LOCUS       NM_000777               1720 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cytochrome P450 family 3 subfamily A member 5
            (CYP3A5), transcript variant 1, mRNA.
ACCESSION   NM_000777
VERSION     NM_000777.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Lambert,J., Petrovitch,D., Himes,K.P., Freiermuth,C.E., Braun,R.S.,
            Brown,J.L., Bischof,J.J., Lyons,M.S., Punches,B.E.,
            Littlefield,A.K., Kisor,D.F. and Sprague,J.E.
  TITLE     Association of genetic variants in CYP3A5, DRD2 and NK1R with
            opioid overdose
  JOURNAL   Chem Biol Interact 403, 111242 (2024)
   PUBMED   39265714
  REMARK    GeneRIF: Association of genetic variants in CYP3A5, DRD2 and NK1R
            with opioid overdose.
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Jiang,J. and Luan,J.
  TITLE     Effect of CYP3A5 Gene Polymorphisms on Tacrolimus Blood
            Concentrations and Adverse Events in Allogeneic Hematopoietic Stem
            Cell Transplant Patients
  JOURNAL   Transplant Proc 56 (7), 1678-1682 (2024)
   PUBMED   39147616
  REMARK    GeneRIF: Effect of CYP3A5 Gene Polymorphisms on Tacrolimus Blood
            Concentrations and Adverse Events in Allogeneic Hematopoietic Stem
            Cell Transplant Patients.
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   ElShereef,C.E., Zaki,H.F., Badary,O.A., Kamal,S., Nagy,M.,
            Makhlouf,D., Kamal,M., Elnadi,I., A Abdelshafi,S., Abou El Naga,S.
            and Saber,M.M.
  TITLE     Correlation of Genetic Polymorphism of CYP3A5 to Cyclophosphamide
            Efficacy and Toxicity in Rhabdomyosarcoma Pediatric Egyptian Cancer
            Patients
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2445-2455 (2024)
   PUBMED   39068579
  REMARK    GeneRIF: Correlation of Genetic Polymorphism of CYP3A5 to
            Cyclophosphamide Efficacy and Toxicity in Rhabdomyosarcoma
            Pediatric Egyptian Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Nkoy,F.L., Stone,B.L., Deering-Rice,C.E., Zhu,A., Lamb,J.G.,
            Rower,J.E. and Reilly,C.A.
  TITLE     Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes
  JOURNAL   Int J Mol Sci 25 (12), 6548 (2024)
   PUBMED   38928254
  REMARK    GeneRIF: Impact of CYP3A5 Polymorphisms on Pediatric Asthma
            Outcomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Ammour,A., Aberkane,M., Boudjema,A., Boughrara,W. and
            Benchekor,S.M.
  TITLE     The Frequencies distribution of CYP3A5 rs776746 and ABCB1 rs1045642
            polymorphisms in the west Algerian population and relationships
            with pharmacogenetics
  JOURNAL   Afr Health Sci 24 (1), 307-312 (2024)
   PUBMED   38962329
  REMARK    GeneRIF: The Frequencies distribution of CYP3A5 rs776746 and ABCB1
            rs1045642 polymorphisms in the west Algerian population and
            relationships with pharmacogenetics.
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Murray,G.I., Pritchard,S., Melvin,W.T. and Burke,M.D.
  TITLE     Cytochrome P450 CYP3A5 in the human anterior pituitary gland
  JOURNAL   FEBS Lett 364 (1), 79-82 (1995)
   PUBMED   7750548
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
  TITLE     Sequence of the 5'-flanking region of CYP3A5: comparative analysis
            with CYP3A4 and CYP3A7
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1741-1747 (1994)
   PUBMED   7811260
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Schuetz,J.D., Molowa,D.T. and Guzelian,P.S.
  TITLE     Characterization of a cDNA encoding a new member of the
            glucocorticoid-responsive cytochromes P450 in human liver
  JOURNAL   Arch Biochem Biophys 274 (2), 355-365 (1989)
   PUBMED   2802615
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Aoyama,T., Yamano,S., Waxman,D.J., Lapenson,D.P., Meyer,U.A.,
            Fischer,V., Tyndale,R., Inaba,T., Kalow,W., Gelboin,H.V. et al.
