LOCUS       NM_001037333            6452 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens cytoplasmic FMR1 interacting protein 2 (CYFIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001037333
VERSION     NM_001037333.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6452)
  AUTHORS   Peng,X., Wellard,N., Ghosh,A., Troakes,C. and Giese,K.P.
  TITLE     Different dysregulations of CYFIP1 and CYFIP2 in distinct types of
            dementia
  JOURNAL   Brain Res Bull 206, 110849 (2024)
   PUBMED   38128786
  REMARK    GeneRIF: Different dysregulations of CYFIP1 and CYFIP2 in distinct
            types of dementia.
REFERENCE   2  (bases 1 to 6452)
  AUTHORS   Peng,Q., Ren,B., Xin,K., Liu,W., Alam,M.S., Yang,Y., Gu,X., Zhu,Y.
            and Tian,Y.
  TITLE     CYFIP2 serves as a prognostic biomarker and correlates with tumor
            immune microenvironment in human cancers
  JOURNAL   Eur J Med Res 28 (1), 364 (2023)
   PUBMED   37735711
  REMARK    GeneRIF: CYFIP2 serves as a prognostic biomarker and correlates
            with tumor immune microenvironment in human cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6452)
  AUTHORS   Biembengut,I.V., Shigunov,P., Frota,N.F., Lourenzoni,M.R. and de
            Souza,T.A.C.B.
  TITLE     Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related
            to Early Infantile Epileptic Encephalopathy
  JOURNAL   Int J Mol Sci 23 (15), 8708 (2022)
   PUBMED   35955843
  REMARK    GeneRIF: Molecular Dynamics of CYFIP2 Protein and Its R87C Variant
            Related to Early Infantile Epileptic Encephalopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6452)
  AUTHORS   Li,Y., Song,X., Liu,L. and Yue,L.
  TITLE     NUAK2 silencing inhibits the proliferation, migration and
            epithelial-to-mesenchymal transition of cervical cancer cells via
            upregulating CYFIP2
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34558636
  REMARK    GeneRIF: NUAK2 silencing inhibits the proliferation, migration and
            epithelialtomesenchymal transition of cervical cancer cells via
            upregulating CYFIP2.
REFERENCE   5  (bases 1 to 6452)
  AUTHORS   Biembengut,I.V., Silva,I.L.Z., Souza,T.A.C.B. and Shigunov,P.
  TITLE     Cytoplasmic FMR1 interacting protein (CYFIP) family members and
            their function in neural development and disorders
  JOURNAL   Mol Biol Rep 48 (8), 6131-6143 (2021)
   PUBMED   34327661
  REMARK    GeneRIF: Cytoplasmic FMR1 interacting protein (CYFIP) family
            members and their function in neural development and disorders.
            Review article
REFERENCE   6  (bases 1 to 6452)
  AUTHORS   Eden,S., Rohatgi,R., Podtelejnikov,A.V., Mann,M. and Kirschner,M.W.
  TITLE     Mechanism of regulation of WAVE1-induced actin nucleation by Rac1
            and Nck
  JOURNAL   Nature 418 (6899), 790-793 (2002)
   PUBMED   12181570
REFERENCE   7  (bases 1 to 6452)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   8  (bases 1 to 6452)
  AUTHORS   Saller,E., Tom,E., Brunori,M., Otter,M., Estreicher,A., Mack,D.H.
            and Iggo,R.
  TITLE     Increased apoptosis induction by 121F mutant p53
  JOURNAL   EMBO J 18 (16), 4424-4437 (1999)
   PUBMED   10449408
REFERENCE   9  (bases 1 to 6452)
  AUTHORS   Witke,W., Podtelejnikov,A.V., Di Nardo,A., Sutherland,J.D.,
            Gurniak,C.B., Dotti,C. and Mann,M.
  TITLE     In mouse brain profilin I and profilin II associate with regulators
            of the endocytic pathway and actin assembly
  JOURNAL   EMBO J 17 (4), 967-976 (1998)
   PUBMED   9463375
REFERENCE   10 (bases 1 to 6452)
  AUTHORS   Kitamura,T., Kitamura,Y., Yonezawa,K., Totty,N.F., Gout,I.,
            Hara,K., Waterfield,M.D., Sakaue,M., Ogawa,W. and Kasuga,M.
