LOCUS       NM_001319217            2603 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens cytochrome P450 family 1 subfamily A member 1
            (CYP1A1), transcript variant 3, mRNA.
ACCESSION   NM_001319217 XM_005254185
VERSION     NM_001319217.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Guo,L., Zhang,X., Li,X., Wang,K., Wang,Y., Abulikemu,A., Su,X.,
            Shu,M., Li,H., Cui,S., Xu,Z., Tian,H., Niu,Y., Yuan,H., He,Z.,
            Sun,X. and Duan,H.
  TITLE     Polycyclic aromatic hydrocarbon and its adducts in peripheral
            blood: Gene and environment interaction among Chinese population
  JOURNAL   Environ Int 190, 108922 (2024)
   PUBMED   39128373
  REMARK    GeneRIF: Polycyclic aromatic hydrocarbon and its adducts in
            peripheral blood: Gene and environment interaction among Chinese
            population.
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Xu,J. and Tan,C.
  TITLE     Interaction between CYP1A1 gene polymorphism and environment
            factors on risk of endometrial cancer
  JOURNAL   Environ Health Prev Med 29, 54 (2024)
   PUBMED   39384367
  REMARK    GeneRIF: Interaction between CYP1A1 gene polymorphism and
            environment factors on risk of endometrial cancer.
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Datkhile,K.D., Patil,S.R., Patil,M.N., Durgawale,P.P.,
            Jagdale,N.J., Deshmukh,V.N., More,A.L., Gudur,R.A. and Gudur,A.K.
  TITLE     Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical
            cancer among rural population of Maharashtra: Findings from a
            hospital-based case-control study
  JOURNAL   J Cancer Res Ther 19 (7), 1925-1930 (2023)
   PUBMED   38376298
  REMARK    GeneRIF: Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of
            cervical cancer among rural population of Maharashtra: Findings
            from a hospital-based case-control study.
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   Dutkiewicz,Z. and Mikstacka,R.
  TITLE     Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2,
            and CYP1B1 Active Sites by Molecular Dynamics Simulations
  JOURNAL   Int J Mol Sci 24 (14), 11481 (2023)
   PUBMED   37511239
  REMARK    GeneRIF: Hydration and Structural Adaptations of the Human CYP1A1,
            CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Jiang,Z., Dragin,N., Jorge-Nebert,L.F., Martin,M.V.,
            Guengerich,F.P., Aklillu,E., Ingelman-Sundberg,M., Hammons,G.J.,
            Lyn-Cook,B.D., Kadlubar,F.F., Saldana,S.N., Sorter,M., Vinks,A.A.,
            Nassr,N., von Richter,O., Jin,L. and Nebert,D.W.
  TITLE     Search for an association between the human CYP1A2 genotype and
            CYP1A2 metabolic phenotype
  JOURNAL   Pharmacogenet Genomics 16 (5), 359-367 (2006)
   PUBMED   16609368
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Jiang,Z., Dalton,T.P., Jin,L., Wang,B., Tsuneoka,Y., Shertzer,H.G.,
            Deka,R. and Nebert,D.W.
  TITLE     Toward the evaluation of function in genetic variability:
            characterizing human SNP frequencies and establishing
            BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus
  JOURNAL   Hum Mutat 25 (2), 196-206 (2005)
   PUBMED   15643613
  REMARK    GeneRIF: Determination of SNP frequencies in the CYP1A1_CYP1A2
            locus.
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
            Nebert,D.W.
  TITLE     Comparison of cytochrome P450 (CYP) genes from the mouse and human
            genomes, including nomenclature recommendations for genes,
            pseudogenes and alternative-splice variants
  JOURNAL   Pharmacogenetics 14 (1), 1-18 (2004)
   PUBMED   15128046
  REMARK    Review article
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   Hayashi,S., Watanabe,J., Nakachi,K. and Kawajiri,K.
