LOCUS       NM_021118               2107 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cylicin 1 (CYLC1), transcript variant 1, mRNA.
ACCESSION   NM_021118 XM_088636 XM_931154 XM_937261 XM_943237
VERSION     NM_021118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Jin,H.J., Fan,Y., Yang,X., Dong,Y., Zhang,X.Z., Geng,X.Y., Yan,Z.,
            Wu,L., Ma,M., Li,B., Lyu,Q., Pan,Y., Liu,M., Kuang,Y. and Chen,S.R.
  TITLE     Disruption in CYLC1 leads to acrosome detachment, sperm head
            deformity, and male in/subfertility in humans and mice
  JOURNAL   Elife 13, 95054 (2024)
   PUBMED   38573307
  REMARK    GeneRIF: Disruption in CYLC1 leads to acrosome detachment, sperm
            head deformity, and male in/subfertility in humans and mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Schneider,S., Kovacevic,A., Mayer,M., Dicke,A.K., Arevalo,L.,
            Koser,S.A., Hansen,J.N., Young,S., Brenker,C., Kliesch,S.,
            Wachten,D., Kirfel,G., Strunker,T., Tuttelmann,F. and Schorle,H.
  TITLE     Cylicins are a structural component of the sperm calyx being
            indispensable for male fertility in mice and human
  JOURNAL   Elife 12, 86100 (2023)
   PUBMED   38013430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Siddiqui,R.A., Sauermann,U., Altmuller,J., Fritzer,E.,
            Nothnagel,M., Dalibor,N., Fellay,J., Kaup,F.J., Stahl-Hennig,C.,
            Nurnberg,P., Krawczak,M. and Platzer,M.
  TITLE     X chromosomal variation is associated with slow progression to AIDS
            in HIV-1-infected women
  JOURNAL   Am J Hum Genet 85 (2), 228-239 (2009)
   PUBMED   19679225
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Ficarro,S., Chertihin,O., Westbrook,V.A., White,F., Jayes,F.,
            Kalab,P., Marto,J.A., Shabanowitz,J., Herr,J.C., Hunt,D.F. and
            Visconti,P.E.
  TITLE     Phosphoproteome analysis of capacitated human sperm. Evidence of
            tyrosine phosphorylation of a kinase-anchoring protein 3 and
            valosin-containing protein/p97 during capacitation
  JOURNAL   J Biol Chem 278 (13), 11579-11589 (2003)
   PUBMED   12509440
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Hess,H., Heid,H., Zimbelmann,R. and Franke,W.W.
  TITLE     The protein complexity of the cytoskeleton of bovine and human
            sperm heads: the identification and characterization of cylicin II
  JOURNAL   Exp Cell Res 218 (1), 174-182 (1995)
   PUBMED   7737358
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Hess,H., Heid,H. and Franke,W.W.
  TITLE     Molecular characterization of mammalian cylicin, a basic protein of
            the sperm head cytoskeleton
  JOURNAL   J Cell Biol 122 (5), 1043-1052 (1993)
   PUBMED   8354692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058019.1, BC126461.1,
            Z22780.1 and BX110674.1.
            
            On May 17, 2019 this sequence version replaced NM_021118.2.
