LOCUS       NM_001287810            6945 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cytoplasmic FMR1 interacting protein 1 (CYFIP1),
            transcript variant 2, mRNA.
ACCESSION   NM_001287810 XM_005272544
VERSION     NM_001287810.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6945)
  AUTHORS   Sheridan,S.D., Horng,J.E., Yeh,H., McCrea,L., Wang,J., Fu,T. and
            Perlis,R.H.
  TITLE     Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment
  JOURNAL   Biol Psychiatry 95 (7), 676-686 (2024)
   PUBMED   37573007
  REMARK    GeneRIF: Loss of Function in the Neurodevelopmental Disease and
            Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells
            Supports a Functional Role in Synaptic Engulfment.
REFERENCE   2  (bases 1 to 6945)
  AUTHORS   Mengzhen,Z., Xinwei,H., Zeheng,T., Nan,L., Yang,Y., Huirong,Y.,
            Kaisi,F., Xiaoting,D., Liucheng,Y. and Kai,W.
  TITLE     Integrated machine learning-driven disulfidptosis profiling: CYFIP1
            and EMILIN1 as therapeutic nodes in neuroblastoma
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 109 (2024)
   PUBMED   38427078
  REMARK    GeneRIF: Integrated machine learning-driven disulfidptosis
            profiling: CYFIP1 and EMILIN1 as therapeutic nodes in
            neuroblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6945)
  AUTHORS   Peng,X., Wellard,N., Ghosh,A., Troakes,C. and Giese,K.P.
  TITLE     Different dysregulations of CYFIP1 and CYFIP2 in distinct types of
            dementia
  JOURNAL   Brain Res Bull 206, 110849 (2024)
   PUBMED   38128786
  REMARK    GeneRIF: Different dysregulations of CYFIP1 and CYFIP2 in distinct
            types of dementia.
REFERENCE   4  (bases 1 to 6945)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6945)
  AUTHORS   Biembengut,I.V., Silva,I.L.Z., Souza,T.A.C.B. and Shigunov,P.
  TITLE     Cytoplasmic FMR1 interacting protein (CYFIP) family members and
            their function in neural development and disorders
  JOURNAL   Mol Biol Rep 48 (8), 6131-6143 (2021)
   PUBMED   34327661
  REMARK    GeneRIF: Cytoplasmic FMR1 interacting protein (CYFIP) family
            members and their function in neural development and disorders.
            Review article
REFERENCE   6  (bases 1 to 6945)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 6945)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: located in the genomic domain between break points 1 and 2
            on chromosome 15, of the Prader-Willi/Angelman syndromes
REFERENCE   8  (bases 1 to 6945)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   9  (bases 1 to 6945)
  AUTHORS   Witke,W., Podtelejnikov,A.V., Di Nardo,A., Sutherland,J.D.,
            Gurniak,C.B., Dotti,C. and Mann,M.
  TITLE     In mouse brain profilin I and profilin II associate with regulators
            of the endocytic pathway and actin assembly
  JOURNAL   EMBO J 17 (4), 967-976 (1998)
   PUBMED   9463375
REFERENCE   10 (bases 1 to 6945)
  AUTHORS   Kobayashi,K., Kuroda,S., Fukata,M., Nakamura,T., Nagase,T.,
            Nomura,N., Matsuura,Y., Yoshida-Kubomura,N., Iwamatsu,A. and
            Kaibuchi,K.
  TITLE     p140Sra-1 (specifically Rac1-associated protein) is a novel
            specific target for Rac1 small GTPase
  JOURNAL   J Biol Chem 273 (1), 291-295 (1998)
   PUBMED   9417078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090764.35, AC011767.12 and
            CB250660.1.
            
            On May 31, 2019 this sequence version replaced NM_001287810.3.
            
            Summary: This gene encodes a protein that regulates cytoskeletal
            dynamics and protein translation. The encoded protein is a
            component of the WAVE regulatory complex (WRC), which promotes
            actin polymerization. This protein also interacts with the synaptic
            functional regulator FMR1 protein and translation initiation factor
            4E to inhibit protein translation. A large chromosomal deletion
            including this gene is associated with increased risk of
            schizophrenia and epilepsy in human patients. Reduced expression of
            this gene has been observed in various human cancers and the
            encoded protein may inhibit tumor invasion. [provided by RefSeq,
            Mar 2022].
