LOCUS       NM_030579               4262 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens cytochrome b5 type B (CYB5B), mRNA.
ACCESSION   NM_030579
VERSION     NM_030579.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   Sung,Y.J., de las Fuentes,L., Schwander,K.L., Simino,J. and
            Rao,D.C.
  TITLE     Gene-smoking interactions identify several novel blood pressure
            loci in the Framingham Heart Study
  JOURNAL   Am J Hypertens 28 (3), 343-354 (2015)
   PUBMED   25189868
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Ramage,H.R., Kumar,G.R., Verschueren,E., Johnson,J.R., Von
            Dollen,J., Johnson,T., Newton,B., Shah,P., Horner,J., Krogan,N.J.
            and Ott,M.
  TITLE     A combined proteomics/genomics approach links hepatitis C virus
            infection with nonsense-mediated mRNA decay
  JOURNAL   Mol Cell 57 (2), 329-340 (2015)
   PUBMED   25616068
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Sparacino-Watkins,C.E., Tejero,J., Sun,B., Gauthier,M.C.,
            Thomas,J., Ragireddy,V., Merchant,B.A., Wang,J., Azarov,I., Basu,P.
            and Gladwin,M.T.
  TITLE     Nitrite reductase and nitric-oxide synthase activity of the
            mitochondrial molybdopterin enzymes mARC1 and mARC2
  JOURNAL   J Biol Chem 289 (15), 10345-10358 (2014)
   PUBMED   24500710
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Zheng,J.S., Arnett,D.K., Lee,Y.C., Shen,J., Parnell,L.D.,
            Smith,C.E., Richardson,K., Li,D., Borecki,I.B., Ordovas,J.M. and
            Lai,C.Q.
  TITLE     Genome-wide contribution of genotype by environment interaction to
            variation of diabetes-related traits
  JOURNAL   PLoS One 8 (10), e77442 (2013)
   PUBMED   24204828
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4262)
  AUTHORS   Murphy,D., Parker,J., Zhou,M., Fadlelmola,F.M., Steidl,C.,
            Karsan,A., Gascoyne,R.D., Chen,H. and Banerjee,D.
  TITLE     Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and
            aggressive non-Hodgkin lymphomas identified as cytochrome B5b
            (CYB5B)
  JOURNAL   Mol Cancer 9, 14 (2010)
   PUBMED   20100355
  REMARK    GeneRIF: The 21 kDa protein overexpressed in Hodgkin Lymphoma and
            aggressive non-Hodgkin Lymphomas is identical to CYB5B.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4262)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4262)
  AUTHORS   Altuve,A., Wang,L., Benson,D.R. and Rivera,M.
  TITLE     Mammalian mitochondrial and microsomal cytochromes b(5) exhibit
            divergent structural and biophysical characteristics
  JOURNAL   Biochem Biophys Res Commun 314 (2), 602-609 (2004)
   PUBMED   14733950
REFERENCE   9  (bases 1 to 4262)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   10 (bases 1 to 4262)
  AUTHORS   Soucy,P. and Luu-The,V.
  TITLE     Assessment of the ability of type 2 cytochrome b5 to modulate
            17,20-lyase activity of human P450c17
  JOURNAL   J Steroid Biochem Mol Biol 80 (1), 71-75 (2002)
   PUBMED   11867265
  REMARK    GeneRIF: could be involved in the differential modulation of 17
            alpha-hydroxylase and 17,20-lyase activities of P450c17 [type2
            cyt-b5]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026464.7 and AC009032.8.
            
            On Jul 17, 2019 this sequence version replaced NM_030579.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation uses the 5'-most in-frame start
            codon, which is conserved in higher primates. An alternative
            downstream start codon, which is more widely conserved, also
            exists. It is possible that leaky scanning by ribosomes would allow
            the downstream start codon to be used, at least some of the time.
