LOCUS       NM_030622               2612 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily S member 1
            (CYP2S1), mRNA.
ACCESSION   NM_030622
VERSION     NM_030622.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2612)
  AUTHORS   Aiyappa-Maudsley,R., Storr,S.J., Rakha,E.A., Green,A.R., Ellis,I.O.
            and Martin,S.G.
  TITLE     CYP2S1 and CYP2W1 expression is associated with patient survival in
            breast cancer
  JOURNAL   J Pathol Clin Res 8 (6), 550-566 (2022)
   PUBMED   35902379
  REMARK    GeneRIF: CYP2S1 and CYP2W1 expression is associated with patient
            survival in breast cancer.
REFERENCE   2  (bases 1 to 2612)
  AUTHORS   Wang,L., Wang,H. and Qi,Y.
  TITLE     CYP2S1 rs338599 polymorphism confers reduced risk to
            anti-tuberculosis drug-induced liver injury and may be a novel
            marker for its risk prediction
  JOURNAL   J Clin Lab Anal 36 (6), e24478 (2022)
   PUBMED   35535391
  REMARK    GeneRIF: CYP2S1 rs338599 polymorphism confers reduced risk to
            anti-tuberculosis drug-induced liver injury and may be a novel
            marker for its risk prediction.
REFERENCE   3  (bases 1 to 2612)
  AUTHORS   Cabrera-Cano,A., Davila-Borja,V.M., Juarez-Mendez,S.,
            Marcial-Quino,J., Gomez-Manzo,S. and Castillo-Rodriguez,R.A.
  TITLE     Hypoxia as a modulator of cytochromes P450: Overexpression of the
            cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in
            hypoxia
  JOURNAL   Cell Biochem Funct 39 (4), 478-487 (2021)
   PUBMED   33377261
  REMARK    GeneRIF: Hypoxia as a modulator of cytochromes P450: Overexpression
            of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells
            in hypoxia.
REFERENCE   4  (bases 1 to 2612)
  AUTHORS   Guo,H., Zeng,B., Wang,L., Ge,C., Zuo,X., Li,Y., Ding,W., Deng,L.,
            Zhang,J., Qian,X., Song,X. and Zhang,P.
  TITLE     Knockdown CYP2S1 inhibits lung cancer cells proliferation and
            migration
  JOURNAL   Cancer Biomark 32 (4), 531-539 (2021)
   PUBMED   34275895
  REMARK    GeneRIF: Knockdown CYP2S1 inhibits lung cancer cells proliferation
            and migration.
REFERENCE   5  (bases 1 to 2612)
  AUTHORS   Rivera,S.P., Wang,F., Saarikoski,S.T., Taylor,R.T., Chapman,B.,
            Zhang,R. and Hankinson,O.
  TITLE     A novel promoter element containing multiple overlapping xenobiotic
            and hypoxia response elements mediates induction of cytochrome
            P4502S1 by both dioxin and hypoxia
  JOURNAL   J Biol Chem 282 (15), 10881-10893 (2007)
   PUBMED   17277313
  REMARK    GeneRIF: identify a novel regulatory cassette that mediates changes
            in Cyp2s1 expression
REFERENCE   6  (bases 1 to 2612)
  AUTHORS   Saarikoski,S.T., Suitiala,T., Holmila,R., Impivaara,O.,
            Jarvisalo,J., Hirvonen,A. and Husgafvel-Pursiainen,K.
  TITLE     Identification of genetic polymorphisms of CYP2S1 in a Finnish
            Caucasian population
  JOURNAL   Mutat Res 554 (1-2), 267-277 (2004)
   PUBMED   15450424
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2612)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   8  (bases 1 to 2612)
  AUTHORS   Smith,G., Wolf,C.R., Deeni,Y.Y., Dawe,R.S., Evans,A.T.,
            Comrie,M.M., Ferguson,J. and Ibbotson,S.H.
