LOCUS       NM_183374               2878 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cytochrome P450 family 26 subfamily C member 1
            (CYP26C1), mRNA.
ACCESSION   NM_183374
VERSION     NM_183374.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Lee,E.J., Kim,M.S., Yim,N.H. and Cha,M.H.
  TITLE     Association of CYP26C1 Promoter Hypomethylation with Small Vessel
            Occlusion in Korean Subjects
  JOURNAL   Genes (Basel) 12 (10), 1622 (2021)
   PUBMED   34681016
  REMARK    GeneRIF: Association of CYP26C1 Promoter Hypomethylation with Small
            Vessel Occlusion in Korean Subjects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2878)
  AUTHORS   Isoherranen,N. and Zhong,G.
  TITLE     Biochemical and physiological importance of the CYP26 retinoic acid
            hydroxylases
  JOURNAL   Pharmacol Ther 204, 107400 (2019)
   PUBMED   31419517
  REMARK    GeneRIF: This review highlights the current knowledge of
            structure-function of CYP26 enzymes and focuses on their role in
            human retinoid metabolism in different tissues.
            Review article
REFERENCE   4  (bases 1 to 2878)
  AUTHORS   Montalbano,A., Juergensen,L., Fukami,M., Thiel,C.T., Hauer,N.H.,
            Roeth,R., Weiss,B., Naiki,Y., Ogata,T., Hassel,D. and Rappold,G.A.
  TITLE     Functional missense and splicing variants in the retinoic acid
            catabolizing enzyme CYP26C1 in idiopathic short stature
  JOURNAL   Eur J Hum Genet 26 (8), 1113-1120 (2018)
   PUBMED   29706635
  REMARK    GeneRIF: CYP26C1 missense variants and one splicing variant were
            identified in six independent individuals with idiopathic short
            stature.
REFERENCE   5  (bases 1 to 2878)
  AUTHORS   Zhong,G., Ortiz,D., Zelter,A., Nath,A. and Isoherranen,N.
  TITLE     CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts
            with Cellular Retinoic Acid Binding Proteins
  JOURNAL   Mol Pharmacol 93 (5), 489-503 (2018)
   PUBMED   29476041
  REMARK    GeneRIF: findings suggest that CYP26C1 is a 4-oxo-atRA hydroxylase
            and may be important in regulating the concentrations of this
            active retinoid in human tissues
REFERENCE   6  (bases 1 to 2878)
  AUTHORS   Rat,E., Billaut-Laden,I., Allorge,D., Lo-Guidice,J.M., Tellier,M.,
            Cauffiez,C., Jonckheere,N., van Seuningen,I., Lhermitte,M.,
            Romano,A., Gueant,J.L. and Broly,F.
  TITLE     Evidence for a functional genetic polymorphism of the human
            retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be
            involved in spina bifida
  JOURNAL   Birth Defects Res A Clin Mol Teratol 76 (6), 491-498 (2006)
   PUBMED   16933217
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2878)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2878)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 2878)
  AUTHORS   Taimi,M., Helvig,C., Wisniewski,J., Ramshaw,H., White,J., Amad,M.,
            Korczak,B. and Petkovich,M.
  TITLE     A novel human cytochrome P450, CYP26C1, involved in metabolism of
            9-cis and all-trans isomers of retinoic acid
  JOURNAL   J Biol Chem 279 (1), 77-85 (2004)
   PUBMED   14532297
  REMARK    GeneRIF: may play a specific role in catabolizing both all-trans
            and 9-cis isomers of retinoic acid.
REFERENCE   10 (bases 1 to 2878)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358613.16 and AY356349.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 5, 2018 this sequence version replaced NM_183374.2.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This enzyme is involved in the catabolism of all-trans- and
            9-cis-retinoic acid, and thus contributes to the regulation of
            retinoic acid levels in cells and tissues. This gene is adjacent to
            a related gene on chromosome 10q23.33. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY356349.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651965.1/ ENSP00000498424.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL358613.16        10430-10895
            467-896             AY356349.1         1-430
            897-900             AL358613.16        12353-12356
            901-1803            AY356349.1         435-1337
            1804-1809           AL358613.16        18098-18103
            1810-2035           AY356349.1         1344-1569
            2036-2878           AL358613.16        18330-19172
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..2878
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /note="cytochrome P450 family 26 subfamily C member 1"
                     /db_xref="GeneID:340665"
                     /db_xref="HGNC:HGNC:20577"
                     /db_xref="MIM:608428"
     exon            1..670
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..2035
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, family 26, subfamily C,
                     polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 26C1"
