LOCUS       NM_000775               1879 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily J member 2
            (CYP2J2), transcript variant 1, mRNA.
ACCESSION   NM_000775
VERSION     NM_000775.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Li,Y., You,C., Liu,Z., He,F., Zhao,F., Song,X., Xie,Z., Wei,S.,
            Yang,Y., Wei,H., Che,F. and Yu,J.
  TITLE     CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive
            intracerebral hemorrhage
  JOURNAL   J Stroke Cerebrovasc Dis 32 (3), 106974 (2023)
   PUBMED   36587509
  REMARK    GeneRIF: CYP2C8 and CYP2J2 gene variations increase the risk of
            hypertensive intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Zhao,B., Huang,J., Lou,X., Yao,K., Ye,M., Mou,Q., Wen,Z., Duan,Q.,
            Zhang,H. and Zhao,Y.
  TITLE     Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation
  JOURNAL   FASEB J 36 (11), e22619 (2022)
   PUBMED   36269280
  REMARK    GeneRIF: Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Ding,Y., Tu,P., Chen,Y., Huang,Y., Pan,X. and Chen,W.
  TITLE     CYP2J2 and EETs protect against pulmonary arterial hypertension
            with lung ischemia-reperfusion injury in vivo and in vitro
  JOURNAL   Respir Res 22 (1), 291 (2021)
   PUBMED   34774051
  REMARK    GeneRIF: CYP2J2 and EETs protect against pulmonary arterial
            hypertension with lung ischemia-reperfusion injury in vivo and in
            vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Zou,X. and Mo,Z.
  TITLE     CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with
            Immune Infiltration in Kidney Renal Clear Cell Carcinoma
  JOURNAL   Biomed Res Int 2021, 3771866 (2021)
   PUBMED   34258261
  REMARK    GeneRIF: CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated
            with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Xu,L. and Chen,L.Y.
  TITLE     Molecular determinant of substrate binding and specificity of
            cytochrome P450 2J2
  JOURNAL   Sci Rep 10 (1), 22267 (2020)
   PUBMED   33335233
  REMARK    GeneRIF: Molecular determinant of substrate binding and specificity
            of cytochrome P450 2J2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Zeldin,D.C., Foley,J., Goldsworthy,S.M., Cook,M.E., Boyle,J.E.,
            Ma,J., Moomaw,C.R., Tomer,K.B., Steenbergen,C. and Wu,S.
  TITLE     CYP2J subfamily cytochrome P450s in the gastrointestinal tract:
            expression, localization, and potential functional significance
  JOURNAL   Mol Pharmacol 51 (6), 931-943 (1997)
   PUBMED   9187259
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Zeldin,D.C., Foley,J., Boyle,J.E., Moomaw,C.R., Tomer,K.B.,
            Parker,C., Steenbergen,C. and Wu,S.
  TITLE     Predominant expression of an arachidonate epoxygenase in islets of
            Langerhans cells in human and rat pancreas
  JOURNAL   Endocrinology 138 (3), 1338-1346 (1997)
   PUBMED   9048644
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Zeldin,D.C., Foley,J., Ma,J., Boyle,J.E., Pascual,J.M.,
            Moomaw,C.R., Tomer,K.B., Steenbergen,C. and Wu,S.
  TITLE     CYP2J subfamily P450s in the lung: expression, localization, and
            potential functional significance
  JOURNAL   Mol Pharmacol 50 (5), 1111-1117 (1996)
   PUBMED   8913342
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Wu,S., Moomaw,C.R., Tomer,K.B., Falck,J.R. and Zeldin,D.C.
