LOCUS       NM_014608               6826 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytoplasmic FMR1 interacting protein 1 (CYFIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_014608
VERSION     NM_014608.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6826)
  AUTHORS   Sheridan,S.D., Horng,J.E., Yeh,H., McCrea,L., Wang,J., Fu,T. and
            Perlis,R.H.
  TITLE     Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment
  JOURNAL   Biol Psychiatry 95 (7), 676-686 (2024)
   PUBMED   37573007
  REMARK    GeneRIF: Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment.
REFERENCE   2  (bases 1 to 6826)
  AUTHORS   Mengzhen,Z., Xinwei,H., Zeheng,T., Nan,L., Yang,Y., Huirong,Y.,
            Kaisi,F., Xiaoting,D., Liucheng,Y. and Kai,W.
  TITLE     Integrated machine learning-driven disulfidptosis profiling: CYFIP1
            and EMILIN1 as therapeutic nodes in neuroblastoma
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 109 (2024)
   PUBMED   38427078
  REMARK    GeneRIF: Integrated machine learning-driven disulfidptosis
            profiling: CYFIP1 and EMILIN1 as therapeutic nodes in
            neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6826)
  AUTHORS   Peng,X., Wellard,N., Ghosh,A., Troakes,C. and Giese,K.P.
  TITLE     Different dysregulations of CYFIP1 and CYFIP2 in distinct types of
            dementia
  JOURNAL   Brain Res Bull 206, 110849 (2024)
   PUBMED   38128786
  REMARK    GeneRIF: Different dysregulations of CYFIP1 and CYFIP2 in distinct
            types of dementia.
REFERENCE   4  (bases 1 to 6826)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6826)
  AUTHORS   Biembengut,I.V., Silva,I.L.Z., Souza,T.A.C.B. and Shigunov,P.
  TITLE     Cytoplasmic FMR1 interacting protein (CYFIP) family members and
            their function in neural development and disorders
  JOURNAL   Mol Biol Rep 48 (8), 6131-6143 (2021)
   PUBMED   34327661
  REMARK    GeneRIF: Cytoplasmic FMR1 interacting protein (CYFIP) family
            members and their function in neural development and disorders.
            Review article
REFERENCE   6  (bases 1 to 6826)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 6826)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: located in the genomic domain between break points 1 and 2
            on chromosome 15, of the Prader-Willi/Angelman syndromes
REFERENCE   8  (bases 1 to 6826)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   9  (bases 1 to 6826)
  AUTHORS   Witke,W., Podtelejnikov,A.V., Di Nardo,A., Sutherland,J.D.,
            Gurniak,C.B., Dotti,C. and Mann,M.
  TITLE     In mouse brain profilin I and profilin II associate with regulators
            of the endocytic pathway and actin assembly
  JOURNAL   EMBO J 17 (4), 967-976 (1998)
   PUBMED   9463375
REFERENCE   10 (bases 1 to 6826)
  AUTHORS   Kobayashi,K., Kuroda,S., Fukata,M., Nakamura,T., Nagase,T.,
            Nomura,N., Matsuura,Y., Yoshida-Kubomura,N., Iwamatsu,A. and
            Kaibuchi,K.
  TITLE     p140Sra-1 (specifically Rac1-associated protein) is a novel
            specific target for Rac1 small GTPase
  JOURNAL   J Biol Chem 273 (1), 291-295 (1998)
   PUBMED   9417078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090764.35, AC011767.12 and
            CB250660.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014608.5.
            
            Summary: This gene encodes a protein that regulates cytoskeletal
            dynamics and protein translation. The encoded protein is a
            component of the WAVE regulatory complex (WRC), which promotes
            actin polymerization. This protein also interacts with the synaptic
            functional regulator FMR1 protein and translation initiation factor
            4E to inhibit protein translation. A large chromosomal deletion
            including this gene is associated with increased risk of
            schizophrenia and epilepsy in human patients. Reduced expression of
            this gene has been observed in various human cancers and the
            encoded protein may inhibit tumor invasion. [provided by RefSeq,
            Mar 2022].
