LOCUS       NM_144970               4244 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome X open reading frame 38 (CXorf38),
            transcript variant 1, mRNA.
ACCESSION   NM_144970
VERSION     NM_144970.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4244)
  AUTHORS   Tan,H.W., Xu,Y.M., Liang,Z.L., Cai,N.L., Wu,Y.Y. and Lau,A.T.Y.
  TITLE     Single-gene knockout-coupled omics analysis identifies C9orf85 and
            CXorf38 as two uncharacterized human proteins associated with ZIP8
            malfunction
  JOURNAL   Front Mol Biosci 9, 991308 (2022)
   PUBMED   36330220
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4244)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 4244)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4244)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4244)
  AUTHORS   Anantharaman,V., Makarova,K.S., Burroughs,A.M., Koonin,E.V. and
            Aravind,L.
  TITLE     Comprehensive analysis of the HEPN superfamily: identification of
            novel roles in intra-genomic conflicts, defense, pathogenesis and
            RNA processing
  JOURNAL   Biol Direct 8, 15 (2013)
   PUBMED   23768067
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB207233.1, CV572553.1, BC025334.1, AC092473.4 and BM969708.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_144970.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1842017.1,
                                           SRR11853564.28715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327877.10/ ENSP00000330488.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DB207233.1         7-122
            117-117             CV572553.1         96-96
            118-1377            BC025334.1         82-1341
            1378-3981           AC092473.4         134073-136676       c
            3982-4244           BM969708.1         17-279              c
FEATURES             Location/Qualifiers
     source          1..4244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..4244
                     /gene="CXorf38"
                     /note="chromosome X open reading frame 38"
                     /db_xref="GeneID:159013"
                     /db_xref="HGNC:HGNC:28589"
                     /db_xref="MIM:301117"
     exon            1..257
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1001
                     /gene="CXorf38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein CXorf38"
                     /codon_start=1
                     /product="uncharacterized protein CXorf38 isoform 1"
                     /protein_id="NP_659407.1"
                     /db_xref="CCDS:CCDS14253.1"
                     /db_xref="GeneID:159013"
                     /db_xref="HGNC:HGNC:28589"
                     /db_xref="MIM:301117"
                     /translation="MVLSELAARLNCAEYKNWVKAGHCLLLLRSCLQGFVGREVLSFH
                     RGLLAAAPGLGPRAVCRGGSRCSPRARQFQPQCQVCAEWKREILRHHVNRNGDVHWGN
                     CRPGRWPVDAWEVAKAFMPRGLADKQGPEECDAVALLSLINSCDHFVVDRKKVTEVIK
                     CRNEIMHSSEMKVSSTWLRDFQMKIQNFLNEFKNIPEIVAVYSRIEQLLTSDWAVHIP
                     EEDQRDGCECEMGTYLSESQVNEIEMQLLKEKLQEIYLQAEEQEVLPEELSNRLEVVK
