LOCUS       NM_001099772            2174 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily B member 1
            (CYP4B1), transcript variant 1, coding, mRNA.
ACCESSION   NM_001099772
VERSION     NM_001099772.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2174)
  AUTHORS   Yin,Y., Tong,L., Wan,Z., Sui,Y., Li,F., Huang,Q. and Zhao,X.
  TITLE     CYP4B1 polymorphisms and the risk of breast cancer in Chinese
            women: a case-control study
  JOURNAL   BMC Cancer 23 (1), 1177 (2023)
   PUBMED   38041008
  REMARK    GeneRIF: CYP4B1 polymorphisms and the risk of breast cancer in
            Chinese women: a case-control study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2174)
  AUTHORS   Yang,Y., Yuan,S., Yan,S., Dong,K. and Yang,Y.
  TITLE     Missense variants in CYP4B1 associated with increased risk of lung
            cancer among Chinese Han population
  JOURNAL   World J Surg Oncol 21 (1), 352 (2023)
   PUBMED   37950293
  REMARK    GeneRIF: Missense variants in CYP4B1 associated with increased risk
            of lung cancer among Chinese Han population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2174)
  AUTHORS   Roder,A., Husken,S., Hutter,M.C., Rettie,A.E., Hanenberg,H.,
            Wiek,C. and Girhard,M.
  TITLE     Spotlight on CYP4B1
  JOURNAL   Int J Mol Sci 24 (3), 2038 (2023)
   PUBMED   36768362
  REMARK    GeneRIF: reviews ability of CYP4B1 to hydroxylate fatty acids and
            fatty alcohols, its role in xenobiotic and endobiotic metabolism,
            and its unusual heme-binding characteristics
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2174)
  AUTHORS   Yu,S., Chen,Z., Cheng,J., Shi,X., Liu,J., Zhong,P. and Song,J.
  TITLE     Case-control study on CYP4B1 gene polymorphism and susceptibility
            to gastric cancer in the chinese Han population
  JOURNAL   BMC Med Genomics 15 (1), 223 (2022)
   PUBMED   36307788
  REMARK    GeneRIF: Case-control study on CYP4B1 gene polymorphism and
            susceptibility to gastric cancer in the chinese Han population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2174)
  AUTHORS   Liu,X., Jia,Y., Shi,C., Kong,D., Wu,Y., Zhang,T., Wei,A. and
            Wang,D.
  TITLE     CYP4B1 is a prognostic biomarker and potential therapeutic target
            in lung adenocarcinoma
  JOURNAL   PLoS One 16 (2), e0247020 (2021)
   PUBMED   33592039
  REMARK    GeneRIF: CYP4B1 is a prognostic biomarker and potential therapeutic
            target in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2174)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2174)
  AUTHORS   McKinnon,R.A., Burgess,W.M., Gonzalez,F.J., Gasser,R. and
            McManus,M.E.
  TITLE     Species-specific expression of CYP4B1 in rabbit and human
            gastrointestinal tissues
  JOURNAL   Pharmacogenetics 4 (5), 260-270 (1994)
   PUBMED   7894498
REFERENCE   8  (bases 1 to 2174)
  AUTHORS   Czerwinski,M., McLemore,T.L., Gelboin,H.V. and Gonzalez,F.J.
  TITLE     Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in
            normal human lung and lung tumors
  JOURNAL   Cancer Res 54 (4), 1085-1091 (1994)
   PUBMED   8313365
REFERENCE   9  (bases 1 to 2174)
  AUTHORS   Yokotani,N., Sogawa,K., Matsubara,S., Gotoh,O., Kusunose,E.,
            Kusunose,M. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA
            library of human placenta. Gene structure and expression
  JOURNAL   Eur J Biochem 187 (1), 23-29 (1990)
   PUBMED   2298205
REFERENCE   10 (bases 1 to 2174)
  AUTHORS   Nhamburo,P.T., Gonzalez,F.J., McBride,O.W., Gelboin,H.V. and
            Kimura,S.