            
            Transcript Variant: This variant (1), as well as variants 2-4,
            encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291604.1, SRR14038197.2164528.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617928.5/ ENSP00000481038.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC090764.35        98159-98240         c
            83-205              AC090764.35        65041-65163         c
            206-295             AC090764.35        64875-64964         c
            296-373             AC090764.35        62734-62811         c
            374-475             AC090764.35        62430-62531         c
            476-657             AC090764.35        61045-61226         c
            658-754             AC090764.35        57283-57379         c
            755-883             AC090764.35        57064-57192         c
            884-988             AC090764.35        54976-55080         c
            989-1080            AC090764.35        51674-51765         c
            1081-1198           AC090764.35        50095-50212         c
            1199-1321           AC090764.35        45778-45900         c
            1322-1447           AC090764.35        43854-43979         c
            1448-1614           AC090764.35        36564-36730         c
            1615-1762           AC090764.35        35660-35807         c
            1763-1916           AC090764.35        34349-34502         c
            1917-2073           AC090764.35        32598-32754         c
            2074-2170           AC090764.35        30051-30147         c
            2171-2247           AC090764.35        28609-28685         c
            2248-2356           AC090764.35        28392-28500         c
            2357-2476           AC090764.35        27066-27185         c
            2477-2676           AC090764.35        21578-21777         c
            2677-2764           AC090764.35        10762-10849         c
            2765-2908           AC090764.35        740-883             c
            2909-2999           AC011767.12        17909-17999
            3000-3130           AC011767.12        19802-19932
            3131-3203           AC011767.12        24574-24646
            3204-3298           AC011767.12        25201-25295
            3299-3537           AC011767.12        26116-26354
            3538-3685           AC011767.12        26873-27020
            3686-6123           AC011767.12        29653-32090
            6124-6826           CB250660.1         14-716              c
FEATURES             Location/Qualifiers
     source          1..6826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..6826
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="cytoplasmic FMR1 interacting protein 1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
     exon            1..82
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..205
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..3850
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="isoform a is encoded by transcript variant 1;
                     cytoplasmic FMRP interacting protein 1; specifically
                     Rac1-associated protein 1; selective hybridizing clone"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 1 isoform
                     a"
                     /protein_id="NP_055423.1"
                     /db_xref="CCDS:CCDS73696.1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
                     /translation="MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNT
                     NFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQP
                     NRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLIT
                     LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHN
                     KITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDG
                     SVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTC
