.W.
  TITLE     A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning,
            expression, and genomic structural characterization
  JOURNAL   Genomics 68 (2), 161-166 (2000)
   PUBMED   10964514
REFERENCE   10 (bases 1 to 3051)
  AUTHORS   Simpson,A.E.
  TITLE     The cytochrome P450 4 (CYP4) family
  JOURNAL   Gen Pharmacol 28 (3), 351-359 (1997)
   PUBMED   9068972
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011517.7, AC020950.8 and
            AC005336.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 25, 2020 this sequence version replaced NM_021187.3.
            
            Summary: This gene, CYP4F11, encodes a member of the cytochrome
            P450 superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This gene is part of a cluster of cytochrome P450 genes on
            chromosome 19. Another member of this family, CYP4F2, is
            approximately 16 kb away. Alternatively spliced transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2514963.1, AF236085.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402119.9/ ENSP00000384588.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC011517.7         5704-6022           c
            320-464             AC020950.8         34287-34431         c
            465-518             AC020950.8         32260-32313         c
            519-646             AC020950.8         32042-32169         c
            647-768             AC020950.8         29591-29712         c
            769-1039            AC020950.8         28642-28912         c
            1040-1106           AC020950.8         27194-27260         c
            1107-1236           AC020950.8         26867-26996         c
            1237-1370           AC020950.8         19592-19725         c
            1371-1398           AC020950.8         19469-19496         c
            1399-1435           AC005336.1         36838-36874         c
            1436-1518           AC005336.1         36541-36623         c
            1519-3051           AC005336.1         34613-36145         c
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..3051
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="cytochrome P450 family 4 subfamily F member 11"
                     /db_xref="GeneID:57834"
                     /db_xref="HGNC:HGNC:13265"
                     /db_xref="MIM:611517"
     exon            1..319
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1696
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.78"
                     /EC_number="1.14.14.79"
                     /EC_number="1.14.14.80"
                     /note="cytochrome P450, subfamily IVF, polypeptide 11;
                     3-hydroxy fatty acids omega-hydroxylase CYP4F11;
                     phylloquinone omega-hydroxylase CYP4F11; cytochrome P450,
                     family 4, subfamily F, polypeptide 11; docosahexaenoic
                     acid omega-hydroxylase; long-chain fatty acid
                     omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4F11"
                     /protein_id="NP_067010.3"
                     /db_xref="CCDS:CCDS12337.1"
                     /db_xref="GeneID:57834"
                     /db_xref="HGNC:HGNC:13265"
                     /db_xref="MIM:611517"
                     /translation="MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDN
                     CRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILC
                     HPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNIL
                     KPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
                     SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRC
                     TLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTA
                     SGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLH
                     PPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENI
                     KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRA
                     EGGLWLRVEPLGANSQ"
     exon            320..464
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            465..518
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            519..646
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            647..768
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1039
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1106
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1236
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1370
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1435
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1518
