LOCUS       XM_005267274            1741 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cytochrome P450 family 46 subfamily A
            member 1 (CYP46A1), transcript variant X3, mRNA.
ACCESSION   XM_005267274
VERSION     XM_005267274.6
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005267274.5.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..1741
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /note="cytochrome P450 family 46 subfamily A member 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 5 ESTs, 48 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
     CDS             100..1167
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /codon_start=1
                     /product="cholesterol 24-hydroxylase isoform X3"
                     /protein_id="XP_005267331.1"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
                     /translation="MNASLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM
                     DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESI
                     RFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHE
                     TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL
                     YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP
                     KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPL
                     DPVLCTLRPRGWQPAPPPPPC"
ORIGIN      
        1 agaccacgga tccctgaagg cagaagacgc accctgtccc tgagtcctgc gcccagcacc
       61 aggcacccca caagccctcc aggaatgccc atagagtgaa tgaatgcctc cttggttagc
      121 ttaatggaaa cattcaacga gaaggctgag cagctggtgg agattctaga agccaaggca
      181 gatgggcaga ccccagtgtc catgcaggac atgctgacct acaccgccat ggacatcctg
      241 gccaaggcag cttttgggat ggagaccagt atgctgctgg gtgcccagaa gcctctgtcc
      301 caggcagtga aacttatgtt ggagggaatc actgcgtccc gcaacactct ggcaaagttc
      361 ctgccaggga agaggaagca gctccgggag gtccgggaga gcattcgctt cctgcgccag
      421 gtgggcaggg actgggtcca gcgccgccgg gaagccctga agaggggcga ggaggttcct
      481 gccgacatcc tcacacagat tctgaaagct gaagagggag cccaggacga cgagggtctg
      541 ctggacaact tcgtcacctt cttcattgct ggtcacgaga cctctgccaa ccacttggcg
      601 ttcacagtga tggagctgtc tcgccagcca gagatcgtgg caaggctgca ggccgaggtg
      661 gatgaggtca ttggttctaa gaggtacctg gatttcgagg acctggggag actgcagtac
      721 ctgtcccagg tcctcaaaga gtcgctgagg ctgtacccac cagcatgggg cacctttcgc
      781 ctgctggaag aggagacctt gattgatggg gtcagagtcc ccggcaacac cccgctcttg
      841 ttcagcacct atgtcatggg gcggatggac acatactttg aggacccgct gactttcaac
      901 cccgatcgct tcggccctgg agcacccaag ccacggttca cctacttccc cttctccctg
      961 ggccaccgct cctgcatcgg gcagcagttt gctcagatgg aggtgaaggt ggtcatggca
     1021 aagctgctgc agaggctgga gttccggctg gtgcccgggc agcgcttcgg gctgcaggag
     1081 caggccacac tcaagccact ggaccccgtg ctgtgcaccc tgcggccccg cggctggcag
     1141 cccgcacccc caccaccccc ctgctgaggg ggcctccagg caggacgaga ctcctcgggc
     1201 aagggccgtg cccgcccacc tctgctgccc acggccaccc acccttctcc cctgccccgt
     1261 cccctgggcc acccttcacg ctggcttcca gcgggccctc tgccgaccgc ctgcttcaca
     1321 cccctcagcg ctccctgtcg cctgcggact ccatggccct tcctggactg gcccttgccc
     1381 aactcccagc caccaccact gtccctacca ctgagccctt gcacaggcca cttgctcaga
     1441 cgagacaccc taactcttgc tcactcccta aagccctctt caggggtcac ctcctccaag
     1501 aagccctcct tgccaccccc cgccggcagg ggcccctcct ctgtgctccc tcggtcacct
     1561 gtgctacctc taacaccaca ctgaccacac tgtatcgtga gtgtccgttg acgtgaccaa
     1621 ttgccctgcc aggctgtcag cgcctcaagg gtagggtctg cgtgtgattt gtctctgagc
     1681 cccctgtgcc cacccagggc ccggcacaga gtcgatgctc aataaatgtg tgttgactgc
     1741 a
//
