LOCUS       NM_001324122            6974 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cytoplasmic FMR1 interacting protein 1 (CYFIP1),
            transcript variant 9, mRNA.
ACCESSION   NM_001324122
VERSION     NM_001324122.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6974)
  AUTHORS   Sheridan,S.D., Horng,J.E., Yeh,H., McCrea,L., Wang,J., Fu,T. and
            Perlis,R.H.
  TITLE     Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment
  JOURNAL   Biol Psychiatry 95 (7), 676-686 (2024)
   PUBMED   37573007
  REMARK    GeneRIF: Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment.
REFERENCE   2  (bases 1 to 6974)
  AUTHORS   Mengzhen,Z., Xinwei,H., Zeheng,T., Nan,L., Yang,Y., Huirong,Y.,
            Kaisi,F., Xiaoting,D., Liucheng,Y. and Kai,W.
  TITLE     Integrated machine learning-driven disulfidptosis profiling: CYFIP1
            and EMILIN1 as therapeutic nodes in neuroblastoma
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 109 (2024)
   PUBMED   38427078
  REMARK    GeneRIF: Integrated machine learning-driven disulfidptosis
            profiling: CYFIP1 and EMILIN1 as therapeutic nodes in
            neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6974)
  AUTHORS   Peng,X., Wellard,N., Ghosh,A., Troakes,C. and Giese,K.P.
  TITLE     Different dysregulations of CYFIP1 and CYFIP2 in distinct types of
            dementia
  JOURNAL   Brain Res Bull 206, 110849 (2024)
   PUBMED   38128786
  REMARK    GeneRIF: Different dysregulations of CYFIP1 and CYFIP2 in distinct
            types of dementia.
REFERENCE   4  (bases 1 to 6974)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6974)
  AUTHORS   Biembengut,I.V., Silva,I.L.Z., Souza,T.A.C.B. and Shigunov,P.
  TITLE     Cytoplasmic FMR1 interacting protein (CYFIP) family members and
            their function in neural development and disorders
  JOURNAL   Mol Biol Rep 48 (8), 6131-6143 (2021)
   PUBMED   34327661
  REMARK    GeneRIF: Cytoplasmic FMR1 interacting protein (CYFIP) family
            members and their function in neural development and disorders.
            Review article
REFERENCE   6  (bases 1 to 6974)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 6974)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: located in the genomic domain between break points 1 and 2
            on chromosome 15, of the Prader-Willi/Angelman syndromes
REFERENCE   8  (bases 1 to 6974)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   9  (bases 1 to 6974)
  AUTHORS   Witke,W., Podtelejnikov,A.V., Di Nardo,A., Sutherland,J.D.,
            Gurniak,C.B., Dotti,C. and Mann,M.
  TITLE     In mouse brain profilin I and profilin II associate with regulators
            of the endocytic pathway and actin assembly
  JOURNAL   EMBO J 17 (4), 967-976 (1998)
   PUBMED   9463375
REFERENCE   10 (bases 1 to 6974)
  AUTHORS   Kobayashi,K., Kuroda,S., Fukata,M., Nakamura,T., Nagase,T.,
            Nomura,N., Matsuura,Y., Yoshida-Kubomura,N., Iwamatsu,A. and
            Kaibuchi,K.
  TITLE     p140Sra-1 (specifically Rac1-associated protein) is a novel
            specific target for Rac1 small GTPase
  JOURNAL   J Biol Chem 273 (1), 291-295 (1998)
   PUBMED   9417078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090764.35, AC011767.12 and
            CB250660.1.
            
            On May 31, 2019 this sequence version replaced NM_001324122.2.
