LOCUS       NM_134268               1962 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens cytoglobin (CYGB), mRNA.
ACCESSION   NM_134268
VERSION     NM_134268.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Zhang,J., Zhang,W., Liu,J., Liu,Y., Jiang,Y., Ainiwaer,A., Chen,H.,
            Gu,Z., Chen,H., Mao,S., Guo,Y., Xu,T., Xu,Y., Wu,Y., Yao,X. and
            Yan,Y.
  TITLE     SOX7 inhibits the malignant progression of bladder cancer via the
            DNMT3B/CYGB axis
  JOURNAL   Mol Biomed 5 (1), 36 (2024)
   PUBMED   39227479
  REMARK    GeneRIF: SOX7 inhibits the malignant progression of bladder cancer
            via the DNMT3B/CYGB axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   De Backer,J. and Hoogewijs,D.
  TITLE     The cytoglobin-dependent transcriptome in melanoma indicates a
            protective function associated with oxidative stress, inflammation
            and cancer-associated pathways
  JOURNAL   Sci Rep 14 (1), 18175 (2024)
   PUBMED   39107431
  REMARK    GeneRIF: The cytoglobin-dependent transcriptome in melanoma
            indicates a protective function associated with oxidative stress,
            inflammation and cancer-associated pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Zweier,J.L., Hemann,C., Kundu,T., Ewees,M.G., Khaleel,S.A.,
            Samouilov,A., Ilangovan,G. and El-Mahdy,M.A.
  TITLE     Cytoglobin has potent superoxide dismutase function
  JOURNAL   Proc Natl Acad Sci U S A 118 (52) (2021)
   PUBMED   34930834
  REMARK    GeneRIF: Cytoglobin has potent superoxide dismutase function.
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Kono,H., Hosomura,N., Amemiya,H., Kawaida,H., Furuya,S., Akaike,H.,
            Kawaguchi,Y., Sudo,M. and Ichikawa,D.
  TITLE     Cytoglobin as a Prognostic Factor for Pancreatic Ductal
            Adenocarcinoma: A Retrospective Analysis of 75 Patients
  JOURNAL   Pancreas 50 (7), 994-999 (2021)
   PUBMED   34629450
  REMARK    GeneRIF: Cytoglobin as a Prognostic Factor for Pancreatic Ductal
            Adenocarcinoma: A Retrospective Analysis of 75 Patients.
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   De Backer,J., Maric,D., Bosman,M., Dewilde,S. and Hoogewijs,D.
  TITLE     A reliable set of reference genes to normalize oxygen-dependent
            cytoglobin gene expression levels in melanoma
  JOURNAL   Sci Rep 11 (1), 10879 (2021)
   PUBMED   34035373
  REMARK    GeneRIF: A reliable set of reference genes to normalize
            oxygen-dependent cytoglobin gene expression levels in melanoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Sawai,H., Kawada,N., Yoshizato,K., Nakajima,H., Aono,S. and
            Shiro,Y.
  TITLE     Characterization of the heme environmental structure of cytoglobin,
            a fourth globin in humans
  JOURNAL   Biochemistry 42 (17), 5133-5142 (2003)
   PUBMED   12718557
  REMARK    GeneRIF: characterization of the heme environmental structure of
            this protein, a fourth globin in humans
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Asahina,K., Kawada,N., Kristensen,D.B., Nakatani,K., Seki,S.,
            Shiokawa,M., Tateno,C., Obara,M. and Yoshizato,K.
  TITLE     Characterization of human stellate cell activation-associated
            protein and its expression in human liver
  JOURNAL   Biochim Biophys Acta 1577 (3), 471-475 (2002)
   PUBMED   12359339
  REMARK    GeneRIF: cloned, deduced amino acid sequence and expressed in
            diseased liver tissue where stellate cells were present
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Trent,J.T. 3rd and Hargrove,M.S.
  TITLE     A ubiquitously expressed human hexacoordinate hemoglobin
  JOURNAL   J Biol Chem 277 (22), 19538-19545 (2002)
   PUBMED   11893755
  REMARK    GeneRIF: A ubiquitously expressed human hexacoordinate hemoglobin
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Burmester,T., Ebner,B., Weich,B. and Hankeln,T.
  TITLE     Cytoglobin: a novel globin type ubiquitously expressed in
            vertebrate tissues
  JOURNAL   Mol Biol Evol 19 (4), 416-421 (2002)
   PUBMED   11919282
  REMARK    GeneRIF: vertebrate myoglobins are in fact a specialized
            intracellular globin that evolved in adaptation to the special
            needs of muscle cells
REFERENCE   10 (bases 1 to 1962)
  AUTHORS   Kawada,N., Kristensen,D.B., Asahina,K., Nakatani,K., Minamiyama,Y.,
            Seki,S. and Yoshizato,K.
  TITLE     Characterization of a stellate cell activation-associated protein
            (STAP) with peroxidase activity found in rat hepatic stellate cells
  JOURNAL   J Biol Chem 276 (27), 25318-25323 (2001)
   PUBMED   11320098
  REMARK    Erratum:[J Biol Chem 2001 Dec 14;276(50):47744-5]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ881744.1, AK098057.1 and AI470692.1.
            
            On Nov 23, 2018 this sequence version replaced NM_134268.4.
