LOCUS       NM_182580               4912 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cytochrome b561 family member D1 (CYB561D1),
            transcript variant 2, mRNA.
ACCESSION   NM_182580
VERSION     NM_182580.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4912)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 4912)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4912)
  AUTHORS   Asard,H., Barbaro,R., Trost,P. and Berczi,A.
  TITLE     Cytochromes b561: ascorbate-mediated trans-membrane electron
            transport
  JOURNAL   Antioxid Redox Signal 19 (9), 1026-1035 (2013)
   PUBMED   23249217
  REMARK    Review article
REFERENCE   4  (bases 1 to 4912)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 4912)
  AUTHORS   Shi,J., Potash,J.B., Knowles,J.A., Weissman,M.M., Coryell,W.,
            Scheftner,W.A., Lawson,W.B., DePaulo,J.R. Jr., Gejman,P.V.,
            Sanders,A.R., Johnson,J.K., Adams,P., Chaudhury,S., Jancic,D.,
            Evgrafov,O., Zvinyatskovskiy,A., Ertman,N., Gladis,M., Neimanas,K.,
            Goodell,M., Hale,N., Ney,N., Verma,R., Mirel,D., Holmans,P. and
            Levinson,D.F.
  TITLE     Genome-wide association study of recurrent early-onset major
            depressive disorder
  JOURNAL   Mol Psychiatry 16 (2), 193-201 (2011)
   PUBMED   20125088
REFERENCE   6  (bases 1 to 4912)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126707.1, AK096354.1, AL355145.31 and AI375149.1.
            
            On Feb 27, 2020 this sequence version replaced NM_182580.2.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2117623.1,
                                           SRR14038194.2403518.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420578.7/ ENSP00000413530.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK126707.1         16-21
            7-996               AK096354.1         1-990
            997-4502            AL355145.31        24577-28082
            4503-4912           AI375149.1         18-427              c
FEATURES             Location/Qualifiers
     source          1..4912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4912
                     /gene="CYB561D1"
                     /note="cytochrome b561 family member D1"
                     /db_xref="GeneID:284613"
                     /db_xref="HGNC:HGNC:26804"
     exon            1..194
                     /gene="CYB561D1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..736
                     /gene="CYB561D1"
                     /EC_number="7.2.1.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytochrome b561 domain-containing protein 1; probable
                     transmembrane reductase CYB561D1; cytochrome b-561 domain
                     containing 1"
                     /codon_start=1
                     /product="probable transmembrane reductase CYB561D1
                     isoform 2"
                     /protein_id="NP_872386.1"
                     /db_xref="CCDS:CCDS800.1"
                     /db_xref="GeneID:284613"
                     /db_xref="HGNC:HGNC:26804"
                     /translation="MQPLEVGLVPAPAGEPRLTRWLRRGSGILAHLVALGFTIFLTAL
                     SRPGTSLFSWHPVFMALAFCLCMAEAILLFSPEHSLFFFCSRKARIRLHWAGQTLAIL
                     CAALGLGFIISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRAARVSRVA
