LOCUS       NM_001031672            6193 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens cytochrome b5 reductase like (CYB5RL), transcript
            variant 1, mRNA.
ACCESSION   NM_001031672
VERSION     NM_001031672.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6193)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 6193)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 6193)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357673.12.
            
            On Jun 2, 2019 this sequence version replaced NM_001031672.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1910382.1,
                                           SRR11853560.1159.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534324.6/ ENSP00000434343.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL357673.12        77167-77221         c
            56-178              AL357673.12        73560-73682         c
            179-475             AL357673.12        72610-72906         c
            476-624             AL357673.12        67939-68087         c
            625-712             AL357673.12        64843-64930         c
            713-817             AL357673.12        61352-61456         c
            818-1021            AL357673.12        56340-56543         c
            1022-6193           AL357673.12        46842-52013         c
FEATURES             Location/Qualifiers
     source          1..6193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..6193
                     /gene="CYB5RL"
                     /note="cytochrome b5 reductase like"
                     /db_xref="GeneID:606495"
                     /db_xref="HGNC:HGNC:32220"
     exon            1..55
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            56..178
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            179..475
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1225
                     /gene="CYB5RL"
                     /EC_number="1.6.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NADH-cytochrome b5 reductase-like"
                     /codon_start=1
                     /product="NADH-cytochrome b5 reductase-like isoform 1"
                     /protein_id="NP_001026842.2"
                     /db_xref="CCDS:CCDS44151.1"
                     /db_xref="GeneID:606495"
                     /db_xref="HGNC:HGNC:32220"
                     /translation="MMAEREEDDDTEEAWMQLRPTEPLPSQCCGSGCSPCVFDLYHRD
                     LARWEAAQASKDRSLLRGPESQSCPSKLNPETFVAFCIIAMDRLTKDTYRVRFALPGN
                     SQLGLRPGQHLILRGIVDDLEIQRAYTPISPANAEGYFEVLIKCYQMGLMSRYVESWR
                     VGDTAFWRGPFGDFFYKPNQYGELLLLAAGTGLAPMVPILQSITDNENDETFVTLVGC
                     FKTFESIYLKTFLQEQARFWNVRTFFVLSQESSSEQLPWSYQEKTHFGHLGQDLIKEL
                     VSCCRRKPFALVCGSAEFTKDIARCLLCAGLTEDSYFLF"
     exon            476..624
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            625..712
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            713..817
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1021
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..6193
                     /gene="CYB5RL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2606..2611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5RL"
                     /note="hexamer: ACTAAA"
     polyA_site      2626
                     /gene="CYB5RL"
                     /note="major polyA site"
     polyA_site      3476
                     /gene="CYB5RL"
     regulatory      3671..3676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5RL"
                     /note="hexamer: AATAAA"
     polyA_site      3693
                     /gene="CYB5RL"
     regulatory      5421..5426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5RL"
                     /note="hexamer: AATAAA"
     polyA_site      5443
                     /gene="CYB5RL"
ORIGIN      