  TITLE     Molecular cloning of p125Nap1, a protein that associates with an
            SH3 domain of Nck
  JOURNAL   Biochem Biophys Res Commun 219 (2), 509-514 (1996)
   PUBMED   8605018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG699081.1, BC011762.1, AL136549.1 and AC008676.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001037333.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.158742.1,
                                           SRR1660805.48154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620254.5/ ENSP00000479968.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               BG699081.1         49-592
            545-2407            BC011762.1         714-2576
            2408-4082           AL136549.1         2450-4124
            4083-6452           AC008676.6         158754-161123       c
FEATURES             Location/Qualifiers
     source          1..6452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..6452
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /note="cytoplasmic FMR1 interacting protein 2"
                     /db_xref="GeneID:26999"
                     /db_xref="HGNC:HGNC:13760"
                     /db_xref="MIM:606323"
     exon            1..73
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            74..213
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3858
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /note="isoform a is encoded by transcript variant 1;
                     p53-inducible protein 121"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 2 isoform
                     a"
                     /protein_id="NP_001032410.1"
                     /db_xref="CCDS:CCDS75364.1"
                     /db_xref="GeneID:26999"
                     /db_xref="HGNC:HGNC:13760"
                     /db_xref="MIM:606323"
                     /translation="MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDT
                     NFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQP
                     NRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLT
                     LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHN
                     RITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDG
                     NVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTC
                     TQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDL
                     ALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAF
                     VEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLIS
                     VLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLE
                     SLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFRE
                     FFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFK
                     KQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYP
                     PSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELE
                     WLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCY
                     NGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFK
                     TICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGIL
                     EFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNI
                     LPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCG
                     LSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEF
                     TAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMA
                     DRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC"
     exon            214..303
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            304..381
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            382..483
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            484..665
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            666..762
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            763..891
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            892..996
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1088
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1206
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1326
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1452
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1619
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1767
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1921
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2078
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2175
