LOCUS       NM_000766               1760 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 2 subfamily A member 13
            (CYP2A13), mRNA.
ACCESSION   NM_000766
VERSION     NM_000766.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Vrzal,R.
  TITLE     Genetic and Enzymatic Characteristics of CYP2A13 in Relation to
            Lung Damage
  JOURNAL   Int J Mol Sci 22 (22), 12306 (2021)
   PUBMED   34830188
  REMARK    GeneRIF: Genetic and Enzymatic Characteristics of CYP2A13 in
            Relation to Lung Damage.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Juvonen,R.O., Jokinen,E.M., Huuskonen,J., Karkkainen,O., Raunio,H.
            and Pentikainen,O.T.
  TITLE     Molecular docking and oxidation kinetics of 3-phenyl coumarin
            derivatives by human CYP2A13
  JOURNAL   Xenobiotica 51 (11), 1207-1216 (2021)
   PUBMED   33703988
  REMARK    GeneRIF: Molecular docking and oxidation kinetics of 3-phenyl
            coumarin derivatives by human CYP2A13.
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Ma,L., Jin,G., Yang,Y., Pang,Y., Wang,W., Zhang,H., Liu,J., Wu,P.,
            Wang,Z., Wang,K., Chang,R., Li,J. and Zhu,Z.
  TITLE     Association between CYP2A13 polymorphisms and lung cancer: A
            protocol for systematic review and meta-analysis
  JOURNAL   Medicine (Baltimore) 99 (50), e23289 (2020)
   PUBMED   33327254
  REMARK    GeneRIF: Association between CYP2A13 polymorphisms and lung cancer:
            A protocol for systematic review and meta-analysis.
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Hua,F., Guo,Y., Sun,Q., Yang,L. and Gao,F.
  TITLE     HapMap-based study: CYP2A13 may be a potential key metabolic enzyme
            gene in the carcinogenesis of lung cancer in non-smokers
  JOURNAL   Thorac Cancer 10 (4), 601-606 (2019)
   PUBMED   30807688
  REMARK    GeneRIF: Study provides evidence that CYP2A13 gene polymorphisms
            may be candidate biomarkers of lung cancer susceptibility in
            Chinese.
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Kim,V., Yeom,S., Lee,Y., Park,H.G., Cho,M.A., Kim,H. and Kim,D.
  TITLE     In vitro functional analysis of human cytochrome P450 2A13 genetic
            variants: P450 2A13*2, *3, *4, and *10
  JOURNAL   J Toxicol Environ Health A 81 (12), 493-501 (2018)
   PUBMED   29652224
  REMARK    GeneRIF: Functional analysis of variations in P450 2A13 allelic
            variants may help to understand the consequences of P450 2A13
            polymorphism in bioactivation of many tobacco-derived carcinogens.
REFERENCE   6  (bases 1 to 1760)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 1760)
  AUTHORS   Smith,G., Stubbins,M.J., Harries,L.W. and Wolf,C.R.
  TITLE     Molecular genetics of the human cytochrome P450 monooxygenase
            superfamily
  JOURNAL   Xenobiotica 28 (12), 1129-1165 (1998)
   PUBMED   9890157
  REMARK    Review article
REFERENCE   8  (bases 1 to 1760)
  AUTHORS   Hoffman,S.M., Fernandez-Salguero,P., Gonzalez,F.J. and
            Mohrenweiser,H.W.
  TITLE     Organization and evolution of the cytochrome P450 CYP2A-2B-2F
            subfamily gene cluster on human chromosome 19
  JOURNAL   J Mol Evol 41 (6), 894-900 (1995)
   PUBMED   8587134
REFERENCE   9  (bases 1 to 1760)
  AUTHORS   Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
            Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
            Idle,J.R. et al.
  TITLE     A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
            human CYP2A genes and identification of variant CYP2A6 alleles
  JOURNAL   Am J Hum Genet 57 (3), 651-660 (1995)
   PUBMED   7668294
REFERENCE   10 (bases 1 to 1760)
  AUTHORS   Fernandez-Salguero,P. and Gonzalez,F.J.
