LOCUS       NM_000767               3071 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily B member 6
            (CYP2B6), mRNA.
ACCESSION   NM_000767
VERSION     NM_000767.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Yamazaki,S., Hishinuma,E., Suzuki,Y., Ueda,A., Kijogi,C.,
            Nakayoshi,T., Oda,A., Saito,S., Tadaka,S., Kinoshita,K.,
            Maekawa,M., Sato,Y., Kumondai,M., Mano,N., Hirasawa,N. and
            Hiratsuka,M.
  TITLE     Functional significance of CYP2B6 gene rare allelic variants
            identified in Japanese individuals
  JOURNAL   Biochem Pharmacol 229, 116515 (2024)
   PUBMED   39218044
  REMARK    GeneRIF: Functional significance of CYP2B6 gene rare allelic
            variants identified in Japanese individuals.
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Eniayewu,O., Akinloye,A., Shenkoya,B., Azuka,U., Bolaji,O.,
            Adejuyigbe,E., Owen,A. and Olagunju,A.
  TITLE     Prenatal efavirenz exposure is independently associated with
            maternal, but not fetal CYP2B6 genotype
  JOURNAL   Pharmacogenet Genomics 34 (8), 253-260 (2024)
   PUBMED   38934229
  REMARK    GeneRIF: Prenatal efavirenz exposure is independently associated
            with maternal, but not fetal CYP2B6 genotype.
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Al-Adl,M., Youssef,M.M., El-Sebaie,A., Refaat,S. and El-Said,A.
  TITLE     The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic
            lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian
            patients
  JOURNAL   Oncol Res 32 (4), 785-797 (2024)
   PUBMED   38560574
  REMARK    GeneRIF: The role of polymorphic cytochrome P450 gene (CYP2B6) in
            B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among
            Egyptian patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Zhou,Y., Dong,H., Fan,J., Zhu,M., Liu,L., Wang,Y., Tang,P. and
            Chen,X.
  TITLE     Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated
            Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and
            Extrahepatic Metabolism
  JOURNAL   Drug Metab Dispos 52 (2), 106-117 (2024)
   PUBMED   38071562
  REMARK    GeneRIF: Cytochrome P450 2B6 and UDP-Glucuronosyltransferase
            Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role
            of Hepatic and Extrahepatic Metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Ma,X., Zang,X., Yang,L., Zhou,W., Li,Y., Wei,J., Guo,J., Han,J.,
            Liang,J. and Jin,T.
  TITLE     Genetic polymorphisms in CYP2B6 may be associated with lung cancer
            risk in the Chinese Han population
  JOURNAL   Expert Rev Respir Med 17 (12), 1297-1305 (2023)
   PUBMED   38166557
  REMARK    GeneRIF: Genetic polymorphisms in CYP2B6 may be associated with
            lung cancer risk in the Chinese Han population.
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. et al.
  TITLE     A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles
  JOURNAL   Am J Hum Genet 57 (3), 651-660 (1995)
   PUBMED   7668294
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Miles,J.S., McLaren,A.W., Gonzalez,F.J. and Wolf,C.R.
  TITLE     Alternative splicing in the human cytochrome P450IIB6 gene: use of
            a cryptic exon within intron 3 and splice acceptor site within exon
            4
  JOURNAL   Nucleic Acids Res 18 (1), 189 (1990)
   PUBMED   2308828
REFERENCE   8  (bases 1 to 3071)
  AUTHORS   Miles,J.S., McLaren,A.W. and Wolf,C.R.
  TITLE     Alternative splicing in the human cytochrome P450IIB6 gene
            generates a high level of aberrant messages
  JOURNAL   Nucleic Acids Res 17 (20), 8241-8255 (1989)
   PUBMED   2813061
REFERENCE   9  (bases 1 to 3071)
  AUTHORS   Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
            Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
  TITLE     cDNA cloning and sequence and cDNA-directed expression of human
            P450 IIB1: identification of a normal and two variant cDNAs derived
            from the CYP2B locus on chromosome 19 and differential expression
            of the IIB mRNAs in human liver
  JOURNAL   Biochemistry 28 (18), 7340-7348 (1989)
   PUBMED   2573390
REFERENCE   10 (bases 1 to 3071)
  AUTHORS   Miles,J.S., Spurr,N.K., Gough,A.C., Jowett,T., McLaren,A.W.,
            Brook,J.D. and Wolf,C.R.