            
            Summary: This gene encodes a sperm head cytoskeletal protein. The
            encoded protein is associated with the calyx of spermatozoa and
            spermatids. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329312.5/ ENSP00000331556.4
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC058019.1         5-20
            17-2027             BC126461.1         1-2011
            2028-2106           Z22780.1           1833-1911
            2107-2107           BX110674.1         339-339
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..2107
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /note="cylicin 1"
                     /db_xref="GeneID:1538"
                     /db_xref="HGNC:HGNC:2582"
                     /db_xref="MIM:300768"
     exon            1..54
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1993
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cylicin I; multiple-band polypeptide I; cylicin, basic
                     protein of sperm head cytoskeleton 1"
                     /codon_start=1
                     /product="cylicin-1 isoform 1"
                     /protein_id="NP_066941.1"
                     /db_xref="CCDS:CCDS35341.1"
                     /db_xref="GeneID:1538"
                     /db_xref="HGNC:HGNC:2582"
                     /db_xref="MIM:300768"
                     /translation="MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRG
                     TNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRH
                     LYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADK
                     TPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKN
                     NPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNY
                     SLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTD
                     AESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASK
                     NDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEP
                     KGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKD
                     IKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSA
                     NSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPKVRRL
                     CWCKMPPPPPKPRYAPLPEAPWIHKLL"
     exon            55..95
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            96..214
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            215..1960
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2107
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /note="hexamer: AATAAA"
     polyA_site      2107
                     /gene="CYLC1"
                     /gene_synonym="CYCL1; SPGFX8"
                     /note="major polyA site"
ORIGIN      
        1 actatgctca agtccaggca acgtacaggc aggggaaatg tctcttccaa ggttgctaaa
       61 agtaaacatc agaacatatg ataattccat tccaatcagt gaatcaagca gaaaatcatg
      121 gaatcaaaaa cactttgctt tgacatttcc caaaccactc cagagaggta caaatgataa
      181 atcaagacct ttgaaatcac aaataacagt tactagacat gacaaaagaa aactagaaga
      241 aggccagaaa ccagctcata aatggataag gcattctttc agaaaaattt tgcaatggcc
      301 acccatttac acagctgcca gggaacagac tccattcaga catctttata cttccaaaac
      361 ccatcttaaa aaagcagaat ataaaaagtc caaagatgaa aaaggaggaa cacctttgaa
      421 gaaagattcc aagaaaaaag gaggttcata tgcaacaaat ccagaatcca agcaaatagt
      481 agaagagaaa actaaaagac aaaatgaggc agataaaact cccttaaaat catcacatga
      541 aaatgaacaa tccaagaagt caaaatccag ttcagaaact aatccagaat cccaaaattc
      601 taagacagtc tcaaaaaatt gttcacaaaa agataagaaa gattcaaaga attccaagaa
      661 gacaaacact gaattcctac atacaaagaa caatccaaag aaagatttga agaggtcaaa
      721 gactagtaat gatcccatat cagagatttg ctcagaaaat agtttaaatg ttgatttcct
      781 catgttagtg ggacagtctg atgatgaatc cataaatttt gatgcatggt taaggaatta
      841 ctcacagaat aattcaaaga attattcttt gaagtataca aagtatacaa agaaggacac
      901 aaaaaagaat gcaaagaaaa gctctgatgc tgaatctgaa gactcaaagg atgctaagaa
      961 agattcaaag aaagttaaga aaaatgtcaa gaaagatgac aagaaaaagg atgtaaagaa
     1021 ggacacagag tctactgatg ctgaatctgg agactcaaag gatgaaagga aagatacaaa
     1081 gaaggataag aaaaaattaa agaaagatga caagaaaaag gacacaaaga agtacccaga
     1141 gtctactgat actgaatcag gagatgcaaa ggatgcaaga aatgattcaa gaaatttgaa
     1201 gaaagcttca aagaatgatg acaagaaaaa ggatgcaaag aaaattacat tctctactga
     1261 ttctgaatct gaactggagt caaaggagag tcagaaagat gaaaaaaagg ataaaaaaga
     1321 ttcaaagaca gataataaaa agtctgtcaa gaatgatgaa gagtctactg atgctgactc
     1381 tgaaccgaag ggagattcaa aaaagggtaa aaaggatgaa aagaagggga agaaagattc
     1441 aaagaaagat gacaaaaaga aggatgcaaa gaaaaatgca gaatctactg aaatggaatc
     1501 tgatttggag ttaaagaagg acaagaaaca ctcaaaggaa aagaaaggtt caaagaaaga
     1561 tatcaagaag gatgcaagaa aggacacaga gtctactgat gctgaatttg atgaatcttc
     1621 caagacaggc tttaaaacat ctacaaaaat caaaggttca gatactgaat ctgaagagtc
     1681 actatataaa cctggggcta agaagaaaat tgatgaatca gatggcacat ctgcaaattc
     1741 aaagatggaa ggactggaat caaagagagg attcagaatg tcatccaaaa agactacatt
     1801 caatgaaaaa ggggaaaaag caagtacagg tagagttcct ccatcaagag aaaaaccacc
     1861 actccctgct tgtgagcctt ctctaccatc accaaaggtc agacgtcttt gttggtgcaa
     1921 gatgcctcct ccacctccaa aaccaagata tgctcctttg cctgaagcac cgtggattca
     1981 taagctgctt taaagaacaa ctgagcactt ggtttcacag aatggcctta ccacagtaag
     2041 caccacctac tctcaaatga gcatttctac ctctgtggaa ctgaaataaa aacaagtctt
     2101 ccatgag
//
