LOCUS       NM_001010969            2535 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily A member 22
            (CYP4A22), transcript variant 1, mRNA.
ACCESSION   NM_001010969 XM_208213
VERSION     NM_001010969.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2535)
  AUTHORS   Huang,K., Ma,T., Li,Q., Zhong,Z., Zhou,Y., Zhang,W., Qin,T.,
            Tang,S., Zhong,J. and Lu,S.
  TITLE     Novel polymorphisms in CYP4A22 associated with susceptibility to
            coronary heart disease
  JOURNAL   BMC Med Genomics 17 (1), 66 (2024)
   PUBMED   38438909
  REMARK    GeneRIF: Novel polymorphisms in CYP4A22 associated with
            susceptibility to coronary heart disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2535)
  AUTHORS   Durairaj,P., Fan,L., Machalz,D., Wolber,G. and Bureik,M.
  TITLE     Functional characterization and mechanistic modeling of the human
            cytochrome P450 enzyme CYP4A22
  JOURNAL   FEBS Lett 593 (16), 2214-2225 (2019)
   PUBMED   31199497
  REMARK    GeneRIF: Study demonstrate that the CYP4A22 gene codes for an
            active enzyme. It catalyzes the hydroxylation of both lauric and
            myristic acids. The structural model of CYP4A22 and substrate
            docking experiments suggest that its broadened spectrum of
            catalyzed reactions results from increased residual mobility of
            active site residue Phe320 and that arginines Arg96 and Arg233 are
            essential for substrate recognition.
REFERENCE   3  (bases 1 to 2535)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2535)
  AUTHORS   Lino Cardenas,C.L., Renault,N., Farce,A., Cauffiez,C., Allorge,D.,
            Lo-Guidice,J.M., Lhermitte,M., Chavatte,P., Broly,F. and
            Chevalier,D.
  TITLE     Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico
            insights from comparative 3D modelling in a French population
  JOURNAL   Gene 487 (1), 10-20 (2011)
   PUBMED   21820496
  REMARK    GeneRIF: Data suggest that results could be helpful for further
            investigations of the potential role of CYP4A variants in the
            genetic susceptibility to cardiovascular diseases such as arterial
            hypertension.
REFERENCE   5  (bases 1 to 2535)
  AUTHORS   Gajendrarao,P., Krishnamoorthy,N., Sakkiah,S., Lazar,P. and
            Lee,K.W.
  TITLE     Molecular modeling study on orphan human protein CYP4A22 for
            identification of potential ligand binding site
  JOURNAL   J Mol Graph Model 28 (6), 524-532 (2010)
   PUBMED   20079672
  REMARK    GeneRIF: A homology model has been constructed for CYP4A22 and
            refined by molecular dynamics simulation.
REFERENCE   6  (bases 1 to 2535)
  AUTHORS   Hiratsuka,M., Nozawa,H., Katsumoto,Y., Moteki,T., Sasaki,T.,
            Konno,Y. and Mizugaki,M.
  TITLE     Genetic polymorphisms and haplotype structures of the CYP4A22 gene
            in a Japanese population
  JOURNAL   Mutat Res 599 (1-2), 98-104 (2006)
   PUBMED   16806293
REFERENCE   7  (bases 1 to 2535)
  AUTHORS   Gainer,J.V., Bellamine,A., Dawson,E.P., Womble,K.E., Grant,S.W.,
            Wang,Y., Cupples,L.A., Guo,C.Y., Demissie,S., O'Donnell,C.J.,
            Brown,N.J., Waterman,M.R. and Capdevila,J.H.
  TITLE     Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid
            synthase is associated with essential hypertension
  JOURNAL   Circulation 111 (1), 63-69 (2005)
   PUBMED   15611369
REFERENCE   8  (bases 1 to 2535)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   9  (bases 1 to 2535)
  AUTHORS   Bellamine,A., Wang,Y., Waterman,M.R., Gainer,J.V. 3rd, Dawson,E.P.,
            Brown,N.J. and Capdevila,J.H.
  TITLE     Characterization of the CYP4A11 gene, a second CYP4A gene in humans
  JOURNAL   Arch Biochem Biophys 409 (1), 221-227 (2003)
   PUBMED   12464262
  REMARK    Erratum:[Arch Biochem Biophys. 2003 Apr 1;412(1):153]
REFERENCE   10 (bases 1 to 2535)
  AUTHORS   Kawashima,H., Naganuma,T., Kusunose,E., Kono,T., Yasumoto,R.,
            Sugimura,K. and Kishimoto,T.