  TITLE     Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product
            that is differentially expressed in adult human liver. cDNA and
            deduced amino acid sequence and distinct specificities of
            cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid
            hormones and cyclosporine
  JOURNAL   J Biol Chem 264 (18), 10388-10395 (1989)
   PUBMED   2732228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC383127.1, BC033862.1 and
            AA076026.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 24, 2018 this sequence version replaced NM_000777.4.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            The encoded protein metabolizes drugs as well as the steroid
            hormones testosterone and progesterone. This gene is part of a
            cluster of cytochrome P450 genes on chromosome 7q21.1. Two
            pseudogenes of this gene have been identified within this cluster
            on chromosome 7. Expression of this gene is widely variable among
            populations, and a single nucleotide polymorphism that affects
            transcript splicing has been associated with susceptibility to
            hypertensions. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04813.1, BC033862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222982.8/ ENSP00000222982.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DC383127.1         31-61
            32-1622             BC033862.1         21-1611
            1623-1720           AA076026.1         240-337
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1720
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /note="cytochrome P450 family 3 subfamily A member 5"
                     /db_xref="GeneID:1577"
                     /db_xref="HGNC:HGNC:2638"
                     /db_xref="MIM:605325"
     exon            1..171
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1609
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /EC_number="1.14.14.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     flavoprotein-linked monooxygenase; cytochrome P450,
                     subfamily IIIA (niphedipine oxidase), polypeptide 5; aryl
                     hydrocarbon hydroxylase; xenobiotic monooxygenase;
                     microsomal monooxygenase; cytochrome P450 3A5; cytochrome
                     P450 HLp2; cytochrome P450-PCN3; cytochrome P450, family
                     3, subfamily A, polypeptide 5"
                     /codon_start=1
                     /product="cytochrome P450 3A5 isoform 1"
                     /protein_id="NP_000768.1"
                     /db_xref="CCDS:CCDS5672.1"
                     /db_xref="GeneID:1577"
                     /db_xref="HGNC:HGNC:2638"
                     /db_xref="MIM:605325"
                     /translation="MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL
                     PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVF
                     TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL
                     RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP
                     LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI
                     DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE
                     IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS
                     MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN
                     MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE"
     exon            172..265
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            266..318
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..418
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..532
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..621
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..770
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..898
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..965
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1126
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1353
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1513
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1720
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="CYP3A5"
                     /gene_synonym="CP35; CYPIIIA5; P450PCN3; PCN3"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgcagg gcagggaagc tccaggcaaa cagcccagca aacagcagca ctcagctaaa
       61 aggaagactc acagaacaca gttgaagaag gaaagtggcg atggacctca tcccaaattt
      121 ggcggtggaa acctggcttc tcctggctgt cagcctggtg ctcctctatc tatatgggac
      181 ccgtacacat ggacttttta agagactggg aattccaggg cccacacctc tgcctttgtt
      241 gggaaatgtt ttgtcctatc gtcagggtct ctggaaattt gacacagagt gctataaaaa
      301 gtatggaaaa atgtggggaa cgtatgaagg tcaactccct gtgctggcca tcacagatcc
      361 cgacgtgatc agaacagtgc tagtgaaaga atgttattct gtcttcacaa atcgaaggtc
      421 tttaggccca gtgggattta tgaaaagtgc catctcttta gctgaggatg aagaatggaa
      481 gagaatacgg tcattgctgt ctccaacctt caccagcgga aaactcaagg agatgttccc
      541 catcattgcc cagtatggag atgtattggt gagaaacttg aggcgggaag cagagaaagg
      601 caagcctgtc accttgaaag acatctttgg ggcctacagc atggatgtga ttactggcac
      661 atcatttgga gtgaacatcg actctctcaa caatccacaa gacccctttg tggagagcac
      721 taagaagttc ctaaaatttg gtttcttaga tccattattt ctctcaataa tactctttcc
      781 attccttacc ccagtttttg aagcattaaa tgtctctctg tttccaaaag ataccataaa
      841 ttttttaagt aaatctgtaa acagaatgaa gaaaagtcgc ctcaacgaca aacaaaagca
      901 ccgactagat ttccttcagc tgatgattga ctcccagaat tcgaaagaaa ctgagtccca
      961 caaagctctg tctgatctgg agctcgcagc ccagtcaata atcttcattt ttgctggcta
     1021 tgaaaccacc agcagtgttc tttccttcac tttatatgaa ctggccactc accctgatgt
     1081 ccagcagaaa ctgcaaaagg agattgatgc agttttgccc aataaggcac cacctaccta
     1141 tgatgccgtg gtacagatgg agtaccttga catggtggtg aatgaaacac tcagattatt
     1201 cccagttgct attagacttg agaggacttg caagaaagat gttgaaatca atggggtatt
     1261 cattcccaaa gggtcaatgg tggtgattcc aacttatgct cttcaccatg acccaaagta
     1321 ctggacagag cctgaggagt tccgccctga aaggttcagt aagaagaagg acagcataga
     1381 tccttacata tacacaccct ttggaactgg acccagaaac tgcattggca tgaggtttgc
     1441 tctcatgaac atgaaacttg ctctaatcag agtccttcag aacttctcct tcaaaccttg
     1501 taaagaaaca cagatcccct tgaaattaga cacgcaagga cttcttcaac cagaaaaacc
     1561 cattgttcta aaggtggatt caagagatgg aaccctaagt ggagaatgag ttattctaag
     1621 gatttctact ttggtcttca agaaagctgt gccccagaac accagagatt tcaacttagt
     1681 caataaaacc ttgaaataaa gatgggctta atctaatgta
//
