LOCUS       NM_001378743            8540 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens CYLD lysine 63 deubiquitinase (CYLD), transcript
            variant 4, mRNA.
ACCESSION   NM_001378743
VERSION     NM_001378743.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8540)
  AUTHORS   Tachizaki,M., Kobori,Y., Kawaguchi,S., Seya,K., Tanaka,H. and
            Imaizumi,T.
  TITLE     Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells
  JOURNAL   Mol Biol Rep 51 (1), 974 (2024)
   PUBMED   39259342
  REMARK    GeneRIF: Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8540)
  AUTHORS   Rinotas,V., Iliaki,K., Pavlidi,L., Meletakos,T., Mosialos,G. and
            Armaka,M.
  TITLE     Cyld restrains the hyperactivation of synovial fibroblasts in
            inflammatory arthritis by regulating the TAK1/IKK2 signaling axis
  JOURNAL   Cell Death Dis 15 (8), 584 (2024)
   PUBMED   39122678
  REMARK    GeneRIF: Cyld restrains the hyperactivation of synovial fibroblasts
            in inflammatory arthritis by regulating the TAK1/IKK2 signaling
            axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8540)
  AUTHORS   Zhang,J. and Zhang,R.
  TITLE     Megalosplenia as an initial manifestation of multiple myeloma with
            a novel CYLD gene mutation: A case report and literature review
  JOURNAL   Medicine (Baltimore) 103 (14), e37624 (2024)
   PUBMED   38579060
  REMARK    GeneRIF: Megalosplenia as an initial manifestation of multiple
            myeloma with a novel CYLD gene mutation: A case report and
            literature review.
            Review article
REFERENCE   4  (bases 1 to 8540)
  AUTHORS   Deng,B., Wang,J., Yang,T., Deng,Z., Yuan,J., Zhang,B., Zhou,Z.,
            Chen,F., Fang,L., Liang,C., Yan,B. and Ai,Y.
  TITLE     TNF and IFNgamma-induced cell death requires IRF1 and ELAVL1 to
            promote CASP8 expression
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38319288
  REMARK    GeneRIF: TNF and IFNgamma-induced cell death requires IRF1 and
            ELAVL1 to promote CASP8 expression.
REFERENCE   5  (bases 1 to 8540)
  AUTHORS   Li,Y., Yang,C., Xie,L., Shi,F., Tang,M., Luo,X., Liu,N., Hu,X.,
            Zhu,Y., Bode,A.M., Gao,Q., Zhou,J., Fan,J., Li,X. and Cao,Y.
  TITLE     CYLD induces high oxidative stress and DNA damage through class I
            HDACs to promote radiosensitivity in nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 15 (1), 95 (2024)
   PUBMED   38287022
  REMARK    GeneRIF: CYLD induces high oxidative stress and DNA damage through
            class I HDACs to promote radiosensitivity in nasopharyngeal
            carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8540)
  AUTHORS   Fenske,C., Banerjee,P., Holden,C. and Carter,N.
  TITLE     Brooke-Spiegler syndrome locus assigned to 16q12-q13
  JOURNAL   J Invest Dermatol 114 (5), 1057-1058 (2000)
   PUBMED   10792569
REFERENCE   7  (bases 1 to 8540)
  AUTHORS   Thomson,S.A., Rasmussen,S.A., Zhang,J. and Wallace,M.R.
  TITLE     A new hereditary cylindromatosis family associated with CYLD1 on
            chromosome 16
  JOURNAL   Hum Genet 105 (1-2), 171-173 (1999)
   PUBMED   10480375
REFERENCE   8  (bases 1 to 8540)
  AUTHORS   Biggs,P.J., Chapman,P., Lakhani,S.R., Burn,J. and Stratton,M.R.
  TITLE     The cylindromatosis gene (cyld1) on chromosome 16q may be the only
            tumour suppressor gene involved in the development of cylindromas
  JOURNAL   Oncogene 12 (6), 1375-1377 (1996)
   PUBMED   8649842
REFERENCE   9  (bases 1 to 8540)
  AUTHORS   Biggs,P.J., Wooster,R., Ford,D., Chapman,P., Mangion,J., Quirk,Y.,
            Easton,D.F., Burn,J. and Stratton,M.R.
