LOCUS       NM_144611               1969 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens cytochrome b5 domain containing 2 (CYB5D2), transcript
            variant 1, mRNA.
ACCESSION   NM_144611
VERSION     NM_144611.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Xie,Y., Shen,Y.T., Kapoor,A., Ojo,D., Wei,F., De Melo,J., Lin,X.,
            Wong,N., Yan,J., Tao,L., Major,P. and Tang,D.
  TITLE     CYB5D2 displays tumor suppression activities towards cervical
            cancer
  JOURNAL   Biochim Biophys Acta 1862 (4), 556-565 (2016)
   PUBMED   26692170
  REMARK    GeneRIF: alysis of CYB5D2 gene expression and genomic alteration
            data available from Oncomeinetrade mark detected significant
            reductions of CYB5D2 mRNA in 40 SCCs and CYB5D2 gene copy number in
            107 SCCs. Collectively, we provide evidence that CYB5D2 is a
            candidate tumor suppressor of cervical tumorigenesis.
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   McGrath,L.M., Cornelis,M.C., Lee,P.H., Robinson,E.B., Duncan,L.E.,
            Barnett,J.H., Huang,J., Gerber,G., Sklar,P., Sullivan,P.,
            Perlis,R.H. and Smoller,J.W.
  TITLE     Genetic predictors of risk and resilience in psychiatric disorders:
            a cross-disorder genome-wide association study of functional
            impairment in major depressive disorder, bipolar disorder, and
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 779-788 (2013)
   PUBMED   24039173
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Kimura,I., Nakayama,Y., Konishi,M., Kobayashi,T., Mori,M., Ito,M.,
            Hirasawa,A., Tsujimoto,G., Ohta,M., Itoh,N. and Fujimoto,M.
  TITLE     Neuferricin, a novel extracellular heme-binding protein, promotes
            neurogenesis
  JOURNAL   J Neurochem 112 (5), 1156-1167 (2010)
   PUBMED   19968755
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087292.14.
            
            On Aug 5, 2019 this sequence version replaced NM_144611.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051697.1, AK172844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301391.8/ ENSP00000301391.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-809               AC087292.14        130248-131056
            810-950             AC087292.14        136942-137082
            951-1137            AC087292.14        141725-141911
            1138-1969           AC087292.14        143917-144748
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1969
                     /gene="CYB5D2"
                     /note="cytochrome b5 domain containing 2"
                     /db_xref="GeneID:124936"
                     /db_xref="HGNC:HGNC:28471"
     exon            1..809
                     /gene="CYB5D2"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..1354
                     /gene="CYB5D2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytochrome b5 domain-containing protein 2;
                     neuferricin"
                     /codon_start=1
                     /product="neuferricin isoform 1 precursor"
                     /protein_id="NP_653212.1"
                     /db_xref="CCDS:CCDS11044.1"
                     /db_xref="GeneID:124936"
                     /db_xref="HGNC:HGNC:28471"
                     /translation="MLRCGGRGLLLGLAVAAAAVMAARLMGWWGPRAGFRLFIPEELS
                     RYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGSHYSGFAGRDASRAFVTGDCSEAGLV
                     DDVSDLSAAEMLTLHNWLSFYEKNYVCVGRVTGRFYGEDGLPTPALTQVEAAITRGLE
                     ANKLQLQEKQTFPPCNAEWSSARGSRLWCSQKSGGVSRDWIGVPRKLYKPGAKEPRCV
                     CVRTTGPPSGQMPDNPPHRNRGDLDHPNLAEYTGCPPLAITCSFPL"
     exon            810..950
                     /gene="CYB5D2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1137
                     /gene="CYB5D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1969
                     /gene="CYB5D2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5D2"
                     /note="hexamer: ATTAAA"
     polyA_site      1969
                     /gene="CYB5D2"
                     /note="major polyA site"
ORIGIN      
        1 gccatctttg ttggggctga caacctgcaa gccaagaagt acgagaaggg ccaggcgcgg
       61 tggctcacgc ctgtaatccc agcactttgg gaggccgaga cgggtggatc acctgaggtc
      121 aggagttcga gaccagcctg accaacgtgg tgaaaccctg tctctactaa atacaaaata
      181 ttagccggac gtgggggcgc gtgcctgtaa tcccagctac ttgggaggct gaggcaggag
      241 aatcgcttga acccgggagg cggaggttgc agtgagccga gattccgcca gtgcactcca
      301 gcctggacaa caagagctaa aactctgtct cagaaaaaaa aaaaaaaagt acctggaaaa
      361 agtcgcagac agcgagcttt tcgccagtgc caggaataca gataaaacga gagagactaa
      421 gggagggagc gcgagcacta gcgcgcgaga gagagagcga gagcgcgcgc gccgatgacg
      481 tcacgctcgg cgtctcggcc atcttagctg tagatagagg cggcaacctc ggaagtgcgg
      541 agcgggtggg cctatataga tgttgaggtg cggaggccgt gggcttttgt tgggcctggc
      601 tgtagccgca gcagcggtaa tggcagcacg gcttatgggc tggtggggtc cccgcgctgg
      661 ctttcgcctt ttcataccgg aggagctgtc tcgctaccgc ggcggcccag gggacccggg
      721 cctgtacttg gcgttgctcg gccgtgtcta cgatgtgtcc tccggccgga ggcactacga
      781 gcctgggtcc cactatagcg gcttcgcagg ccgagacgca tccagagctt tcgtgaccgg
      841 ggactgttct gaagcaggcc tcgtggatga cgtatccgac ctgtcagccg ctgagatgct
      901 gacacttcac aattggcttt cattctatga gaagaattat gtgtgtgttg ggagggtgac
      961 aggacggttc tacggagagg atgggctgcc caccccggca ctgacccagg tagaagctgc
     1021 gatcaccaga ggcttggagg ccaacaaact acagctgcaa gagaagcaga cattcccgcc
     1081 gtgcaacgcg gagtggagct cagccagggg cagccggctc tggtgctccc agaagagtgg
     1141 aggtgtgagc agagactgga ttggcgtccc caggaagctg tataagccag gtgctaagga
     1201 gccccgctgc gtgtgtgtga gaaccaccgg cccccctagt ggccagatgc cggacaaccc
     1261 tccacacaga aatcgtgggg acctggacca cccaaacttg gcagagtaca caggctgccc
     1321 accgctagcc atcacatgct cctttccact ctaagccgta gcctcttctg ttaataacac
     1381 acagagagct ctgccaagca cctgagtagg cccttgacac ttgtgtgccc tgggatgcct
     1441 cctggcgcga atcaggaggg tctggaagga ctctggctat attctgcaaa tgtggctcat
     1501 gccccttacc gtggctcggc gttgtggtgc ctgagggaca gccggccacc tgcccagtac
     1561 tggtcagctt ttcaacacta ttccctttga cctactggcc atcttcctca cagccctcag
     1621 atatcaacgg gcacaaataa gaccaactca atttccactt gaatttacaa ccaaaagcct
     1681 gctgagttga ttacagctgg gccaatacag tacgaggcaa taacaaatta gtgtgggttg
     1741 attctggaat tggaaaagct tttgcttgta tggatacagc aaatccagat gtctctgaac
     1801 aaagcaacaa tttaaagcaa cgacattttc tgtcctttaa gcacttaaaa tcaggtgtgg
     1861 tgtgttttca aaggcagaag tctgcatttt gagcaaaagg tggcttccca gctctaacaa
     1921 ggtaactggt tagcatgaca ttaaagcttg ggcaaggctt caaacttaa
//