  TITLE     Genetic linkage of lung cancer-associated MspI polymorphisms with
            amino acid replacement in the heme binding region of the human
            cytochrome P450IA1 gene
  JOURNAL   J Biochem 110 (3), 407-411 (1991)
   PUBMED   1722803
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
            Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
  TITLE     Xenobiotic responsive element in the 5'-upstream region of the
            human P-450c gene
  JOURNAL   J Biochem 110 (2), 232-236 (1991)
   PUBMED   1761516
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   Kawajiri,K., Nakachi,K., Imai,K., Yoshii,A., Shinoda,N. and
            Watanabe,J.
  TITLE     Identification of genetically high risk individuals to lung cancer
            by DNA polymorphisms of the cytochrome P450IA1 gene
  JOURNAL   FEBS Lett 263 (1), 131-133 (1990)
   PUBMED   1691986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK223108.1 and BC023019.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 30, 2018 this sequence version replaced NM_001319217.1.
            
            Summary: This gene, CYP1A1, encodes a member of the cytochrome P450
            superfamily of enzymes. The cytochrome P450 proteins are
            monooxygenases which catalyze many reactions involved in drug
            metabolism and synthesis of cholesterol, steroids and other lipids.
            This protein localizes to the endoplasmic reticulum and its
            expression is induced by some polycyclic aromatic hydrocarbons
            (PAHs), some of which are found in cigarette smoke. The enzyme's
            endogenous substrate is unknown; however, it is able to metabolize
            some PAHs to carcinogenic intermediates. The gene has been
            associated with lung cancer risk. A related family member, CYP1A2,
            is located approximately 25 kb away from CYP1A1 on chromosome 15.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1, and encodes isoform 1. Variants 1 and 3
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1012871.1,
                                           SRR7346977.1041362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379727.8/ ENSP00000369050.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK223108.1         1-36
            37-2603             BC023019.1         1-2567
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2603
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /note="cytochrome P450 family 1 subfamily A member 1"
                     /db_xref="GeneID:1543"
                     /db_xref="HGNC:HGNC:2595"
                     /db_xref="MIM:108330"
     exon            1..88
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            89..942
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1656
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="isoform 1 is encoded by transcript variant 3;
                     flavoprotein-linked monooxygenase; cytochrome P1-450,
                     dioxin-inducible; xenobiotic monooxygenase; aryl
                     hydrocarbon hydroxylase; cytochrome P450, subfamily I
                     (aromatic compound-inducible), polypeptide 1; cytochrome
                     P450 1A1; cytochrome P450-C; cytochrome P450-P1;
                     cytochrome P450 form 6; cytochrome P450, family 1,
                     subfamily A, polypeptide 1; hydroperoxy icosatetraenoate
                     dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1A1 isoform 1"
                     /protein_id="NP_001306146.1"
                     /db_xref="CCDS:CCDS10268.1"
                     /db_xref="GeneID:1543"
                     /db_xref="HGNC:HGNC:2595"
                     /db_xref="MIM:108330"
                     /translation="MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPW
                     GWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDD
                     FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE
                     EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV
                     NLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKG
                     HIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV
                     MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR
                     DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF
                     GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM
                     QLRS"
     exon            943..1069
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1159
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1283
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1370
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2603
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /note="hexamer: AATAAA"
     polyA_site      2598
                     /gene="CYP1A1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; CYPIA1; P1-450;
                     P450-C; P450DX"
                     /note="major polyA site"
ORIGIN      
        1 gaaggtgaca gttccttgga accttccctg atccttgtga tcccaggctc caagagtcca
       61 cccttcccag ctcagctcag tacctcagca gccacctcca agatccctac actgatcatg
      121 cttttcccaa tctccatgtc ggccacggag tttcttctgg cctctgtcat cttctgtctg
      181 gtattctggg taatcagggc ctcaagacct caggtcccca aaggcctgaa gaatccacca
      241 gggccatggg gctggcctct gattgggcac atgctgaccc tgggaaagaa cccgcacctg
      301 gcactgtcaa ggatgagcca gcagtatggg gacgtgctgc agatccgaat tggctccaca
      361 cccgtggtgg tgctgagcgg cctggacacc atccggcagg ccctggtgcg gcagggcgat
      421 gatttcaagg gccggcccga cctctacacc ttcaccctca tcagtaatgg tcagagcatg
      481 tccttcagcc cagactctgg accagtgtgg gctgcccgcc ggcgcctggc ccagaatggc
      541 ctgaaaagtt tctccattgc ctctgaccca gcctcctcaa cctcctgcta cctggaagag
      601 catgtgagca aggaggctga ggtcctgata agcacgttgc aggagctgat ggcagggcct
      661 gggcacttta acccctacag gtatgtggtg gtatcagtga ccaatgtcat ctgtgccatt
      721 tgctttggcc ggcgctatga ccacaaccac caagaactgc ttagcctagt caacctgaat
      781 aataatttcg gggaggtggt tggctctgga aacccagctg acttcatccc tattcttcgc
      841 tacctaccca acccttccct gaatgccttc aaggacctga atgagaagtt ctacagcttc
      901 atgcagaaga tggtcaagga gcactacaaa acctttgaga agggccacat ccgggacatc
      961 acagacagcc tgattgagca ctgtcaggag aagcagctgg atgagaacgc caatgtccag
     1021 ctgtcagatg agaagatcat taacatcgtc ttggacctct ttggagctgg gtttgacaca
     1081 gtcacaactg ctatctcctg gagcctcatg tatttggtga tgaaccccag ggtacagaga
     1141 aagatccaag aggagctaga cacagtgatt ggcaggtcac ggcggccccg gctctctgac
     1201 agatcccatc tgccctatat ggaggccttc atcctggaga ccttccgaca ctcttccttc
     1261 gtccccttca ccatccccca cagcacaaca agagacacaa gtttgaaagg cttttacatc
     1321 cccaaggggc gttgtgtctt tgtaaaccag tggcagatca accatgacca gaagctatgg
     1381 gtcaacccat ctgagttcct acctgaacgg tttctcaccc ctgatggtgc tatcgacaag
     1441 gtgttaagtg agaaggtgat tatctttggc atgggcaagc ggaagtgtat cggtgagacc
     1501 attgcccgct gggaggtctt tctcttcctg gctatcctgc tgcaacgggt ggaattcagc
     1561 gtgccactgg gcgtgaaggt ggacatgacc cccatctatg ggctaaccat gaagcatgcc
     1621 tgctgtgagc acttccaaat gcagctgcgc tcttaggtgc ttgagagccc tgaggcctag
     1681 actctgtcta cctggtctgg ttgggcagcc agaccagcag gctggcctat gtggtctaag
     1741 gttcagcctg aaactcatag acactgatct ggctgcagtt ttgctatctg ggctgtgggc
     1801 aagcctaagg gatcctgcct gcccctaccc tggacttgcc tctgcacacc ctccagagac
     1861 aacaggtaaa acagggccac atagatgctg atggagcctt cccaagttgt gcttgagcca
     1921 ggaggcctgc tagggttagg aggtccttag gcctctgaga agctctgaag aactctctgg
     1981 aagcccctgg gcccagtacc tagctggctc tgtgagggtg ctgactggct tcagcaagtt
     2041 agaactagcc aaaccaggac cctgtccaat ctttgacaat tgggagctgc caagagtgaa
     2101 gggaagagac agcccaggat actggcacag aggtagtctc actgcttgaa ctaggctgag
     2161 caatctgacc ctatgggtct aggacacagt tcctgggaac atcacattcc tctgcccttc
     2221 ctgcaggcag gaacaaacag ggctgccttc tggccttgta agacccttat tgctgtcctg
     2281 gaggggctgg ggacttgtgt ctgcggggat cagagcgcac agggagtgca catatccagg
     2341 caccaggact agggctggag tgaggggggg gtatttcaat taccttctat tggtctccct
     2401 tctctacact cttgtaataa aatgtctatt tttaatgttt gtacacaaca atccttctat
     2461 tctagcctgc attgagcttg catgcttgca taagagctta agaaccattg atttaatgta
     2521 atagggaaaa ttctaaccca ggtatccaaa aatgtgtaag aacaactacc tgagctaaat
     2581 aaagatattg ttcagaaatc cta
//
