LOCUS       NM_017781               2322 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily W member 1
            (CYP2W1), mRNA.
ACCESSION   NM_017781
VERSION     NM_017781.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Aiyappa-Maudsley,R., Storr,S.J., Rakha,E.A., Green,A.R., Ellis,I.O.
            and Martin,S.G.
  TITLE     CYP2S1 and CYP2W1 expression is associated with patient survival in
            breast cancer
  JOURNAL   J Pathol Clin Res 8 (6), 550-566 (2022)
   PUBMED   35902379
  REMARK    GeneRIF: CYP2S1 and CYP2W1 expression is associated with patient
            survival in breast cancer.
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Nole,P., Duijndam,B., Stenman,A., Juhlin,C.C., Kozyra,M.,
            Larsson,C., Ingelman-Sundberg,M. and Johansson,I.
  TITLE     Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is
            Only Rarely Expressed in Adrenocortical Carcinomas
  JOURNAL   PLoS One 11 (9), e0162379 (2016)
   PUBMED   27598485
  REMARK    GeneRIF: Normal adrenal tissue lacks CYP2W1 enzyme expression;
            adrenocortical carcinomas generally do not express the enzyme as
            well.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Li,Y., Kang,X., Yang,G., Dai,P., Chen,C. and Wang,H.
  TITLE     Identification of Genetic Polymorphisms of CYP2W1 in the Three Main
            Chinese Ethnicities: Han, Tibetan, and Uighur
  JOURNAL   Drug Metab Dispos 44 (9), 1510-1515 (2016)
   PUBMED   27307299
  REMARK    GeneRIF: showed that the genetic pattern of CYP2W1 is
            interethnically different among the three Chinese populations, and
            this finding can extend our understanding of population genetics of
            CYP2W1 in the Chinese population
            Erratum:[Drug Metab Dispos. 2017 Oct;45(10):1113. doi:
            10.1124/dmd.117.069153err.. PMID: 28923842]
REFERENCE   4  (bases 1 to 2322)
  AUTHORS   Guo,J., Johansson,I., Mkrtchian,S. and Ingelman-Sundberg,M.
  TITLE     The CYP2W1 enzyme: regulation, properties and activation of
            prodrugs
  JOURNAL   Drug Metab Rev 48 (3), 369-378 (2016)
   PUBMED   27257736
  REMARK    GeneRIF: summarizes the history, distribution, polymorphism,
            membrane topology, function and possible role in cancer therapy of
            CYP2W1.
            Review article
REFERENCE   5  (bases 1 to 2322)
  AUTHORS   Zhao,Y., Wan,D., Yang,J., Hammock,B.D. and Ortiz de Montellano,P.R.
  TITLE     Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1
            Toward Endogenous Substrates
  JOURNAL   Drug Metab Dispos 44 (5), 771-780 (2016)
   PUBMED   26936974
REFERENCE   6  (bases 1 to 2322)
  AUTHORS   Gomez,A., Karlgren,M., Edler,D., Bernal,M.L., Mkrtchian,S. and
            Ingelman-Sundberg,M.
  TITLE     Expression of CYP2W1 in colon tumors: regulation by gene
            methylation
  JOURNAL   Pharmacogenomics 8 (10), 1315-1325 (2007)
   PUBMED   17979506
  REMARK    GeneRIF: The expression of CYP2W1 is colon tumor-specific and is
            associated with methylation status of the CYP2W1 gene, suggesting a
            potential causal link between the gene hypomethylation and its
            enhanced expression.
REFERENCE   7  (bases 1 to 2322)
  AUTHORS   Yoshioka,H., Kasai,N., Ikushiro,S., Shinkyo,R., Kamakura,M.,
            Ohta,M., Inouye,K. and Sakaki,T.
  TITLE     Enzymatic properties of human CYP2W1 expressed in Escherichia coli
  JOURNAL   Biochem Biophys Res Commun 345 (1), 169-174 (2006)
   PUBMED   16677611
REFERENCE   8  (bases 1 to 2322)
  AUTHORS   Wu,Z.L., Sohl,C.D., Shimada,T. and Guengerich,F.P.
  TITLE     Recombinant enzymes overexpressed in bacteria show broad catalytic
            specificity of human cytochrome P450 2W1 and limited activity of
            human cytochrome P450 2S1
  JOURNAL   Mol Pharmacol 69 (6), 2007-2014 (2006)
   PUBMED   16551781
REFERENCE   9  (bases 1 to 2322)
  AUTHORS   Karlgren,M., Gomez,A., Stark,K., Svard,J., Rodriguez-Antona,C.,
            Oliw,E., Bernal,M.L., Ramon y Cajal,S., Johansson,I. and
            Ingelman-Sundberg,M.