  TITLE     Identification of a new P450 expressed in human lung: complete cDNA
            sequence, cDNA-directed expression, and chromosome mapping
  JOURNAL   Biochemistry 28 (20), 8060-8066 (1989)
   PUBMED   2574990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017758.1, BM977596.1 and
            AL356793.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001099772.1.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum. In rodents,
            the homologous protein has been shown to metabolize certain
            carcinogens; however, the specific function of the human protein
            has not been determined. Multiple transcript variants have been
            found for this gene. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017758.1, AK313170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371923.9/ ENSP00000360991.4
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1871              BC017758.1         1-1871
            1872-2110           BM977596.1         16-254              c
            2111-2174           AL356793.19        17672-17735
FEATURES             Location/Qualifiers
     source          1..2174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2174
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /note="cytochrome P450 family 4 subfamily B member 1"
                     /db_xref="GeneID:1580"
                     /db_xref="HGNC:HGNC:2644"
                     /db_xref="MIM:124075"
     exon            1..216
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1575
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /EC_number="1.14.14.1"
                     /note="isoform a is encoded by transcript variant 1,
                     coding; microsomal monooxygenase; cytochrome P450,
                     subfamily IVB, polypeptide 1; cytochrome P450 4B1;
                     cytochrome P450-HP; cytochrome P450, family 4, subfamily
                     B, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 4B1 isoform a"
                     /protein_id="NP_001093242.1"
                     /db_xref="CCDS:CCDS41328.1"
                     /db_xref="GeneID:1580"
                     /db_xref="HGNC:HGNC:2644"
                     /db_xref="MIM:124075"
                     /translation="MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMD
                     KFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKA
                     VYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTES
                     TRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSD
                     LTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK
                     KIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMAL
                     YPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPV
                     TFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAG
                     PRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP
                     GSGK"
     exon            217..358
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            359..403
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            404..531
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            532..656
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            657..811
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            812..918
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1109
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1243
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1308
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1391
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..2174
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2090..2095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="CYP4B1"
                     /gene_synonym="CYPIVB1; P-450HP"
                     /note="major polyA site"
ORIGIN      
        1 aggtcagatg aaggctaggt ggctggaact gcaaccatgg tgcccagctt cctctccctg
       61 agcttctcct ccttgggcct gtgggcttct gggctgatct tggtcttagg ctttctcaag
      121 ctcatccacc tgctgctgcg gaggcagacg ttggctaagg ctatggacaa attcccaggg
      181 cctcccaccc actggctttt tggacatgcc ctcgagatcc aggagacggg gagcctggac
      241 aaagtggtgt cctgggccca ccagttcccg tatgcccacc cactctggtt cggacagttc
      301 attggcttcc tgaacatcta tgagcctgac tatgccaaag ctgtgtacag ccgtggggac
      361 cctaaggccc ctgatgtgta tgacttcttc ctccagtgga ttgggagagg cctgctggtt
      421 cttgaggggc ccaagtggtt gcagcaccgc aagctgctca cacctggctt tcattatgat
      481 gtgctgaagc cctatgtggc cgtgttcact gagtctacac gtatcatgct ggacaagtgg
      541 gaagagaaag ctcgggaggg taagtccttt gacatcttct gcgatgtggg tcacatggcg
      601 ctgaacacac tcatgaagtg cacctttgga agaggagaca ccggcctggg ccacagcagg
      661 gacagcagct actaccttgc agtcagcgat ctcactctgt tgatgcagca gcgccttgtg
      721 tccttccagt accataatga cttcatctac tggctcaccc cacatggccg ccgcttcctg
      781 cgggcctgcc aggtggccca tgaccataca gaccaggtca tcagggagcg gaaggcagcc
      841 ctgcaggatg agaaggtgcg gaagaagatc cagaaccgga ggcacctgga cttcctggac
      901 attctcctgg gtgcccggga tgaagatgac atcaaactgt cagatgcaga cctccgggct
      961 gaagtggaca cattcatgtt tgaaggccat gacaccacca ccagtggtat ctcctggttt
     1021 ctctactgca tggccctgta ccctgagcac cagcatcgtt gtagagagga ggtccgcgag
     1081 atcctagggg accaggactt cttccagtgg gatgatctgg gcaaaatgac ttatctgacc
     1141 atgtgcatca aggagagctt ccgcctctac ccacctgtgc cccaggtgta ccgccagctc
     1201 agcaagcctg tcacctttgt ggatggccgg tctctacctg caggaagcct gatctctatg
     1261 catatctatg ccctccatag gaacagtgct gtatggcccg accctgaggt ctttgactct
     1321 ctgcgctttt ccactgagaa tgcatccaaa cgccatccct ttgcctttat gcccttctct
     1381 gctgggccca ggaactgcat tgggcagcag tttgccatga gtgagatgaa ggtggtcaca
     1441 gccatgtgct tgctccgctt tgagttctct ctggacccct cacggctgcc catcaagatg
     1501 ccccagcttg tcctgcgctc caagaatggc tttcacctcc acctgaagcc actgggccct
     1561 gggtctggga agtagctctg atgagaatgg ggtcccagat ggctcaggct gtgacctccc
     1621 tgggcaccac cctccccagg ctgggtgtgg aggagttggg gccccctgcc ttcaggaggc
     1681 ttgtagttta gaagggaagt aggcattacc atagacgact cctagaggac agtgctatgt
     1741 aaaaatgtgt gtctataaat gtttatcatg catgtattct agagctcatt catttattca
     1801 acaaacattt ggtgagcacc tatttcgttc gagaaacttc atttatctcc tataattggc
     1861 aaacttaaaa atgcagcaga aacttacatt ccaaccttag agactcatag tgagcacaag
     1921 gaaagttttg ccctgagatt catggttatg gctgggtacc accaaataga agaatggctt
     1981 aggggagtgc cccttcactg agatgtgttt ctttgttgaa ctttgtgtgt gtgtgtttag
     2041 aatataacag acataagaaa aaattaccta aatgaagact gtacaaaata ataaataatt
     2101 ctgaagcaga ctctcttgta accatcactg aagtcaagaa atatggaata tggtatcact
     2161 gatgtgtctt ctgc
//