            
            Summary: This gene encodes a protein that regulates cytoskeletal
            dynamics and protein translation. The encoded protein is a
            component of the WAVE regulatory complex (WRC), which promotes
            actin polymerization. This protein also interacts with the synaptic
            functional regulator FMR1 protein and translation initiation factor
            4E to inhibit protein translation. A large chromosomal deletion
            including this gene is associated with increased risk of
            schizophrenia and epilepsy in human patients. Reduced expression of
            this gene has been observed in various human cancers and the
            encoded protein may inhibit tumor invasion. [provided by RefSeq,
            Mar 2022].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2532466.1,
                                           SRR11853560.9395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC090764.35        98159-98240         c
            83-205              AC090764.35        65041-65163         c
            206-295             AC090764.35        64875-64964         c
            296-373             AC090764.35        62734-62811         c
            374-475             AC090764.35        62430-62531         c
            476-657             AC090764.35        61045-61226         c
            658-754             AC090764.35        57283-57379         c
            755-883             AC090764.35        57064-57192         c
            884-988             AC090764.35        54976-55080         c
            989-1080            AC090764.35        51674-51765         c
            1081-1198           AC090764.35        50095-50212         c
            1199-1321           AC090764.35        45778-45900         c
            1322-1447           AC090764.35        43854-43979         c
            1448-1614           AC090764.35        36564-36730         c
            1615-1762           AC090764.35        35660-35807         c
            1763-1910           AC090764.35        34754-34901         c
            1911-2064           AC090764.35        34349-34502         c
            2065-2221           AC090764.35        32598-32754         c
            2222-2318           AC090764.35        30051-30147         c
            2319-2395           AC090764.35        28609-28685         c
            2396-2504           AC090764.35        28392-28500         c
            2505-2624           AC090764.35        27066-27185         c
            2625-2824           AC090764.35        21578-21777         c
            2825-2912           AC090764.35        10762-10849         c
            2913-3056           AC090764.35        740-883             c
            3057-3147           AC011767.12        17909-17999
            3148-3278           AC011767.12        19802-19932
            3279-3351           AC011767.12        24574-24646
            3352-3446           AC011767.12        25201-25295
            3447-3685           AC011767.12        26116-26354
            3686-3833           AC011767.12        26873-27020
            3834-6271           AC011767.12        29653-32090
            6272-6974           CB250660.1         14-716              c
FEATURES             Location/Qualifiers
     source          1..6974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..6974
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="cytoplasmic FMR1 interacting protein 1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
     exon            1..82
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..205
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..295
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..373
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..475
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..657
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..754
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..883
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..988