                     /protein_id="NP_899230.2"
                     /db_xref="CCDS:CCDS7425.1"
                     /db_xref="GeneID:340665"
                     /db_xref="HGNC:HGNC:20577"
                     /db_xref="MIM:608428"
                     /translation="MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRA
                     STLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENV
                     RTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPR
                     LQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLV
                     ENLFSLPLDVPFSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARE
                     LGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRA
                     CGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALR
                     TFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYI
                     PFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFF
                     HPLTPSVAGNGLCL"
     exon            671..895
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1171
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1327
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1657
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2878
                     /gene="CYP26C1"
                     /gene_synonym="FFDD4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggttaaac gactggagga gggacaggtg gggcgggggt ctgcagacca ggttggcaac
       61 actggtgagt tgctcttctt tcgccctcct tcccttcttc tatccaaagg gtgctgagcc
      121 cgggaggagg tgggaggtgc cccgcggagc cgggagtgag cgttcccgag gcagcaggca
      181 ccttcgagag ggactggcat ttgggcccag gagccaggaa aaagtcctga gcgtgccggc
      241 ctcgaggaag gcacgttccc taagggcgca cggtcactgc agtctttcac cgtccgtctg
      301 tttttagaac agagttctgg cctgagctta taaatctcgg gctttgcccc caaaccccag
      361 gccttttgcg gacggaacag gtgagcactg cgcactgctc gcgccccggt tcttgcgtcc
      421 cctgctctcc ctgcgctctg agcggcctgg cccccgcggg ctcatcatgt tcccttgggg
      481 gctgagctgc ctgtcagtgc tgggggcggc gggcactgct ctcctgtgcg cgggcctgct
      541 gctcagcctg gcccagcacc tctggaccct ccgctggatg ctgagccggg accgggcctc
      601 caccctgcct ctgcccaagg gctccatggg gtggcccttc ttcggcgaaa cgctgcactg
      661 gttagttcag ggctcgcgct tccacagttc tcgccgagag cgctatggga cagtgttcaa
      721 gacgcacctg ctgggcaggc cagtgatccg cgtgagcggc gcggagaacg tgcgcaccat
      781 cctgctgggc gagcaccgcc tggtgcgcag ccagtggccg cagagtgcgc acatcctgct
      841 gggctcgcac acactgctag gtgcggtcgg cgagccgcac cggcggcggc gcaaggtcct
      901 ggcgcgcgtg ttcagccgcg ccgcgctgga gcgctacgtg ccgcgcctgc agggggcgct
      961 gcggcatgag gtgcgctcct ggtgcgcggc gggcgggccg gtctcagtct acgacgcctc
     1021 caaagcgctc accttccgca tggccgcgcg catcctgctg gggttgcggc tggacgaggc
     1081 gcagtgcgcc acgctggccc ggaccttcga gcagctcgtg gagaacctct tctcactgcc
     1141 tctggacgtt cccttcagtg gcctacgcaa gggcatccgg gcaagggacc agctgcatcg
     1201 gcacctggag ggggccattt ctgagaagct tcacgaggac aaggctgcag agccgggtga
     1261 tgccctcgac ctaatcattc acagtgcaag ggagctgggc catgagccct ccatgcagga
     1321 gctgaaggag tcggctgtgg agctcctctt cgccgccttc ttcaccacgg ccagtgccag
     1381 cacctcgctc gtcctgctgc tactgcagca tccggcggcc atcgccaaga ttcgggagga
     1441 gctggtggcg caggggctgg ggcgcgcgtg cggctgcgcg cccggggccg ctgggggcag
     1501 cgaggggccc ccgcccgact gcggctgcga gcccgacctc agcctcgcgg cgctgggccg
     1561 tctgcgctac gtcgactgcg tggtcaagga ggtgctgcgc ctcctgccgc cagtgtccgg
     1621 gggctaccgc accgccctgc gcaccttcga gctcgacggc taccagatcc ccaagggctg
     1681 gagcgtgatg tatagcatcc gggacacgca cgagacggct gcggtgtacc gcagccctcc
     1741 cgaaggcttc gatccagagc gcttcggcgc agcgcgcgaa gattcccggg gcgcctccag
     1801 ccgcttccat tacatcccgt tcggcggcgg tgcgcgcagc tgcctcggcc aggagctggc
     1861 gcaagccgtg ctccagctgc tagctgtgga gctagtgcgc accgcgcgct gggaactggc
     1921 cacacccgcc ttccccgcca tgcagacggt gcccatcgtg cacccagtgg acgggctgcg
     1981 gctctttttc caccccctca cgccttcggt tgcggggaat gggctatgcc tctgacatgc
     2041 ttgcgctcta ggacacggct tggccggtgg ctatggcgcg cacgcagcgc cacccatctg
     2101 ccgctcccca ttgtagcgtc gcgcgcccac tctttcactc gttcaacaat ctttcaacaa
     2161 atgttcgcca aacgcggatg tgtgccggac tcgaggaagg aggagggcga gccaccgctg
     2221 ccgcgccaga gaagcatcta agcccatggg aagatgcctt ctgcgctccg cgcccagagg
     2281 aaggaaaatg tcgtgggcca agcaggaatg gagggaatag atagatcccc acgaggtgct
     2341 gcttggcttc cccttcccga gccaatccag ggagggtgca tggatggggg aaggcgaggt
     2401 aggggtggca ggggagtggg aatattgcaa ctcggggaca ttgcagagac ccgacgcacg
     2461 cggtgggacc tgcaaccctt gtaaggaagc gggcacgccg tgggcgcaac cctggcctgg
     2521 ctttgggcca tagaaaaaac acgcagagga tgcctgacgg aaggccctct ggcagctggc
     2581 gtctggcttc gtgcgccttg gccactctgc cggtctcggc ggaaactagc aactgtgggc
     2641 acttccaggc tcgaaagggc tcaaggtcac cggattctgc tggccacttc ttaaaaggaa
     2701 aaattcctac cttaagaagg catttactct tgtcatgtat acagaggaga ataggcacac
     2761 caacacgtct ccaacgctgg attattttca tgggaggttg agacataatt agagaggttt
     2821 gagatatttg taccaaaaat aggaaggcca agaaataaag tgtcttggga gcggttga
//
