LOCUS       NM_001013403            1279 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome X open reading frame 66 (CXorf66), mRNA.
ACCESSION   NM_001013403 XM_298053
VERSION     NM_001013403.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Delgado,A.P., Hamid,S., Brandao,P. and Narayanan,R.
  TITLE     A novel transmembrane glycoprotein cancer biomarker present in the
            X chromosome
  JOURNAL   Cancer Genomics Proteomics 11 (2), 81-92 (2014)
   PUBMED   24709545
  REMARK    GeneRIF: The SGPX gene is a putative novel cancer biomarker.
            [Meta-analysis]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590077.19, BC137148.1 and AA758774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001013403.2.
            
            Summary: The protein encoded by this gene is predicted to be a type
            I membrane protein, however, its exact function is not known.
            [provided by RefSeq, Sep 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.69558.1, BC137148.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370540.2/ ENSP00000359571.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL590077.19        56753-56755         c
            4-1241              BC137148.1         1-1238
            1242-1279           AA758774.1         6-43                c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.1"
     gene            1..1279
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /note="chromosome X open reading frame 66"
                     /db_xref="GeneID:347487"
                     /db_xref="HGNC:HGNC:33743"
     exon            1..113
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1111
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /note="uncharacterized protein CXorf66; RP11-35F15.2;
                     secreted glycoprotein, X-linked"
                     /codon_start=1
                     /product="uncharacterized protein CXorf66 precursor"
                     /protein_id="NP_001013421.1"
                     /db_xref="CCDS:CCDS35411.1"
                     /db_xref="GeneID:347487"
                     /db_xref="HGNC:HGNC:33743"
                     /translation="MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYL
                     RRNLLILVGIIIMVFVFICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTA
                     SQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSY
                     PKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYS
                     SHPQNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVA
                     KTYRPLVNDISEAKEKNTQNLHVSSKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYS
                     EVDSDKVIIITCDRGYNQVTSEVTLND"
     exon            114..267
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1279
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /note="hexamer: AATAAA"
     polyA_site      1279
                     /gene="CXorf66"
                     /gene_synonym="SGPX"
                     /note="major polyA site"
ORIGIN      
        1 aaatcatttg aaccaagttg cggacatgaa tcttgttatt tgtgtcctac ttttgtccat
       61 ttggaaaaat aattgcatga ctacaaacca aaccaatgga tcttctacta caggagataa
      121 acctgttgaa tcaatgcaga caaaattgaa ctaccttaga agaaatctac tcattttagt
      181 tggtattatc atcatggttt ttgtctttat ctgtttttgt tatctccatt ataattgtct
      241 gagcgatgat gcgtccaaag caggaatggt caagaaaaaa ggcatagcag ccaagtcatc
      301 taaaacatca ttcagtgaag ccaagacagc ctctcaatgc agtccagaaa cacaacccat
      361 gctatctact gcagacaagt catctgattc atcgagtcca gaaagggcat ccgcacaatc
      421 cagcacagaa aaattaatca gaccctcaag tctacaaaag ccatccatac caaacagtgc
      481 aggaaagtta actaggccat catatccaaa aaggtcatcc aagtcatcat gctcaaaaaa
      541 attaagcaag tcatctcacc tggaaaaggc acataagaaa ggcagcctag aaaaattatg
      601 taagctagac tatgcgtgta agctagccag ttcagataag ccagtcaggc cacctcagct
      661 attcaagcca ctttattcat ctcatccaca aaatgaaatc tcaccatcca agccattcgg
      721 tccacaggaa ttggctaagc ctcccaaaca ttttaatcca aaaaggtcag tgagtctagg
      781 cagggcagcc ttattatcca actctgaatt agctgaaact tgtcaaccct acaagaaaaa
      841 acatcttgtt gccaaaactt ataggccttt ggtcaatgat atttctgagg caaaggagaa
      901 aaacactcaa aacctacatg tttcaagcaa agtcaagtcc tcttccaggt cctttcgtaa
      961 gttagattcc aggaacaatg catacggtga tcatgtgaat gacagtgata cgatgaaata
     1021 ttatagtgag gttgacagtg ataaagttat aatcattacg tgtgacagag ggtacaatca
     1081 agtcacctct gaagtaaccc taaatgatta ggagctcaac aaaaataaaa tccaagtgtg
     1141 aaagagcaaa cttataccaa ctattttatg ctcatcatcc cttaagaaac cagtagaggg
     1201 aaaaatcact atcaagatca cccatatctg tcttggaggc gatttatttt aaaaatatca
     1261 ataaaatgca tgacataaa
//