            
            Transcript Variant: This variant (2), as well as variants 1, 3, and
            4, encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2181560.1, AY763578.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC090764.35        98159-98240         c
            83-201              AC090764.35        65783-65901         c
            202-324             AC090764.35        65041-65163         c
            325-414             AC090764.35        64875-64964         c
            415-492             AC090764.35        62734-62811         c
            493-594             AC090764.35        62430-62531         c
            595-776             AC090764.35        61045-61226         c
            777-873             AC090764.35        57283-57379         c
            874-1002            AC090764.35        57064-57192         c
            1003-1107           AC090764.35        54976-55080         c
            1108-1199           AC090764.35        51674-51765         c
            1200-1317           AC090764.35        50095-50212         c
            1318-1440           AC090764.35        45778-45900         c
            1441-1566           AC090764.35        43854-43979         c
            1567-1733           AC090764.35        36564-36730         c
            1734-1881           AC090764.35        35660-35807         c
            1882-2035           AC090764.35        34349-34502         c
            2036-2192           AC090764.35        32598-32754         c
            2193-2289           AC090764.35        30051-30147         c
            2290-2366           AC090764.35        28609-28685         c
            2367-2475           AC090764.35        28392-28500         c
            2476-2595           AC090764.35        27066-27185         c
            2596-2795           AC090764.35        21578-21777         c
            2796-2883           AC090764.35        10762-10849         c
            2884-3027           AC090764.35        740-883             c
            3028-3118           AC011767.12        17909-17999
            3119-3249           AC011767.12        19802-19932
            3250-3322           AC011767.12        24574-24646
            3323-3417           AC011767.12        25201-25295
            3418-3656           AC011767.12        26116-26354
            3657-3804           AC011767.12        26873-27020
            3805-6242           AC011767.12        29653-32090
            6243-6945           CB250660.1         14-716              c
FEATURES             Location/Qualifiers
     source          1..6945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..6945
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="cytoplasmic FMR1 interacting protein 1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
     exon            1..82
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..201
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..324
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..3969
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="isoform a is encoded by transcript variant 2;
                     cytoplasmic FMRP interacting protein 1; specifically
                     Rac1-associated protein 1; selective hybridizing clone"
                     /codon_start=1
                     /product="cytoplasmic FMR1-interacting protein 1 isoform
                     a"
                     /protein_id="NP_001274739.1"
                     /db_xref="CCDS:CCDS73696.1"
                     /db_xref="GeneID:23191"
                     /db_xref="HGNC:HGNC:13759"
                     /db_xref="MIM:606322"
                     /translation="MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNT
                     NFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQP
                     NRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLIT
                     LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHN
                     KITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDG
                     SVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTC
                     TSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFD
                     LALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFA
                     LVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQ
                     SVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTML
                     ESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFR
                     EFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRF
                     NKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL
                     PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVEL
                     DGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYC
                     YNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHF
                     QVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGI
                     LEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQN
                     ILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCC
                     GLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHE
                     FTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKM
                     VERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS"
     exon            325..414
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..492
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..594
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..776
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..873
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1002
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1107
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1199
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1317
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1440
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1566
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1733
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1881
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2035
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2192
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2289
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2366
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2475
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2595
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2795
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2883
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3027
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3118
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3249
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3322
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3417
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3656
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3804
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..6945
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      4532
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="major polyA site"
     regulatory      5618..5623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAG"
     polyA_site      5644
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
     regulatory      6927..6932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      6945
                     /gene="CYFIP1"
                     /gene_synonym="P140SRA-1; SHYC; SRA-1; SRA1"
ORIGIN      
        1 attcccggcc agcccgagtg actcactcgg ccaaggaaac tcccagggcc cgcccaggac
       61 ccccaagccg ccgcggacgc agaatgtggc tcagctgccc ctggtcccat cccagggcag
      121 agctcctcct gagtaccctt gagactggag cagattcagc agaaggcaga ttgccccctc
      181 tccctggagc tggctctgaa gcccaggatg gcggcccagg tgactctgga ggacgcgctg
      241 tccaacgtgg acctcctgga ggagctgccc ctgcccgacc agcagccctg catcgagccc
      301 ccgccatcct cgctgctcta ccagccaaat ttcaacacta actttgaaga cagaaatgca
      361 tttgttactg gcatcgcaag atacattgaa caagccaccg tccactctag catgaacgag
      421 atgctggagg agggccaaga atatgctgtc atgctgtaca cctggaggag ctgctcccgg