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1080
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1198
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1321
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1447
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1614
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1762
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1910
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2064
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1917..3998
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="isoform d is encoded by transcript variant 9;
                     cytoplasmic FMRP interacting protein 1; specifically
                     Rac1-associated protein 1; selective hybridizing clone"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 1 isoform
                     d"
                     /protein_id="NP_001311051.1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
                     /translation="MVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTH
                     LINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMME
                     YVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS
                     LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYK
                     SLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPY
                     GRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKAL
                     NLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTL
                     MEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLI
                     EQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGT
                     PQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVE
                     FHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLL
                     KVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCF
                     QPPIHQSLASS"
     exon            2065..2221
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2318
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2395
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2504
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2624
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2824
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2912
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3056
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3147
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3278
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3351
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3446
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3685
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3833
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..6974
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4542..4547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      4561
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="major polyA site"
     regulatory      5647..5652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAG"
     polyA_site      5673
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
     regulatory      6956..6961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      6974
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
ORIGIN      
        1 attcccggcc agcccgagtg actcactcgg ccaaggaaac tcccagggcc cgcccaggac
       61 ccccaagccg ccgcggacgc agcccaggat ggcggcccag gtgactctgg aggacgcgct
      121 gtccaacgtg gacctcctgg aggagctgcc cctgcccgac cagcagccct gcatcgagcc
      181 cccgccatcc tcgctgctct accagccaaa tttcaacact aactttgaag acagaaatgc
      241 atttgttact ggcatcgcaa gatacattga acaagccacc gtccactcta gcatgaacga
      301 gatgctggag gagggccaag aatatgctgt catgctgtac acctggagga gctgctcccg
      361 ggccatccca caggtgaaat gtaacgagca gcctaacaga gtggaaatct acgagaaaac
      421 cgtggaggtt ctggagcctg aggtcacaaa actgatgaat ttcatgtact tccagagaaa
      481 tgccattgag cgtttctgcg gggaagtgag gcgcctgtgc catgccgaga ggaggaagga
      541 cttcgtgtca gaagcctacc tgatcacact gggcaaattc atcaacatgt tcgctgtgct