  TITLE     Cutaneous expression of cytochrome P450 CYP2S1: individuality in
            regulation by therapeutic agents for psoriasis and other skin
            diseases
  JOURNAL   Lancet 361 (9366), 1336-1343 (2003)
   PUBMED   12711469
REFERENCE   9  (bases 1 to 2612)
  AUTHORS   Saito,S., Iida,A., Sekine,A., Kawauchi,S., Higuchi,S., Ogawa,C. and
            Nakamura,Y.
  TITLE     Catalog of 680 variations among eight cytochrome p450 (CYP) genes,
            nine esterase genes, and two other genes in the Japanese population
  JOURNAL   J Hum Genet 48 (5), 249-270 (2003)
   PUBMED   12721789
REFERENCE   10 (bases 1 to 2612)
  AUTHORS   Rylander,T., Neve,E.P., Ingelman-Sundberg,M. and Oscarson,M.
  TITLE     Identification and tissue distribution of the novel human
            cytochrome P450 2S1 (CYP2S1)
  JOURNAL   Biochem Biophys Res Commun 281 (2), 529-535 (2001)
   PUBMED   11181079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP284240.1, BC033691.1 and
            AY358603.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030622.7.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum. In rodents,
            the homologous protein has been shown to metabolize certain
            carcinogens; however, the specific function of the human protein
            has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358603.1, SRR1803615.81606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310054.9/ ENSP00000308032.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BP284240.1         13-41
            30-1591             BC033691.1         1-1562
            1592-2109           AY358603.1         1589-2106
            2110-2612           BC033691.1         2081-2583
FEATURES             Location/Qualifiers
     source          1..2612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2612
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /note="cytochrome P450 family 2 subfamily S member 1"
                     /db_xref="GeneID:29785"
                     /db_xref="HGNC:HGNC:15654"
                     /db_xref="MIM:611529"
     exon            1..223
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1561
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /EC_number="5.3.99.5"
                     /EC_number="4.2.1.152"
                     /note="cytochrome P540, subfamily IIS, polypeptide 1;
                     cytochrome P450 2S1; cytochrome P450, family 2, subfamily
                     S, polypeptide 1; thromboxane-A synthase; hydroperoxy
                     icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 2S1 precursor"
                     /protein_id="NP_085125.1"
                     /db_xref="CCDS:CCDS12573.1"
                     /db_xref="GeneID:29785"
                     /db_xref="HGNC:HGNC:15654"
                     /db_xref="MIM:611529"
                     /translation="MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGN
                     LLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRG
                     TVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETF
                     QGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQ
                     TYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKM
                     AQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNR
                     ELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEV
                     FPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAEL
                     FLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR"
     exon            224..389
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..539
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..700
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..880