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2252
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2361
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2481
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2681
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2769
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2913
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3004
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3135
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3208
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3303
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3542
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3690
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..6452
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6423..6428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /note="hexamer: ATTAAA"
     polyA_site      6452
                     /gene="CYFIP2"
                     /gene_synonym="DEE65; EIEE65; PIR121"
                     /note="major polyA site"
ORIGIN      
        1 agagcatcct gcgccccggc gcggggccct gcggtagcct caggcccctc ccctggaccc
       61 gccgcagagc cagtgcagaa tacagaaact gcagccatga ccacgcacgt caccctggaa
      121 gatgccctgt ccaacgtgga cctgcttgaa gagcttcccc tccccgacca gcagccatgc
      181 atcgagcctc caccttcctc catcatgtac caggctaact ttgacacaaa ctttgaggac
      241 aggaatgcat ttgtcacggg cattgcaagg tacattgagc aggctacagt ccactccagc
      301 atgaatgaga tgctggagga aggacatgag tatgcggtca tgctgtacac ctggcgcagc
      361 tgttcccggg ccattcccca ggtgaaatgc aacgagcagc ccaaccgagt agagatctat
      421 gagaagacag tagaggtgct ggagccggag gtcaccaagc tcatgaagtt catgtatttt
      481 cagcgcaagg ccatcgagcg gttctgcagc gaggtgaagc ggctgtgcca tgccgagcgc
      541 aggaaggact ttgtctctga ggcctacctc ctgacccttg gcaagttcat caacatgttt
      601 gctgtcctgg atgagctaaa gaacatgaag tgcagcgtca agaatgacca ctctgcctac
      661 aagagggcag cacagttcct gcggaagatg gcagatcccc agtctatcca ggagtcgcag
      721 aacctttcca tgttcctggc caaccacaac aggatcaccc agtgtctcca ccagcaactt
      781 gaagtgatcc caggctatga ggagctgctg gctgacattg tcaacatctg tgtggattac
      841 tacgagaaca agatgtacct gactcccagt gagaaacata tgctcctcaa ggtgatgggc
      901 tttggcctct acctaatgga tggaaatgtc agtaacattt acaaactgga tgccaagaag
      961 agaattaatc ttagcaaaat tgataaattc tttaagcagc tgcaggtggt gccccttttc
     1021 ggcgacatgc agatagagct ggccagatac attaagacca gtgctcacta tgaagagaac
     1081 aagtccaagt ggacgtgcac ccagagcagc atcagccccc agtacaatat ctgcgagcag
     1141 atggttcaga tccgggatga ccacatccgc ttcatctccg agctcgctcg ctacagcaac
     1201 agtgaggtgg tgacgggctc agggctggac agccagaagt cagacgagga gtatcgcgag
     1261 ctcttcgacc tagccctgcg gggtctgcag cttctatcca agtggagcgc ccacgtcatg
     1321 gaggtgtact cttggaagct ggttcatccc acagacaagt tctgcaacaa ggactgtcct
     1381 ggcaccgcgg aggaatatga gagagccaca cgctacaatt acaccagtga ggaaaaattt
     1441 gccttcgttg aggtgatcgc catgatcaaa ggcctgcagg tgctcatggg caggatggag
     1501 agcgtcttca accaggccat caggaacacc atctacgcgg cattgcagga cttcgcccag
     1561 gtgacgctgc gtgagcccct gcggcaggcg gtacggaaga agaagaatgt cctcatcagc
     1621 gtcctacagg caattcgaaa gaccatctgt gactgggagg gagggcgaga gccccctaat
     1681 gacccatgct tgagagggga gaaggacccc aaaggtggat ttgatatcaa ggtgccccgg
     1741 cgtgctgtgg ggccatccag cacacagctg tacatggtgc ggaccatgct tgaatcactc
     1801 attgcagaca aaagcggctc caagaagacc ctgaggagca gcctggatgg acccattgtc
     1861 ctcgccatag aggactttca caaacagtcc ttcttcttca cacatctgct caacatcagt
     1921 gaagccctgc agcagtgttg tgacctctcc cagctctggt tccgagaatt cttcctggag
     1981 ttaaccatgg gccgacgaat ccagttcccc atcgagatgt ccatgccctg gattctaacg
     2041 gaccatatcc tggaaaccaa agaaccttcc atgatggagt atgtcctcta ccctctggat
     2101 ctgtacaacg acagcgccta ctatgctctg accaagttta aaaagcagtt cctgtacgat
     2161 gagatagaag ctgaggtgaa cctgtgtttt gatcagtttg tctacaagct ggcagaccag
     2221 atctttgctt actacaaagc catggctggc agtgtcctgt tggataaacg ttttcgagct
     2281 gagtgtaaga attatggcgt catcattccg tatccaccgt ccaatcgcta tgaaacactg
     2341 ctgaagcaga gacacgtcca gctgttgggt agatcaattg acttgaacag actcattacc
     2401 cagcgcatct ctgccgccat gtataaatcc ttggaccaag ctatcagccg ctttgagagt
     2461 gaggacctga cctccattgt ggagctggag tggctgctgg agattaaccg gctcacgcat
     2521 cggctgctct gtaagcatat gacgctggac agcttcgatg ccatgttccg agaggccaat
     2581 cacaatgtgt ccgcccccta tggccgtatc accctgcatg tcttctggga actgaacttt
     2641 gactttctcc ccaactactg ctacaatggg tccactaacc gttttgtgcg gactgccatt
     2701 cctttcaccc aagaaccaca acgagacaaa cctgccaacg tccagcctta ttacctctat
     2761 ggatccaagc ctctcaacat tgcctacagc cacatctaca gctcctacag gaatttcgtg