      601 ggacgagctg aagaacatga agtgcagtgt gaagaacgac cactcagcgt acaagagggc
      661 cgctcagttt ttacgtaaaa tggcagatcc acagtccatc caggaatcgc agaatctgtc
      721 catgttcctg gccaatcata acaagatcac acagtctctg cagcagcagc tcgaagtgat
      781 ttctggctac gaagagctcc tggcagatat tgtgaatctg tgtgtggatt actacgagaa
      841 caggatgtat ttgacgccca gtgagaaaca catgcttctc aaagtcatgg gatttggtct
      901 gtacctgatg gatgggagtg tcagtaacat ctataagttg gatgccaaga aaagaataaa
      961 cttatccaaa atcgacaagt acttcaagca actccaggtg gttccgctat ttggggacat
     1021 gcaaatagaa ctggcaagat atatcaagac cagcgcccac tacgaggaaa ataaatctcg
     1081 atggacgtgc acatcctccg gcagcagccc tcagtacaac atctgcgagc agatgatcca
     1141 gatccgcgag gaccacatgc gcttcatttc ggagctggcg cgctacagca acagcgaggt
     1201 ggtcacgggc tcgggccgcc aggaggccca gaagacggac gcggagtacc gcaagctctt
     1261 cgacctggcg ctgcagggcc tgcagctgtt gtcgcagtgg agcgcgcacg tgatggaagt
     1321 gtattcctgg aagcttgtgc accccaccga caagtactcc aacaaggact gccccgacag
     1381 cgctgaagag tacgagcgtg ccacgcgcta caactacacc agcgaggaga agtttgccct
     1441 agtggaggtg atcgccatga tcaaaggcct gcaggtgctg atgggcagga tggagagcgt
     1501 gttcaaccac gccatccggc acaccgtcta tgccgcactg caggacttct cccaggtgac
     1561 ccttagggag ccgctgcggc aggccatcaa gaagaagaag aacgtcatcc agagtgtcct
     1621 gcaggccatc aggaagaccg tgtgtgactg ggagacgggg catgagccct tcaatgaccc
     1681 agccttgcgg ggcgagaagg accccaagag cggcttcgac ataaaagtac cacgccgcgc
     1741 cgtgggaccc tccagcactc agctctacct ggtgcgcacc atggccgagt ccttgggctc
     1801 tgccgagctg ctcaggcagc tcaagtctct gggcatggag aggctcttgc atgcggttaa
     1861 cacgtttctg aggcagtcgt gcacctacct acccctttta acctttggtg ctttacatgg
     1921 tgagaaccat gctagagtcc ctcattgcag acaaaagtgg ttccaagaaa accttgagaa
     1981 gtagccttga ggggcccacc atattggaca tagaaaaatt tcatcgagag tcattcttct
     2041 acactcactt gataaatttc agtgaaacgc tgcagcagtg ctgtgacctt tcgcagctgt
     2101 ggttccgaga gttcttcctg gagctgacca tgggcaggag gatccagttc cccattgaga
     2161 tgtcgatgcc ctggatcctg acggaccaca tcctggagac caaggaggca tcgatgatgg
     2221 agtacgtgct ctactccctg gacctgtaca atgacagcgc ccactacgcg ctcaccaggt
     2281 tcaacaagca gttcctgtac gacgaaattg aggccgaggt gaatctatgt tttgaccaat
     2341 ttgtttacaa gctagcagac cagatatttg cctattataa ggttatggca ggaagtttgc
     2401 ttcttgataa acggttacga tcagaatgca agaatcaggg agccacgatc cacctcccgc
     2461 cgtctaaccg ctacgagacg ctgctgaagc agaggcatgt gcagctcctc ggcagatcaa
     2521 tagacctcaa tcgtctgatc acccagcgcg tctcagcagc catgtataag tccctagaac
     2581 tggcgattgg acgatttgaa agtgaagatt tgacctccat agttgagctg gatggcctgt
     2641 tggaaatcaa ccgcatgacc cacaagctgc tgagccggta cctgacgctg gacggcttcg
     2701 acgccatgtt ccgggaggcc aaccacaacg tgtcagcgcc ctacgggagg atcaccctgc
     2761 acgtcttctg ggagctcaac tatgacttcc tgcccaacta ctgctacaac ggctctacca
     2821 accggtttgt tcggacagtg ttaccatttt ctcaggaatt tcaaagagat aagcagccta
     2881 atgcacagcc tcagtatctg catggatcca aggctttgaa cttggcctac tccagcattt
     2941 acggcagcta ccggaacttc gtgggacctc cacactttca agtcatctgc cggcttctcg
     3001 gctaccaggg tatcgccgtg gtcatggagg agctgctgaa ggtcgtcaag agcctgctgc
     3061 aaggcacaat cctgcagtac gtgaagacgc tgatggaggt gatgcccaag atctgccgcc
     3121 tgccccggca cgagtacggc tctcctggta tcctggagtt cttccaccac cagctgaagg
     3181 acatcgtgga gtacgcagag ctgaagacgg tgtgcttcca gaacctgcgg gaggtgggga
     3241 acgccatcct cttctgcctg ctcatcgagc agagcctgtc tttagaagaa gtgtgtgacc
     3301 tgctgcacgc ggctcctttc cagaacatct tgccgcgagt ccatgtgaaa gagggggaga
     3361 gacttgatgc caaaatgaaa agactagaat caaagtacgc cccgctgcat cttgtcccac
     3421 tgattgaaag actggggacc cctcagcaaa ttgccatcgc aagagagggg gacctgctga
     3481 caaaggagcg cctctgctgc ggcctgtcca tgtttgaggt catcctgaca cggatccgga
     3541 gctttctgga tgaccccatc tggcgcgggc ctctgcccag caatggggtc atgcatgtgg
     3601 acgagtgtgt ggagtttcac agactgtgga gtgccatgca gtttgtctac tgcattcccg
     3661 tggggacaca cgagttcaca gtcgagcagt gctttggtga tgggctacac tgggctggct
     3721 gtatgatcat cgtacttctt gggcagcagc ggcgttttgc tgtgctggat ttctgctacc