  TITLE     Tumor-specific expression of the novel cytochrome P450 enzyme,
            CYP2W1
  JOURNAL   Biochem Biophys Res Commun 341 (2), 451-458 (2006)
   PUBMED   16426568
  REMARK    GeneRIF: CYP2W1 is expressed human colonic and adrenal gland
            neoplasms, but not normal tissue, and is expressed in rat fetal and
            adult colon
REFERENCE   10 (bases 1 to 2322)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073957.7 and BC025761.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017781.2.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025761.1, SRR9304716.433123.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308919.12/ ENSP00000310149.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC073957.7         104241-104258
            19-2322             BC025761.1         1-2304
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2322
                     /gene="CYP2W1"
                     /note="cytochrome P450 family 2 subfamily W member 1"
                     /db_xref="GeneID:54905"
                     /db_xref="HGNC:HGNC:20243"
                     /db_xref="MIM:615967"
     exon            1..205
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1504
                     /gene="CYP2W1"
                     /note="cytochrome P450 2W1; CYPIIW1; cytochrome P450,
                     family 2, subfamily W, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 2W1 precursor"
                     /protein_id="NP_060251.2"
                     /db_xref="CCDS:CCDS5319.2"
                     /db_xref="GeneID:54905"
                     /db_xref="HGNC:HGNC:20243"
                     /db_xref="MIM:615967"
                     /translation="MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNL
                     HLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPI
                     AIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDG
                     YRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFN
                     VYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDD
                     PEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGR
                     TPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSV
                     LLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGL
                     LQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPRP"
     exon            206..368
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..518
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..676
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..850
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..989
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1174
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1316
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2322
                     /gene="CYP2W1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2W1"
                     /note="hexamer: AATACA"
     polyA_site      2322
                     /gene="CYP2W1"
                     /note="major polyA site"
ORIGIN      
        1 aggggagtgg agcctcacca gccacgtcct catggccctg ctgctcttgc tgttcctggg
       61 cctcctgggg ctctgggggc tgctctgcgc ctgcgcccaa gacccctccc cagctgcccg
      121 gtggcccccg gggcctcgcc cgctgccgct cgtcgggaac ctgcacttgc tgcgtctgtc
      181 gcaacaggac cggtccctga tggagctctc agaacgctac gggccggtgt tcaccgtgca
      241 cctggggcgc cagaagacgg tggtgctgac ggggttcgag gcggtcaaag aggcgctggc
      301 gggccccggg caggagctgg ccgaccggcc tcccatcgcc atcttccagc tcatccagcg
      361 aggtggaggc atcttcttct catctggggc gcgctggagg gctgcccgcc agttcacggt
      421 gcgtgccctg cacagcctgg gcgtgggccg ggagccggtg gctgacaaga ttctgcagga
      481 gctgaaatgc ctctctgggc agctggatgg ctacagaggc cggcccttcc cgctggccct
      541 actgggctgg gctccctcca atatcacctt cgcgctcctc ttcggccgcc gatttgacta
      601 ccgggacccc gtgtttgtgt ccctgctggg tctcatcgat gaggtcatgg tcctcttggg
      661 gtcccctggc ctgcagctgt tcaacgtcta cccatggctc ggggccctgc tccagctgca
      721 ccggcccgtc ctgcgcaaga tcgaggaggt ccgtgccatt ctgaggaccc tcctggaggc
      781 gcggaggccc cacgtgtgcc cgggggaccc cgtgtgcagc tatgtggacg ccctgatcca
      841 gcagggacag ggggatgacc ccgagggcct gtttgctgag gccaacgcgg tggcctgcac
      901 cctggacatg gtcatggccg ggacggagac gacctcggcc acgctgcagt gggccgcact
      961 tctgatgggc cggcacccgg acgtgcaggg ccgggtgcag gaggagctag accgcgtgct
     1021 gggccctggg cggactcccc ggctggagga ccagcaggct ctgccctaca caagcgccgt
     1081 gctccacgag gtgcagcggt tcatcacgct cctgccgcac gtgccccgct gcaccgcggc
     1141 cgacacacag ctgggcggct tcctgctccc caagggcacg cccgtgattc ccctgctgac
     1201 ctcggtgctc ctggatgaga cacagtggca gaccccaggc cagttcaacc ccggccattt
     1261 cctggacgcg aatgggcact ttgtgaagcg ggaggccttc ctgcctttct ctgcaggccg
     1321 ccgcgtctgt gttggggagc gcctggccag gaccgagctc ttcctgctgt ttgccggcct
     1381 cctgcagagg taccgcctgc tgcccccgcc tggcgtcagt ccggcctccc tggacaccac
     1441 gcccgcccgg gcttttacca tgaggccgag ggcccaggcc ctgtgtgcgg tgcccaggcc
     1501 ctaggagctc ccccagcccc caggtcctcc tgaccactcc cctcccagcc ctgggtcctc
     1561 ccaccctctc tcctcccacc ccacagctcg gactgctctg ggagggccct gaggactccc
     1621 accctcaccc ccacccccac agggtcagca actgcttccg gttacaccca ggactacccc
     1681 tgcccgaccc tgtgggaccc ccacccctct gatgctgtct gcagctcagt ccctgccagc
     1741 ccccaggagc gcctccaggg ccccgcccac tctcccaccc ctgaagctgc actcccaccc
     1801 acctagctcc ccccagggcc ccccagcacc tacagctggg gctgcaggga gacaacgggt
     1861 ggctgcatcc agccagagac aggcgcaggt gggtgtcctc agcgtgcgag ccctgcaccc
     1921 cccaggtcct gggactcctg cagaccccac tccattcccg ctcctggaac acttcctgca
     1981 gctgtgcctg gaggcagtcg gcctgcagtg ccagactctg agccaagcca ctggggccat
     2041 gcgtatgact ggtgcaggga ggcaaggccc acattctcct tcagagacag gcactggcgc
     2101 cagaggcttc cttggggcgg ggggagggca cctcagcccc tgaagacaag cagcactgca
     2161 gtggcaaaaa tggaaacact gacccggtgc ggtggctcat gcctgtaatc ccagcacttt
     2221 gggaggccga ggcaggcgaa tcacgaggtc aggagttcga gaccagcctg cccaacatgg
     2281 tgaaaccctg tctctactaa aaatacaaaa aaattaaccg ag
//
