LOCUS       NM_152761               1549 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome X open reading frame 58 (CXorf58),
            transcript variant 1, mRNA.
ACCESSION   NM_152761
VERSION     NM_152761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Duek,P., Mary,C., Zahn-Zabal,M., Bairoch,A. and Lane,L.
  TITLE     Functionathon: a manual data mining workflow to generate functional
            hypotheses for uncharacterized human proteins and its application
            by undergraduate students
  JOURNAL   Database (Oxford) 2021 (2021)
   PUBMED   34318869
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1549)
  AUTHORS   Paik,Y.K., Overall,C.M., Deutsch,E.W., Hancock,W.S. and Omenn,G.S.
  TITLE     Progress in the Chromosome-Centric Human Proteome Project as
            Highlighted in the Annual Special Issue IV
  JOURNAL   J Proteome Res 15 (11), 3945-3950 (2016)
   PUBMED   27809547
REFERENCE   5  (bases 1 to 1549)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK058173.1 and AC079376.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_152761.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058173.1, BC117346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379211.8/ ENSP00000368511.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK058173.1         1-76
            77-324              AC079376.26        118028-118275       c
            325-414             AC079376.26        115985-116074       c
            415-1547            AK058173.1         415-1547
            1548-1549           AC079376.26        86848-86849         c
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..1549
                     /gene="CXorf58"
                     /note="chromosome X open reading frame 58"
                     /db_xref="GeneID:254158"
                     /db_xref="HGNC:HGNC:26356"
     exon            1..324
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            325..460
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1343
                     /gene="CXorf58"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein CXorf58"
                     /codon_start=1
                     /product="uncharacterized protein CXorf58 isoform 1"
                     /protein_id="NP_689974.2"
                     /db_xref="CCDS:CCDS14209.1"
                     /db_xref="GeneID:254158"
                     /db_xref="HGNC:HGNC:26356"
                     /translation="MNRSSNVPRKGILKSGTRSLQKVRRVHFANARNARSLLSMLKDI
                     SAQIIQRAWLSHTNKMIFRLLKHAICAAEFYVTHEILKKVAPLEAKLIKDPTMQCKIR
                     FRFRGETFPPFIVFKIFLHTDGHGYKYFSGKNVLMPSSKAVDDACKLMGERKFHRIIM
                     EDERIFPKSKVTDIMDVVTMQDYVQYRSFFDEAPAFSGGRNNSWRKLNLENIPRTMLM
                     YDIVHYSESGVISNRLRNEMKFLLQRPVTQEIHKHQLRIVSEIRGPYLTVQPLYRPYK
                     QQNQVKFLGRRSKQAQMKVEKMRKVYLAKEKNTSEVTEPKTGPSGTKDNYHLHSIF"
     exon            461..560
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            561..655
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            656..767
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            768..899
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1129
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1283
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1549
                     /gene="CXorf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXorf58"
                     /note="hexamer: AATAAA"
     polyA_site      1549
                     /gene="CXorf58"
                     /note="major polyA site"
ORIGIN      
        1 gtggacggta cgcggaggcg cgaggaggga ggcgcctggc gttgccgcgg cgctgggaaa
       61 ctgtctttgc agcggcgact gggcgcccag cggcgtgtac tgggatttct gtgagcagag
      121 gctgccgaga gggggcgctt ggagggccac cggcggcttc gaaagcttcg cagccggaag
      181 ccgccggttg gcggcctgga tttaccttac gaaaggtttt aaccaaggac ttgaggtttc
      241 tcaggtttta aatttaaact aatatgctgt gtcctttaat cggaaaaggc tctgacctta
      301 ttttttcccg ttaagaaaca agcgattact tcattggagg gaaaatgaat cgttcctcaa
      361 atgtaccacg taaaggtatt ctgaaatcag gtacaagatc cttacaaaaa gttcgcagag
      421 tacatttcgc aaatgcacga aatgcaagat cattactatc aatgcttaaa gacatttcag
      481 ctcaaataat acagagggct tggttatctc atacaaacaa aatgatattt cgactcctaa
      541 aacacgcaat ttgtgcagcg gaattctatg taacacatga aatactgaag aaagtggccc
      601 ccttagaggc taagcttatt aaggatccta ctatgcagtg taaaattaga ttcagattta
      661 gaggtgaaac gtttccacct ttcatcgtgt ttaaaatttt tcttcatact gatggccatg
      721 gttacaagta ttttagtgga aaaaatgtat taatgccgtc aagtaaggca gtggatgatg
      781 cttgcaaact aatgggggaa aggaaatttc accgtataat tatggaagat gaacgtattt
      841 tcccgaagtc caaagtaact gatataatgg atgttgtcac catgcaagat tatgtacaat
      901 atcgcagttt tttcgatgag gcccctgcat tttctggcgg cagaaataac agctggcgca
      961 aattaaatct tgaaaatatt cccaggacaa tgctaatgta tgacatagtt cattattcag
     1021 agtctggagt gatctcaaac cgtctacgaa atgaaatgaa gtttctgtta cagagaccag
     1081 taacgcaaga gatccataag caccagctac ggattgtttc tgaaattagg ggtccatact
     1141 taactgtcca acctctatat cggccctaca aacagcaaaa tcaagttaaa tttctgggtc
     1201 gtcgatccaa gcaagctcaa atgaaagttg aaaaaatgag aaaagtttat ttggctaaag
     1261 aaaaaaatac ttctgaggtg actgaaccaa aaacgggccc atcaggtaca aaggataact
     1321 atcatctcca ctccatcttt tgacattgtg aaaactaagg aatctatgtc agagtgtcag
     1381 ctggaaaaag aaaaaaggac tcattttcct ggtatcaaaa cttggcagct ggtgattctc
     1441 catcatgata atgaacagtt aattgacaga aaaccaaagt tgtttaacaa tctgcttgtc
     1501 tgtctataaa taatgagtat gtgtaataaa ggaaaataac atagaataa
//