  TITLE     Human fatty acid omega-hydroxylase, CYP4A11: determination of
            complete genomic sequence and characterization of purified
            recombinant protein
  JOURNAL   Arch Biochem Biophys 378 (2), 333-339 (2000)
   PUBMED   10860550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC148248.1 and AL135960.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001010969.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This gene is part of a cluster of cytochrome P450 genes on
            chromosome 1p33. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY280371.1, BC148248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371891.8/ ENSP00000360958.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1635              BC148248.1         17-1651
            1636-2535           AL135960.1         128224-129123       c
FEATURES             Location/Qualifiers
     source          1..2535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2535
                     /gene="CYP4A22"
                     /note="cytochrome P450 family 4 subfamily A member 22"
                     /db_xref="GeneID:284541"
                     /db_xref="HGNC:HGNC:20575"
                     /db_xref="MIM:615341"
     exon            1..240
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1605
                     /gene="CYP4A22"
                     /EC_number="1.14.14.80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytochrome P450 4A22K; CYPIVA22; fatty acid
                     omega-hydroxylase; lauric acid omega-hydroxylase;
                     long-chain fatty acid omega-monooxygenase; cytochrome
                     P450, family 4, subfamily A, polypeptide 22"
                     /codon_start=1
                     /product="cytochrome P450 4A22 isoform 1"
                     /protein_id="NP_001010969.2"
                     /db_xref="CCDS:CCDS30707.1"
                     /db_xref="GeneID:284541"
                     /db_xref="HGNC:HGNC:20575"
                     /db_xref="MIM:615341"
                     /translation="MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWL
                     LKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDP
                     DYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVG
                     LMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYI
                     QAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK
                     EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL
                     YALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE
                     LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPF
                     SGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRR
                     LPNPCEDKDQL"
     exon            241..382
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            383..427
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            428..555
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            556..680
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            681..835
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            836..942
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1133
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1267
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1332
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1409
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2535
                     /gene="CYP4A22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4A22"
                     /note="hexamer: AATAAA"
     polyA_site      2535
                     /gene="CYP4A22"
                     /note="major polyA site"
ORIGIN      
        1 tcagagagag gaaggggcac tcagagatcc agcaggtgct gcaccatgag tgtctctgtc
       61 ctgagcccca gcagacgcct gggtggtgtc tccgggatcc tccaagtgac ctccctgctc
      121 attctgcttc tgctgctgat caaggcagct cagctctacc tgcataggca gtggctgctc
      181 aaagccctcc agcagttccc gtgccctccc tcccactggc tcttcgggca catccaggag
      241 ttccaacacg accaggagct acaacggatt caggaacggg tgaagacatt cccaagtgcc
      301 tgtccttatt ggatatgggg aggcaaagtt cgtgtccagc tctatgaccc tgactatatg
      361 aaggtgattc tggggagatc agacccgaaa tcccatggat cctacaaatt cctggctcca
      421 cggattgggt acggcttgct cctgttgaat gggcagacat ggttccagca tcgacggatg
      481 ctgaccccag ccttccacaa tgacatcctg aagccatacg tggggctcat ggcagactct
      541 gtacgagtga tgctggacaa atgggaagag ctccttggcc aggattcccc tctggaggtc
      601 tttcagcacg tctccttgat gaccctggac accatcatga agagtgcctt cagccatcag
      661 ggcagcatcc aggtggacag gaattctcag tcctacatcc aggccattag tgacctgaac
      721 agcctggttt tttgctgtat gaggaatgcc tttcatgaga atgacaccat ctacagcctg
      781 acctctgctg gccgctggac acaccgcgcc tgccagctgg cccatcagca cacagaccaa
      841 gtgatccaac tgaggaaggc tcaactacag aaggaggggg agctggagaa gatcaagagg
      901 aagaggcact tggattttct ggacatcctc ctcttggcca aaatggagaa tgggagcatc
      961 ttgtcagaca aggacctccg tgctgaggtg gacacgttca tgtttgaggg ccacgacacc
     1021 acagccagtg ggatctcctg gatcctctat gctctggcca cacaccccaa gcatcaggag
     1081 aggtgccggg aggagatcca tggcctcctg ggtgatggag cctccatcac ctggaaccac
     1141 ctggaccaga tgccctacac caccatgtgc attaaggagg cactgaggct ctacccaccg
     1201 gtgccaggca ttggaagaga gctcagcact cccgtcacct tccctgatgg gcgctccttg
     1261 cccaaaggta tcatggtcct cctctccatt tatggccttc accacaaccc aaaagtgtgg
     1321 cccaacctag aggtgtttga cccttcccgt tttgcaccgg gttctgctca acacagccac
     1381 gctttcctgc ccttctcagg aggatcaagg aactgcatcg ggaaacaatt tgccatgaac
     1441 cagctgaagg tggccagggc cctgaccctg ctccgctttg agctgctgcc tgatcccacc
     1501 aggatcccca tccccatggc acgacttgtg ttgaaatcca aaaatggaat ccacctgcgt
     1561 ctcaggaggc tccctaaccc ttgtgaagac aaggaccagc tttgagggcc tccacctgcc
     1621 atcctgtctt cctgaccccc actcctatct cctgcctgtc tgcctctgtc ctgctttctg
     1681 tctgcccacc ttcccttctt cccacctgcc tgctgtcccc cagtctgcct gcccttctct
     1741 ctctcacctt tctccaagct ccctacctgc ttgtctacct gtctcctacc cacctgtata
     1801 tcttgttggg agaaaagctg agtgttggga gaagctgagg ccgagcttgc atgtctgaca
     1861 taatgtaaaa gagtcttgaa tcatgtccag gatccagggt ctaaaacccc ttgtggcctt
     1921 tggaacacca agctctgtgc tgaagggtgg aaggctaccc tgacgcacca taatctaagc
     1981 ccggggcata aaacccctcg tggcttggat agaatccagg gctcgtggct ctggaatgtg
     2041 tctggacttg ctggctcctc gctccttgct ctcccaggat caattgtatc ttgagttaaa
     2101 agaacctgct ctccattatc tcaagtaaca gagcagatgc taaaccgtca cagctgtaaa
     2161 tcatgtgctt aatgcaacat gccctttcga cccacccccc attctcacca cctgtttctt
     2221 tgtttgatca ccaataaata atctgcactt ccagagctcg gggccttcac agcctccata
     2281 cttagctttg gcgccctgga cccactttct ctctcaaact gtcttttctc attcctttga
     2341 ctctgccgga ctttgtcacc cccacaacct ggtgttgggt ccgataaccc caacatccct
     2401 gaatctccac ccacctccca aactcctgcc tgccctccag actgtctgcc catacacctg
     2461 tctccttctt cctgcctgct tgtctgttcc tatattagtt tcctattgct gctgtaataa
     2521 actatcacaa tctca
//
