LOCUS       NM_001256497            2260 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens CYP3A7-CYP3A51P readthrough (CYP3A7-CYP3A51P), mRNA.
ACCESSION   NM_001256497
VERSION     NM_001256497.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Rodriguez-Antona,C., Axelson,M., Otter,C., Rane,A. and
            Ingelman-Sundberg,M.
  TITLE     A novel polymorphic cytochrome P450 formed by splicing of CYP3A7
            and the pseudogene CYP3AP1
  JOURNAL   J Biol Chem 280 (31), 28324-28331 (2005)
   PUBMED   15937338
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Finta,C. and Zaphiropoulos,P.G.
  TITLE     The human cytochrome P450 3A locus. Gene evolution by capture of
            downstream exons
  JOURNAL   Gene 260 (1-2), 13-23 (2000)
   PUBMED   11137287
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Itoh,S., Yanagimoto,T., Tagawa,S., Hashimoto,H., Kitamura,R.,
            Nakajima,Y., Okochi,T., Fujimoto,S., Uchino,J. and Kamataki,T.
  TITLE     Genomic organization of human fetal specific P-450IIIA7 (cytochrome
            P-450HFLa)-related gene(s) and interaction of transcriptional
            regulatory factor with its DNA element in the 5' flanking region
  JOURNAL   Biochim Biophys Acta 1130 (2), 133-138 (1992)
   PUBMED   1562592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069294.5, AF315325.1 and AC005020.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001256497.2.
            
            Summary: This locus represents readthrough transcription between
            the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A,
            polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily
            A, polypeptide 51, pseudogene) genes, which are members of the
            CYP3A gene cluster on chromosome 7. The downstream pseudogene is
            not known to be independently transcribed. The readthrough
            transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the
            pseudogene. It encodes a CYP3A isoform with a novel C-terminus.
            This isoform is only expressed in alleles containing a T nucleotide
            at the -6 position of a splice acceptor in the pseudogene, which
            enables correct splicing of the upstream CYP3A7 exons to the
            pseudogene exons. It should be noted that the reference genome
            sequence represents the CYP3A7_39256 T->A allele, and thus this
            haplotype is unlikely to produce the readthrough transcript.
            [provided by RefSeq, Jan 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF315325.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 1551, 1578
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC069294.5         84191-84293
            104-1711            AF315325.1         1-1608
            1712-2260           AC005020.5         10584-11132
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2260
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /note="CYP3A7-CYP3A51P readthrough"
                     /db_xref="GeneID:100861540"
                     /db_xref="HGNC:HGNC:51504"
     exon            1..174
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1711
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /EC_number="1.14.14.1"
                     /note="CYP3A7-CYP3AP1 readthrough; Cytochrome P450 3A7;
                     Cytochrome P450-HFLA"
                     /codon_start=1
                     /product="CYP3A7-CYP3A51P protein"
                     /protein_id="NP_001243426.2"
                     /db_xref="GeneID:100861540"
                     /db_xref="HGNC:HGNC:51504"
                     /translation="MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPL
                     PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
                     TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
                     RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
                     FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
                     DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
                     IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
                     VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