  TITLE     A novel human cytochrome P450 gene (P450IIB): chromosomal
            localization and evidence for alternative splicing
  JOURNAL   Nucleic Acids Res 16 (13), 5783-5795 (1988)
   PUBMED   2899870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011541.7, BC067431.1 and
            AC023172.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 1, 2018 this sequence version replaced NM_000767.4.
            
            Summary: This gene, CYP2B6, encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and its
            expression is induced by phenobarbital. The enzyme is known to
            metabolize some xenobiotics, such as the anti-cancer drugs
            cyclophosphamide and ifosphamide. Transcript variants for this gene
            have been described; however, it has not been resolved whether
            these transcripts are in fact produced by this gene or by a closely
            related pseudogene, CYP2B7. Both the gene and the pseudogene are
            located in the middle of a CYP2A pseudogene found in a large
            cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F
            subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29874.1, BC067431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324071.10/ ENSP00000324648.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC011541.7         37656-37672
            18-697              BC067431.1         1-680
            698-698             AC023172.1         22057-22057
            699-843             BC067431.1         682-826
            844-844             AC023172.1         22203-22203
            845-1538            BC067431.1         828-1521
            1539-3071           AC023172.1         29676-31208
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3071
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /note="cytochrome P450 family 2 subfamily B member 6"
                     /db_xref="GeneID:1555"
                     /db_xref="HGNC:HGNC:2615"
                     /db_xref="MIM:123930"
     exon            1..195
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1500
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IIB
                     (phenobarbital-inducible), polypeptide 6; cytochrome P450
                     IIB1; 1,4-cineole 2-exo-monooxygenase; cytochrome P450,
                     family 2, subfamily B, polypeptide 6"
                     /codon_start=1
                     /product="cytochrome P450 2B6"
                     /protein_id="NP_000758.1"
                     /db_xref="CCDS:CCDS12570.1"
                     /db_xref="GeneID:1555"
                     /db_xref="HGNC:HGNC:2615"
                     /db_xref="MIM:123930"
                     /translation="MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLL
                     QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA
                     MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS
                     KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE
                     LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEK
                     SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP
                     HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL
                     STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF
                     TTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR"
     exon            196..358
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            359..508
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            509..669
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            670..846
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            847..988
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1176
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1318
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..3071
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /note="hexamer: AATAAA"
     polyA_site      3065
                     /gene="CYP2B6"