  TITLE     Familial cylindromatosis (turban tumour syndrome) gene localised to
            chromosome 16q12-q13: evidence for its role as a tumour suppressor
            gene
  JOURNAL   Nat Genet 11 (4), 441-443 (1995)
   PUBMED   7493027
REFERENCE   10 (bases 1 to 8540)
  AUTHORS   Dubois,A. and Rajan,N.
  TITLE     CYLD Cutaneous Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32298062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007728.4.
            
            Summary: This gene is encodes a cytoplasmic protein with three
            cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains
            that functions as a deubiquitinating enzyme. Mutations in this gene
            have been associated with cylindromatosis, multiple familial
            trichoepithelioma, and Brooke-Spiegler syndrome. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427738.8/ ENSP00000392025.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC007728.4         108882-108920       c
            40-119              AC007728.4         108165-108244       c
            120-746             AC007728.4         100804-101430       c
            747-1049            AC007728.4         99100-99402         c
            1050-1155           AC007728.4         96582-96687         c
            1156-1164           AC007728.4         75832-75840         c
            1165-1263           AC007728.4         74729-74827         c
            1264-1380           AC007728.4         73065-73181         c
            1381-1760           AC007728.4         70962-71341         c
            1761-1926           AC007728.4         69595-69760         c
            1927-2068           AC007728.4         68540-68681         c
            2069-2191           AC007728.4         66555-66677         c
            2192-2283           AC007728.4         64060-64151         c
            2284-2350           AC007728.4         63154-63220         c
            2351-2483           AC007728.4         59316-59448         c
            2484-2592           AC007728.4         58301-58409         c
            2593-2711           AC007728.4         57342-57460         c
            2712-2928           AC007728.4         56578-56794         c
            2929-8540           AC007728.4         49071-54682         c
FEATURES             Location/Qualifiers
     source          1..8540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..8540
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /note="CYLD lysine 63 deubiquitinase"
                     /db_xref="GeneID:1540"
                     /db_xref="HGNC:HGNC:2584"
                     /db_xref="MIM:605018"
     exon            1..39
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            40..119
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..746
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..3113
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 4;
                     ubiquitin specific peptidase like 2; ubiquitin
                     thiolesterase CYLD; cylindromatosis (turban tumor
                     syndrome); probable ubiquitin carboxyl-terminal hydrolase
                     CYLD; ubiquitin-specific-processing protease CYLD;
                     deubiquitinating enzyme CYLD; ubiquitin thioesterase CYLD"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase CYLD
                     isoform 1"
                     /protein_id="NP_001365672.1"