        1 agagactggg aggaacctgg aaaatcctca cgtgaggtga agcgcaggcg agtagggcca
       61 gacatggtgg ctcatgcctg taatctcagc actttgggag actgagatga gaagatcact
      121 tgaggccagg agttcgagac cagactggca acatagtgag accctgtctc tacaaaatgc
      181 tggccaagga gcagggcctg cgcccgtggt ctcatagagc ctggcctgtt ctggaagagc
      241 acccagttgt tccttctagg ctgcccaagc cccactgatg atggctgaga gggaagagga
      301 cgacgacact gaggaagcct ggatgcagct acggcccaca gaacccttgc cttcccagtg
      361 ctgcggcagt ggctgctcac cctgtgtgtt tgacctctat caccgagatc tggcaaggtg
      421 ggaggcagcc caagccagca aggacaggag cctgctgcgt gggccagagt cacagagctg
      481 cccctccaag ctgaacccag agaccttcgt ggccttctgc atcattgcca tggacaggct
      541 cactaaggac acctaccgtg tccggtttgc tctacccggg aacagccagc ttggcctgcg
      601 gcccggccag cacctcatcc tacgagggat agtagatgac ttagaaattc agagagccta
      661 tacgcccatc agccctgcca acgcagaagg atactttgaa gtgttaatta agtgctacca
      721 gatggggctg atgtcccggt atgttgagtc ctggagagta ggagacacag ctttctggcg
      781 aggacctttc ggagatttct tctataaacc aaaccagtat ggtgagctcc tcttgctggc
      841 tgcgggcacg ggcctggccc ccatggtgcc tatcctgcag agcatcacag acaatgagaa
      901 tgacgagact tttgtcactc tggtcggttg cttcaagacc tttgagagca tctacctgaa
      961 aaccttcctc caagagcagg cccgtttctg gaatgtccgt accttctttg tactcagcca
     1021 ggagagctcc tcagagcagc ttccctggag ttaccaagag aaaacccact ttggccacct
     1081 gggccaggac ctaattaaag agctggtcag ctgctgtcgg agaaagccat tcgcactggt
     1141 ctgtggctcg gctgagttca ccaaagacat agccaggtgc ttactgtgcg caggcctcac
     1201 tgaggactcc tatttcctct tctagccctg gcctctcttc caaagcctag gccatgagcc
     1261 tgctactggg acccaggaag gagcacagac tggaatcaga agacacggag tccaggcctg
     1321 gtcctgctgc tcatttgcca ggtgaccttg ggcaagtgtc tttactgctc agaacctcta
     1381 cttctcatct gccccatgag gttaatcact cctcctggcc tcctactatg tagaaggagg
     1441 atgggctgta ggggccctga ggaggtgagc aaccagcctg ggagtcaggg aggactcttc
     1501 agaggaagcc aagtccaggc tgagccccag gaggagtagg agttgggcag gggaagagtc
     1561 gggaggagct tccctggccc ctccgattag aggatctaat gggggctcca actgtggcct
     1621 cagcaccatc tcggattagg ggctcctgag tgtgtaggga aggacacggg agaggcttag
     1681 agctctttgg aggaggattc tgcctttcct ccagtgccat gagcctgaca catgaaggtc
     1741 ttgggttcta tgacttgacc acatcctgag agcaaggtgg ggccctcgac tgtcttgtat
     1801 tggccccaag cctttcttgc tgtgaacagc ttcattctca gtcccctttc ctggctcaaa
     1861 aatcgagcct agcaaaagaa gaggcacggg aaggaaacgc ccctccctcc tcctgcaggc
     1921 agccactcag cctgtgcctt cagcttggtg ccctggtgat ggttgctatg gagatctaaa
     1981 gatagagcag gagtcaggag acctgggtcc ctctcccagc ttgtcccact gagcggctgc
     2041 cgatcacggt ccacccaccc caggaacctg gcacccctat cccaggaacc cagtgcccct
     2101 gggcagcgca ctgcagttaa tgaattctgc cttcaacagc ctgggctcta gcgtgctgca
     2161 ccagcttggg ctagctacag gcagtcccag aattggaata ttaagccatg gaatcttaga
     2221 gttagacttt tatagtcata gaaatgtact cttcaccata tcaaagctga aagttcagga
     2281 ctctaagaaa catacagtgt gacagactta tcgtatacac gggaaactga agcccagtga
     2341 gactaaatga cttgcccagg gtaaaacagt ccatggcaga gccagcacta gaagcctcct
     2401 agcttcaacc tcatgtgcca attctgcatc agtgattttc gaactgcgct ctacaggaag
     2461 caagggttct ttgcatagca gcagtgaaag gacagctcca gatggatccc cagtaccccc
     2521 ttcaaccaga gcagctgcat ttttatccca ttcatatatt ggggttttga attattttta
     2581 tttgtacaaa aggattttcc tagccactaa aaaaaatggc aacaaatctc tctgctgtgt
     2641 cacatttaat aaataattgt gacacatagc tggggggtgg tgctggaggt ttcagaccgc
     2701 ctcacaggca gagttccagg gtcagagagc atggagtact gtgtgtgacc ttcttccaga
     2761 agcacgggca caggagcatg ttaaaggccc tgaaaagacc agtggcaaag aaactccttt
     2821 cattttgttt aatccagagt ttttcaagct tatttaacta tagaacactt ttctgtgggt
     2881 ttcgtagcct ctttctagca cagtatagtg agtgggaaag gccctgactg agagtcaaag
     2941 attctgagca ggaaccatga tctcttcctg cctagtatgt gacttgagca agacactttt
     3001 cctctcccca ggcctctgag gtctgcgagt tttcctccac cctttcctct ccctcagttt
     3061 gcacatccta ttgactcagc tccaaatagc gggggcctgt caggagcctg actctgttca
