LOCUS       NM_000771               2561 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily C member 9
            (CYP2C9), mRNA.
ACCESSION   NM_000771
VERSION     NM_000771.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Guo,L., Zhang,X., Li,X., Wang,K., Wang,Y., Abulikemu,A., Su,X.,
            Shu,M., Li,H., Cui,S., Xu,Z., Tian,H., Niu,Y., Yuan,H., He,Z.,
            Sun,X. and Duan,H.
  TITLE     Polycyclic aromatic hydrocarbon and its adducts in peripheral
            blood: Gene and environment interaction among Chinese population
  JOURNAL   Environ Int 190, 108922 (2024)
   PUBMED   39128373
  REMARK    GeneRIF: Polycyclic aromatic hydrocarbon and its adducts in
            peripheral blood: Gene and environment interaction among Chinese
            population.
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Jara-Prado,A., Guerrero-Camacho,J.L., Angeles-Lopez,Q.D.,
            Ochoa-Morales,A., Davila-Ortiz de Montellano,D.J.,
            Ramirez-Garcia,M.A., Breda-Yepes,M., Duron,R.M.,
            Delgado-Escueta,A.V., Barrios-Gonzalez,D.A. and
            Martinez-Juarez,I.E.
  TITLE     Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for
            Juvenile Myoclonic Epilepsy
  JOURNAL   Neurol Sci 45 (4), 1635-1643 (2024)
   PUBMED   37875597
  REMARK    GeneRIF: Association of variants in the ABCB1, CYP2C19 and CYP2C9
            genes for Juvenile Myoclonic Epilepsy.
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Rasool,G.S., Al-Awadi,S.J., Hussien,A.A. and Al-Attar,M.M.
  TITLE     Genetic variation of CYP2C9 gene and its correlation with
            cardiovascular disease risk factors
  JOURNAL   Mol Biol Rep 51 (1), 105 (2024)
   PUBMED   38227154
  REMARK    GeneRIF: Genetic variation of CYP2C9 gene and its correlation with
            cardiovascular disease risk factors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Avsar,O.
  TITLE     Identification of the effects of pathogenic genetic variations of
            human CYP2C9 and CYP2D6: an in silico approach
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (4), 356-376 (2024)
   PUBMED   37747773
  REMARK    GeneRIF: Identification of the effects of pathogenic genetic
            variations of human CYP2C9 and CYP2D6: an in silico approach.
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Ramakrishnan,K., Kesavan,R., Venkatraman,S., Narayan,S.K.,
            Kumar,R.R. and Shewade,D.
  TITLE     Impact of CYP2C9*2 and *3 polymorphisms on valproate-associated
            adverse drug reactions in individuals living with epilepsy: a
            case-control study
  JOURNAL   Per Med 20 (5), 417-424 (2023)
   PUBMED   37811569
  REMARK    GeneRIF: Impact of CYP2C9*2 and *3 polymorphisms on
            valproate-associated adverse drug reactions in individuals living
            with epilepsy: a case-control study.
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Ohgiya,S., Komori,M., Ohi,H., Shiramatsu,K., Shinriki,N. and
            Kamataki,T.
  TITLE     Six-base deletion occurring in messages of human cytochrome P-450
            in the CYP2C subfamily results in reduction of tolbutamide
            hydroxylase activity
  JOURNAL   Biochem Int 27 (6), 1073-1081 (1992)
   PUBMED   1445376
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Srivastava,P.K., Yun,C.H., Beaune,P.H., Ged,C. and Guengerich,F.P.
  TITLE     Separation of human liver microsomal tolbutamide hydroxylase and
            (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes
  JOURNAL   Mol Pharmacol 40 (1), 69-79 (1991)
   PUBMED   1857342
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
            Goldstein,J.A.
  TITLE     Cloning and expression of complementary DNAs for multiple members
            of the human cytochrome P450IIC subfamily
  JOURNAL   Biochemistry 30 (13), 3247-3255 (1991)
   PUBMED   2009263
  REMARK    Erratum:[Biochemistry. 1993 Feb 9;32(5):1390. doi:
            10.1021/bi00056a025.. PMID: 8095407]
REFERENCE   10 (bases 1 to 2561)
  AUTHORS   Veronese,M.E., Mackenzie,P.I., Doecke,C.J., McManus,M.E.,
            Miners,J.O. and Birkett,D.J.