                     /db_xref="CCDS:CCDS45482.1"
                     /db_xref="GeneID:1540"
                     /db_xref="HGNC:HGNC:2584"
                     /db_xref="MIM:605018"
                     /translation="MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKG
                     SIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLA
                     ITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSG
                     IFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAG
                     PGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNW
                     DGRFDGVQLCSFACVESTILLHINDIIPALSESVTQERRPPKLAFMSRGVGDKGSSSH
                     NKPKATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEVAEDPAKSLTEIS
                     TDFDRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSVMEELN
                     TAPVQESPPLAMPPGNSHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELED
                     ECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGY
                     LSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRP
                     KEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDP
                     EEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFIN
                     SNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYE
                     CRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPC
                     QNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGE
                     YLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK"
     exon            747..1049
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1155
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1164
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1263
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1380
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1760
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1926
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2068
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2191
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2283
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2350
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2483
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2592
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2711
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2928
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..8540
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /note="hexamer: AATAAA"
     polyA_site      3487
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /note="major polyA site"
     regulatory      8517..8522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /note="hexamer: ATTAAA"
     polyA_site      8540
                     /gene="CYLD"
                     /gene_synonym="BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8;
                     MFT; MFT1; SBS; TEM; USPL2"
                     /note="major polyA site"
ORIGIN      
        1 aggtagcagg tttggctgcg cgggggccgc gcgtcggagt ttcccccttt ctagggtgag
       61 gatggttcta cacagccacc cggagttcct tagttgaaag gtgcgccctg ctgtgacagc
      121 atggacacca cgttgctgaa aacatgcttt gggactgcca ctgaatttat cttttgcggt
      181 tttatgacaa agttattagt agtttccctt ttttgaatta gtattttgaa gttaatatca
      241 caatgagttc aggcttatgg agccaagaaa aagtcacttc accctactgg gaagagcgga
      301 ttttttactt gcttcttcaa gaatgcagcg ttacagacaa acaaacacaa aagctcctta