                     TSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD
                     LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA
                     LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQ
                     SVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTML
                     ESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFR
                     EFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRF
                     NKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL
                     PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVEL
                     DGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYC
                     YNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHF
                     QVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGI
                     LEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQN
                     ILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCC
                     GLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHE
                     FTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKM
                     VERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS"
     exon            206..295
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..373
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..475
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..657
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..754
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..883
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..988
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1080
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1198
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1321
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1447
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1614
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1762
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1916
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2073
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2170
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2247
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2356
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2476
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2676
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2764
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2908
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2999
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3130
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3203
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3298
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3537
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3685
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..6826
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="major polyA site"
     regulatory      5499..5504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAG"
     polyA_site      5525
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
     regulatory      6808..6813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      6826
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
ORIGIN      
        1 attcccggcc agcccgagtg actcactcgg ccaaggaaac tcccagggcc cgcccaggac
       61 ccccaagccg ccgcggacgc agcccaggat ggcggcccag gtgactctgg aggacgcgct
      121 gtccaacgtg gacctcctgg aggagctgcc cctgcccgac cagcagccct gcatcgagcc
      181 cccgccatcc tcgctgctct accagccaaa tttcaacact aactttgaag acagaaatgc
      241 atttgttact ggcatcgcaa gatacattga acaagccacc gtccactcta gcatgaacga
      301 gatgctggag gagggccaag aatatgctgt catgctgtac acctggagga gctgctcccg
      361 ggccatccca caggtgaaat gtaacgagca gcctaacaga gtggaaatct acgagaaaac
      421 cgtggaggtt ctggagcctg aggtcacaaa actgatgaat ttcatgtact tccagagaaa
      481 tgccattgag cgtttctgcg gggaagtgag gcgcctgtgc catgccgaga ggaggaagga