      481 gccatcccac aggtgaaatg taacgagcag cctaacagag tggaaatcta cgagaaaacc
      541 gtggaggttc tggagcctga ggtcacaaaa ctgatgaatt tcatgtactt ccagagaaat
      601 gccattgagc gtttctgcgg ggaagtgagg cgcctgtgcc atgccgagag gaggaaggac
      661 ttcgtgtcag aagcctacct gatcacactg ggcaaattca tcaacatgtt cgctgtgctg
      721 gacgagctga agaacatgaa gtgcagtgtg aagaacgacc actcagcgta caagagggcc
      781 gctcagtttt tacgtaaaat ggcagatcca cagtccatcc aggaatcgca gaatctgtcc
      841 atgttcctgg ccaatcataa caagatcaca cagtctctgc agcagcagct cgaagtgatt
      901 tctggctacg aagagctcct ggcagatatt gtgaatctgt gtgtggatta ctacgagaac
      961 aggatgtatt tgacgcccag tgagaaacac atgcttctca aagtcatggg atttggtctg
     1021 tacctgatgg atgggagtgt cagtaacatc tataagttgg atgccaagaa aagaataaac
     1081 ttatccaaaa tcgacaagta cttcaagcaa ctccaggtgg ttccgctatt tggggacatg
     1141 caaatagaac tggcaagata tatcaagacc agcgcccact acgaggaaaa taaatctcga
     1201 tggacgtgca catcctccgg cagcagccct cagtacaaca tctgcgagca gatgatccag
     1261 atccgcgagg accacatgcg cttcatttcg gagctggcgc gctacagcaa cagcgaggtg
     1321 gtcacgggct cgggccgcca ggaggcccag aagacggacg cggagtaccg caagctcttc
     1381 gacctggcgc tgcagggcct gcagctgttg tcgcagtgga gcgcgcacgt gatggaagtg
     1441 tattcctgga agcttgtgca ccccaccgac aagtactcca acaaggactg ccccgacagc
     1501 gctgaagagt acgagcgtgc cacgcgctac aactacacca gcgaggagaa gtttgcccta
     1561 gtggaggtga tcgccatgat caaaggcctg caggtgctga tgggcaggat ggagagcgtg
     1621 ttcaaccacg ccatccggca caccgtctat gccgcactgc aggacttctc ccaggtgacc
     1681 cttagggagc cgctgcggca ggccatcaag aagaagaaga acgtcatcca gagtgtcctg
     1741 caggccatca ggaagaccgt gtgtgactgg gagacggggc atgagccctt caatgaccca
     1801 gccttgcggg gcgagaagga ccccaagagc ggcttcgaca taaaagtacc acgccgcgcc
     1861 gtgggaccct ccagcactca gctttacatg gtgagaacca tgctagagtc cctcattgca
     1921 gacaaaagtg gttccaagaa aaccttgaga agtagccttg aggggcccac catattggac
     1981 atagaaaaat ttcatcgaga gtcattcttc tacactcact tgataaattt cagtgaaacg
     2041 ctgcagcagt gctgtgacct ttcgcagctg tggttccgag agttcttcct ggagctgacc
     2101 atgggcagga ggatccagtt ccccattgag atgtcgatgc cctggatcct gacggaccac
     2161 atcctggaga ccaaggaggc atcgatgatg gagtacgtgc tctactccct ggacctgtac
     2221 aatgacagcg cccactacgc gctcaccagg ttcaacaagc agttcctgta cgacgaaatt
     2281 gaggccgagg tgaatctatg ttttgaccaa tttgtttaca agctagcaga ccagatattt
     2341 gcctattata aggttatggc aggaagtttg cttcttgata aacggttacg atcagaatgc
     2401 aagaatcagg gagccacgat ccacctcccg ccgtctaacc gctacgagac gctgctgaag
     2461 cagaggcatg tgcagctcct cggcagatca atagacctca atcgtctgat cacccagcgc
     2521 gtctcagcag ccatgtataa gtccctagaa ctggcgattg gacgatttga aagtgaagat
     2581 ttgacctcca tagttgagct ggatggcctg ttggaaatca accgcatgac ccacaagctg
     2641 ctgagccggt acctgacgct ggacggcttc gacgccatgt tccgggaggc caaccacaac
     2701 gtgtcagcgc cctacgggag gatcaccctg cacgtcttct gggagctcaa ctatgacttc
     2761 ctgcccaact actgctacaa cggctctacc aaccggtttg ttcggacagt gttaccattt
     2821 tctcaggaat ttcaaagaga taagcagcct aatgcacagc ctcagtatct gcatggatcc
     2881 aaggctttga acttggccta ctccagcatt tacggcagct accggaactt cgtgggacct
     2941 ccacactttc aagtcatctg ccggcttctc ggctaccagg gtatcgccgt ggtcatggag
     3001 gagctgctga aggtcgtcaa gagcctgctg caaggcacaa tcctgcagta cgtgaagacg
     3061 ctgatggagg tgatgcccaa gatctgccgc ctgccccggc acgagtacgg ctctcctggt
     3121 atcctggagt tcttccacca ccagctgaag gacatcgtgg agtacgcaga gctgaagacg
     3181 gtgtgcttcc agaacctgcg ggaggtgggg aacgccatcc tcttctgcct gctcatcgag
     3241 cagagcctgt ctttagaaga agtgtgtgac ctgctgcacg cggctccttt ccagaacatc
     3301 ttgccgcgag tccatgtgaa agagggggag agacttgatg ccaaaatgaa aagactagaa
     3361 tcaaagtacg ccccgctgca tcttgtccca ctgattgaaa gactggggac ccctcagcaa
     3421 attgccatcg caagagaggg ggacctgctg acaaaggagc gcctctgctg cggcctgtcc
     3481 atgtttgagg tcatcctgac acggatccgg agctttctgg atgaccccat ctggcgcggg
     3541 cctctgccca gcaatggggt catgcatgtg gacgagtgtg tggagtttca cagactgtgg
     3601 agtgccatgc agtttgtcta ctgcattccc gtggggacac acgagttcac agtcgagcag
     3661 tgctttggtg atgggctaca ctgggctggc tgtatgatca tcgtacttct tgggcagcag