      361 aagtaccgaa gggaagtata ggacagtata ttcaagatcg ttctgtgggg cattcaagga
      421 ttccttctgc aaaaggcaag aaaaatcaga ttggattaaa aattctagag caacctcatg
      481 cagttctctt tgttgatgaa aaggatgttg tagagataaa tgaaaagttc acagagttac
      541 ttttggcaat taccaattgt gaggagaggt tcagcctgtt taaaaacaga aacagactaa
      601 gtaaaggcct ccaaatagac gtgggctgtc ctgtgaaagt acagctgaga tctggggaag
      661 aaaaatttcc tggagttgta cgcttcagag gacccctgtt agcagagagg acagtctccg
      721 gaatattctt tggagttgaa ttgctggaag aaggtcgtgg tcaaggtttc actgacgggg
      781 tgtaccaagg gaaacagctt tttcagtgtg atgaagattg tggcgtgttt gttgcattgg
      841 acaagctaga actcatagaa gatgatgaca ctgcattgga aagtgattac gcaggtcctg
      901 gggacacaat gcaggtcgaa cttcctcctt tggaaataaa ctccagagtt tctttgaagg
      961 ttggagaaac aatagaatct ggaacagtta tattctgtga tgttttgcca ggaaaagaaa
     1021 gcttaggata ttttgttggt gtggacatgg ataaccctat tggcaactgg gatggaagat
     1081 ttgatggagt gcagctttgt agttttgcgt gtgttgaaag tacaattcta ttgcacatca
     1141 atgatatcat cccagcttta tcagagagtg tgacgcagga aaggaggcct cccaaacttg
     1201 cctttatgtc aagaggtgtt ggggacaaag gttcatccag tcataataaa ccaaaggcta
     1261 caggatctac ctcagaccct ggaaatagaa acagatctga attattttat accttaaatg
     1321 ggtcttctgt tgactcacaa ccacaatcca aatcaaaaaa tacatggtac attgatgaag
     1381 ttgcagaaga ccctgcaaaa tctcttacag agatatctac agactttgac cgttcttcac
     1441 caccactcca gcctcctcct gtgaactcac tgaccaccga gaacagattc cactctttac
     1501 cattcagtct caccaagatg cccaatacca atggaagtat tggccacagt ccactttctc
     1561 tgtcagccca gtctgtaatg gaagagctaa acactgcacc cgtccaagag agtccaccct
     1621 tggccatgcc tcctgggaac tcacatggtc tagaagtggg ctcattggct gaagttaagg
     1681 agaaccctcc tttctatggg gtaatccgtt ggatcggtca gccaccagga ctgaatgaag
     1741 tgctcgctgg actggaactg gaagatgagt gtgcaggctg tacggatgga accttcagag
     1801 gcactcggta tttcacctgt gccctgaaga aggcgctgtt tgtgaaactg aagagctgca
     1861 ggcctgactc taggtttgca tcattgcagc cggtttccaa tcagattgag cgctgtaact
     1921 ctttagcatt tggaggctac ttaagtgaag tagtagaaga aaatactcca ccaaaaatgg
     1981 aaaaagaagg cttggagata atgattggga agaagaaagg catccagggt cattacaatt
     2041 cttgttactt agactcaacc ttattctgct tatttgcttt tagttctgtt ctggacactg
     2101 tgttacttag acccaaagaa aagaacgatg tagaatatta tagtgaaacc caagagctac
     2161 tgaggacaga aattgttaat cctctgagaa tatatggata tgtgtgtgcc acaaaaatta
     2221 tgaaactgag gaaaatactt gaaaaggtgg aggctgcatc aggatttacc tctgaagaaa
     2281 aagatcctga ggaattcttg aatattctgt ttcatcatat tttaagggta gaacctttgc
     2341 taaaaataag atcagcaggt caaaaggtac aagattgtta cttctatcaa atttttatgg
     2401 aaaaaaatga gaaagttggc gttcccacaa ttcagcagtt gttagaatgg tcttttatca
     2461 acagtaacct gaaatttgca gaggcaccat catgtctgat tattcagatg cctcgatttg
     2521 gaaaagactt taaactattt aaaaaaattt ttccttctct ggaattaaat ataacagatt
     2581 tacttgaaga cactcccaga cagtgccgga tatgtggagg gcttgcaatg tatgagtgta
     2641 gagaatgcta cgacgatccg gacatctcag ctggaaaaat caagcagttt tgtaaaacct
     2701 gcaacactca agtccacctt catccgaaga ggctgaatca taaatataac ccagtgtcac
     2761 ttcccaaaga cttacccgac tgggactgga gacacggctg catcccttgc cagaatatgg
     2821 agttatttgc tgttctctgc atagaaacaa gccactatgt tgcttttgtg aagtatggga
     2881 aggacgattc tgcctggctc ttctttgaca gcatggccga tcgggatggt ggtcagaatg
     2941 gcttcaacat tcctcaagtc accccatgcc cagaagtagg agagtacttg aagatgtctc
     3001 tggaagacct gcattccttg gactccagga gaatccaagg ctgtgcacga agactgcttt