                     RLKLYHLTCGLVVYLMATVTVLLGMYSVWFQAQIKGAAWYLCLALPVYPALVIMHQIS
                     RSYLPRKKMEM"
     exon            195..232
                     /gene="CYB561D1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..4912
                     /gene="CYB561D1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4888..4893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CYB561D1"
                     /note="hexamer: ATTAAA"
     polyA_site      4912
                     /gene="CYB561D1"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgttc gggcagctgg agtgtacggg cccgcgggcc acggccatgc agcccctgga
       61 ggtaggtctg gttcccgctc cagctgggga gccgagactg acccgctggc tgcggagagg
      121 cagtgggatc ttggcgcacc tggtagcttt gggcttcacc atctttctga cagcgctgtc
      181 ccggccagga accagtcttt tctcctggca ccctgtattc atggccttgg cgttctgcct
      241 ctgcatggct gaagccatcc tactcttctc acctgaacac tccctgttct tcttctgctc
      301 ccgaaaagca cggatccggc tccactgggc agggcagacc ctagccatcc tctgtgcagc
      361 tctgggcctg ggcttcatca tctccagcag gacccgcagt gagctgcctc atctggtgtc
      421 ctggcacagc tgggtgggag ccctgacact gctggccact gctgtccagg cactgtgtgg
      481 gctctgcctc ctttgtcccc gggcagccag ggtctcaagg gtggctcgcc tcaagctcta
      541 ccatctgaca tgtggactgg tggtctacct gatggctaca gtaacggtgc ttctgggcat
      601 gtactcagta tggttccagg cccagatcaa aggtgcggcc tggtacctgt gcctggcact
      661 gcccgtctat ccagccctgg tgatcatgca ccagatttcc agatcctact tgccgaggaa
      721 gaaaatggaa atgtgagttc ctgcgaacgc tgaatctagg tgggacgctt gccttgaaca
      781 tcatggttcc tttggtgatc tataagggat ctatttaaga agtggtcagg ttttcgcact
      841 tcttggctgg tccagggact gcagaaacca aagctgctat tgttgaggaa taattcagtg
      901 ggtcaaaatg gggagatgta ctgggtatga gtggaaggtg atggagagcc tgatcctgaa
      961 gcctctactt gatgagagac agagttttgg gtggtgatag tgatgtgctg gtggtcattt
     1021 cttgcttgtg tgcctgatga aaaactgggt tcctgtaagt tatgaatggc atccagggat
     1081 atttgggtta cttttaagaa agcagtgtga tgtagtggag agagcccatg ggtcttattt
     1141 atgggatatg gtcctcttag gctctgttgt acaaccttag gtacattcca tatcttaaga
     1201 ccactgtttc ttcatctgtg aaatgtttct aaacaatctc taagtccctt ccttctctaa
     1261 tatacagcgt ctgtcaggtc gatgtctcag aacactctcc cagctgtgga ccacgtggac
     1321 cacttagcag actcaggggg tagttcttta ctctcccttt actaccctgg agggacagct
     1381 ctgcccttga ggcccttcag aaatttgtgc tgatttggtc cctgtgccag ggcacagggg
     1441 gtcaggcact gtggaaagaa gggactcagg tgagggtctt ctggactcta agacggtaaa
     1501 ggcactaaag tcactttaaa gcttttggag aagcaggagg gcattggctt aaccaagccg
     1561 aaggctgctg gctgggctgc ctagcccagc taagatcttc cttcagccca cctcaggatc
     1621 cgggcttgag ggctgcaggg cctgcgtgcg ctccctcccc cgaaatcact tctcagggca
     1681 aaggagcccc aggcatctca tgctttgccc ttcttagggc tcaggttctt gccttagcac
     1741 atagcttctg ggagcttttt tgaagcattt cataagggcc aaggaagtgg ggcagggctt
     1801 ttctgatcca aagaaaacaa agtttctctg gttacccctc ttcccttgtt atctaagctt
     1861 tcctcagttg tcatctcttc ccagctcttt ggtccaagag ggggctgagt ttggtgccag
     1921 ctggcaaatg agggctggac tctcttccct ccagagacca ccccgctcct tgctgcagct
     1981 gaaagtagtt ccccaggctg ccctcggtgg tgaggactgg atgctagact gctgagctgt
     2041 ggtctgggct cagttgagaa gataggatct ccctagatca tggcaaggcc tgacaacagc
     2101 tgagccagga aagtgctgct gaggcaagtc gacatagctc acagggaact ctgggaagcc
     2161 tgggatgtag gcgctggagc tccagttccc aggagcaggg gcaggtgttc ctagatgtta
     2221 gtgttgtgga tgtccttggt cttctgaaga ttcaggtcct cctctccggg tagcttagaa