  TITLE     The CYP2A gene subfamily: species differences, regulation,
            catalytic activities and role in chemical carcinogenesis
  JOURNAL   Pharmacogenetics 5 Spec No, S123-S128 (1995)
   PUBMED   7581481
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008962.9, AF209774.1 and
            BM975825.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000766.4.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum. Although its
            endogenous substrate has not been determined, it is known to
            metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major
            nitrosamine specific to tobacco. This gene is part of a large
            cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F
            subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF209774.1, AY513609.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330436.4/ ENSP00000332679.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC008962.9         66786-66806
            22-1506             AF209774.1         1-1485
            1507-1760           BM975825.1         17-270              c
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1760
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /note="cytochrome P450 family 2 subfamily A member 13"
                     /db_xref="GeneID:1553"
                     /db_xref="HGNC:HGNC:2608"
                     /db_xref="MIM:608055"
     exon            1..201
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1506
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IIA
                     (phenobarbital-inducible), polypeptide 13; cytochrome
                     P450, family 2, subfamily A, polypeptide 13"
                     /codon_start=1
                     /product="cytochrome P450 2A13"
                     /protein_id="NP_000757.2"
                     /db_xref="CCDS:CCDS12571.1"
                     /db_xref="GeneID:1553"
                     /db_xref="HGNC:HGNC:2608"
                     /db_xref="MIM:608055"
                     /translation="MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIG
                     NYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRG
                     EQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDAL
                     RGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQ
                     LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQ
                     EEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
                     IGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVF
                     PMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
                     LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR"
     exon            202..364
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            365..514
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            515..675
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            676..852
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            853..994
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1182
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1324
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1760
                     /gene="CYP2A13"
                     /gene_synonym="CPAD; CYP2A; CYPIIA13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctatcatc ccactgccac catgctggcc tcagggctgc ttctggtgac cttgctggcc
       61 tgcctgactg tgatggtctt gatgtcagtc tggcggcaga ggaagagcag ggggaagctg
      121 cctccgggac ccaccccatt gcccttcatt ggaaactacc tgcagctgaa cacagagcag
      181 atgtacaact ccctcatgaa gatcagtgag cgctatggcc ctgtgttcac cattcacttg
      241 gggccccggc gggtcgtggt gctgtgcgga catgatgccg tcaaggaggc tctggtggac
      301 caggctgagg agttcagcgg gcgaggcgag caggccacct tcgactggct cttcaaaggc
      361 tatggcgtgg cgttcagcaa cggggagcgc gccaagcagc tccggcgctt ctccatcgcc
      421 accctaaggg gttttggcgt gggcaagcgc ggcatcgagg aacgcatcca ggaggaggcg
      481 ggcttcctca tcgacgccct ccggggcacg cacggcgcca atatcgatcc caccttcttc
      541 ctgagccgca cagtctccaa tgtcatcagc tccattgtct ttggggaccg ctttgactat
      601 gaggacaaag agttcctgtc actgttgcgc atgatgctgg gaagcttcca gttcacggca
      661 acctccacgg ggcagctcta tgagatgttc tcttcggtga tgaaacacct gccaggacca
      721 cagcaacagg cctttaagga gctgcaaggg ctggaggact tcatcgccaa gaaggtggag
      781 cacaaccagc gcacgctgga tcccaattcc ccacgggact tcatcgactc ctttctcatc
      841 cgcatgcagg aggaggagaa gaaccccaac acagagttct acttgaagaa cctggtgatg
      901 accaccctga acctcttctt tgcgggcact gagaccgtga gcaccaccct gcgctacggt
      961 ttcctgctgc tcatgaagca cccagaggtg gaggccaagg tccatgagga gattgacaga
     1021 gtgatcggca agaaccggca gcccaagttt gaggaccggg ccaagatgcc ctacacagag
     1081 gcagtgatcc acgagatcca aagatttgga gacatgctcc ccatgggttt ggcccacagg
     1141 gtcaacaagg acaccaagtt tcgggatttc ttcctcccta agggcactga agtgttccct
     1201 atgctgggct ccgtgctgag agaccccagg ttcttctcca acccccggga cttcaatccc
     1261 cagcacttcc tggataagaa ggggcagttt aagaagagtg atgcttttgt gcccttttcc
     1321 atcggaaagc ggtactgttt tggagaaggc ctggccagaa tggagctctt tctcttcttc
     1381 accaccatca tgcagaactt tcgcttcaag tcccctcagt cgcctaagga tatcgacgtg
     1441 tcccccaaac acgtgggctt tgccacgatc ccacgaaact acaccatgag cttcctgccc
     1501 cgctgagcga gggctgtgct ggtgcagggc tggtgggcgg ggccagggaa acggccgggg
     1561 caggggcggg gcttgtggga ggggcggggc taagaatggg ggcagtgggg gaaggaaggg
     1621 gagaggtggt tagagggaac agaagaaaca gaaggggctc agttcacctt gatgatgtcc
     1681 ttcagagctg tgatgagagg aagggaaacc ttacagtatg ctacaaagag tagtaataat
     1741 agcagctctt atttcctgaa
//