            The use of the downstream start codon would result in a protein
            that is 4 aa shorter at the N-terminus. There is no experimental
            evidence showing which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.13820.1,
                                           SRR11853564.11043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000307892.13/
                                                  ENSP00000308430.8
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC026464.7         149739-149977
            240-368             AC026464.7         172270-172398
            369-398             AC026464.7         173235-173264
            399-427             AC026464.7         184213-184241
            428-3063            AC026464.7         187550-190185
            3064-4262           AC009032.8         167232-168430       c
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4262
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="cytochrome b5 type B"
                     /db_xref="GeneID:80777"
                     /db_xref="HGNC:HGNC:24374"
                     /db_xref="MIM:611964"
     exon            1..239
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..518
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="type 2 cyt-b5; outer mitochondrial membrane
                     cytochrome b5; cytochrome b5 type B (outer mitochondrial
                     membrane)"
                     /codon_start=1
                     /product="cytochrome b5 type B"
                     /protein_id="NP_085056.2"
                     /db_xref="CCDS:CCDS10880.2"
                     /db_xref="GeneID:80777"
                     /db_xref="HGNC:HGNC:24374"
                     /db_xref="MIM:611964"
                     /translation="MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLV
                     IHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPS
                     DLKPESGSKDPSKNDTCKSCWAYWILPIIGAVLLGFLYRYYTSESKSS"
     exon            240..368
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            369..398
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            399..427
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /inference="alignment:Splign:2.1.0"
     exon            428..4262
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="major polyA site"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
                     /note="hexamer: AATAAA"
     polyA_site      4262
                     /gene="CYB5B"
                     /gene_synonym="CYB5-M; CYPB5M; OMB5"
ORIGIN      
        1 gaaggctgag cgcgggctct caaggaaagt agtcgcggaa tctcagttag cggtggagag
       61 gcagtatgtc cggttcaatg gcgactgcgg aagctagcgg cagcgatggg aaagggcagg
      121 aagtcgagac ctcagtcacc tattaccggt tggaggaggt ggcaaagcgc aactccttga
      181 aggaactgtg gcttgtgatc catgggcgag tctacgatgt cacccgcttc ctcaacgagc
      241 accctggagg agaagaggtt ctgctggaac aagctggtgt agatgcaagt gaaagctttg
      301 aagatgtagg acactcttct gatgccagag aaatgctaaa gcagtactac attggtgata
      361 tccatccgag tgaccttaaa cctgaaagtg gtagcaagga cccttcaaaa aatgatacat
      421 gcaaaagttg ctgggcatat tggattttac ccatcatagg cgctgttctc ttaggtttcc
      481 tgtaccgcta ctacacatcg gaaagcaaat cctcctgagg aggccttgct gaagttagaa
      541 agtgcatcca ctttggggcg aaaactagag acttgcttgg gggctgcaga agtgccctct
      601 cctcgaatcc tgccagttgc attcttcccc cttggagcca agacgattgg ccagacatca
      661 cctcagatct gagaccagcg tcttccatct ctcagagcct tactcccaaa gtacctgctc
      721 actgttccgt gttgaacaat tgccggtgtt tcctctcttc actggtttcc atgagtaccc
      781 ttatatttca caactttctg ttcataagtt atagtgacat tgctctttgg taaaaatgcc
      841 tgctttccaa tactttgatt gcatattaga cattcttaac agggcggcag tctagtgttg
      901 aaagttttat ttttccattt ttcttttaag taaatttttt ttaaaaaatt ctgatttagg
      961 gctaggtgtg gtggctcagg cctgtaatcc tggcactttg ggaggccaag gtgggaagat
     1021 cgcttgaggc caagagttca agaccagcct gggcaacata gcgagacccc tatctgtatt
     1081 aaaaaaaaat ctgatttaat tcttttattt atcataaggg gtttaattcc tgaagtaaag
