LOCUS       NM_000778               2530 bp    mRNA    linear   PRI 16-MAY-2021
DEFINITION  Homo sapiens cytochrome P450 family 4 subfamily A member 11
            (CYP4A11), transcript variant 1, mRNA.
ACCESSION   NM_000778
VERSION     NM_000778.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Huang Z, Jiang Y and Zhou Y.
  TITLE     The role of cytochrome P450 gene rs1126742 polymorphism and risk of
            hypertension: a systematic review and meta-analysis
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32373936
  REMARK    GeneRIF: The role of cytochrome P450 gene rs1126742 polymorphism
            and risk of hypertension: a systematic review and meta-analysis.
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Jing C, Wang T, Ma R, Cao H, Wang Z, Liu S, Chen D, Zhang J, Wu Y,
            Zhang Y, Wu J and Feng J.
  TITLE     New genetic variations discovered in KRAS wild-type cetuximab
            resistant chinese colorectal cancer patients
  JOURNAL   Mol Carcinog 59 (5), 478-491 (2020)
   PUBMED   32141150
  REMARK    GeneRIF: Mutation in CYP4A11 gene is associated with cetuximab
            resistance in colorectal cancer.
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Gao H, Cao Y, Xia H, Zhu X and Jin Y.
  TITLE     CYP4A11 is involved in the development of nonalcoholic fatty liver
            disease via ROSinduced lipid peroxidation and inflammation
  JOURNAL   Int J Mol Med 45 (4), 1121-1129 (2020)
   PUBMED   32124935
  REMARK    GeneRIF: CYP4A11 is involved in the development of nonalcoholic
            fatty liver disease via ROSinduced lipid peroxidation and
            inflammation.
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Yu K, Zhang T and Li X.
  TITLE     Genetic role of CYP4A11 polymorphisms in the risk of developing
            cardiovascular and cerebrovascular diseases
  JOURNAL   Ann Hum Genet 82 (6), 370-381 (2018)
   PUBMED   30132788
  REMARK    GeneRIF: The rs1126742 T/C polymorphism of CYP4A11 is more likely
            to be a genetic risk factor for the hypertension cases in the
            Caucasian population. Moreover, whereas the AG genotype of CYP4A11
            rs9332978 may be associated with an increased risk of hypertension,
            the AA genotype of rs9333025 may be linked to a decreased risk of
            cardiovascular and cerebrovascular diseases. [meta-analysis]
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Sirotina S, Ponomarenko I, Kharchenko A, Bykanova M, Bocharova A,
            Vagaytseva K, Stepanov V, Churnosov M, Solodilova M and Polonikov
            A.
  TITLE     A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is
            Associated with Susceptibility to Coronary Artery Disease
  JOURNAL   Dis Markers 2018, 5812802 (2018)
   PUBMED   29484037
  REMARK    GeneRIF: Haplotype G-C-A of CYP4A11 was associated with increased
            risk of coronary artery disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM and Nebert
            DW.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Kawashima H, Kusunose E, Kikuta Y, Kinoshita H, Tanaka S, Yamamoto
            S, Kishimoto T and Kusunose M.
  TITLE     Purification and cDNA cloning of human liver CYP4A fatty acid
            omega-hydroxylase
  JOURNAL   J Biochem 116 (1), 74-80 (1994)
   PUBMED   7798189
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Imaoka S, Ogawa H, Kimura S and Gonzalez FJ.
  TITLE     Complete cDNA sequence and cDNA-directed expression of CYP4A11, a
            fatty acid omega-hydroxylase expressed in human kidney
  JOURNAL   DNA Cell Biol 12 (10), 893-899 (1993)
   PUBMED   8274222
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE
            and Johnson EF.
  TITLE     Characterization of a cDNA encoding a human kidney, cytochrome
            P-450 4A fatty acid omega-hydroxylase and the cognate enzyme
            expressed in Escherichia coli
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 161-166 (1993)
   PUBMED   7679927
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Kawashima H, Kusunose E, Kubota I, Maekawa M and Kusunose M.