  TITLE     Molecular cloning and expression of CYP2J2, a human cytochrome P450
            arachidonic acid epoxygenase highly expressed in heart
  JOURNAL   J Biol Chem 271 (7), 3460-3468 (1996)
   PUBMED   8631948
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC032594.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000775.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and is thought
            to be the predominant enzyme responsible for epoxidation of
            endogenous arachidonic acid in cardiac tissue. Multiple transcript
            variants have been found for this gene. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37143.2, BC032594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371204.4/ ENSP00000360247.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1879              BC032594.1         29-1907
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..1879
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /note="cytochrome P450 family 2 subfamily J member 2"
                     /db_xref="GeneID:1573"
                     /db_xref="HGNC:HGNC:2634"
                     /db_xref="MIM:601258"
     exon            1..237
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1536
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /EC_number="5.4.4.7"
                     /EC_number="1.14.14.73"
                     /EC_number="1.14.14.74"
                     /note="microsomal monooxygenase; flavoprotein-linked
                     monooxygenase; cytochrome P450, subfamily IIJ (arachidonic
                     acid epoxygenase) polypeptide 2; cytochrome P450, family
                     2, subfamily J, polypeptide 2; albendazole monooxygenase
                     (hydroxylating); albendazole monooxygenase
                     (sulfoxide-forming); hydroperoxy icosatetraenoate
                     isomerase"
                     /codon_start=1
                     /product="cytochrome P450 2J2"
                     /protein_id="NP_000766.2"
                     /db_xref="CCDS:CCDS613.1"
                     /db_xref="GeneID:1573"
                     /db_xref="HGNC:HGNC:2634"
                     /db_xref="MIM:601258"
                     /translation="MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYP
                     PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI
                     HMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ
                     EEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV
                     TYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD
                     FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ
                     EKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAG
                     YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLG
                     EQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV"
     exon            238..400
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..550
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..711
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..888
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1030
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1218
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1357
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1879
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /note="hexamer: CATAAA"
     polyA_site      1879
                     /gene="CYP2J2"
                     /gene_synonym="CPJ2; CYPIIJ2"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagagc aggaggacgt ctgagccatg ctcgcggcga tgggctctct ggcggctgcc
       61 ctctgggcag tggtccatcc tcggactctc ctactgggca ctgtcgcctt tctgctcgct
      121 gctgactttc tcaaaagacg gcgcccaaag aactacccgc cggggccctg gcgcctgccc
      181 ttccttggca acttcttcct tgtggacttc gagcagtcgc acctggaggt tcagctgttt
      241 gtgaagaaat atgggaacct ttttagcttg gagcttggtg acatatctgc agttcttatt
      301 actggcttgc ccttaatcaa agaagccctt atccacatgg accaaaactt tgggaaccgc
      361 cccgtgaccc ctatgcgaga acatatcttt aagaaaaatg gattgattat gtcaagtggc
      421 caggcatgga aggagcaaag aaggttcact ctgacagcac taaggaactt tggtttagga
      481 aagaagagct tagaggaacg cattcaggag gaggcccaac acctcactga agcaataaaa
      541 gaggagaacg gacagccttt tgaccctcat ttcaagatca acaatgcagt ttccaatatc
      601 atttgctcca tcaccttcgg agaacgcttt gagtaccagg atagttggtt tcagcagctg
      661 ctgaagttac tagatgaagt cacatacttg gaggcttcaa agacatgcca gctctacaat
      721 gtctttccat ggataatgaa attcctgcct ggaccccacc aaactctctt cagcaactgg
      781 aaaaaactga aattgtttgt ttctcatatg attgacaaac acagaaagga ttggaatcct
      841 gcagaaacaa gagactttat tgatgcttac cttaaagaaa tgtcaaagca cacaggcaat
      901 cctacttcaa gtttccatga agaaaacctc atctgcagca ccctggacct cttctttgcc
      961 ggaaccgaga caacttccac aactctgcga tgggctctgc tttatatggc cctctaccca
     1021 gaaatccaag aaaaagtaca agctgagatt gacagagtga ttggccaggg gcagcagccg
     1081 agcacagccg cccgggagtc catgccctac accaatgctg tcatccatga ggtgcagaga
     1141 atgggcaaca tcatccccct gaacgttccc agggaagtga cagttgatac cactttggct
     1201 gggtaccacc tgcccaaggg taccatgatc ctgaccaatt tgacggcgct gcacagggac
     1261 cccacagagt gggccacccc tgacacattc aatccggacc attttctgga gaatggacag
     1321 tttaagaaaa gggaagcctt tatgcctttc tcaataggaa agcgggcatg cctcggagaa
     1381 cagttggcca ggactgagct gtttattttc ttcacttccc ttatgcaaaa atttaccttc
     1441 aggcccccaa acaatgagaa gctgagcctg aagtttagaa tgggtatcac catttcccca
     1501 gtcagtcacc gcctctgcgc tgttcctcag gtgtaatatt gttaagaaag aaaggggcaa
     1561 ggaaagtaag aagacatggc acgtgttctg aaaccactgg tgtctgctca gatgtgttgg
     1621 gacaaaatga aagtgacttt caagaaagat cagaggaatt tgactcagag aaaactagat
     1681 ccaaatccca gctctactgt ctcgtccgaa ttagccttgg gaaaatcatt tatatgctaa
     1741 ataatttacc tttttatcta ggagatgaaa agaggataat gtttccttcc ataaagaaag
     1801 ttcttgtaag aatcaaaaga aatggtgagc tttaagtggt ttgtaaacca taaaacacat
     1861 cataaaagtt ctatctata
//
