LOCUS       NM_001916               1191 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytochrome c1 (CYC1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001916
VERSION     NM_001916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Perez-Mejias,G., Olloqui-Sariego,J.L., Guerra-Castellano,A.,
            Diaz-Quintana,A., Calvente,J.J., Andreu,R., De la Rosa,M.A. and
            Diaz-Moreno,I.
  TITLE     Physical contact between cytochrome c1 and cytochrome c increases
            the driving force for electron transfer
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (12), 148277 (2020)
   PUBMED   32717223
  REMARK    GeneRIF: Physical contact between cytochrome c1 and cytochrome c
            increases the driving force for electron transfer.
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Suzuki,H., Hosokawa,Y., Nishikimi,M. and Ozawa,T.
  TITLE     Structural organization of the human mitochondrial cytochrome c1
            gene
  JOURNAL   J Biol Chem 264 (3), 1368-1374 (1989)
   PUBMED   2536365
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Nishikimi,M., Ohta,S., Suzuki,H., Tanaka,T., Kikkawa,F., Tanaka,M.,
            Kagawa,Y. and Ozawa,T.
  TITLE     Nucleotide sequence of a cDNA encoding the precursor to human
            cytochrome c1
  JOURNAL   Nucleic Acids Res 16 (8), 3577 (1988)
   PUBMED   2836796
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Nishikimi,M., Suzuki,H., Yamaguchi,M., Matsukage,A., Yoshida,M.C.
            and Ozawa,T.
  TITLE     Assignment of the human cytochrome c1 gene to chromosome 8
  JOURNAL   Biochem Int 16 (4), 655-660 (1988)
   PUBMED   2839188
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Nishikimi,M., Suzuki,H., Ohta,S., Sakurai,T., Shimomura,Y.,
            Tanaka,M., Kagawa,Y. and Ozawa,T.
  TITLE     Isolation of a cDNA clone for human cytochrome c1 from a lambda
            gt11 expression library
  JOURNAL   Biochem Biophys Res Commun 145 (1), 34-39 (1987)
   PUBMED   3036122
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   Shimomura,Y., Nishikimi,M. and Ozawa,T.
  TITLE     Novel purification of cytochrome c1 from mitochondrial Complex III.
            Reconstitution of antimycin-insensitive electron transfer with the
            iron-sulfur protein and cytochrome c1
  JOURNAL   J Biol Chem 260 (28), 15075-15080 (1985)
   PUBMED   2999105
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Smith,H.T., Ahmed,A.J. and Millett,F.
  TITLE     Electrostatic interaction of cytochrome c with cytochrome c1 and
            cytochrome oxidase
  JOURNAL   J Biol Chem 256 (10), 4984-4990 (1981)
   PUBMED   6262312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104592.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001916.4.
            
            Summary: This gene encodes a subunit of the cytochrome bc1 complex,
            which plays an important role in the mitochondrial respiratory
            chain by transferring electrons from the Rieske iron-sulfur protein
            to cytochrome c. Mutations in this gene may cause mitochondrial
            complex III deficiency, nuclear type 6. [provided by RefSeq, Dec
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.160191.1,
                                           SRR1163655.670400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000318911.5/
                                                  ENSP00000317159.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC104592.6         18673-18825
            154-350             AC104592.6         19430-19626
            351-477             AC104592.6         19721-19847
            478-635             AC104592.6         19934-20091
            636-796             AC104592.6         20181-20341
            797-897             AC104592.6         20631-20731
            898-1191            AC104592.6         20829-21122
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1191
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /note="cytochrome c1"
                     /db_xref="GeneID:1537"
                     /db_xref="HGNC:HGNC:2579"
                     /db_xref="MIM:123980"
     exon            1..153
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1002
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /EC_number="7.1.1.8"
                     /note="cytochrome c1, heme protein, mitochondrial; complex
                     III subunit 4; complex III subunit IV; cytochrome b-c1
                     complex subunit 4; ubiquinol-cytochrome-c reductase
                     complex cytochrome c1 subunit; cytochrome c-1"
                     /codon_start=1
                     /product="cytochrome c1, heme protein, mitochondrial
                     precursor"
                     /protein_id="NP_001907.3"
                     /db_xref="CCDS:CCDS6415.1"
                     /db_xref="GeneID:1537"
                     /db_xref="HGNC:HGNC:2579"
                     /db_xref="MIM:123980"
                     /translation="MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQA
                     VALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLL
                     SSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNE
                     DGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGY
                     CEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRW
                     ASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK"
     exon            154..350
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            351..477
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            478..635
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            636..796
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            797..897
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1191
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1169..1174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /note="hexamer: AATAAA"
     polyA_site      1191
                     /gene="CYC1"
                     /gene_synonym="MC3DN6; UQCR4"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgcg cggaggaggc caagatggcg gcagctgcgg cttcgcttcg cggggtagtg
       61 ttgggcccgc ggggcgcggg gctcccgggc gcgcgtgccc ggggtctgct gtgcagcgcg
      121 cgtcccgggc agctcccgct acggacacct caggcagtgg ccttgtcgtc gaagtctggc
      181 ctttcccgag gccggaaagt gatgctgtca gcgctgggca tgctggcggc agggggtgcg
      241 gggctggcca tggctctgca ttcggctgtg agtgccagtg acctggagct gcaccccccc
      301 agctatccgt ggtctcaccg tggcctcctc tcttccttgg accacaccag catccggagg
      361 ggtttccagg tatataagca ggtgtgcgcc tcctgccaca gcatggactt cgtggcctac
      421 cgccacctgg tgggcgtgtg ctacacggag gatgaagcta aggagctggc tgcggaggtg
      481 gaggttcaag acggccccaa tgaagatggg gagatgttca tgcggccagg gaagctgttc
      541 gactatttcc caaaaccata ccccaacagt gaggctgctc gagctgccaa caacggagca
      601 ttgccccctg acctcagcta catcgtgcga gctaggcatg gtggtgagga ctacgtcttc
      661 tccctgctca cgggctactg cgagccaccc accggggtgt cactgcggga aggtctctac
      721 ttcaacccct actttcctgg ccaggccatt gccatggccc ctcccatcta cacagatgtc
      781 ttagagtttg acgatggcac cccagctacc atgtcccaga tagccaagga tgtgtgcacc
      841 ttcctgcgct gggcatctga gccagagcac gaccatcgaa aacgcatggg gctcaagatg
      901 ttgatgatga tggctctgct ggtgcccctg gtctacacca taaagcggca caagtggtca
      961 gtcctgaaga gtcggaagct ggcatatcgg ccgcccaagt gaccctgtcc agtgtctgct
     1021 tgccatcctg ccagaacagg ccctcaagcc caagagccat cccaggcctg ttcaggcctc
     1081 agctaagcct ctcttcatct ggaagaagag gcaagggggc aggagaccag gctctagctc
     1141 tgggccctcc ttcagccccc atcatgggaa taaattaatt ttctcaatgt a
//