                     EFLRNNEDLRNGLTEDMQKLDSLCLHQKLDSQEPGRQTPDRKA"
     exon            258..392
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     exon            393..512
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     exon            513..662
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     exon            663..842
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1002
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..4244
                     /gene="CXorf38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1206..1211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXorf38"
                     /note="hexamer: AATAAA"
     polyA_site      1228
                     /gene="CXorf38"
     regulatory      4227..4232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CXorf38"
                     /note="hexamer: TATAAA"
     polyA_site      4244
                     /gene="CXorf38"
                     /note="major polyA site"
ORIGIN      
        1 gtccgccacg ccccgcaacc tcctggttcc aagtgggaga catggtgctg tcggagctag
       61 cggcgcgcct caactgcgcc gagtacaaga actgggtgaa ggcgggccac tgcctgttac
      121 tgctgcgcag ctgcctgcag ggtttcgtcg gccgcgaggt gctctccttc caccgcggcc
      181 tactcgccgc agcccccggc ctggggcccc gcgccgtctg ccgcggcggc tcacggtgca
      241 gccctcgcgc ccgccagttt cagcctcagt gtcaggtgtg cgctgaatgg aaaagggaga
      301 ttttgagaca tcatgtcaac agaaatggag atgtgcactg gggaaactgc cggccgggcc
      361 gctggcccgt ggacgcctgg gaggtggcca aggccttcat gccccgagga ctagcagaca
      421 aacaaggacc tgaggaatgt gatgcagttg ctcttttaag tctcatcaac tcctgcgatc
      481 acttcgtggt tgatcgaaag aaagtcacag aggtaattaa atgtcgtaat gagatcatgc
      541 actcttcaga gatgaaagta tcttctacgt ggcttcgaga ttttcagatg aagatccaaa
      601 attttctgaa tgaattcaag aacatcccag agattgtggc agtatactcc agaatagaac
      661 agctgttgac gtctgactgg gctgttcaca tccccgagga agatcagcga gatgggtgtg
      721 aatgtgaaat gggaacttac ctgagtgaga gccaagtcaa tgaaatagaa atgcagttac
      781 taaaggagaa acttcaagag atatatcttc aagcagaaga acaagaggtg ttgcctgaag
      841 agctctcaaa tcgactggaa gtggtgaagg aatttctgag aaacaatgag gatcttagaa
      901 atggccttac agaagatatg cagaagctag acagcctctg tctacatcaa aaactggatt
      961 cacaggaacc tgggagacaa acacctgaca ggaaggcctg aggttgcccg tcaacaaaaa
     1021 tcaggcatgt tctgtgaaag tcagcatggc ttccatctca gacatccttt tctgtgcaaa
     1081 aggaaaaagt taccagagta ttgtacccaa acaaaaagga atttttgttg ttttgtcctg
     1141 gactttcctc taactctttg gaactatttt aatatttata aacttggggt tgtataatct
     1201 attgcaataa aaaatattag atactctatg ccaaaacttg ctaccaggcc aggtgtgatg
     1261 gctcacacct gtaatcccca gcactttggg aggccaaggc gggcggatca cctgaggtca
     1321 ggagttcgag accagcctgg ccaacatggc gaaaccccat ctctacttaa aaaaaaatac
     1381 aaatattagc cgggcgtggt ggcatgtgcc tgtaatccca gctactcggg aggctgaggc
     1441 aggagaatcg cttgaacctg ggaggcagag gttgcagtga gctgagacca tgccactgta
     1501 ctccagcctg ggcaatagag cgagattctg tctcccaaaa aaacaaaaaa caacaacaaa
     1561 acttgctacc acccagggat tttctgctat ttaaaaggtg aatttctttt ctggtactaa
     1621 actgtagctg cttaacttag taaaggctgt gtttggccag gcctgtgcca gaggctcacc
     1681 tggagtgctc cacccactgg caggcaagtc ctattcctat tcacccagga tccccaaggc