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1022
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1210
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1352
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2612
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2612
                     /gene="CYP2S1"
                     /gene_synonym="CYPIIS1"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgcgg agcgcctggg agaggagaag gagccgacct gccgagatgg aggcgaccgg
       61 cacctgggcg ctgctgctgg cgctggcgct gctcctgctg ctgacgctgg cgctgtccgg
      121 gaccagggcc cgaggccacc tgccccccgg gcccacgccg ctaccactgc tgggaaacct
      181 cctgcagcta cggcccgggg cgctgtattc agggctcatg cggctgagta agaagtacgg
      241 accggtgttc accatctacc tgggaccctg gcggcctgtg gtggtcctgg ttgggcagga
      301 ggctgtgcgg gaggccctgg gaggtcaggc tgaggagttc agcggccggg gaaccgtagc
      361 gatgctggaa gggacttttg atggccatgg ggttttcttc tccaacgggg agcggtggag
      421 gcagctgagg aagtttacca tgcttgctct gcgggacctg ggcatgggga agcgagaagg
      481 cgaggagctg atccaggcgg aggcccggtg tctggtggag acattccagg ggacagaagg
      541 acgcccattc gatccctccc tgctgctggc ccaggccacc tccaacgtag tctgctccct
      601 cctctttggc ctccgcttct cctatgagga taaggagttc caggccgtgg tccgggcagc
      661 tggtggtacc ctgctgggag tcagctccca ggggggtcag acctacgaga tgttctcctg
      721 gttcctgcgg cccctgccag gcccccacaa gcagctcctc caccacgtca gcaccttggc
      781 tgccttcaca gtccggcagg tgcagcagca ccaggggaac ctggatgctt cgggccccgc
      841 acgtgacctt gtcgatgcct tcctgctgaa gatggcacag gaggaacaaa acccaggcac
      901 agaattcacc aacaagaaca tgctgatgac agtcatttat ttgctgtttg ctgggacgat
      961 gacggtcagc accacggtcg gctataccct cctgctcctg atgaaatacc ctcatgtcca
     1021 aaagtgggta cgtgaggagc tgaatcggga gctgggggct ggccaggcac caagcctagg
     1081 ggaccgtacc cgcctccctt acaccgacgc ggttctgcat gaggcgcagc ggctgctggc
     1141 gctggtgccc atgggaatac cccgcaccct catgcggacc acccgcttcc gagggtacac
     1201 cctgccccag ggcacggagg tcttccccct ccttggctcc atcctgcatg accccaacat
     1261 cttcaagcac ccagaagagt tcaacccaga ccgtttcctg gatgcagatg gacggttcag
     1321 gaagcatgag gcgttcctgc ccttctcctt agggaagcgt gtctgccttg gagagggcct
     1381 ggcaaaagcg gagctcttcc tcttcttcac caccatccta caagccttct ccctggagag
     1441 cccgtgcccg ccggacaccc tgagcctcaa gcccaccgtc agtggccttt tcaacattcc
     1501 cccagccttc cagctgcaag tccgtcccac tgaccttcac tccaccacgc agaccagatg
     1561 aaggaaggca acttggaagt ggtgggtgcc caggacggtg cctccagcct caacagtggg
     1621 catggacagg gttaatgtct ccagagtgta cactgcaggc agccacattt acacgcctgc
     1681 agttgttttc cggagtctgt cccacggccc acacgctcac ttgactcatg ctgctaagat
     1741 gcacaaccgc acacccatac acaactacaa gggccacaaa gcaactgctg ggttagcttt
     1801 ccacagacat aaatatagtc catctgcaat cacaagcaca tagccaggta acccaccaac
     1861 tcccctggat ctgcagccca cacgtgggag tctggctgtc accttcacaa gccacagaaa
     1921 cggccacaca tgttcacagc tcacacgccc tctccattca tcgaacttct cagtgtccct
     1981 gtccctggtg cctggcacag ggaacagcat gccccctccg gggtcatgcc acccagagac
     2041 tgtcgctgtc tatggcccca actcatgctc cctctcttgg ctacaccact ctcccagcct
     2101 gtgaccaccg atgtccacac acccccaacc acttgtccac acagctaccc acgtacgaca
     2161 tcgtcctggc tccccagagt atcttcccac tgagacacgc cgcccccaca gaggcacagt
     2221 ccccagccac ctctgcaact gcagccctca gtcacccctt tttaagcacc ctgattctac
     2281 caaatgcaaa cacatctggg tctgcgatta tgcacagaga ctttggacat acgaggaccc
     2341 tcagaccgga ggaacacctg cccaacccca acacgtgctt atgtaaccac gtggaaagcg
     2401 gcccctgctg cccctccaca cacacataca cactcactga tctacagccc ctgttcggcg
     2461 tcagagtccc cactagaccc agtggaaggg gttagagacc aagtaggggc cagtttccaa
     2521 ttcaccctgt cagggagtga gccggatctg acgttccttg tgacttaagg gtccggcttg
     2581 ggaattaaag tttgtttctg gcctttagcc ta
//