     3721 cggcgttttg ctgtgctgga tttctgctac catctactta aagtccagaa acatgatggc
     3781 aaagatgaga ttattaaaaa tgtgcctttg aagaagatgg tggagagaat tcgcaagttc
     3841 cagattctca atgatgagat catcaccatc ctggataagt acctgaagtc aggcgacggg
     3901 gagggcacgc cagtggagca tgtgcgctgc ttccagccgc ccatccacca gtccctcgcc
     3961 agcagctgag ggcacgcgct gcactccgta actcaacatg gcatgccttt ctctccgtaa
     4021 actatttagt gagattttta gggactattt ttcagtatct ctgtacctgt taaagggggt
     4081 gcttttcgat ctaaaaactt aattttataa aattgactta tttttctaga ctaaaattgt
     4141 atatgctttt ggtaattagg aactcttgag aatattggct gctgattgtt gccatcacgt
     4201 tcctacaaaa ttgtttttct atgggatgtt ctggcagctg tgtcataaaa tgctgctggg
     4261 ttcattcatt cattccataa gaaacttaat accagcaaat gcattaaatc ccttgccagt
     4321 taccattaac tgtaactatt tagcttttgt ttagggatct ttctgatggt cttttatgag
     4381 caatcttagt tctaagtcat tgttcccatc ccttttttgt gtgtttcaga aaatagtgaa
     4441 cttgattccc ctgcttccac taaatccagt tgtgacaaaa tctaacgtga catcagatcg
     4501 aaaggttata gaaataaaac taatgagatc tatttgtgtt catttattta ctctaaccct
     4561 gtgctgcctg gcttggcaag gaactctaac ctgaactcac ataccaggcc agctgggatg
     4621 gaggtcacct ctaaggctga ggtgggatgg gaccgtgaca ccatcccata taccgctcac
     4681 ctcagcacag gtttagcttt atatttaggg ttccgcaggc aaatgaggtg taaaacggcc
     4741 gtgttggctg ctccaatctg gatatgaaga ggctactcag tgcctctctg ttacctgtgc
     4801 ccatgacctg gaggaagcca gcaatgtggg aggagatcag tcaggcccag tgggtgctgc
     4861 acaaagggac cgggagcacc gagtccagcc ttcagctgtc cccgatccac agggctcaca
     4921 tggctggagc tggttcacat gatctgtcag aatgaaaaac aatcggtcta gactaccagt
     4981 agagtcacga acatgtttga gaaactaaag ccatatttta aaaagtacta aggcaatgag
     5041 gttctgaaaa tcctaactaa ctgaatggaa aaagatgcta tgcctgttta ttgtagatga
     5101 atactacaga taaacacaag tccagcatga ttaactgaac tcactttata ttgtagcctg
     5161 gcagtcattt tacattattt ggagtattgc aaccttcacc aattttaaaa ttttctatgg
     5221 atgccaagtt gccataaaaa gcaggcctcg cctacttttc cggaggcctt tggaaactgt
     5281 ccagaagcat atgatgcacg gcacagaaaa gtagtaagtg tacgaaccat cctgttacac
     5341 tgccaaactc actcaagtga catgaagcct aacaaacaat tattctttct ttataaaaag
     5401 ttccctaaaa atgcttttgg taatgtgaat taataaccct ggggccagca ttctgctgca
     5461 gatttagagg tggtagctgt gcttatctta gaaactacag aataggatga aaaattatgg
     5521 taaaacttaa tcaattacca agttttataa ggcttaatta tataccaaat atgtaatacc
     5581 ttaggtataa gacaatctca agtgctacaa aatgttaaat aagaatttat tatttattaa
     5641 cctatgcatg ttcaaatgag tctctgtcct caagggggag aaaactggtt cttttatgta
     5701 caaagcacag atgtaggtac agtatataaa cagatacgta gtacatctgt agtattaaaa
     5761 tggcatggga ggaggcagtt agaaaaaaca tctaaaacag ctccttagaa ggccaataat
     5821 aaagttggaa aaaagggagt ttccacgcag ccagtggtga gctgcatggg ataccagcac
     5881 cattggcagg ggaggccctc ggggagtgat ggcttggcgc tggcgcacca ctgggtaacc
     5941 tccaggcagg agccacaggc tggaacaggc gaacactttc ttcccatcac ctaggtggaa
     6001 attaattctg ccaatacttt tttttaaagg ccagtcaatg gttatgagtg gataggttca
     6061 aagctgaatg gagttcatta gacctttttt attattctac cttttctgca tatgtttgca
     6121 gttttccatc gacttcttca taaacaaaca ttttctagaa accaaaatat gtagtggccc
     6181 aaaggagctc ttaagcaaag tacttggtac aaagagacca tattctataa acatgttaag
     6241 tttgttctaa gcattcagac ttttagaata agaacttcat ttcaactttt tattataaca
     6301 tgagctaaat ttaagaaaca accctagtct tctatttccc agagctgttc aaagtctaaa
     6361 tgacaatata actcattatg aaaatatact gaaaagtaca agagctgatg taaaacggta
     6421 atcaaggttc caggcatcat gggattaggg taactgaaga ataaacccag ccaggctgca
     6481 acagcaggca ggatgtgctg gcttgatgag gtgctaaggc catcgaatgc tcagaggaag
     6541 ccggattcac ggtgatcatc tcaacctgag aaatcgttcc ttggggtgat ttctgccctt
     6601 ttttttgttt tgtaagaaag aggttccttc attcagtaac ttagttttcc cttaataaat
     6661 atttcaaaaa taaaaccaat catcatcaaa caaacaggag ccacttttgt aggtaaggta
     6721 aatcacagga taatgtattg ggataactct gtttttttaa aataaaaaag ccttacatgg
     6781 tcagggattg atggagtggg gatgacaaat gcacatttca gactttcatc accaatgaaa
     6841 aaataaagca ttttcataga cttaaaactg tcattagtgc attcggcttt tggagaaggg
     6901 atgaaaatgt aaaatacttc tacaacaata aaatgttaat agaaa
//