     3121 gacaccaggg aaacaacagc acaccaggca gatgcagtta tgtccatcgg ggaacttaca
     3181 gcctagcaag gaaggcagca attcaacctg taagtctaaa agtgatgggt gtcatgaaaa
     3241 ggtaagtgca gggtgctggg agagtggttg gcaggggctt tagcctagtc tagggagagc
     3301 ccaggggcac accactgcca gcggggatag aggcttcaaa agctttgaag tcactcatat
     3361 taagagtgtt gccggacacg gtggctcatg cctgtaatcc cagcactttg ggaggctgcg
     3421 gcaggcagat tgcctgagcc cagaagttcg aggccagcct ggccaacatg acaaaaccct
     3481 gtctctacaa aaaaaaaaaa aaaaaaaaga ttaaccttat gtggtggtat gcgcctgtag
     3541 tcccagctac tttggaggct gaggtgggag tattgcttga gccaaggagg tcgaggctac
     3601 agtgagctgt gattgagcca ctgcactcca atctgtgtga cagagcaaga ccctgtctca
     3661 aaataataat aataaaatca aaaagagtgt taagggggtc tccacttaag gagtagagag
     3721 tccggggcag ttctcgtatc tctgtccttg tctcatttta gatgtttaga tatttagata
     3781 ttatacaagg ccacccagtg gtaaccaacc tagaatgtgt tggcctcctc ttcccctcac
     3841 tccgtgtagg ttctgtgcag cctggctgct ggtggcatct cttatcatgg gacattggtg
     3901 gggacccagc cgtgcccttg gtgccaagaa gcctaaaggg ctcctgtcgc ctggaaactt
     3961 gagagtgcag ggtcgggtgc tgtgccccac aaggtgctga gcaagcccaa gaagaagagt
     4021 gtggggtgtg gtgtgtgagt tcagacctct tggagctgtg ggggcatggt tcccatcagc
     4081 tgctgttcct ctgatgatgc ccactgcgtg ttgtgggagg cgtggccacc gtgtgatgtt
     4141 gtagtaggag aagggagact taggagctag acatgatacg caggcatcaa gaggtcaacc
     4201 aggtgtccac aatctgtgag ccacacagag ctctctttgt gcatatgcat cccaagcttc
     4261 aggaaggcaa cagctactag agggcctgag gacagattct tggtcgcaga agcggcattg
     4321 gctttagttc agccctcacc atgtttacca acgtcacttc tgtgttcccc tcatgggtct
     4381 cccagctccc agtctccatg ccacctccac gctgagacca gaccagtttt ccccacacac
     4441 aaatccaagc ctgtcactcc cctgcttgaa atccttccct gtctccctgt ggccttgggg
     4501 tagggcctct ctgctctgcc acctctccag actttttgta tgccaccgcc cactcacacc
     4561 cacctctcag gctccaaaca tgttctcttg cgtcagctca tcccttacac tcgctgcttc
     4621 ctctgcctgg ccagcctccc accttccgat ctcccactca ccttttttgc ctcctcatct
     4681 tttgaggtct cagctcagtg tcacttcctc ccgggagcct cgcctgtctc ttccactcca
     4741 gcttggtcag tgagcagaga ggcttgtgtg cttttctgtc gctgtaccca taagtgtcat
     4801 ctgcatgtga gcatgagggc cggcccattg tacccctaac aggggaggat gctcagcact
     4861 tcctggatgt cgaatacctg agcgataaac aactaatgtt caggaagtgc tttccaggtg
     4921 gcaaaaggtg tttcctctac tttgaagcaa gaatcttcac caatatacat gctattttat
     4981 taccccaatt tactgatgag gaaactaagc ttctgagact tcaagcgatt ttccaaggtc
     5041 atgtagggat acacaagttc cagcatgtga ttgtggtaaa ggttgtgtgt gacacatgag
     5101 tgcaaccaga gatgtgtata aagattgtta ctgggccggg cgcggtggct cacacctgta
     5161 atcccagcac tttgggaggc cgaggcaggt ggatcacgag gtcaggagat tgagaccatc
     5221 ctggctaaca cggtgaaacc ccgtctgtac taaaaataca aaaaattagc caggcgtggc
     5281 atgcgcctat agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccggga
     5341 ggcggagctt gcagggagcc aagattgtgc cactgcgctc cagcctgggc gacagagcga
     5401 gactccatct taaaaaaaat aataaaagga ttgttattga tgaccaggtg cggtggctca
     5461 tgcctgtaat cccaacactt tgggaggctg aggtgggcag atcacctgag gtcaggagtt
     5521 tgagaccatg ctggccaaca tggtgaaacc ctgtctctac tacagataga aaaattagct
     5581 gggcatggtg gtgcgcacct gtaatcccag ctacttggga ggctgaggca ggagaattgc
     5641 ttaaacccag gaggcggagg ttgcagtgag cccagatggc accactgcac tccagcctgg
     5701 gtgacagagc gagactcagt gccccccaaa aaaagatttt tattgctgca ttctctgaaa
     5761 tagcaaggaa ttaaaaactg cctgtagata cagcaattaa agtgaactcc atccgcatgt
     5821 accaatatag acgaagtcct aaaaacataa taactaagtg aaatgtacat tgtgaaagga
     5881 tagctacagt gagatacctg tacttggaaa ctgtaaaaac ccaaaataat gctaaatgct
     5941 caggaagaga cagagacaca ccagcttcaa ggatagtggt ggcctgtggt gataggtgga
     6001 agggaatggg atggggtgat ggggttttta gccatatctg tatttgtatt ttactataaa
     6061 aatacttgac ataaacatga caaaatatga acccctggta aatctgggca atgagttccc
     6121 caatgtctac tatattattt tctacctttt tctgtttttc aaatagttcc ataattaaac
     6181 atttaaaaaa aaa
//