                     NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETFVDMEPIHM
                     DFLRSLAFQGPHLCFFWELLCPTIRSR"
     exon            175..268
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            269..321
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            322..421
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            536..624
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..773
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            774..901
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            902..968
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1129
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1356
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1519
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1600
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1701
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2260
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /note="hexamer: TATAAA"
     polyA_site      2008
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /note="hexamer: AATAAA"
     polyA_site      2260
                     /gene="CYP3A7-CYP3A51P"
                     /gene_synonym="CYP3A7; CYP3A7-3AP1; CYP3A7-CYP3AP1;
                     CYP3A7.1L; CYPIIIA7"
                     /note="major polyA site"
ORIGIN      
        1 actgctgtgc agggcaggaa agctccacac acacagccca gcaaacagca gcacgctgct
       61 gaaaaaaaga ctcagaggag agagataagg aaggaaagta gtgatggatc tcatcccaaa
      121 cttggccgtg gaaacctggc ttctcctggc tgtcagcctg atactcctct atctatatgg
      181 aacccgtaca catggacttt ttaagaagct tggaattcca gggcccacac ctctgccttt
      241 tttgggaaat gctttgtcct tccgtaaggg ctattggacg tttgacatgg aatgttataa
      301 aaagtataga aaagtctggg gtatttatga ctgtcaacag cctatgctgg ctatcacaga
      361 tcccgacatg atcaaaacag tgctagtgaa agaatgttat tctgtcttca caaaccggag
      421 gcctttcggg ccagtgggat ttatgaaaaa tgccatctct atagctgagg atgaagaatg
      481 gaagagaata cgatcattgc tgtctccaac attcaccagc ggaaaactca aggagatggt
      541 ccctatcatt gcccagtatg gagatgtgtt ggtgagaaat ctgaggcggg aagcagagac
      601 aggcaagcct gtcaccttga aacacgtctt tggggcctac agcatggatg tgatcactag
      661 cacatcattt ggagtgagca tcgactctct caacaatcca caagacccct ttgtggaaaa
      721 caccaagaag cttttaagat ttaatccatt agatccattc gttctctcaa taaaagtctt
      781 tccattcctt accccaattc ttgaagcatt aaatatcact gtgtttccaa gaaaagttat
      841 aagttttcta acaaaatctg taaaacagat aaaagaaggt cgcctcaaag agacacaaaa
      901 gcaccgagtg gatttccttc agctgatgat tgactctcag aattcaaaag actctgagac
      961 ccacaaagct ctgtctgatc tggagctcat ggcccaatca attatcttta tttttgctgg
     1021 ctatgaaacc acgagcagtg ttctctcctt cattatatat gaactggcca ctcaccctga
     1081 tgtccagcag aaagtgcaga aggaaattga tacagtttta cccaataagg caccacccac
     1141 ctatgatact gtgctacagt tggagtatct tgacatggtg gtgaatgaaa cactcagatt
     1201 attcccagtt gctatgagac ttgagagggt ctgcaaaaaa gatgttgaaa tcaatgggat
     1261 gtttattccc aaaggggtgg tggtgatgat tccaagctat gttcttcatc atgacccaaa
     1321 gtactggaca gagcctgaga agttcctccc tgaaaggttc agtaaaaaga acaaggacaa
     1381 catagatcct tacatataca caccctttgg aagtggaccc agaaactgca ttggcatgag
     1441 gtttgctctc gtgaacatga aacttgctct agtcagagtc cttcagaact tctccttcaa
     1501 accttgtaaa gaaacacaga tccccctgaa attacgcttt ggaggacttc ttctaacaga
     1561 aaaacccatt gttctaaagg ctgagtcaag ggatgagacc tttgtagata tggagcccat
     1621 tcacatggac tttttaagaa gcttggcatt ccagggccca cacctctgct ttttttggga
     1681 actactttgt cctaccatca gatcccgctg aaattacgct taggaggact tcttcaacca
     1741 gaaaaaccca ttgttctaaa ggttgagtca agggatggga ccgtaagtgg aacctgaatt
     1801 tccctaagga cttctgcttt gctcttcaaa aaagctgtga cctagaacac cagagacctc
     1861 aaattacttt gtgaatagta ccctgaaatg aagatgggct tcatccactg tactgcataa
     1921 ataaccaggg attctgtaca tgcactgagc tctctccctg tctgtgtaga gtgttatact
     1981 tgggaatata aaggaagtga ccaaatcagt gcttgggaag tagatttggc ttctttgttt
     2041 ctcacaggac aatctcagcc acccctagtt agcaccatta actcctcctg agctctgata
     2101 aaagaatcaa aatttctcaa taatttcatc caaaattatt aatgaaaata agaattattt
     2161 tgatggctct aacagtgaca tttatatcat ctgttttatc tggagcattc tataataagt
     2221 ttatattaag caaatcaata aaaacctctt acaaaagtat
//