                     /gene_synonym="CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6;
                     EFVM; IIB1; P450"
                     /note="major polyA site"
ORIGIN      
        1 gtgcagggca gtcagaccag gaccatggaa ctcagcgtcc tcctcttcct tgcactcctc
       61 acaggactct tgctactcct ggttcagcgc caccctaaca cccatgaccg cctcccacca
      121 gggccccgcc ctctgcccct tttgggaaac cttctgcaga tggatagaag aggcctactc
      181 aaatcctttc tgaggttccg agagaaatat ggggacgtct tcacggtaca cctgggaccg
      241 aggcccgtgg tcatgctgtg tggagtagag gccatacggg aggcccttgt ggacaaggct
      301 gaggccttct ctggccgggg aaaaatcgcc atggtcgacc cattcttccg gggatatggt
      361 gtgatctttg ccaatggaaa ccgctggaag gtgcttcggc gattctctgt gaccactatg
      421 agggacttcg ggatgggaaa gcggagtgtg gaggagcgga ttcaggagga ggctcagtgt
      481 ctgatagagg agcttcggaa atccaagggg gccctcatgg accccacctt cctcttccag
      541 tccattaccg ccaacatcat ctgctccatc gtctttggaa aacgattcca ctaccaagat
      601 caagagttcc tgaagatgct gaacttgttc taccagactt tttcactcat cagctctgta
      661 ttcggccagc tgtttgagct cttctctggc ttcttgaaat actttcctgg ggcacacagg
      721 caagtttaca aaaacctgca ggaaatcaat gcttacattg gccacagtgt ggagaagcac
      781 cgtgaaaccc tggaccccag cgcccccaag gacctcatcg acacctacct gctccacatg
      841 gaaaaagaga aatccaacgc acacagtgaa ttcagccacc agaacctcaa cctcaacacg
      901 ctctcgctct tctttgctgg cactgagacc accagcacca ctctccgcta cggcttcctg
      961 ctcatgctca aataccctca tgttgcagag agagtctaca gggagattga acaggtgatt
     1021 ggcccacatc gccctccaga gcttcatgac cgagccaaaa tgccatacac agaggcagtc
     1081 atctatgaga ttcagagatt ttccgacctt ctccccatgg gtgtgcccca cattgtcacc
     1141 caacacacca gcttccgagg gtacatcatc cccaaggaca cagaagtatt tctcatcctg
     1201 agcactgctc tccatgaccc acactacttt gaaaaaccag acgccttcaa tcctgaccac
     1261 tttctggatg ccaatggggc actgaaaaag actgaagctt ttatcccctt ctccttaggg
     1321 aagcggattt gtcttggtga aggcatcgcc cgtgcggaat tgttcctctt cttcaccacc
     1381 atcctccaga acttctccat ggccagcccc gtggccccag aagacatcga tctgacaccc
     1441 caggagtgtg gtgtgggcaa aataccccca acataccaga tccgcttcct gccccgctga
     1501 aggggctgag ggaagggggt caaaggattc cagggtcatt cagtgtcccc gcctctgtag
     1561 acaatggctc tgactccccg caacttcctg cctctgagag acctgctaca agccagcttc
     1621 cttcccctcc atggcaccag ttgtctgagg tcacattgca agtgagtgca ggagtgagat
     1681 tatcgaaaat tataatatac aaaatcatat atatatatat gttcttgttt tttgagacag
     1741 agtctcacac tgttgcccag gctggagtgc agtggcgtga tctcggctca ctgcaacctc
     1801 cacccccggg gatcaagcaa ctctcctgcc tcagcctccc tagtagctgg gattacaggc
     1861 atgcactacc acgcttggct aatttttgta tttttagtag agatggggtt tcactgtgta
     1921 ggccaggctg gtctcgaact cctgaactca agtgattcac ccaccttagc ctcccaaagt
     1981 gctgggatta caggcgtgag tcaccgtgcc cagccatgta tatatataat tttaaaaatt
     2041 aagctgaaat tcacataaca taaaattagc tgttttaaag tgtaaaattt agtggcgtgt
     2101 ggttcattca caaagctgta caaccaccac catctagttc caaacatttt ctttttttct
     2161 gagatggagt ctcactctgt cacccaggtt cgagttcagt ggtgccatct ctgtccactg
     2221 caacctccac atcctgggtt caagtgattc tcctgcctca gcctctggag gagctggtat
     2281 cacaggcgtc ccccaccacg cctggctaaa ttttgtattt ttaggtggtc ttgaactcct
     2341 gatgtcaggt gattctccta gctccaaatg ttttcattat ctctccccca acaaaaccca
     2401 tacctatcaa gctgtcactc cccatacccc attctctttt tcatctcggc ccctgtcaat
     2461 ctggtttttg tcactatgga cttaccaatt ctgaatattt cccataaaca gaatcataca
     2521 atatttgatt tttttttttt ttttgaaact aagccttgct ctgtctccca ggctggagtg
     2581 ctatggtgca atttttgttc actgcaacct ctgccttcca agatcaagag attctccagt
     2641 ctcagctccc aagtagctgg gattacaggc atgtactacc atgcctggct aattttcttg
     2701 tagttttagt agggacatgt tggccaggct ggtggtgagc tcctggcctc aggtgatcca
     2761 cccacctcag tgttccaaag tgctgatatt acaggcataa tatgtgatct tttgtgtctg
     2821 gttgctttca tgttgaatgc tatttttgag gttcatgcct gttgtagacc acagtcacac
     2881 actgctgtag tcttccccag tcctcattcc cagctgcctc ttcctactgc ttccgtctat
     2941 caaaaagccc ccttggccca ggttccctga gctgtgggat tctgcactgg tgctttggat
     3001 tccctgatat gttccttcaa atctgctgag aattaaataa acatctctaa agcctgacct
     3061 ccccacgtca a
//