     2281 gtaaggaggt tggtttgatt caatagtatg gggacagaat ggggacagca agggcagaag
     2341 tgtcctctcc acgtaactca ttatgcccct cctgggggag attgcatctc caggacaagc
     2401 atctaaagga ggcccctgct gtgcagaggg gtattgttcc tgtctctttc attgtcctcc
     2461 ctcctctcaa actctccagt gtggtgtgaa ctcagaagaa acggttactg gggctgcatg
     2521 gagaatttca cctgcggtga ttttgatcca gggactgcat ctcctctttc ctcatcacag
     2581 ccagtgctga gaggctcctt ctacctgccg cagggtagga gggccaggca aagttcacca
     2641 gcttgctcta agagcaagca ggcaatgccg taaagcctga gcctgcctga ggtgctgcct
     2701 cctcccaggt ggtgcggggg ctggtgggcg ggcgggcagg cgtgctgaca gccggcagtt
     2761 tgcgtgggct gtgccatctg atgtctattc ccagccctgg gaggaagggg gagtcattta
     2821 tattctgcag gaggaagggg ccccagctgt cgcctttctg accagcaggc ctggagggca
     2881 ggggcacaga gcagagagga gggcactggt ggtctcctgc ttagcctggt ctgactgcag
     2941 tgtagggaat aggtcaccag gaggagccct tcatcctggc aggccggatt gtggagggac
     3001 ttccctcccc ctcttttcca tttctccctc catcaccacc tgccctcaca tcctggggca
     3061 gcagctggac agccattaga cctcagtgcc agggcactct tcctccagct gggatctcag
     3121 tggctcccag ctgcatgggc tcctgcttgt gtgttccctc ctccgccatc ctctgttccc
     3181 cgcacctccc ttattctgct catgtctggg gtattcactt ggctcctcag caaggaagca
     3241 aacgccttgg aggagaagca catggttgcc cttttgtcct tgctccctgg ctagggaaag
     3301 ctgctagtgg tcagcctgtt ttgccttttt ttaaaaaaaa aaaaaaagcc agggcagggt
     3361 gcttagattt taaaaatttg cgtgtcattt gcacaaattt tcatatcaag ctaagtcctg
     3421 attccaaatt tgattatatt ccaaatttga ttatattcca aatttgatta tattcagatt
     3481 caaccttgag gacattagaa atatagatgg cttctgtatc caaatctgaa tggaaatgag
     3541 attacccttc tgggttcaga tacccctccc aagcccccgt cttttctgta accacccctc
     3601 ctctgagccc catcatggct ggggttggta tggaatggga gcagctctgt atctggggaa
     3661 gtcctccagc ctcaccttct tggctcttaa gtggtaggct gttaccactt gccagcctgg
     3721 gcctcctctc tccccaccct ttcacaaggc aggctgccct tccgcactca ctggcccatc
     3781 ccttctttct catcgtccca cccttccacc cccgtgcatg gctgctgtag gtctggtttt
     3841 tttggttttt gtttttttta agacggagtc tcactctgcc gccaggctgg agtgcagtgg
     3901 cagaatcttg gctcactgca acctctgcct cccaggttca agcgattctc ctgcctcagc
     3961 ctcccgagta gctgggacta caggcacgtg ccaccatatc cagctaattt ttgtattttt
     4021 agtagagatg gggtttcacc atgttggcca ggatctcttg acctcgtgat ctgcccgcct
     4081 cggcctccca aagtgctgtg attacaggcg tgagccaccg tgcctagcca ggtcttgttt
     4141 tgaaaacctc actgtgggag attcaggcat cctccctaag ccagctggcc gctgtgctaa
     4201 agcctgttca gagttaataa taatcattag ctgaatggtg ctggggcctt tcagcttcag
     4261 atctctaagc acttgcaggc tgagtcagtc agccctcacc ttccccctcc ttcctgggct
     4321 gcagagtgta acagaatggg aaggcactgt gggaaggaag tcaggaatct tgctgctagc
     4381 cacgccttgc agtgacttct cgtctgggag tgggcactga gtcctctcag taaactaata
     4441 agacttgcac ctgacaaagg tcaagatatg tagggaacac agtgtatgct aggctgagac
     4501 ctatggtggt ggcaggggtg gctgttgagc ctgaacttcc agtactcctg cccttccttc
     4561 tgtttacctg gcttggccta cagggggcac ccctggtctt gatgcctcaa gcccagcatt
     4621 tctgggtccc ctctgcaagc tcagagagca gggaggcttc tggtagtgct cttgatgctc
     4681 ctgtgtctgg ttggcacaaa gatcctgtgt aacatgaaat gaaaggtgca tcagcttggg
     4741 ggctgggaaa cctgcagtat gggtttactc cgtccctatc actggtgtgg ctgtgggcaa
     4801 accacttatt gcctgaccta cctcacaggg atgttgtgag ggtttgatga gagaatgaat
     4861 gttaatagga attggaaaat tcaaagcatt aaacacatgt aaacaggtgg ta
//