     1141 gtttgcacct attaaactta aaactgccaa atgatttttg ttcttttatg tgcgtgataa
     1201 aaatacaaag aatggtgtgg ccacctcctc cctttcaagc tagggcagca ggtagctctt
     1261 cccagcccct gagcccagcc ccttcccaag tggtgccgga caaaaaacta catggccctt
     1321 tcgtgtcttg ggggtggaaa ggtagggatg aattggggtg atagaaccct ggtgaattca
     1381 gagtaatctt tctttagaaa actggtgttt tctaaagaaa caggatagga gtttagagaa
     1441 ggcaccaaag ctttcacttt ggtttggcac cagtttctaa ccatctgttt tttctaccct
     1501 agctatcttt tattggtaaa atataaatgt ataattatgt ttgtagagct ttaccaagga
     1561 gtttccctcc ttttttgttt gttgattagc aaatttttga ttctccattt tccaaaagta
     1621 agagactcca gcatggcctt ctgtttgccc cgcagtaaag taacttccat ataaaatggt
     1681 atttgaaagt gagagttcat gacaacagac cgttttccat ttcatctgta ttttatctcc
     1741 gtgactccaa cttgtgggtt tgttctgttt ttccatgaga ataaaatact ggcggttttt
     1801 ttctcagatg tgtgttcatt gagaagtagg ttactagaat tatgttactg tgtcttattg
     1861 gttcaatgat gatttctctg gcatattaga cttttatttt ttcccccatg gaagcacttg
     1921 aggaaataaa tagtacactg gctgttttct gccagcaact gtggtgattt ttctccctgt
     1981 cctttgagaa ttgctagtct gcttctgagc cattgtcata tccagcaggg agcagcttgg
     2041 ttcaagaagg accatagagg ctgctcagca tctcctccct ccctcccagc ttgccaggga
     2101 tttgatgaga caggaaactg cccagcaaac cagggactgc ccatgtaaac tatttaagaa
     2161 aaagttcaac ccaggtcttg tatcctgtga tttagcagtt gaatgaatac agaattcatc
     2221 aaaataatat taaccttgta cttgcacact tggatatatt tgggagtaat tttaggagat
     2281 ttctggctga cttttattat cagggatatg ggtttagtaa agcttttatc tttagaaaaa
     2341 tgtttgtatg cattataaga tgctactttt aagacaatat tgaaaaaaac tttggttatt
     2401 atttaacaaa agtggtatga cttgatgctt ctctatttaa aggcaaggaa ggattggtat
     2461 atgattgcct gtaataaata aattgcgtga ttattggagt acattggggt aaaagtaaag
     2521 aacagaggag tattgaggag cttgaaaggg aacattcaaa ctaaagccaa gcctgaagat
     2581 aacttgaatc agttgtaaaa gtgtgttggc aatgtccgaa attgaatgaa aaacatctgg
     2641 cttataagaa atgttaaaga actaccatct taagtaaaat tggtgttttt gttattttta
     2701 aggtaaatgc caatgcaaaa ggtatgtttt tctacttcac attggttttc ttttcctgtt
     2761 tacatctgca cttgtttttt gctgagagcc agaggaaaag ataattagac tttgtctctt
     2821 ccacccatga aatcccccag tacccagggc ttcttctgaa ctactgccga tgtgatgtca
     2881 ctttgtatct ggaaaatcac tttggggtcc atttactgtt attttgttgc ctacaaaaac
     2941 agccaggtga aagctaaatc ttgtgtgaga gtttgcagag gtttttctat acaataaagt
     3001 agtatagcac actagccaaa tccatccaaa aggacctttt ttttaggaag tagacttgaa
     3061 ttcacaaaac agtcttgaca tgggtagctg gtgaaaaacc ctctggagag caagtggagc
     3121 cagtccccat tggctgacag tgccacctgg agctggtctc tggggtgttc ggttgtttat
     3181 tcctgaggaa gactagctgc tgctgctgct gctgctgcaa actgtactgt acacatcatg
     3241 gctgctggac acgaaggagg aggtgagaga agtttcatgc taccgaaata gagggtgttg
     3301 gtaccactgc ccctggcctg agagccaggg tttaaacctg cctcagtaga gtctagtttg
     3361 aaatgacacc aaaattcctc agcccctact cagcaattgg ttttggtttc caaatgactt
     3421 ctgcatttgt aaagataaca gagtggtggg gtcaaagttt atcttgtgtt tagatctctt
     3481 caagactgct taagcaaaaa caaaaatccc ttggaaccta tcgtttgagc ctgtaaagtt
     3541 gttttagcag ttgtcataaa tgcatatgtt gtgaaatcag aacactgtcg agtttatact
     3601 catttagctg caatgtggga caatgaaaaa tgctttacag gcctggagta tcattactta
     3661 tggtatctcc tgctttaaaa tctcaagcga tatctatctg gttaaattcc attttaggag
     3721 attgagatgc agaacgttaa tgttcattac ctcctcctac cccaagagaa atggattcag
     3781 acatgtcttg tctcaacaag aaattgattt ttttttaaac tatcttattc tgttgccaaa
     3841 tatcacagaa gtaatgagga gtttagttac atttggctgt tgtgctctga aagagccagg
     3901 tttggaattt gtgggggtga tctaggaaga aggttccaaa gaagcagagg catttgtcaa
     3961 gttacctacc ctatatccag catcctcctc atgagcttca gtagctgctc tttgcccacg
     4021 cttgtatcct acgtttgcta tttgggcaaa ccattacttc agttatttaa cttccctttt
     4081 tttttaactt cacctttgac tatgaacaag taacggtaac attccttttg tgtattcaat
     4141 aatgcagtta gtttaccttt ttcagaatat tttgaacaaa gatctttgtc tctttctgct
     4201 ggaatgcgca cacagtgaac gtttgttaga actacacaca ataaagacac tgttttcctt
     4261 tt
//