      541 cttcgtgtca gaagcctacc tgatcacact gggcaaattc atcaacatgt tcgctgtgct
      601 ggacgagctg aagaacatga agtgcagtgt gaagaacgac cactcagcgt acaagagggc
      661 cgctcagttt ttacgtaaaa tggcagatcc acagtccatc caggaatcgc agaatctgtc
      721 catgttcctg gccaatcata acaagatcac acagtctctg cagcagcagc tcgaagtgat
      781 ttctggctac gaagagctcc tggcagatat tgtgaatctg tgtgtggatt actacgagaa
      841 caggatgtat ttgacgccca gtgagaaaca catgcttctc aaagtcatgg gatttggtct
      901 gtacctgatg gatgggagtg tcagtaacat ctataagttg gatgccaaga aaagaataaa
      961 cttatccaaa atcgacaagt acttcaagca actccaggtg gttccgctat ttggggacat
     1021 gcaaatagaa ctggcaagat atatcaagac cagcgcccac tacgaggaaa ataaatctcg
     1081 atggacgtgc acatcctccg gcagcagccc tcagtacaac atctgcgagc agatgatcca
     1141 gatccgcgag gaccacatgc gcttcatttc ggagctggcg cgctacagca acagcgaggt
     1201 ggtcacgggc tcgggccgcc aggaggccca gaagacggac gcggagtacc gcaagctctt
     1261 cgacctggcg ctgcagggcc tgcagctgtt gtcgcagtgg agcgcgcacg tgatggaagt
     1321 gtattcctgg aagcttgtgc accccaccga caagtactcc aacaaggact gccccgacag
     1381 cgctgaagag tacgagcgtg ccacgcgcta caactacacc agcgaggaga agtttgccct
     1441 agtggaggtg atcgccatga tcaaaggcct gcaggtgctg atgggcagga tggagagcgt
     1501 gttcaaccac gccatccggc acaccgtcta tgccgcactg caggacttct cccaggtgac
     1561 ccttagggag ccgctgcggc aggccatcaa gaagaagaag aacgtcatcc agagtgtcct
     1621 gcaggccatc aggaagaccg tgtgtgactg ggagacgggg catgagccct tcaatgaccc
     1681 agccttgcgg ggcgagaagg accccaagag cggcttcgac ataaaagtac cacgccgcgc
     1741 cgtgggaccc tccagcactc agctttacat ggtgagaacc atgctagagt ccctcattgc
     1801 agacaaaagt ggttccaaga aaaccttgag aagtagcctt gaggggccca ccatattgga
     1861 catagaaaaa tttcatcgag agtcattctt ctacactcac ttgataaatt tcagtgaaac
     1921 gctgcagcag tgctgtgacc tttcgcagct gtggttccga gagttcttcc tggagctgac
     1981 catgggcagg aggatccagt tccccattga gatgtcgatg ccctggatcc tgacggacca
     2041 catcctggag accaaggagg catcgatgat ggagtacgtg ctctactccc tggacctgta
     2101 caatgacagc gcccactacg cgctcaccag gttcaacaag cagttcctgt acgacgaaat
     2161 tgaggccgag gtgaatctat gttttgacca atttgtttac aagctagcag accagatatt
     2221 tgcctattat aaggttatgg caggaagttt gcttcttgat aaacggttac gatcagaatg
     2281 caagaatcag ggagccacga tccacctccc gccgtctaac cgctacgaga cgctgctgaa
     2341 gcagaggcat gtgcagctcc tcggcagatc aatagacctc aatcgtctga tcacccagcg
     2401 cgtctcagca gccatgtata agtccctaga actggcgatt ggacgatttg aaagtgaaga
     2461 tttgacctcc atagttgagc tggatggcct gttggaaatc aaccgcatga cccacaagct
     2521 gctgagccgg tacctgacgc tggacggctt cgacgccatg ttccgggagg ccaaccacaa
     2581 cgtgtcagcg ccctacggga ggatcaccct gcacgtcttc tgggagctca actatgactt
     2641 cctgcccaac tactgctaca acggctctac caaccggttt gttcggacag tgttaccatt
     2701 ttctcaggaa tttcaaagag ataagcagcc taatgcacag cctcagtatc tgcatggatc
     2761 caaggctttg aacttggcct actccagcat ttacggcagc taccggaact tcgtgggacc
     2821 tccacacttt caagtcatct gccggcttct cggctaccag ggtatcgccg tggtcatgga
     2881 ggagctgctg aaggtcgtca agagcctgct gcaaggcaca atcctgcagt acgtgaagac
     2941 gctgatggag gtgatgccca agatctgccg cctgccccgg cacgagtacg gctctcctgg
     3001 tatcctggag ttcttccacc accagctgaa ggacatcgtg gagtacgcag agctgaagac
     3061 ggtgtgcttc cagaacctgc gggaggtggg gaacgccatc ctcttctgcc tgctcatcga
     3121 gcagagcctg tctttagaag aagtgtgtga cctgctgcac gcggctcctt tccagaacat
     3181 cttgccgcga gtccatgtga aagaggggga gagacttgat gccaaaatga aaagactaga
     3241 atcaaagtac gccccgctgc atcttgtccc actgattgaa agactgggga cccctcagca
     3301 aattgccatc gcaagagagg gggacctgct gacaaaggag cgcctctgct gcggcctgtc
     3361 catgtttgag gtcatcctga cacggatccg gagctttctg gatgacccca tctggcgcgg
     3421 gcctctgccc agcaatgggg tcatgcatgt ggacgagtgt gtggagtttc acagactgtg
     3481 gagtgccatg cagtttgtct actgcattcc cgtggggaca cacgagttca cagtcgagca
     3541 gtgctttggt gatgggctac actgggctgg ctgtatgatc atcgtacttc ttgggcagca
     3601 gcggcgtttt gctgtgctgg atttctgcta ccatctactt aaagtccaga aacatgatgg
