LOCUS       NM_000783               2117 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytochrome P450 family 26 subfamily A member 1
            (CYP26A1), transcript variant 1, mRNA.
ACCESSION   NM_000783
VERSION     NM_000783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Yu,Y., Wang,Y., Zou,Y. and Yu,Y.
  TITLE     CYP26A1 Is a Novel Cancer Biomarker of Pancreatic Carcinoma:
            Evidence from Integration Analysis and In Vitro Experiments
  JOURNAL   Dis Markers 2022, 5286820 (2022)
   PUBMED   35707714
  REMARK    GeneRIF: CYP26A1 Is a Novel Cancer Biomarker of Pancreatic
            Carcinoma: Evidence from Integration Analysis and In Vitro
            Experiments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Wei,D.P., Li,D.D., Gu,A.Q., Ji,W.H., Yang,Y. and Peng,J.P.
  TITLE     A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse
            maternal-foetal interface
  JOURNAL   J Cell Mol Med 25 (3), 1771-1782 (2021)
   PUBMED   33438367
  REMARK    GeneRIF: A novel Cytochrome P450 26A1 expressing NK cell subset at
            the mouse maternal-foetal interface.
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Guo,P., Ji,Z., Jiang,H., Huang,X., Wang,C. and Pan,B.
  TITLE     Identification of a novel CYP26A1 mutation in a Chinese family with
            congenital microtia
  JOURNAL   Int J Pediatr Otorhinolaryngol 139, 110488 (2020)
   PUBMED   33197841
  REMARK    GeneRIF: Identification of a novel CYP26A1 mutation in a Chinese
            family with congenital microtia.
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Isoherranen,N. and Zhong,G.
  TITLE     Biochemical and physiological importance of the CYP26 retinoic acid
            hydroxylases
  JOURNAL   Pharmacol Ther 204, 107400 (2019)
   PUBMED   31419517
  REMARK    GeneRIF: This review highlights the current knowledge of
            structure-function of CYP26 enzymes and focuses on their role in
            human retinoid metabolism in different tissues.
            Review article
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Chen,P.H., Chuang,L.Y., Wu,K.C., Wang,Y.H., Shieh,T.Y., Sheu,J.J.,
            Chang,H.W. and Yang,C.H.
  TITLE     Application of simulation-based CYP26 SNP-environment barcodes for
            evaluating the occurrence of oral malignant disorders by odds
            ratio-based binary particle swarm optimization: A case-control
            study in the Taiwanese population
  JOURNAL   PLoS One 14 (8), e0220719 (2019)
   PUBMED   31465460
  REMARK    GeneRIF: The combined effects of the novel CYP26 single nucleotide
            polymorphisms -environment approach may predict the risk of
            occurrence of oral malignant disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2117)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   7  (bases 1 to 2117)
  AUTHORS   White,J.A., Beckett,B., Scherer,S.W., Herbrick,J.A. and
            Petkovich,M.
  TITLE     P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse
            chromosome 19C2-3
  JOURNAL   Genomics 48 (2), 270-272 (1998)
   PUBMED   9521883
REFERENCE   8  (bases 1 to 2117)
  AUTHORS   Ray,W.J., Bain,G., Yao,M. and Gottlieb,D.I.
  TITLE     CYP26, a novel mammalian cytochrome P450, is induced by retinoic
            acid and defines a new family
  JOURNAL   J Biol Chem 272 (30), 18702-18708 (1997)
   PUBMED   9228041
REFERENCE   9  (bases 1 to 2117)
  AUTHORS   White,J.A., Beckett-Jones,B., Guo,Y.D., Dilworth,F.J., Bonasoro,J.,
            Jones,G. and Petkovich,M.
  TITLE     cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI)
            identifies a novel family of cytochromes P450
  JOURNAL   J Biol Chem 272 (30), 18538-18541 (1997)
   PUBMED   9228017
REFERENCE   10 (bases 1 to 2117)
  AUTHORS   Duell,E.A., Kang,S. and Voorhees,J.J.
  TITLE     Retinoic acid isomers applied to human skin in vivo each induce a
            4-hydroxylase that inactivates only trans retinoic acid
  JOURNAL   J Invest Dermatol 106 (2), 316-320 (1996)
   PUBMED   8601734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358613.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000783.3.