  TITLE     Purification and NH2-terminal amino acid sequences of human and rat
            kidney fatty acid omega-hydroxylases
  JOURNAL   Biochim Biophys Acta 1123 (2), 156-162 (1992)
   PUBMED   1739747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD014132.1, S67580.1, D26481.1
            and AL731892.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000778.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and
            hydroxylates medium-chain fatty acids such as laurate and
            myristate. Multiple transcript variants have been found for this
            gene. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.68480.1, L04751.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310638.9/ ENSP00000311095.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CD014132.1         9-20
            13-1343             S67580.1           11-1341
            1344-1876           D26481.1           1316-1848
            1877-2530           AL731892.6         46438-47091         c
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2530
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /note="cytochrome P450 family 4 subfamily A member 11"
                     /db_xref="GeneID:1579"
                     /db_xref="HGNC:HGNC:2642"
                     /db_xref="MIM:601310"
     exon            1..238
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1603
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.80"
                     /note="isoform 1 is encoded by transcript variant 1; fatty
                     acid omega-hydroxylase; P450HL-omega; alkane-1
                     monooxygenase; lauric acid omega-hydroxylase; cytochrome
                     P450, subfamily IVA, polypeptide 11; cytochrome P450 4A11;
                     20-HETE synthase; cytochrome P450HL-omega; cytochrome
                     P-450HK-omega; 20-hydroxyeicosatetraenoic acid synthase;
                     long-chain fatty acid omega-monooxygenase; cytochrome
                     P450, family 4, subfamily A, polypeptide 11"
                     /codon_start=1
                     /product="cytochrome P450 4A11 isoform 1"
                     /protein_id="NP_000769.2"
                     /db_xref="CCDS:CCDS543.1"
                     /db_xref="GeneID:1579"
                     /db_xref="HGNC:HGNC:2642"
                     /db_xref="MIM:601310"
                     /translation="MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWL
                     LKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDP
                     DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG
                     LMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYI
                     QAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK
                     EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL
                     YALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE
                     LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPF
                     SGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRR
                     LPNPCEDKDQL"
     exon            239..380
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            381..425
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            426..553
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            554..678
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            679..833
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            834..940
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1131
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1265
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1330
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1407
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..2530
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="CYP4A11"
                     /gene_synonym="CP4Y; CYP4A2; CYP4AII; CYPIVA11"
                     /note="major polyA site"
ORIGIN      
        1 agagagaggt aggggcactc agagatccag caggtgctgc accatgagtg tctctgtgct
       61 gagccccagc agactcctgg gtgatgtctc tggaatcctc caagcggcct ccctgctcat
      121 tctgcttctg ctgctgatca aggcagttca gctctacctg cacaggcagt ggctgctcaa
      181 agccctccag cagttcccgt gccctccctc ccactggctc ttcgggcaca tccaggagct
      241 ccaacaggac caggagctac aacggattca gaaatgggtg gagacattcc caagtgcctg
      301 tcctcattgg ctatggggag gcaaagttcg tgtccagctc tatgaccctg actatatgaa
      361 ggtgattctg gggagatcag acccgaaatc ccatggttcc tacagattcc tggctccatg
      421 gattgggtac ggcttgctcc tgttgaatgg gcagacatgg ttccagcatc gacggatgct
      481 gaccccagcc ttccactatg acatcctgaa gccctatgtg gggctcatgg cagactctgt
      541 acgagtgatg ctggacaaat gggaagagct ccttggccag gattcccctc tggaggtctt
      601 tcagcacgtc tccttgatga ccctggacac catcatgaag tgtgccttca gccatcaggg
      661 cagcatccag gtggacagga attctcagtc ctacatacag gccattagtg acctgaacaa
      721 cctggttttt tcccgtgtga ggaatgcctt tcaccagaat gacaccatct acagcctgac
      781 ctctgctggc cgctggacac accgcgcctg ccagctggcc catcagcaca cagaccaagt
      841 gatccaactg aggaaggctc aactacagaa ggagggggag ctggagaaga tcaagaggaa
      901 gaggcatttg gattttctgg atatcctcct cttggccaaa atggagaatg ggagcatctt
      961 gtcagacaag gacctccgtg ctgaggtgga cacgttcatg tttgagggcc acgacaccac
     1021 agccagtggg atctcctgga tcctctatgc tctggccaca caccccaagc atcaggagag
     1081 gtgccgggag gagatccaca gcctcctggg tgatggagcc tccatcacct ggaaccacct
     1141 ggaccagatg ccctacacca ccatgtgcat taaggaggca ctgaggctct acccaccggt
     1201 gccaggcatt ggcagagagc tcagcactcc cgtcaccttc cctgatgggc gctccttgcc
     1261 caaaggtatc atggtcctcc tctccattta tggccttcac cacaacccaa aagtgtggcc
     1321 caacccagag gtgtttgacc ctttccgttt tgcaccgggt tctgctcaac acagccacgc
     1381 tttcctgccc ttctcaggag gatcaaggaa ctgcatcggg aaacaatttg ccatgaacga
     1441 gctgaaggtg gccacggccc tgaccctgct ccgctttgag ctgctgcctg atcccaccag
     1501 gatccccatc cccattgcac gacttgtgtt gaaatccaaa aatggaatcc acctgcgtct
     1561 caggaggctc cctaaccctt gtgaagacaa ggaccagctt tgagggcctc cacctgccgt
     1621 cctgtcttcc tgacccccgc ttctgtcccc ttcctgtctg cccatatcct gttttctgtc
     1681 tgcccacctt cccttcttcc cacctgcctg ctgtccccca gtctgcctgc ccttctctct
     1741 ctcacctttc tccaggctcc ctacctgctt gtctacctgt ctcctaccca cctgtatctc
     1801 ttgttgggag aaaagctgag tgttgggaga agctgaggcc gagcttgcat gtctgacata
     1861 atgtaaaaga gtcttggatc atgtccagga tccagggtct aaaacccctt gtggcctttg
     1921 gaacaccaag ctctgtgctg aagggtggaa ggctaccctg acgcaccata atctaagccc
     1981 ggggcataaa acccctcgtg gcttggatag aatccagggc tcgtggctct ggaatgtgtc
     2041 tgaacttgct gcctcctcgc tccttgctct cccaggatca attgtatctt gagttaaaag
     2101 aacctgctct ccattatctc aagtagcaga gcagatgcta aaccgtcaca gctgtaaatc
     2161 atgtgcttaa tgcaacatgc cctttcgacc cccacattct caccacctgt ttctttgttt
     2221 gatcaccaat aaataatctg cacttccaga gctcggggcc ttcacagcct ccatccttag
     2281 ctttggcgcc ctggacccac tttctctctc aaactgtctt ttctcactgc tttgactctg
     2341 ccggactttg tcacccccac gacctggtgt tgggtctgaa caccccaaca tccctgaatc
     2401 tccacccacc tcccaaactc ctgcctgccc tccagactgt ctgcccatac acctgtctcc
     2461 ttcttcctgc ctgcttgtct gttcctatat tagtttccta ttactgctgt aataaactat
     2521 cacaatctca
//
