LOCUS       NM_000765               2079 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens cytochrome P450 family 3 subfamily A member 7
            (CYP3A7), mRNA.
ACCESSION   NM_000765
VERSION     NM_000765.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Qi,G., Han,C., Zhou,Y. and Wang,X.
  TITLE     Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and
            GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur,
            and Han Chinese populations
  JOURNAL   Clin Exp Pharmacol Physiol 49 (2), 219-227 (2022)
   PUBMED   34689350
  REMARK    GeneRIF: Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7,
            and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian,
            Uyghur, and Han Chinese populations.
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Dong,Y., Xu,Q., Li,R., Tao,Y., Zhang,Q., Li,J., Ma,Z., Shen,C.,
            Zhong,M., Wang,Z. and Qiu,X.
  TITLE     CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients
            rather than donors influence tacrolimus concentrations in the early
            stages after liver transplantation
  JOURNAL   Gene 809, 146007 (2022)
   PUBMED   34688813
  REMARK    GeneRIF: CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in
            recipients rather than donors influence tacrolimus concentrations
            in the early stages after liver transplantation.
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Yamazoe,Y. and Tohkin,M.
  TITLE     Development of template systems for ligand interactions of CYP3A5
            and CYP3A7 and their distinctions from CYP3A4 template
  JOURNAL   Drug Metab Pharmacokinet 38, 100357 (2021)
   PUBMED   33866277
  REMARK    GeneRIF: Development of template systems for ligand interactions of
            CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Finta,C. and Zaphiropoulos,P.G.
  TITLE     The human cytochrome P450 3A locus. Gene evolution by capture of
            downstream exons
  JOURNAL   Gene 260 (1-2), 13-23 (2000)
   PUBMED   11137287
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Itoh,S., Yanagimoto,T., Tagawa,S., Hashimoto,H., Kitamura,R.,
            Nakajima,Y., Okochi,T., Fujimoto,S., Uchino,J. and Kamataki,T.
  TITLE     Genomic organization of human fetal specific P-450IIIA7 (cytochrome
            P-450HFLa)-related gene(s) and interaction of transcriptional
            regulatory factor with its DNA element in the 5' flanking region
  JOURNAL   Biochim Biophys Acta 1130 (2), 133-138 (1992)
   PUBMED   1562592
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   Komori,M., Nishio,K., Kitada,M., Shiramatsu,K., Muroya,K., Soma,M.,
            Nagashima,K. and Kamataki,T.
  TITLE     Fetus-specific expression of a form of cytochrome P-450 in human
            livers
  JOURNAL   Biochemistry 29 (18), 4430-4433 (1990)
   PUBMED   2350547
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   Komori,M., Nishio,K., Fujitani,T., Ohi,H., Kitada,M., Mima,S.,
            Itahashi,K. and Kamataki,T.
  TITLE     Isolation of a new human fetal liver cytochrome P450 cDNA clone:
            evidence for expression of a limited number of forms of cytochrome
            P450 in human fetal livers
  JOURNAL   Arch Biochem Biophys 272 (1), 219-225 (1989)
   PUBMED   2786707
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Komori,M., Nishio,K., Ohi,H., Kitada,M. and Kamataki,T.
  TITLE     Molecular cloning and sequence analysis of cDNA containing the
            entire coding region for human fetal liver cytochrome P-450
  JOURNAL   J Biochem 105 (2), 161-163 (1989)
   PUBMED   2722762
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Wrighton,S.A. and Vandenbranden,M.
