LOCUS       NM_001291284            1142 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cytochrome b561 family member D2 (CYB561D2),
            transcript variant 2, mRNA.
ACCESSION   NM_001291284 XM_005264832
VERSION     NM_001291284.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Asard,H., Barbaro,R., Trost,P. and Berczi,A.
  TITLE     Cytochromes b561: ascorbate-mediated trans-membrane electron
            transport
  JOURNAL   Antioxid Redox Signal 19 (9), 1026-1035 (2013)
   PUBMED   23249217
  REMARK    Review article
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Recuenco,M.C., Rahman,M.M., Sakamoto,Y., Takeuchi,F., Hori,H. and
            Tsubaki,M.
  TITLE     Functional characterization of the recombinant human tumour
            suppressor 101F6 protein, a cytochrome b(561) homologue
  JOURNAL   J Biochem 153 (2), 233-242 (2013)
   PUBMED   23235316
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Recuenco,M.C., Fujito,M., Rahman,M.M., Sakamoto,Y., Takeuchi,F. and
            Tsubaki,M.
  TITLE     Functional expression and characterization of human 101F6 protein,
            a homologue of cytochrome b561 and a candidate tumor suppressor
            gene product
  JOURNAL   Biofactors 34 (3), 219-230 (2008)
   PUBMED   19734123
  REMARK    GeneRIF: The protein exhibits the characteristics typical of
            members of the cytochrome b561 family, being a hydrophobic,
            transmembrane heme protein. It is capable of oxidation-reduction
            reaction and is a candidate tumor suppressor gene product.
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Townsley,F.M., Aristarkhov,A., Beck,S., Hershko,A. and
            Ruderman,J.V.
  TITLE     Dominant-negative cyclin-selective ubiquitin carrier protein
            E2-C/UbcH10 blocks cells in metaphase
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2362-2367 (1997)
   PUBMED   9122200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002481.1, AF040704.1 and BC047691.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001291284.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.632640.1,
                                           SRR1163658.335338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425346.6/ ENSP00000400454.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC002481.1         8019-8029           c
            12-1127             AF040704.1         2-1117
            1128-1142           BC047691.1         1190-1204
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1142
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /note="cytochrome b561 family member D2"
                     /db_xref="GeneID:11068"
                     /db_xref="HGNC:HGNC:30253"
                     /db_xref="MIM:607068"
     exon            1..123
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /inference="alignment:Splign:2.1.0"
     exon            124..275
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..817
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /EC_number="7.2.1.3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     cytochrome b561 domain-containing protein 2; putative
                     tumor suppressor protein 101F6; transmembrane ascorbate
                     ferrireductase; transmembrane reductase CYB561D2; tumor
                     suppressor cytochrome b561"
                     /codon_start=1
                     /product="transmembrane reductase CYB561D2 isoform 1"
                     /protein_id="NP_001278213.1"
                     /db_xref="CCDS:CCDS2827.1"
                     /db_xref="GeneID:11068"
                     /db_xref="HGNC:HGNC:30253"
                     /db_xref="MIM:607068"
                     /translation="MALSAETESHIYRALRTASGAAAHLVALGFTIFVAVLARPGSSL
                     FSWHPVLMSLAFSFLMTEALLVFSPESSLLHSLSRKGRARCHWVLQLLALLCALLGLG
                     LVILHKEQLGKAHLVTRHGQAGLLAVLWAGLQCSGGVGLLYPKLLPRWPLAKLKLYHA
                     TSGLVGYLLGSASLLLGMCSLWFTASVTGAAWYLAVLCPVLTSLVIMNQVSNAYLYRK
                     RIQP"
     exon            276..313
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1142
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1123..1128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /note="hexamer: AGTAAA"
     polyA_site      1123
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
     polyA_site      1142
                     /gene="CYB561D2"
                     /gene_synonym="101F6; TSCytb; TSP10; XXcos-LUCA11.4"
                     /note="major polyA site"
ORIGIN      
        1 agacgtcgca cccggaagta aagcggctcc gtgacggagc ggcggtgcgc gcggcagggc
       61 ccggagtatc ccgctttctt tggaggaaac caccgcatca gatctgcgct gcggcagagg
      121 caggctacaa ccactagcac ggctgacgat ggccctttct gcggagaccg agtcacacat
      181 ctaccgagct ctgcgtactg cttctggcgc tgccgcccac cttgtggccc tgggctttac
      241 catctttgtg gctgtgcttg ccaggcctgg ctccagcctg ttctcctggc acccggtgct
      301 tatgtctttg gctttctcct tcctgatgac cgaggcacta ctggtgtttt ctcctgagag
      361 ttcgctgctg cactccctct cacggaaagg ccgagcacgc tgccactggg tgctgcagct
      421 gctggccctg ctgtgtgcac tgctgggcct cggccttgtc atcctccaca aagagcagct
      481 tggcaaagcc cacctggtta cgcggcatgg gcaggcaggg ctgctggctg tgctgtgggc
      541 agggctgcag tgctcaggtg gggtggggct gctctacccc aagctgctgc cccgatggcc
      601 cctggcgaag ctcaagctat accatgctac ttctgggctg gtgggctacc tgctgggtag
      661 tgccagcctc ttgctgggca tgtgctcact ctggttcact gcctctgtca ctggtgcagc
      721 ctggtacctg gctgtattat gccctgtcct caccagcttg gtcattatga accaggtgag
      781 caatgcctac ctataccgca agaggatcca accatgagct cttcccagcc taggggaagc
      841 ctggatttgc ccctccatgt aggagctggg cctagggacc tgttgaactc tctcagctga
      901 gtcaggggac acctcaggca ctgggacagt tgggcatttg gaggcccgtg tgtgaattcc
      961 tgctcctcat gctggagtgc ctcccatttc cttccccttt ctctgtcatc ccagaggaac
     1021 ataggcatca tgtgtctgga tgaagctggg gctgcaagac tgcctctcct gcaaggcagc
     1081 tcatacttgt actgtatgtt cagaaatttt aggagagaaa aaagtaaaaa atttgtaaaa
     1141 aa
//