     2821 gggccacctc atttcaagac tatctgcaga ctcctgggtt atcagggcat cgctgtggtc
     2881 atggaggaac tgctaaagat tgtgaagagc ttgctccaag gaaccattct ccagtatgtg
     2941 aaaacactga tagaggtgat gcccaagata tgccgcttgc cccgacatga gtatggctcc
     3001 ccagggatcc tggagttctt ccaccaccag ctgaaggaca tcattgagta cgcagagctc
     3061 aaaacagacg tgttccagag cctgagggaa gtgggcaatg ccatcctctt ctgcctcctc
     3121 atagagcaag ctctgtctca ggaggaggtc tgcgatttgc tccatgccgc acccttccaa
     3181 aacatcttgc ctagagtcta catcaaagag ggggagcgcc tggaggtccg gatgaaacgt
     3241 ctggaagcca agtatgcccc gctccacctg gtccctctga tcgagcggct ggggacccct
     3301 cagcaaatcg ccattgctcg cgagggtgac ctcctgacca aggagcggct gtgctgtggc
     3361 ctgtccatgt tcgaggtcat cctgacccgc attcggagct acctgcagga ccccatctgg
     3421 cggggcccac cgcccaccaa tggcgtcatg cacgtcgatg agtgtgtgga gttccaccgg
     3481 ctgtggagcg ccatgcagtt cgtgtactgc atccctgtgg gaaccaacga gttcacagct
     3541 gagcagtgtt tcggcgatgg cttgaactgg gctggttgct ccatcattgt cctgctgggc
     3601 cagcagcgtc gctttgacct gttcgacttc tgttaccacc tgctaaaagt gcagaggcag
     3661 gacgggaagg atgaaatcat taagaatgtg cccctgaaga agatggccga ccggatcagg
     3721 aagtatcaga tcttgaacaa tgaggttttt gccatcctga acaaatacat gaagtccgtg
     3781 gagacagaca gttccactgt ggagcatgtg cgctgcttcc agccacccat ccaccagtcc
     3841 ttggccacca cttgctaagc agaagatcct gcagaccctt atctggagga ggaagagaag
     3901 caggagagag aaagccacag ccagcctgcc ataggatcca actggacaac gtgtgggatg
     3961 gacctggaaa caagcacctc cccaaacaca tcaccactcc ctagggcggg gcctgtgcat
     4021 gctctcccat gacatctcca tgctggtttc tccatagcat aaatgaaaaa aaaaaaaaaa
     4081 aagtaaacag ggcagtgtgt gctttttctt ttctcccccc tcaactatat taagaactcc
     4141 tagtttcacc ctttctccat cccatcatcc cacctatctg tggttgcttc ccaagacctc
     4201 ctcccaagat agacatctcc tacccagtgc ccttgtgtga ccccaggact caagtctcag
     4261 actgtgaaca gatgtggcca tgcccagaga cgccagcctg gccagaaggg catgcctcag
     4321 cttactactt catctctcct ggttccctcc ctgcagtgcc ccgggtgtca tcttctccca
     4381 ctctgggtac cagggattct accacatagg cttcccaaag ccccattcta actcccctct
     4441 ctcagggaag ccctagagag aggtccaaaa agcattcaca gctgtatcac actctatgca
     4501 ggtggggtag gagactgatc aggcctgctg tggggaagca gtatgtatga acacagccag
     4561 aaatgtcata gtccaaacag gatgctttca ggccatctca gctgcttgat ggtgagatgg
     4621 ttcccttatt ccttcaggaa aggcttagca ttgggccaca taggggaagc agctttgaac
     4681 aaatcagtca tagcactgcc tatagcatta gccagtgacc aaattaggga caacgtcttg
     4741 gcacagaatt gcttatcaag gaacatttcc acaagaaaga aaatattaag gggttatttc
     4801 cacagaagcc caaaacgtct tggaaacaca gaggtgagga ggaggaatag taattgtcaa
     4861 tgagctttta ataccaagat acaccccctg cccccaaaga agagtcctct tttagggaat
     4921 cagaaccttc attgtcctag aagctgaaag attcttggaa cattttagct tttactctca
     4981 acttgctgtt ctctttacat tccttaagtt agactttcgg gtgtggcttc tctcccaggg
     5041 gtaacattta cttccatttt ctagactgaa ccaaaagtct tctgcagaat ctcccaccga
     5101 gtgtggtaag aaggaaggac aaaaggcttt aggatataaa tttcatgtta cagagcatgt
     5161 cattgtcaaa ggaaatctgt ggccctgaga ttttaagaac ataaaatgtg acatttgata
     5221 tttctccagc ccagggaagt aagatggtta gcaatggttg ccttaatcaa atggtcccat
     5281 ttttaacccc aaaggaagtg cccacagcaa gaggtttgtg tgatgcactt atgtcctccg
     5341 gtgaggaaag ggggccacat atgaaaggcc ccttaggtca gatcctgaga gtagcacatt
     5401 tgagtgcaga ttcctgggcc ccacctcaaa cctactaatt ctgaatctct gggaataggg
     5461 ccaggaaatc tgccctttct acaaactacc caagttgttc tgttgcacat caatgtttgg
     5521 gaaccactgc tgtaagggaa tcattctggt caccttgagc tttgagctac cactaagcca
     5581 tgaaagaaaa tacatcatac agggaagaga gaagggagga ggttccaagt agtaactggc
     5641 agatcctcct gtctggaggt accaccttct attctggttt ctgacttttc cttcttgatg
     5701 accatagatg tgttccagag gcaaaagaga cacattatcc cagatggcag aacatgcttt
     5761 caaaacatat aaaatgtcaa agttccagat ccttctacat ctttagtcct gtctgaggat
     5821 ggtagctggc tctctgtagc tgatagatgg ctagagttcc atccaaatcc ttgaccacga
     5881 cttcatggag atttgaataa tctatttgat gagatttcta tttcaataac ccacctctct
     5941 caccccacat tcatatccct aaatttgacc ctctgggccg agtcacatta ccttcaggag
     6001 acttgatccc agtagactga ggtcttccct ttcagcagaa agatttcatt tccctggctt
     6061 gccagtggca ctgatttccg aacacccaat gagtttaata ttctttcctc cttggcatta
     6121 ctgccccagc ctctttttat tttttttgtg tgtgtctaat aaccaggaaa aaaataaagc
     6181 ttaggtttta aaaagtttta aaaataatct gtttcagaaa ctgtcaaatg taccatattt
     6241 gtattaagag ttgttgggaa tttttgtaca atgaatttac atttatttat ggtgacatat
     6301 ttacgcttgt gatcaaataa tgatgttaaa ttcttaaatc atatttgcta tgcagctgaa
     6361 gatgatattt tgatttgtat tttgggggta cctgtgttga gttgataaac atttccatct
     6421 tcattaaaac tgcttccaaa ctagtaaaac ca
//