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..3051
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="hexamer: AACAAA"
     polyA_site      1752
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="major polyA site"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="hexamer: AATAAA"
     polyA_site      2850
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
     regulatory      2978..2983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="hexamer: AATACA"
     polyA_site      3002
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
     regulatory      3031..3036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
                     /note="hexamer: AATATA"
     polyA_site      3051
                     /gene="CYP4F11"
                     /gene_synonym="CYPIVF11"
ORIGIN      
        1 agagccttcc ctgatctgcc tccagcactg cccatccttg cccctttcca ctgtccttgg
       61 agcttcctgg gcccttccct gggcctcagg atcccaccct ccatcccgtc tgccctgcag
      121 gatgccgcag ctgagcctgt cctggctggg cctcgggccc gtggcagcat ccccgtggct
      181 gcttctgctg ctggttggag gctcctggct cctggcccgc gtcctggcct ggacctacac
      241 cttctatgac aactgccgcc gcctccagtg ttttcctcaa cccccgaaac agaactggtt
      301 ttggggacac cagggcctgg tcactcccac ggaagagggc atgaagacat tgacccagct
      361 ggtgaccaca tatccccagg gctttaagtt gtggctgggt cctaccttcc ccctcctcat
      421 tttatgccac cctgacatta tccggcctat caccagtgcc tcagctgctg tcgcacccaa
      481 ggatatgatt ttctatggct tcctgaagcc ctggctgggg gatgggctcc tgctgagtgg
      541 tggtgacaag tggagccgcc accgtcggat gttgacgcct gccttccatt tcaacatctt
      601 gaagccttat atgaagattt tcaacaagag tgtgaacatc atgcacgaca agtggcagcg
      661 cctggcctca gagggcagcg ccagactgga catgtttgaa cacatcagcc tcatgacctt
      721 ggacagtctg cagaaatgtg tcttcagctt tgaaagcaat tgtcaggaga agcccagtga
      781 atatattgcc gccatcttgg agctcagtgc ctttgtagaa aagagaaacc agcagattct
      841 cttgcacacg gacttcctgt attatctcac tcctgatggg cagcgcttcc gcagggcctg
      901 ccacctggtg cacgacttca cagatgccgt catccaggag cggcgctgca ccctccccac
      961 tcagggtatt gatgatttcc tcaagaacaa ggcaaagtcc aagactttag acttcattga
     1021 tgtgcttctg ctgagcaagg atgaagatgg gaaggaattg tctgatgagg acataagagc
     1081 agaagctgac accttcatgt ttgagggcca tgacactaca gccagtggtc tctcctgggt
     1141 cctataccac cttgcaaagc acccagaata ccaggaacag tgccggcaag aagtgcaaga
     1201 gcttctgaag gaccgtgaac ctatagagat tgaatgggac gacctggccc agctgccctt
     1261 cctgaccatg tgcattaagg agagcctgcg gttgcatccc ccagtcccgg tcatctcccg
     1321 atgttgcacg caggactttg tgctcccaga cggccgcgtc atccccaaag gcattgtctg
     1381 cctcatcaat attatcggga tccattacaa cccaactgtg tggccagacc ctgaggtcta
     1441 cgaccccttc cgtttcgacc aagagaacat caaggagagg tcacctctgg cttttattcc
     1501 cttctcggca gggcccagaa actgcatcgg gcaggcgttc gccatggctg agatgaaggt
     1561 ggtcctggcg ctcaccctgc tgcacttccg catcctgccg acccacactg aaccccgcag
     1621 gaaacccgag ctgatattgc gcgcagaggg tggactttgg ctgcgggtgg agcccctggg
     1681 tgcgaactca cagtgactgt cctacccacc cacccacctc tgtagagtcc cagaaacaaa
     1741 actatgctga cacctctgct tgagcctcgt tgacagccag catggggctc ctggggactg
     1801 gtgggatcta agaaagggag gtgagtgggt ggaggcaggg tgacgtctct gaacccaaaa
     1861 ccctgacggc ctctctggct gagcacaggg catctaggcc cttagtgggt tctcccagag
     1921 cccaagtaaa aactttatcc tgtgggcagt agggagccct gggaggtgtt tgagcaggag
     1981 agggaacagg attaagaatg ggtttaagga gcaagactga gactctgatt cagcgagaaa
     2041 caaccatagg ggcagatccc ttcatctgtc ctgggaatgt cctcccaaga ctggagtcct
     2101 cagctcagaa caaagggaaa ggggtgcagc ttccaccctg gcaggctctc agaaattttt
     2161 agttcctttt tccaccaact tcccacccct gtttctcccc ctcccagtgc gttctctctg
     2221 tgactctctt cccttacttt cagaggcata ggatctggag ccagactgct tgggctcaag
     2281 tcctggctct gctgcgtgac ttgagcaagt taattcctct ctctgtgcct cggttccctc
     2341 aaccatataa tggagacaac agcattacct atatcagggt tttcctgagg tctcaatata
     2401 agggactcag agctgtgcct ggcacacaat gaatgctaaa tatatggagc cattattatt
     2461 tcctgtctca gaaagtctgg ctgttaaaga atgttgtctt tcaagatcgt tatttctacc
     2521 acgactttaa aggctgtgtt ttggaactca aaggcaaaaa ttctaatatc tgtgctcctt
     2581 gaacaacctc ttctcctaga gggctgtgca tataagatat gtatatatat atatatatta
     2641 tatatatata tatatacaca cacacacaca cacacacaca catatataca tatacacaca
     2701 cacacacaca cacacacaca cacacacaca tatatatata tatatatttt tttttttttc
     2761 ctgaggatgg tgaaggtacc tgactgtgtg aggtggtagg agaatgagag aaacctcagt
     2821 cagtgtctca aaataaaatc ctgctacaaa cattgatctc ttttcatagc ctaagggatg
     2881 ttgcatcgct aaaccctgtt gacttctcta atctcttctg tagctgatct ccttcccttg
     2941 ctacactcgg ttactctggc cttgattctg atctccaaat acattatatt ttttatttgg
     3001 gaccatcgta ttgcctttgc acctttatca aatataagtt gcctatattt a
//