     3061 gtgatgcata tatgtgcatg taccagagtc caacaatgag tttgtacaaa taactggggt
     3121 catcgggaaa ggcaaagaaa ctgaaggcag agtcctaacg ttgcatctta ttcgagctgg
     3181 cagttctgtt cacgtccatt gccggcaatg gatgtctttg tggtgatgat ccttcagaaa
     3241 aggatgcctc tgtttaaaaa caaattgctt ttgtgtccct gaagtattta ataagaagca
     3301 ttttgcactc tagaaagtat gtttgtgttg gttttttaag aagtctaaat gaagttatta
     3361 atacctgaag ctttaagtta agtgcattga tcatatgata tttttggaag catacaattt
     3421 taattgtgga agtttaaagc ctcttttagt ccattgagaa tgtaaataaa tgtgtcttct
     3481 ttatggacca aggatatgaa atcatttttc ttttgtagct aacggttgcc ttgaggaaga
     3541 aataatttgg ttttattaag agtctactct caatccagtt attagagatg tactgagttt
     3601 gatttgttaa tcctttctat atactgctga tcttgcatgt ctacaatctg ctcagttttt
     3661 ctgtgtttct gcaatagtgg tcagaaaaat acttaaattc ccttaatggt gttgttttct
     3721 atttgttctg gttttgagat aaatgagtga ttctgtcccc aaatgtccat ttttgaagtg
     3781 attttcctgg aggattaggg tatttagcag ttgaagctct tcattcatag tagttactgt
     3841 cagctaacag gttttttaag gcttttaact attaatattt tatggaatgg ggcaaagtaa
     3901 attgatgaaa gaattggagt gataatagtc ctttacaaac atacagtcca taagaaaatg
     3961 aatttggcat atagaattat tacaatttcc tgggagagat ggatatttaa acctctatta
     4021 ttttagacaa gactgtctag aacttaagtt tgatctgtca gccagtactc ccattaaatt
     4081 cagtgtagtt tcacttgata gaatcagata tgttatcgaa atgttagcag cagcttcatc
     4141 ctccttctga ttaaagtaag tagaaatggg atgttttgtt taataacagc catagtgtgt
     4201 gtttagacca cagcggatgt tgtagaccag gaccatagat gatacatgtc agtgctgtgg
     4261 aatgtgcatt ctctgagtgt tgttttgtgg tatcattgtc tttcctgaat gactttctaa
     4321 ctgtgcagaa aggcagaaaa gtcatcatat gtatatgtca tatgacttta taaaatattt
     4381 aatgtgacaa aaagtggaaa gaatctttac aaaccctgca attacttttt taaaggcact
     4441 tttactcttt ggttttatca ttccattttg ctaatattta ctagctttat aaattacagt
     4501 aaggtacaaa aactcatctt gtaatatttt catttttgaa gtgaaaaagt acatatattt
     4561 tgcacaaggt tttatactgc taagtgcttg gttggggtgg tgagatgatg attagatcag
     4621 gggtgaggct gagagactct gggtttaggg ctagccctgc ctccatctcc cttgggtaaa
     4681 atgaagggtg tggggtaaaa gatgcataag gccttttcta gctctgacag cctagaagtc
     4741 caatcaccct gtaataaata tgtgttgaat gaagaaatgg gtgaatgagc ttgtcaatgt
     4801 gattttaaaa aattgactac ctggaggaat gattaggaat ctaaatgaag ccagccctcg
     4861 gtatctgcag gtttctcatc catggattca accaactgca aatggaaaat acgatttttt
     4921 ttaaaaaaag gatggttaca tccgtattga acatgtacag acttttttct tgtcattatt
     4981 ctctgaacaa tacaagaact ctttatgtag catttacatt tattaggtat tataagtaat
     5041 ctagagatta tttaattaaa atatacagga ggatgtgtgt cagttatatg caaattctgt
     5101 accattttgt atcagggaat tgagcatctt cagatgttgg tatctgcagg gatcctggaa
     5161 ccaaacccct gcagatacta agggctgacg atctaggtaa gactggattt aacagttgga
     5221 aaaaaaaaaa aaaaaggaga gagaagacag ttcctttcct gtagaaatta aaacaaaata
     5281 caaattgagg aagctctgct acccaggctg tcatggtaga gaacttgaag aagacctgtt
     5341 tggatggaca cctggtttca aaagtcaggt gtggagactg ttaaatggga gggcctcatc
     5401 cataaatgat ttctggcaac gtcttcttca ggtggagctt gacgtctttt taatgttact
     5461 tggggaggga gtgctcatta agggatgcca gggccagctc tggtggttcc tggggaggct
     5521 gcgtccttcc ctgcttctgc atgtcatgag gcagcaggaa ggtttcccct gcacctgtct
     5581 gtcctggctc cctctgggta gccccctact gttctgtgct tcagcacagc ctggtttgtc
     5641 aagaggcaca tagttggggc tgggctgcat ggcacagggg cttatgtgcc tgctggttat
     5701 ttaattttca gccttaagtt ttctttaata ttttcctgtt ggctatttaa aggttttggt
     5761 tatcttttat tccttatcta caatcaagat gacaatgtaa ttgaattatc ttatttataa
