LOCUS       NM_001145140            1854 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chromosome X open reading frame 49 (CXorf49), mRNA.
ACCESSION   NM_001145140 XM_001715406 XM_001715695 XM_001716527
VERSION     NM_001145140.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Arcaro,A., Daga,M., Cetrangolo,G.P., Ciamporcero,E.S., Lepore,A.,
            Pizzimenti,S., Petrella,C., Graf,M., Uchida,K., Mamone,G.,
            Ferranti,P., Ames,P.R., Palumbo,G., Barrera,G. and Gentile,F.
  TITLE     Generation of Adducts of 4-Hydroxy-2-nonenal with Heat Shock 60 kDa
            Protein 1 in Human Promyelocytic HL-60 and Monocytic THP-1 Cell
            Lines
  JOURNAL   Oxid Med Cell Longev 2015, 296146 (2015)
   PUBMED   26078803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX276092.9.
            
            On Aug 14, 2020 this sequence version replaced NM_001145140.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.157279.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535490.3/ ENSP00000480355.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1358              BX276092.9         65524-66881         c
            1359-1515           BX276092.9         64791-64947         c
            1516-1592           BX276092.9         64171-64247         c
            1593-1638           BX276092.9         63843-63888         c
            1639-1680           BX276092.9         63247-63288         c
            1681-1854           BX276092.9         62967-63140         c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1854
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /note="chromosome X open reading frame 49"
                     /db_xref="GeneID:100130361"
                     /db_xref="HGNC:HGNC:30891"
     exon            1..1358
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1679
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /codon_start=1
                     /product="uncharacterized protein CXorf49"
                     /protein_id="NP_001138612.1"
                     /db_xref="CCDS:CCDS75991.1"
                     /db_xref="GeneID:100130361"
                     /db_xref="HGNC:HGNC:30891"
                     /translation="MSSPDKVSVCGAGFDLEGGKKAGSRTASPGAPGAHSHGLDLGVP
                     GSGDGKSESGFTDPEGFSFESESELIEQGRVVLWGREGRPGTPVDDQGDVVDYSFYLA
                     DEPAAIVPPPSVQGHPFPEGAAAEGSAENWADAEVGPSGRDVLGHSPGKWQQASAGRL
                     HLCGPGPVRAWKNPERGSKSRWSLRVDPQQPSAKGPTRLPTHDSDSADESSDLPLMKV
                     GICRNEGSQAKPGSPKKRADTSRQASFHCKESYLPVPGRFLTSAPRGLTPVAERPAVG
                     ELEDSPQKKMQSRAWGKVEVRPSCSGAAAAGALPQGLSRRKMAGGKKSLGGASQLALG
                     RGFPACGERLSAAPPEPATFPPFSGVRPQGMSKKPQKPKHSSPGKKPAGRKTRESQAA
                     AREDNDPNRDEVPRAQLPTHRPGLPRLSVRRGEFSSSDPNIRAPQLPGTSEPSAYSPG
                     GLVPRRHAPSGNQQPPVHPPRPERQQQPPGAQGCPRCIWLQREIEDLTQQLAAMQFLT
                     DKFQDL"
     exon            1359..1515
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1592
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1638
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1680
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1854
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="CXorf49"
                     /gene_synonym="CXorf49B"
                     /note="major polyA site"
ORIGIN      
        1 gcggtggtgt cccgaaggcc tcactgtttc tgtcgcgtgg cccgctcagc tgggcttggc
       61 tgggctcagc tctccgctcc cgccgttacc aggacgaccg tctccccgca gcccaggctg
      121 cccggactgg cgccatgagc tcccccgaca aggtgtccgt ttgtggggcc ggtttcgacc
      181 tggagggtgg caaaaaggct ggctcccgca cggccagccc cggagcccca ggggcccaca
      241 gccacggcct cgatttgggg gtgccgggca gcggcgatgg caagagcgag agcgggttca
      301 cagatccaga gggcttcagc ttcgagtctg agagcgaatt gatagagcaa ggaagggtgg
      361 tgctctgggg ccgggaaggc cggccaggca ccccggtgga tgaccaaggg gacgttgtgg
      421 actactcatt ctacctggct gacgaaccag ccgccatcgt gccgccgccc agcgtccagg
      481 gacacccgtt cccagaaggt gccgctgccg aagggtcggc tgagaattgg gcagatgcgg
      541 aggtcggtcc cagtgggaga gacgtgctgg gccacagccc tggaaaatgg cagcaggcct
      601 ctgccggccg tctccacctc tgcggtcctg ggccagtgcg ggcctggaag aacccggaaa
      661 ggggctcgaa gagcagatgg agcctccgcg tggatcccca gcagccctct gcgaaaggcc
      721 ccaccaggct gcctacccac gactctgatt ccgcagatga gagcagcgac ttaccactga
      781 tgaaggtagg catttgccgc aacgaaggaa gccaggccaa gcccggcagc cccaagaagc
      841 gagcagacac atccagacag gcaagcttcc actgcaagga gagttacctg cctgtgccgg
      901 gccgtttcct gacctctgct ccccgcggac tcactccagt cgcagagagg ccggctgtgg
      961 gagagctgga ggactctccc cagaagaaaa tgcagagcag ggcctgggga aaggtggagg
     1021 tcaggcccag ctgctcagga gctgctgctg caggggccct gccccagggc ctttcgagga
     1081 ggaagatggc cggggggaag aagtccctag ggggtgcctc tcaactggcc ctggggagag
     1141 gctttcctgc ctgcggagag agactctcag ccgctccccc ggagccggcc accttcccgc
     1201 cattctctgg tgtgcggcca caggggatgt ccaagaaacc ccaaaagcct aagcacagca
     1261 gccctgggaa gaaaccagca gggaggaaga ccagggagtc ccaggctgcg gccagagaag
     1321 ataatgaccc aaatagagat gaggtcccaa gagcccaact tcccacccac aggccaggac
     1381 tgcctcgcct gtctgtgcgt cgtggagaat tcagcagtag cgaccccaac atcagagctc
     1441 cccaacttcc gggaacttca gagccctcgg cctacagccc gggaggcctc gtgcccagac
     1501 gccatgcacc ctccggtaac cagcagccgc ctgtccatcc cccaagaccg gaaaggcagc
     1561 agcagccccc gggagcccag ggctgtcctc ggtgcatctg gctgcagagg gaaattgagg
     1621 accttacaca gcagctagcg gccatgcagt tcctcactga caagttccag gacctttgaa
     1681 gttggagcca gcatcttcct acaagatgaa cagctgccac ctttggagct ccggagctgc
     1741 agccaagcgg gttccctcca tatcctgttc agccagggct tcctctcttc cgctgcattt
     1801 gcccccttcc caacgcagtt caaagcaatt tgaaataaag tcgttctcat attc
//