            
            Summary: This gene encodes a globin protein found in vertebrate
            cells. The encoded protein is described as a hexacoordinate
            hemoglobin which binds ligand differently from the pentacoordinate
            hemoglobins involved in oxygen transport, and may be involved in
            protection during oxidative stress. This gene is located on
            chromosome 17 in the same region as a retinal gene which is mutated
            in progressive rod-cone degeneration, but in the opposite
            orientation. [provided by RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029798.1, SRR14038195.1013127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293230.10/ ENSP00000293230.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               BQ881744.1         197-506
            311-1960            AK098057.1         154-1803
            1961-1962           AI470692.1         9-10                c
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1962
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /note="cytoglobin"
                     /db_xref="GeneID:114757"
                     /db_xref="HGNC:HGNC:16505"
                     /db_xref="MIM:608759"
     exon            1..310
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..740
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /EC_number="1.15.1.1"
                     /note="stellate cell activation-associated protein;
                     histoglobin; pseudoperoxidase CYGB; nitrite reductase
                     CYGB; superoxide dismutase CYGB; nitric oxygen dioxygenase
                     CYGB"
                     /codon_start=1
                     /product="cytoglobin"
                     /protein_id="NP_599030.1"
                     /db_xref="CCDS:CCDS11746.1"
                     /db_xref="GeneID:114757"
                     /db_xref="HGNC:HGNC:16505"
                     /db_xref="MIM:608759"
                     /translation="MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVA
                     ILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKV
                     SSVLALVGKAHALKHKVEPVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYS
                     HVTAAYKEVGWVQQVPNATTPPATLPSSGP"
     exon            311..542
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /inference="alignment:Splign:2.1.0"
     exon            543..706
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1962
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /note="hexamer: ATTAAA"
     polyA_site      1962
                     /gene="CYGB"
                     /gene_synonym="HGB; NOD; STAP"
                     /note="major polyA site"
ORIGIN      
        1 acacacacac ccggcgcgca cagacacacg ctccctccct ccgcgctcta cccctcgccc
       61 gcccgccgcg cacgcagccg gccccggctc ccggcgcccc gcgccccgcg ccccgcgccc
      121 cgccaccgcc gccgccgagc aaagccgggc tgggcttgga gctgctcatg gagaaagtgc
      181 caggcgagat ggagatcgag cgcagggagc ggagcgagga gctgtccgag gcggagagga
      241 aggcggtgca ggctatgtgg gcccggctct atgccaactg cgaggacgtg ggggtggcca
      301 tcctggtgag gttctttgtg aacttcccct cggccaagca gtacttcagc cagttcaagc
      361 acatggagga tcccctggag atggagcgga gcccccagct gcggaagcac gcctgccgag
      421 tcatgggggc cctcaacact gtcgtggaga acctgcatga ccccgacaag gtgtcctctg
      481 tgctcgccct tgtggggaaa gcccacgccc tcaagcacaa ggtggaaccg gtgtacttca
      541 agatcctctc tggggtcatt ctggaggtgg tcgccgagga atttgccagt gacttcccac
      601 ctgagacgca gagagcctgg gccaagctgc gtggcctcat ctacagccac gtgaccgctg
      661 cctacaagga agtgggctgg gtgcagcagg tccccaacgc caccacccca ccggccacac
      721 tgccctcttc ggggccgtag gacccctaac tccacccccc tccctggcag cacctcgagc
      781 agaaggccga gttctgaaga ccctccttga cgctccattt ctgggtgcca aggaagctgg
      841 aggaatccct gactcaactt ccccgaagga ggcctctgtg gcggccaggg tccccccctg
      901 gagctgctgg gaggcggcgc tggctgcctg gatgctgacc ccagcgcggc gggcagagcg
      961 gggcccactc ttcttagctt ttctactcac tgttagagag agacctagct gagcggctgg
     1021 caggaagcgg gacaggtcta ggagtccctt agggaataaa ccagccccgt ttctatcagc
     1081 ccggccagca tgcaggtctc cacatcacca tctagagtat cacgcacaca tctaccatat
     1141 atacagatat attctatata cgagctatat ataaatatat atatacatat atatatacac
     1201 acatacatat ctagaatgtg tatccgcggc gcccagaagc ctcggtttgg cccacctgtg
     1261 agtggggcag ggaggggttc cggttgtgca gagaacagag tgttctggca aagaggaaat
     1321 cccacagcag cgcagaggac ctgggcctgg aggggcaggg ctggggcaac ccggcttggc
     1381 ggcaaagccc agccccttct cagaccagct ccccacattc ctgaattcca cttccaggca
     1441 gaaaggagtg ggctccccct actccctcag aggaactgac tcaccggctg tcctagaatg
     1501 ggcaggggca gagcgaagtt ctgggtggga tgaccgcact gggggagggg cctcagtcca
     1561 gaaacctcga ccgctagctc cacctgcctt ggccaccagg gcagccccgg gggatccggg
     1621 ctgctgggca gcaggtcggc gggaccacat gcctgggtct caccctcagc tccgagggcc
     1681 gagggctttc cccaccccac cctcctcctg gccggcagtc ggccctgtct attcatctgc
     1741 gtcaggcttg ccaggggggc cccccgtgtg tgccccttgg tcacgtgtgt cgtcttcaag
     1801 gatgttttgc tgctgtggct cctgctgtgt cccctcctgg cccatcctca tcctcatctt
     1861 catcctcatc ctcatctgtg caaccgcccg tcctcctttt ctagtttctg atgtttgtaa
     1921 ccagacccag ctgtgtcatt aaacagaccc gttcttgctg ta
//