     3661 caaagatgag attattaaaa atgtgccttt gaagaagatg gtggagagaa ttcgcaagtt
     3721 ccagattctc aatgatgaga tcatcaccat cctggataag tacctgaagt caggcgacgg
     3781 ggagggcacg ccagtggagc atgtgcgctg cttccagccg cccatccacc agtccctcgc
     3841 cagcagctga gggcacgcgc tgcactccgt aactcaacat ggcatgcctt tctctccgta
     3901 aactatttag tgagattttt agggactatt tttcagtatc tctgtacctg ttaaaggggg
     3961 tgcttttcga tctaaaaact taattttata aaattgactt atttttctag actaaaattg
     4021 tatatgcttt tggtaattag gaactcttga gaatattggc tgctgattgt tgccatcacg
     4081 ttcctacaaa attgtttttc tatgggatgt tctggcagct gtgtcataaa atgctgctgg
     4141 gttcattcat tcattccata agaaacttaa taccagcaaa tgcattaaat cccttgccag
     4201 ttaccattaa ctgtaactat ttagcttttg tttagggatc tttctgatgg tcttttatga
     4261 gcaatcttag ttctaagtca ttgttcccat cccttttttg tgtgtttcag aaaatagtga
     4321 acttgattcc cctgcttcca ctaaatccag ttgtgacaaa atctaacgtg acatcagatc
     4381 gaaaggttat agaaataaaa ctaatgagat ctatttgtgt tcatttattt actctaaccc
     4441 tgtgctgcct ggcttggcaa ggaactctaa cctgaactca cataccaggc cagctgggat
     4501 ggaggtcacc tctaaggctg aggtgggatg ggaccgtgac accatcccat ataccgctca
     4561 cctcagcaca ggtttagctt tatatttagg gttccgcagg caaatgaggt gtaaaacggc
     4621 cgtgttggct gctccaatct ggatatgaag aggctactca gtgcctctct gttacctgtg
     4681 cccatgacct ggaggaagcc agcaatgtgg gaggagatca gtcaggccca gtgggtgctg
     4741 cacaaaggga ccgggagcac cgagtccagc cttcagctgt ccccgatcca cagggctcac
     4801 atggctggag ctggttcaca tgatctgtca gaatgaaaaa caatcggtct agactaccag
     4861 tagagtcacg aacatgtttg agaaactaaa gccatatttt aaaaagtact aaggcaatga
     4921 ggttctgaaa atcctaacta actgaatgga aaaagatgct atgcctgttt attgtagatg
     4981 aatactacag ataaacacaa gtccagcatg attaactgaa ctcactttat attgtagcct
     5041 ggcagtcatt ttacattatt tggagtattg caaccttcac caattttaaa attttctatg
     5101 gatgccaagt tgccataaaa agcaggcctc gcctactttt ccggaggcct ttggaaactg
     5161 tccagaagca tatgatgcac ggcacagaaa agtagtaagt gtacgaacca tcctgttaca
     5221 ctgccaaact cactcaagtg acatgaagcc taacaaacaa ttattctttc tttataaaaa
     5281 gttccctaaa aatgcttttg gtaatgtgaa ttaataaccc tggggccagc attctgctgc
     5341 agatttagag gtggtagctg tgcttatctt agaaactaca gaataggatg aaaaattatg
     5401 gtaaaactta atcaattacc aagttttata aggcttaatt atataccaaa tatgtaatac
     5461 cttaggtata agacaatctc aagtgctaca aaatgttaaa taagaattta ttatttatta
     5521 acctatgcat gttcaaatga gtctctgtcc tcaaggggga gaaaactggt tcttttatgt
     5581 acaaagcaca gatgtaggta cagtatataa acagatacgt agtacatctg tagtattaaa
     5641 atggcatggg aggaggcagt tagaaaaaac atctaaaaca gctccttaga aggccaataa
     5701 taaagttgga aaaaagggag tttccacgca gccagtggtg agctgcatgg gataccagca
     5761 ccattggcag gggaggccct cggggagtga tggcttggcg ctggcgcacc actgggtaac
     5821 ctccaggcag gagccacagg ctggaacagg cgaacacttt cttcccatca cctaggtgga
     5881 aattaattct gccaatactt ttttttaaag gccagtcaat ggttatgagt ggataggttc
     5941 aaagctgaat ggagttcatt agaccttttt tattattcta ccttttctgc atatgtttgc
     6001 agttttccat cgacttcttc ataaacaaac attttctaga aaccaaaata tgtagtggcc
     6061 caaaggagct cttaagcaaa gtacttggta caaagagacc atattctata aacatgttaa
     6121 gtttgttcta agcattcaga cttttagaat aagaacttca tttcaacttt ttattataac
     6181 atgagctaaa tttaagaaac aaccctagtc ttctatttcc cagagctgtt caaagtctaa
     6241 atgacaatat aactcattat gaaaatatac tgaaaagtac aagagctgat gtaaaacggt
     6301 aatcaaggtt ccaggcatca tgggattagg gtaactgaag aataaaccca gccaggctgc
     6361 aacagcaggc aggatgtgct ggcttgatga ggtgctaagg ccatcgaatg ctcagaggaa
     6421 gccggattca cggtgatcat ctcaacctga gaaatcgttc cttggggtga tttctgccct
     6481 tttttttgtt ttgtaagaaa gaggttcctt cattcagtaa cttagttttc ccttaataaa
     6541 tatttcaaaa ataaaaccaa tcatcatcaa acaaacagga gccacttttg taggtaaggt
     6601 aaatcacagg ataatgtatt gggataactc tgttttttta aaataaaaaa gccttacatg
     6661 gtcagggatt gatggagtgg ggatgacaaa tgcacatttc agactttcat caccaatgaa
     6721 aaaataaagc attttcatag acttaaaact gtcattagtg cattcggctt ttggagaagg
     6781 gatgaaaatg taaaatactt ctacaacaat aaaatgttaa tagaaa
//