     5821 cacggttcgt gattcatgat tcatgattac aagtagaaaa tatgtcatgt tcctcacctc
     5881 caaataaata tgtgtgtgtc tgtgtgtgtg tatatatgta tgtggcggag agggagagag
     5941 tggggaagga gagcagtgtt atcatacata gagaggctaa atgtgtccca tccctcactg
     6001 tcagctttat aaaggagttt gactccatcc acagaagaat gttttataag actaggaaaa
     6061 cacgttgaaa actaggataa acagcaacaa aaatcaacta aatatgttgt tactgttgct
     6121 aaggattttc tccttagaat aatttaggat ttttaaaaat ttctgtttgc caaatgctgt
     6181 agataaatgg ccagattctt cctatcccta ggattccttt attatttttt ttcacagatt
     6241 ttgagaacaa gggggagaga tagtatggaa gattaagatt ccattaatct tatagaactg
     6301 tgttgtcacc caaattcctg cttgtttgaa catggcatct tcatagattc aggattcact
     6361 accctctata gctggatctt gaaaattatc tggccagata attttgcatc tgcttggatg
     6421 attgtagact gagatgtgag tggaggataa agtattagac ttttgctgag taactgccaa
     6481 ccaagaagta tttatcggac acttactagg tgcctaggat tgtatcagag ggaatatgaa
     6541 atgtgtccct gccctaccta gttttaacga cagaatatct attaaaggct acttagctga
     6601 agggtaaggg tgacaggtct aggggaagct ttgggaggtg gtgtgctgtg acagaaaaag
     6661 tggcagagta gggacgagag acctgcattc tagccctgtt tctgtcactt gctctgtaca
     6721 cttagacaac agcttgacct cttgagcttt agtttcctcc tctgcataat gagagggtta
     6781 gactactgaa ttgtatggga aaaaaataca aattcctggg tcctaggcca tgcctgctga
     6841 atccgactgt tcaggaagag gcctaggaaa tctgtgaggg aatccccagg ggaatctcgt
     6901 gaccagccag gtgtgaaatc tgctaactgg aagatctcaa agcttccttc actttttgtg
     6961 attttgtggt catgtaacgt tactgtatta ttctacgtaa atgtgggtac ttggatgttt
     7021 atcatactgt ttctctgtgt ttacatacta atttgtgtaa gaaatgcatt ttagtctgtg
     7081 tacctcaacc tgctgtttgt ttcctagagg tgttagtagt ctttaaatac aagtaagact
     7141 taagaggata tttgatgtta tttacctgga tattttcttc cccttttatt tatttagagg
     7201 aaattgagat tctaggagcc aaaaaaatga aaacaaaatt ctaaggcaaa gttaaagaaa
     7261 aaaattacat tatttcttac catttgctac tttataatga aaatttaaaa attatatggg
     7321 aagatttttc tctgggataa caaatccttg tcataaagta agaggtcttt ttaaagtagg
     7381 taggctataa ggcctgtaat ttaaaataat actcctttct ctagggtttg gtgcaattct
     7441 ccattaatga agataacatt tgaattcccc aaagcaggtg aggagtcggg gaggagaaag
     7501 cgatgttaaa atgaaaactc actgcaaaag aggaggcaga ggaagaagga atgtaaaccc
     7561 cttaaagcag atgtgtgtgg ggccttatga agaccaggat tctgcgggtg tcaggggatt
     7621 gcccctcttg acagagacta gggttttaga ctgaggcttc ctgcagggtg ttcgcattgc
     7681 ccttctccgt tccccttcag acctttctgg ggagaagagg tgggaggagg ggagaaagac
     7741 tgttcatctt attctgaatc ctggagcagc tgaaggtttt ctcttgagtc aggatgcagt
     7801 ggtaatgcat taaccagcaa gtgtggccaa ggataatgaa aaagtgggaa aggaaggtcc
     7861 tcctcctccc tgattgtagc atccagcagt ctctgtagcc aggttactca agaaccacat
     7921 ttgatttcct ggccctttgc cttggcagtg atggcatttt tatttcactg tgttttaaag
     7981 tcttcattta tttttataac atgggttagg gagaagggcc acaaatggag ggattgtcct
     8041 ttcaagcacc acagcttcag ataaaattag tactttcaaa tattgtccac tttaacttaa
     8101 aaaattctag agggattata ttggagactc aactgccctt ggttttagtt tataaaatgg
     8161 cctagtactg tggaatttta attttagaaa gtcttagcat cagatcataa acattcatta
     8221 aaagaactca catcccatct gaaacttccc aggggagttg ggattcttag tagattggta
     8281 gaaaggggct cattttctac tgcatttccc atttttggta tcttgttcag catgttttat
     8341 ttttatttct tgtctgcaga acatcctata tttatgagaa cattctttaa gaagaccacc
     8401 acatagaata ccccttccta tcagctcgct ctgatttagc cttaattttg ttaaattttt
     8461 tagagatgaa tgaagtgctg ctgtggaaag aaatgtacat atactatttc tgtatcatta
     8521 aaattacatt tttatggttc
//