  TITLE     Tolbutamide and phenytoin hydroxylations by cDNA-expressed human
            liver cytochrome P4502C9
  JOURNAL   Biochem Biophys Res Commun 175 (3), 1112-1118 (1991)
   PUBMED   2025243
  REMARK    Erratum:[Biochem Biophys Res Commun 1991 Nov 14;180(3);1527]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ993098.1, BC125054.1,
            S46963.1, CB162706.1, AL359672.19 and BG562738.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 10, 2018 this sequence version replaced NM_000771.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and its
            expression is induced by rifampin. The enzyme is known to
            metabolize many xenobiotics, including phenytoin, tolbutamide,
            ibuprofen and S-warfarin. Studies identifying individuals who are
            poor metabolizers of phenytoin and tolbutamide suggest that this
            gene is polymorphic. The gene is located within a cluster of
            cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289420.1, DRR138522.115622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260682.8/ ENSP00000260682.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BJ993098.1         1-25
            26-1652             BC125054.1         1-1627
            1653-1861           S46963.1           1591-1799
            1862-1910           CB162706.1         57-105
            1911-1911           AL359672.19        60728-60728
            1912-2375           CB162706.1         106-569
            2376-2417           BG562738.1         173-214
            2418-2418           AL359672.19        61235-61235
            2419-2560           BG562738.1         216-357
            2561-2561           AL359672.19        61378-61378
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..2561
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /note="cytochrome P450 family 2 subfamily C member 9"
                     /db_xref="GeneID:1559"
                     /db_xref="HGNC:HGNC:2623"
                     /db_xref="MIM:601130"
     exon            1..193
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1498
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.14.51"
                     /EC_number="1.14.14.52"
                     /EC_number="1.14.14.53"
                     /note="microsomal monooxygenase; xenobiotic monooxygenase;
                     flavoprotein-linked monooxygenase; cytochrome P-450
                     S-mephenytoin 4-hydroxylase; cytochrome P-450MP;
                     cytochrome P450 PB-1; cytochrome P450, family 2, subfamily
                     C, polypeptide 9"
                     /codon_start=1
                     /product="cytochrome P450 2C9"
                     /protein_id="NP_000762.2"
                     /db_xref="CCDS:CCDS7437.1"
                     /db_xref="GeneID:1559"
                     /db_xref="HGNC:HGNC:2623"
                     /db_xref="MIM:601130"
                     /translation="MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQ
                     IGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPL
                     AERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK
                     ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN
                     FSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKH
                     NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN
                     RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLT
                     SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLT
                     SILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV"
     exon            194..356
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            357..506
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            507..667
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            668..844
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            845..986