  TITLE     Isolation and characterization of human fetal liver cytochrome
            P450HLp2: a third member of the P450III gene family
  JOURNAL   Arch Biochem Biophys 268 (1), 144-151 (1989)
   PUBMED   2492179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX643367.1, D00408.1,
            BX647143.1 and AC069294.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000765.4.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes, which participate in drug metabolism and
            the synthesis of cholesterol, steroids and other lipids. This
            enzyme hydroxylates testosterone and dehydroepiandrosterone
            3-sulphate, which is involved in the formation of estriol during
            pregnancy. This gene is part of a cluster of related genes on
            chromosome 7q21.1. Naturally-occurring readthrough transcription
            occurs between this gene and the downstream CYP3A51P pseudogene and
            is represented by GeneID:100861540. [provided by RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00408.1, BC069780.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336374.4/ ENSP00000337450.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BX643367.1         2-101
            101-2071            D00408.1           1-1971
            2072-2078           BX647143.1         2308-2314
            2079-2079           AC069294.5         114351-114351
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2079
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /note="cytochrome P450 family 3 subfamily A member 7"
                     /db_xref="GeneID:1551"
                     /db_xref="HGNC:HGNC:2640"
                     /db_xref="MIM:605340"
     exon            1..174
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1615
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /EC_number="1.14.14.1"
                     /note="aryl hydrocarbon hydroxylase; microsomal
                     monooxygenase; xenobiotic monooxygenase;
                     flavoprotein-linked monooxygenase; cytochrome P450,
                     subfamily IIIA, polypeptide 7; cytochrome P450-HFLA;
                     cytochrome P450, family 3, subfamily A, polypeptide 7"
                     /codon_start=1
                     /product="cytochrome P450 3A7"
                     /protein_id="NP_000756.3"
                     /db_xref="CCDS:CCDS5673.1"
                     /db_xref="GeneID:1551"
                     /db_xref="HGNC:HGNC:2640"
                     /db_xref="MIM:605340"
                     /translation="MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPL
                     PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
                     TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
                     RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
                     FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
                     DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
                     IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
                     VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
                     NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA"
     exon            175..268
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..321
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..421
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..624
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..773
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..901
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..968
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1129
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1356
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1519
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..2079
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /note="hexamer: AATAAA"
     polyA_site      2079
                     /gene="CYP3A7"
                     /gene_synonym="CP37; CYPIIIA7; P-450(HFL33); P-450111A7;
                     P450-HFLA; P450HLp2"
                     /note="major polyA site"
ORIGIN      
        1 actgctgtgc agggcaggaa agctccacac acacagccca gcaaacagca gcacgctgct
       61 gaaaaaaaga ctcagaggag agagataagg aaggaaagta gtgatggatc tcatcccaaa
      121 cttggccgtg gaaacctggc ttctcctggc tgtcagcctg atactcctct atctatatgg
      181 aacccgtaca catggacttt ttaagaagct tggaattcca gggcccacac ctctgccttt
      241 tttgggaaat gctttgtcct tccgtaaggg ctattggacg tttgacatgg aatgttataa
      301 aaagtataga aaagtctggg gtatttatga ctgtcaacag cctatgctgg ctatcacaga
      361 tcccgacatg atcaaaacag tgctagtgaa agaatgttat tctgtcttca caaaccggag
      421 gcctttcggg ccagtgggat ttatgaaaaa tgccatctct atagctgagg atgaagaatg
      481 gaagagaata cgatcattgc tgtctccaac attcaccagc ggaaaactca aggagatggt
      541 ccctatcatt gcccagtatg gagatgtgtt ggtgagaaat ctgaggcggg aagcagagac
      601 aggcaagcct gtcaccttga aacacgtctt tggggcctac agcatggatg tgatcactag
      661 cacatcattt ggagtgagca tcgactctct caacaatcca caagacccct ttgtggaaaa
      721 caccaagaag cttttaagat ttaatccatt agatccattc gttctctcaa taaaagtctt
      781 tccattcctt accccaattc ttgaagcatt aaatatcact gtgtttccaa gaaaagttat
      841 aagttttcta acaaaatctg taaaacagat aaaagaaggt cgcctcaaag agacacaaaa
      901 gcaccgagtg gatttccttc agctgatgat tgactctcag aattcaaaag actctgagac
      961 ccacaaagct ctgtctgatc tggagctcat ggcccaatca attatcttta tttttgctgg
     1021 ctatgaaacc acgagcagtg ttctctcctt cattatatat gaactggcca ctcaccctga
     1081 tgtccagcag aaagtgcaga aggaaattga tacagtttta cccaataagg caccacccac
     1141 ctatgatact gtgctacagt tggagtatct tgacatggtg gtgaatgaaa cactcagatt
     1201 attcccagtt gctatgagac ttgagagggt ctgcaaaaaa gatgttgaaa tcaatgggat
     1261 gtttattccc aaaggggtgg tggtgatgat tccaagctat gttcttcatc atgacccaaa
     1321 gtactggaca gagcctgaga agttcctccc tgaaaggttc agtaaaaaga acaaggacaa
     1381 catagatcct tacatataca caccctttgg aagtggaccc agaaactgca ttggcatgag
     1441 gtttgctctc gtgaacatga aacttgctct agtcagagtc cttcagaact tctccttcaa
     1501 accttgtaaa gaaacacaga tccccctgaa attacgcttt ggaggacttc ttctaacaga
     1561 aaaacccatt gttctaaagg ctgagtcaag ggatgagacc gtaagtggag cctgatttcc
     1621 ctaaggactt ctggtttgct ctttaagaaa gctgtgcccc agaacaccag agacctcaaa
     1681 ttactttaca aatagaaccc tgaaatgaag acgggcttca tccaatgtgc tgcataaata
     1741 atcagggatt ctgtacgtgc attgtgctct ctcatggtct gtatagagtg ttatacttgg
     1801 taatatagag gagatgacca aatcagtgct ggggaagtag atttggcttc tctgcttctc
     1861 ataggactat ctccaccacc cccagttagc accattaact cctcctgagc tctgataaca
     1921 taattaacat ttctcaataa tttcaaccac aatcattaat aaaaatagga attattttga
     1981 tggctctaac agtgacattt atatcatgtg ttatatctgt agtattctat agtaagcttt
     2041 atattaagca aatcaataaa aacctcttta caaaagtat
//