     3781 atctacttaa agtccagaaa catgatggca aagatgagat tattaaaaat gtgcctttga
     3841 agaagatggt ggagagaatt cgcaagttcc agattctcaa tgatgagatc atcaccatcc
     3901 tggataagta cctgaagtca ggcgacgggg agggcacgcc agtggagcat gtgcgctgct
     3961 tccagccgcc catccaccag tccctcgcca gcagctgagg gcacgcgctg cactccgtaa
     4021 ctcaacatgg catgcctttc tctccgtaaa ctatttagtg agatttttag ggactatttt
     4081 tcagtatctc tgtacctgtt aaagggggtg cttttcgatc taaaaactta attttataaa
     4141 attgacttat ttttctagac taaaattgta tatgcttttg gtaattagga actcttgaga
     4201 atattggctg ctgattgttg ccatcacgtt cctacaaaat tgtttttcta tgggatgttc
     4261 tggcagctgt gtcataaaat gctgctgggt tcattcattc attccataag aaacttaata
     4321 ccagcaaatg cattaaatcc cttgccagtt accattaact gtaactattt agcttttgtt
     4381 tagggatctt tctgatggtc ttttatgagc aatcttagtt ctaagtcatt gttcccatcc
     4441 cttttttgtg tgtttcagaa aatagtgaac ttgattcccc tgcttccact aaatccagtt
     4501 gtgacaaaat ctaacgtgac atcagatcga aaggttatag aaataaaact aatgagatct
     4561 atttgtgttc atttatttac tctaaccctg tgctgcctgg cttggcaagg aactctaacc
     4621 tgaactcaca taccaggcca gctgggatgg aggtcacctc taaggctgag gtgggatggg
     4681 accgtgacac catcccatat accgctcacc tcagcacagg tttagcttta tatttagggt
     4741 tccgcaggca aatgaggtgt aaaacggccg tgttggctgc tccaatctgg atatgaagag
     4801 gctactcagt gcctctctgt tacctgtgcc catgacctgg aggaagccag caatgtggga
     4861 ggagatcagt caggcccagt gggtgctgca caaagggacc gggagcaccg agtccagcct
     4921 tcagctgtcc ccgatccaca gggctcacat ggctggagct ggttcacatg atctgtcaga
     4981 atgaaaaaca atcggtctag actaccagta gagtcacgaa catgtttgag aaactaaagc
     5041 catattttaa aaagtactaa ggcaatgagg ttctgaaaat cctaactaac tgaatggaaa
     5101 aagatgctat gcctgtttat tgtagatgaa tactacagat aaacacaagt ccagcatgat
     5161 taactgaact cactttatat tgtagcctgg cagtcatttt acattatttg gagtattgca
     5221 accttcacca attttaaaat tttctatgga tgccaagttg ccataaaaag caggcctcgc
     5281 ctacttttcc ggaggccttt ggaaactgtc cagaagcata tgatgcacgg cacagaaaag
     5341 tagtaagtgt acgaaccatc ctgttacact gccaaactca ctcaagtgac atgaagccta
     5401 acaaacaatt attctttctt tataaaaagt tccctaaaaa tgcttttggt aatgtgaatt
     5461 aataaccctg gggccagcat tctgctgcag atttagaggt ggtagctgtg cttatcttag
     5521 aaactacaga ataggatgaa aaattatggt aaaacttaat caattaccaa gttttataag
     5581 gcttaattat ataccaaata tgtaatacct taggtataag acaatctcaa gtgctacaaa
     5641 atgttaaata agaatttatt atttattaac ctatgcatgt tcaaatgagt ctctgtcctc
     5701 aagggggaga aaactggttc ttttatgtac aaagcacaga tgtaggtaca gtatataaac
     5761 agatacgtag tacatctgta gtattaaaat ggcatgggag gaggcagtta gaaaaaacat
     5821 ctaaaacagc tccttagaag gccaataata aagttggaaa aaagggagtt tccacgcagc
     5881 cagtggtgag ctgcatggga taccagcacc attggcaggg gaggccctcg gggagtgatg
     5941 gcttggcgct ggcgcaccac tgggtaacct ccaggcagga gccacaggct ggaacaggcg
     6001 aacactttct tcccatcacc taggtggaaa ttaattctgc caatactttt ttttaaaggc
     6061 cagtcaatgg ttatgagtgg ataggttcaa agctgaatgg agttcattag acctttttta
     6121 ttattctacc ttttctgcat atgtttgcag ttttccatcg acttcttcat aaacaaacat
     6181 tttctagaaa ccaaaatatg tagtggccca aaggagctct taagcaaagt acttggtaca
     6241 aagagaccat attctataaa catgttaagt ttgttctaag cattcagact tttagaataa
     6301 gaacttcatt tcaacttttt attataacat gagctaaatt taagaaacaa ccctagtctt
     6361 ctatttccca gagctgttca aagtctaaat gacaatataa ctcattatga aaatatactg
     6421 aaaagtacaa gagctgatgt aaaacggtaa tcaaggttcc aggcatcatg ggattagggt
     6481 aactgaagaa taaacccagc caggctgcaa cagcaggcag gatgtgctgg cttgatgagg
     6541 tgctaaggcc atcgaatgct cagaggaagc cggattcacg gtgatcatct caacctgaga
     6601 aatcgttcct tggggtgatt tctgcccttt tttttgtttt gtaagaaaga ggttccttca
     6661 ttcagtaact tagttttccc ttaataaata tttcaaaaat aaaaccaatc atcatcaaac
     6721 aaacaggagc cacttttgta ggtaaggtaa atcacaggat aatgtattgg gataactctg
     6781 tttttttaaa ataaaaaagc cttacatggt cagggattga tggagtgggg atgacaaatg
     6841 cacatttcag actttcatca ccaatgaaaa aataaagcat tttcatagac ttaaaactgt
     6901 cattagtgca ttcggctttt ggagaaggga tgaaaatgta aaatacttct acaacaataa
     6961 aatgttaata gaaa
//