     1741 tgggctggga tataaatgtt gggataggaa agaaatattt cctttttaga ggaaagcaag
     1801 aagaaacatt gcctgaaagg tgattttcta gtcatttcca attagtacag aaatgttact
     1861 gcctctgggt gcagtggttc acgcctgtaa tcccagcact gtgggcggat cacttgagcc
     1921 caggagtttg agaccaacct gggcaagatg gcgagacccc atctctacaa aaaaatttaa
     1981 aaattacctg ggcatggtgg cacacacctt tattctcagc tactcaggtg gctgaggtgg
     2041 gaggatccct tgagcccagg tggtcaaggc tgtggtgagc tatgatcatg ccactgcact
     2101 ccagcctggg tagcagaaca agaccctgtc tcaaaaaaaa aaaaacccca aaaactgtta
     2161 ctactaggtt ggagtagcct aaggcagtag ggcaaggagg tgggcccagg ctggtctgtg
     2221 gggagctgga gaatggtgac tcgagtgacc agtggacagg caggacccag gccagcatta
     2281 caagcgggga tgtcaggcag gagcagggga gcttctcgct tggcagctgg tttatggtac
     2341 acttttgaaa agtaagctcc cagggcctgg ccctcacatg ctcagtgaat atttgactga
     2401 agggtcccct catagcttgg gagtattcac aggcctaaat gttagttata ctattagcta
     2461 agcctggtcc tttgttacga aatttaaaaa tgaaattgca acattcttgt ggaaattcaa
     2521 agacatcatt ttctttcaac aaattcacac attcgttcat gcttcttcta taccttttac
     2581 ccctaaagtc atccactcct gagttcctcc tgctggtttc ccaaactgcg caatgactgc
     2641 cccatcatag gcagtggtcc gtggagtcgg cctcactttc gcctttcccc gcatctactt
     2701 gtttccaagg ccagtggtac ttaactgggt caagttgcct gtggaccttc aggaacagaa
     2761 ttgccatgtt cctcactgcc tgcaggaaag gctccattcc aagcccagtg aagatgtgtg
     2821 cctatccagc cgcccaccaa ggatgtcatc tgtagaatgg gtggagggca ggggtttatt
     2881 tggtgtatat ttttacatta aaatgcactt aatatcactt tgtaaagccc agatgagtgc
     2941 aaatgtgcct gtaacttcct cctttaatct gtccaggtag tatttagtct ttagtcttac
     3001 attttctttc tccctttatt tcatgaaatt ccttgagaaa acttcaacag taaagaaaga
     3061 aatttcattc atctcacaac tcttccaaac gaggaaactt agtgaaatat ttcagagctt
     3121 ctagatgtga ggtacaaaac ttgggatcaa atggaatctt gattcactaa ccaatttaag
     3181 atctgacttc taattttagg aactttgggt tatgaacgct tccattttat acctgtgtct
     3241 agttagtttc tgcctatcta tccaagaagc ttttatcaag ggtccaccat gtgccagcca
     3301 ctgaagtaga tataaataca aggatgtgta aggtatggat gatggtatac gaactgtcat
     3361 cttactggat ttgtccgctc tgttaaagat acggttccga aaacttttta aagccctaga
     3421 gagggcttta aggcaatgta gcatcatata tagaggcatc aacctgttca tatctttcta
     3481 tttaacagaa ctgtgcacct gggcacaagg gtgtgcacaa caggatgtgt acagcagcac
     3541 tgttaaagtg tagcacatcc atactacagg atcttatgca actgttggaa agaatgaagc
     3601 gatgctgcac tgtggtcatg cagtgatctc taagacatat taactagaaa gcaaaaggtt
     3661 taacaatgta tagcagctgg gcgcagtgac tcgcgcctgt aatcccagca ctttgggagg
     3721 ctgagtaggg cggatcacct gaggtcagga gtttgagacc aacctggcca atgtggcgaa
     3781 acgctgtctc tactaaaact acaaaaatta gctgggcgtg gtggcgcgtg cctgtaatcc
     3841 cagctactcg gcaggctgag gcaggagaat cgcttgaact ggggaggtgg aggttgcagt
     3901 gagccgagat cacaccactg cattccagcc tgggtgacag agggagactc cgtctctaaa
     3961 aaacaacccc ccccccccaa aaaaaaaaat gcatagcaag ctgtaatgct ctttgtgttt
     4021 tagaatagta gaggtctgga aagttgtttg cttttcccca gttttttttt gctgtgttac
     4081 ctctgaaggg aattgaggta gaggggagag ttagaaggaa tattcggctt ttctatttta
     4141 tatcctccta ggtgaaattt ttacaacaaa catgtactgg tgtattttga aatgttttta
     4201 aatttttgta tttcaaaata ataaaatata aattcaaact gcaa
//