            
            Summary: This gene encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This endoplasmic reticulum protein acts on retinoids, including
            all-trans-retinoic acid (RA), with both 4-hydroxylation and
            18-hydroxylation activities. This enzyme regulates the cellular
            level of retinoic acid which is involved in regulation of gene
            expression in both embryonic and adult tissues. Two alternatively
            spliced transcript variants of this gene, which encode the distinct
            isoforms, have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.42524.1, AK075374.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000224356.5/ ENSP00000224356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AL358613.16        23525-23755
            232-456             AL358613.16        23940-24164
            457-747             AL358613.16        24411-24701
            748-906             AL358613.16        24781-24939
            907-1041            AL358613.16        25458-25592
            1042-1194           AL358613.16        26176-26328
            1195-2116           AL358613.16        26595-27516
            2117-2117           AL358613.16        27517-27517
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..2117
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /note="cytochrome P450 family 26 subfamily A member 1"
                     /db_xref="GeneID:1592"
                     /db_xref="HGNC:HGNC:2603"
                     /db_xref="MIM:602239"
     exon            1..231
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1536
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /EC_number="1.14.-.-"
                     /note="isoform 1 is encoded by transcript variant 1; P450,
                     retinoic acid-inactivating, 1; retinoic acid-metabolizing
                     cytochrome; retinoic acid 4-hydroxylase; cytochrome P450,
                     subfamily XXVIA, polypeptide 1; cytochrome P450 26A1;
                     hP450RAI; cytochrome P450RAI; cytochrome P450 retinoic
                     acid-inactivating 1; cytochrome P450, family 26, subfamily
                     A, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 26A1 isoform 1"
                     /protein_id="NP_000774.2"
                     /db_xref="CCDS:CCDS7426.1"
                     /db_xref="GeneID:1592"
                     /db_xref="HGNC:HGNC:2603"
                     /db_xref="MIM:602239"
                     /translation="MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPL
                     PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
                     GEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEV
                     GSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT
                     RNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIE
                     HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKG
                     LLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
                     NVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI
                     LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI"
     exon            232..456
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..747
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..906
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1041
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1194
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..2117
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /note="hexamer: AATAAA"
     polyA_site      1728
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /note="major polyA site"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /note="hexamer: AATAAA"
     polyA_site      2117
                     /gene="CYP26A1"
                     /gene_synonym="CP26; CYP26; P450RAI; P450RAI1"
                     /note="major polyA site"
ORIGIN      
        1 gctggcggcg gcggcaggtg gcgcgggagg tcgcggcgcg ccatggggct cccggcgctg
       61 ctggccagtg cgctctgcac cttcgtgctg ccgctgctgc tcttcctggc tgcgatcaag
      121 ctctgggacc tgtactgcgt gagcggccgc gaccgcagtt gtgccctccc attgcccccc
      181 gggactatgg gcttcccctt ctttggggaa accttgcaga tggtactgca gcggaggaag
      241 ttcctgcaga tgaagcgcag gaaatacggc ttcatctaca agacgcatct gttcgggcgg
      301 cccaccgtac gggtgatggg cgcggacaat gtgcggcgca tcttgctcgg agagcaccgg
      361 ctggtgtcgg tccactggcc agcgtcggtg cgcaccattc tgggatctgg ctgcctctct
      421 aacctgcacg actcctcgca caagcagcgc aagaaggtga ttatgcgggc cttcagccgc
      481 gaggcactcg aatgctacgt gccggtgatc accgaggaag tgggcagcag cctggagcag
      541 tggctgagct gcggcgagcg cggcctcctg gtctaccccg aggtgaagcg cctcatgttc
      601 cgaatcgcca tgcgcatcct actgggctgc gaaccccaac tggcgggcga cggggactcc
      661 gagcagcagc ttgtggaggc cttcgaggaa atgacccgca atctcttctc gctgcccatc
      721 gacgtgccct tcagcgggct gtaccggggc atgaaggcgc ggaacctcat tcacgcgcgc
      781 atcgagcaga acattcgcgc caagatctgc gggctgcggg catccgaggc gggccagggc
      841 tgcaaagacg cgctgcagct gttgatcgag cactcgtggg agaggggaga gcggctggac
      901 atgcaggcac taaagcaatc ttcaaccgaa ctcctctttg gaggacacga aaccacggcc
      961 agtgcagcca catctctgat cacttacctg gggctctacc cacatgttct ccagaaagtg
     1021 cgagaagagc tgaagagtaa gggtttactt tgcaagagca atcaagacaa caagttggac
     1081 atggaaattt tggaacaact taaatacatc gggtgtgtta ttaaggagac ccttcgactg
     1141 aatcccccag ttccaggagg gtttcgggtt gctctgaaga cttttgaatt aaatggatac
     1201 cagattccca agggctggaa tgttatctac agtatctgtg atactcatga tgtggcagag
     1261 atcttcacca acaaggaaga atttaatcct gaccgattca tgctgcctca cccagaggat
     1321 gcatccaggt tcagcttcat tccatttgga ggaggcctta ggagctgtgt aggcaaagaa
     1381 tttgcaaaaa ttcttctcaa aatatttaca gtggagctgg ccaggcattg tgactggcag
     1441 cttctaaatg gacctcctac aatgaaaacc agtcccaccg tgtatcctgt ggacaatctc
     1501 cctgcaagat tcacccattt ccatggggaa atctgatgag cttgaatgtt caaacctgag
     1561 acttattgga agtgtacata tgagttttta aggagtgttg tgttgacttt atatttaatt
     1621 tctaaatgta tattataata tttatgtgtt ttgactatac taccacaatc tttaaatatt
     1681 aaaataatga atttgtatca tttccaaata aagtaaaatt tgaaggtact tttctggtat
     1741 tttaagattc ctgttgggta aaactcacca gtttagtatt ttcttagtgt atttaaccag
     1801 attttacaat gcctacctgg acttatttgt catctttgca tctgttttct gtgagaagaa
     1861 atcttagctg ttttttatgt taacagttat tagaaaatat atgtctgtgt gtgttattcc
     1921 agacgtatct ctgtaaattc ttctacagtc acttagattc cctatttgga aaattgatcc
     1981 aagttaattt aatttttttt tggtttgctg tactttaggg aaagatgaac ctgaaaaggt
     2041 aacactgaga actgtcactc taacctctcc agcttatcta acatgtcata aacataataa
     2101 atctgtgttg tccaata
//