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1174
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1316
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2561
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /note="hexamer: AATAAA"
     polyA_site      1861
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /note="major polyA site"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /note="hexamer: ATTAAA"
     polyA_site      2139
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
                     /note="hexamer: AATACA"
     polyA_site      2561
                     /gene="CYP2C9"
                     /gene_synonym="CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9;
                     P450IIC9"
ORIGIN      
        1 gtcttaacaa gaagagaagg cttcaatgga ttctcttgtg gtccttgtgc tctgtctctc
       61 atgtttgctt ctcctttcac tctggagaca gagctctggg agaggaaaac tccctcctgg
      121 ccccactcct ctcccagtga ttggaaatat cctacagata ggtattaagg acatcagcaa
      181 atccttaacc aatctctcaa aggtctatgg ccctgtgttc actctgtatt ttggcctgaa
      241 acccatagtg gtgctgcatg gatatgaagc agtgaaggaa gccctgattg atcttggaga
      301 ggagttttct ggaagaggca ttttcccact ggctgaaaga gctaacagag gatttggaat
      361 tgttttcagc aatggaaaga aatggaagga gatccggcgt ttctccctca tgacgctgcg
      421 gaattttggg atggggaaga ggagcattga ggaccgtgtt caagaggaag cccgctgcct
      481 tgtggaggag ttgagaaaaa ccaaggcctc accctgtgat cccactttca tcctgggctg
      541 tgctccctgc aatgtgatct gctccattat tttccataaa cgttttgatt ataaagatca
      601 gcaatttctt aacttaatgg aaaagttgaa tgaaaacatc aagattttga gcagcccctg
      661 gatccagatc tgcaataatt tttctcctat cattgattac ttcccgggaa ctcacaacaa
      721 attacttaaa aacgttgctt ttatgaaaag ttatattttg gaaaaagtaa aagaacacca
      781 agaatcaatg gacatgaaca accctcagga ctttattgat tgcttcctga tgaaaatgga
      841 gaaggaaaag cacaaccaac catctgaatt tactattgaa agcttggaaa acactgcagt
      901 tgacttgttt ggagctggga cagagacgac aagcacaacc ctgagatatg ctctccttct
      961 cctgctgaag cacccagagg tcacagctaa agtccaggaa gagattgaac gtgtgattgg
     1021 cagaaaccgg agcccctgca tgcaagacag gagccacatg ccctacacag atgctgtggt
     1081 gcacgaggtc cagagataca ttgaccttct ccccaccagc ctgccccatg cagtgacctg
     1141 tgacattaaa ttcagaaact atctcattcc caagggcaca accatattaa tttccctgac
     1201 ttctgtgcta catgacaaca aagaatttcc caacccagag atgtttgacc ctcatcactt
     1261 tctggatgaa ggtggcaatt ttaagaaaag taaatacttc atgcctttct cagcaggaaa
     1321 acggatttgt gtgggagaag ccctggccgg catggagctg tttttattcc tgacctccat
     1381 tttacagaac tttaacctga aatctctggt tgacccaaag aaccttgaca ccactccagt
     1441 tgtcaatgga tttgcctctg tgccgccctt ctaccagctg tgcttcattc ctgtctgaag
     1501 aagagcagat ggcctggctg ctgctgtgca gtccctgcag ctctctttcc tctggggcat
     1561 tatccatctt tcactatctg taatgccttt tctcacctgt catctcacat tttcccttcc
     1621 ctgaagatct agtgaacatt cgacctccat tacggagagt ttcctatgtt tcactgtgca
     1681 aatatatctg ctattctcca tactctgtaa cagttgcatt gactgtcaca taatgctcat
     1741 acttatctaa tgttgagtta ttaatatgtt attattaaat agagaaatat gatttgtgta
     1801 ttataattca aaggcatttc ttttctgcat gttctaaata aaaagcatta ttatttgctg
     1861 agtcagttta ttagaccttc cttcttttat gcataatgta ggtcagaaat taaagaaaat
     1921 agagttccag gaggccatgc tggttctcaa aatgataagg acagaaagga caaagaggaa
     1981 gagggtaggg aagctatttt gggtgagtgt tagagttact tgaggattgg atttgaaagt
     2041 gagaaactgt gtccaggggc agctctaacc tctagggaaa tattcagagg atcagtcaaa
     2101 gggtggaatg gacattaaat gctagaattc ttatatccac attggtgttc cttttttttt
     2161 gagacaaagt cttgctctgt cacccaggct ggagtgcagt ggtgtgatct cagctctcta
     2221 taacctccgc ctcccaggtt caagtgattc tcctgcctca gcctcctgag tagctgggat
     2281 tacaggtgca tgccaccaca cctggctaat tttttgtatt tttagtacag acgggttttc
     2341 accgtgttag ccaggatggt cttaatctcc tgaccttgtg atctgcctgc ctcagcctcc
     2401 caaagtgctg ggattacagg tgtgagccac tgcgcctggc ctggtgttac tttgaagtgt
     2461 cattacttta tctctaaata aagaatcaga ttacttttat tacttcatgt ttccaactta
     2521 gaatgatgta atgaagtata aatacatgct ttcatatcgc t
//
